High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS

Authors: Mohamed Ismail, Gareth Davies, Graham Sproat, Tiziana Monteverde, Jonathan Tart, Marta Acebrón-García-de-Eulate, Andrea Gohlke, David Hancock, Santosh Adhikari, Sandra Stefanovic-Barrett, David M Smith, Vikki Flemington, Emma S. Gleave-Hanford, Geoffrey A. Holdgate, Jason G. Kettle, Julian Downward

Source: SLAS Discovery, Vol 29, Iss 8, Pp 100197- (2024)

Subject Terms: PI 3-kinase, KRAS, NanoBiT assay, Drug discovery, Assay development, High throughput screening, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555224000595; https://doaj.org/toc/2472-5552

Access URL: https://doaj.org/article/ce753bb5efca48b380631a1a108578b9

A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models.

Authors: Dharaminder Singh, Sudhir P Deosarkar, Elaine Cadogan, Vikki Flemington, Alysha Bray, Jingwen Zhang, Ronald S Reiserer, David K Schaffer, Gregory B Gerken, Clayton M Britt, Erik M Werner, Francis D Gibbons, Tomasz Kostrzewski, Christopher E Chambers, Emma J Davies, Antonio Ramos Montoya, Jacqueline H L Fok, David Hughes, Kristin Fabre, Matthew P Wagoner, John P Wikswo, Clay W Scott

Source: PLoS Biology, Vol 20, Iss 5, p e3001624 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/55008e3ff350462b806cde78444e0ef3

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

Authors: Matthew J. Sale, Emma Minihane, Noel R. Monks, Rebecca Gilley, Frances M. Richards, Kevin P. Schifferli, Courtney L. Andersen, Emma J. Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R. Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I. Jodrell, Paul D. Smith, Simon J. Cook

Source: Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/03dfbb8e162440b8bfec0b14545e606c

I'm hiking the length of New Zealand on honeymoon

Authors: Vikki Flemington

Source: Times, The (United Kingdom). 02/24/2024, p55-55. 1.

Structure-Guided Design ofHighly Selective and PotentCovalent Inhibitors of ERK1/2.

Authors: Richard A. Ward, Nicola Colclough, Mairi Challinor, JuditE. Debreczeni, Kay Eckersley, Gary Fairley, Lyman Feron, Vikki Flemington, Mark A. Graham, Ryan Greenwood, Philip Hopcroft, Tina D. Howard, Michael James, Clifford D. Jones, Christopher R. Jones, Jonathan Renshaw, Karen Roberts, Lindsay Snow, Michael Tonge, Kay Yeung

Source: Journal of Medicinal Chemistry; Jun2015, Vol. 58 Issue 11, p4790-4801, 12p