GPNMB expression identifies TSC1/2/mTOR‐associated and MiT family translocation‐driven renal neoplasms

Authors: Salles, Daniela C, Asrani, Kaushal, Woo, Juhyung, Vidotto, Thiago, Liu, Hans B, Vidal, Igor, Matoso, Andres, Netto, George J, Argani, Pedram, Lotan, Tamara L

Source: Journal of pathology. 257(2):158-171

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Assessment of MYC/PTEN Status by Gene-Protein Assay in Grade Group 2 Prostate Biopsies

Authors: Salles, Daniela C., Vidotto, Thiago, Faisal, Farzana A., Tosoian, Jeffrey J., Guedes, Liana B., Muranyi, Andrea, Bai, Isaac, Singh, Shalini, Yan, Dongyao, Shanmugam, Kandavel, Lotan, Tamara L.

Source: In The Journal of Molecular Diagnostics August 2021 23(8):1030-1041

Sexual Dimorphism in Outcomes of Non–muscle-invasive Bladder Cancer: A Role of CD163+ Macrophages, B cells, and PD-L1 Immune Checkpoint

Authors: Chenard, Stephen, Jackson, Chelsea, Vidotto, Thiago, Chen, Lina, Hardy, Céline, Jamaspishvilli, Tamara, Berman, David, Siemens, D. Robert, Koti, Madhuri ^⁎

Source: In European Urology Open Science July 2021 29:50-58

High throughput assessment of biomarkers in tissue microarrays using artificial intelligence: PTEN loss as a proof-of-principle in multi-center prostate cancer cohorts

Authors: Harmon, Stephanie A., Patel, Palak G., Sanford, Thomas H., Caven, Isabelle, Iseman, Rachael, Vidotto, Thiago, Picanço, Clarissa, Squire, Jeremy A., Masoudi, Samira, Mehralivand, Sherif, Choyke, Peter L., Berman, David M., Turkbey, Baris, Jamaspishvili, Tamara

Source: In Modern Pathology February 2021 34(2):478-489

Reciprocal YAP1 loss and INSM1 expression in neuroendocrine prostate cancer

Authors: Asrani, Kaushal, Torres, Alba FC, Woo, Juhyung, Vidotto, Thiago, Tsai, Harrison K, Luo, Jun, Corey, Eva, Hanratty, Brian, Coleman, Ilsa, Yegnasubramanian, Srinivasan, De Marzo, Angelo M, Nelson, Peter S, Haffner, Michael C, Lotan, Tamara L

Source: Journal of pathology. 255(4):425-437

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Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis

Authors: Sakita, Juliana Y, Bader, Michael, Santos, Emerson S, Garcia, Sergio B, Minto, Stefania B, Alenina, Natalia, Brunaldi, Mariângela O, Carvalho, Milene C, Vidotto, Thiago, Gasparotto, Bianca, Martins, Ronaldo B, Silva, Wilson A, Brandão, Marcus L, Leite, Caio A, Cunha, Fernando Q, Karsenty, Gerard, Squire, Jeremy A, Uyemura, Sergio A, Kannen, Vinicius

Source: Journal of pathology. 249(1):102-113

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122966020.0x000001&indx=1&recIds=ETOCvdc_100122966020.0x000001

DNA damage repair gene mutations and their association with tumor immune regulatory gene expression in muscle invasive bladder cancer subtypes

Authors: Vidotto, Thiago, Nersesian, Sarah, Graham, Charles, Siemens, D., Koti, Madhuri

Source: Journal for immunotherapy of cancer. 7(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190706291.0x000001&indx=1&recIds=ETOCvdc_100190706291.0x000001

PTEN‐deficient prostate cancer is associated with an immunosuppressive tumor microenvironment mediated by increased expression of IDO1 and infiltrating FoxP3+ T regulatory cells

Authors: Vidotto, Thiago, Saggioro, Fabiano P., Jamaspishvili, Tamara, Chesca, Deise L., Picanço de Albuquerque, Clarissa G., Reis, Rodolfo B., Graham, Charles H., Berman, David M., Siemens, D. Robert, Squire, Jeremy A., Koti, Madhuri

Source: Prostate. 79(9):969-979

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Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer

Authors: Vidotto, Thiago, Tiezzi, Daniel, Squire, Jeremy

Source: Molecular cytogenetics. 11(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161107615.0x000001&indx=1&recIds=ETOCvdc_100161107615.0x000001

Increased STAT1 Expression in High Grade Serous Ovarian Cancer Is Associated With a Better Outcome

Authors: Josahkian, Juliana A., Saggioro, Fabiano Pinto, Vidotto, Thiago, Ventura, Henrique Torres, Candido dos Reis, Francisco José, de Sousa, Christiani Bisinoto, Tiezzi, Daniel Guimarães, de Andrade, Jurandyr Moreira, Koti, Madhuri, Squire, Jeremy A.

Source: International journal of gynecological cancer. 28(3):459-465

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100055622626.0x000001&indx=1&recIds=ETOCvdc_100055622626.0x000001

Deep learning (DL) algorithms to predict prostate cancer progression on low/intermediate-risk needle core biopsies.

Authors: Ding, Chien-Kuang Cornelia, Vidotto, Thiago, Erak, Eric, De Paula Oliveira, Lia, Bonthu, Saikiran, Kondragunta, Chaith, Joshi, Uttara, Singhal, Nitin, De Marzo, Angelo M, Lotan, Tamara L.

Source: Journal of Clinical Oncology; 2024 Supplement 4, Vol. 42, p335-335, 97p

PD27-11 COMPARISON OF PROSTATE BIOPSY GRADE OBTAINED BY HUMAN PATHOLOGISTS VERSUS AN ARTIFICIAL INTELLIGENCE ALGORITHM FOR PREDICTING BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY

Authors: Calle, Claire de la, Vidotto, Thiago, Erak, Eric, Salles, Daniela, Dairo, Oluwademilade, Pavlovich, Christian, Han, Misop, Cho, Joonyoung, Suh, In Hye, Chang, Hye Yoon, Kim, Sun Woo, Gorin, Michael, Lotan, Tamara

Source: Journal of urology. 209(4):e746-e746

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190188770.0x000001&indx=1&recIds=ETOCvdc_100190188770.0x000001

An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss.

Authors: Asrani, Kaushal, Woo, Juhyung, Mendes, Adrianna A., Schaffer, Ethan, Vidotto, Thiago, Villanueva, Clarence Rachel, Feng, Kewen, Oliveira, Lia, Murali, Sanjana, Liu, Hans B., Salles, Daniela C., Lam, Brandon, Argani, Pedram, Lotan, Tamara L.

Source: Nature Communications; 11/10/2022, Vol. 13 Issue 1, p1-15, 15p

Subject Terms: TRANSCRIPTION factors, LYSOSOMES, GROWTH factors, AMINO acids, RAPAMYCIN, ESTRONE

Transcriptional landscape of PTEN loss in primary prostate cancer.

Authors: Imada, Eddie Luidy, Sanchez, Diego Fernando, Dinalankara, Wikum, Vidotto, Thiago, Ebot, Ericka M., Tyekucheva, Svitlana, Franco, Gloria Regina, Mucci, Lorelei Ann, Loda, Massimo, Schaeffer, Edward Matthew, Lotan, Tamara, Marchionni, Luigi

Source: BMC Cancer; 7/26/2021, Vol. 21 Issue 1, p1-13, 13p

Subject Terms: NON-coding RNA, PROSTATE cancer, GENETIC regulation, IMMUNE system, IMMUNOHISTOCHEMISTRY

Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes.

Authors: Weiner, Adam B., Vidotto, Thiago, Liu, Yang, Mendes, Adrianna A., Salles, Daniela C., Faisal, Farzana A., Murali, Sanjana, McFarlane, Matthew, Imada, Eddie L., Zhao, Xin, Li, Ziwen, Davicioni, Elai, Marchionni, Luigi, Chinnaiyan, Arul M., Freedland, Stephen J., Spratt, Daniel E., Wu, Jennifer D., Lotan, Tamara L., Schaeffer, Edward M.

Source: Nature Communications; 2/10/2021, Vol. 12 Issue 1, p1-10, 10p

Subject Terms: PLASMA cells, BLACK men, PROSTATE cancer, GENE expression profiling, WHITE men, EXOCRINE glands

Risk Stratification of Prostate Cancer Through Quantitative Assessment of PTEN Loss (qPTEN).

Authors: Jamaspishvili, Tamara, Patel, Palak G, Niu, Yi, Vidotto, Thiago, Caven, Isabelle, Livergant, Rachel, Fu, Winnie, Kawashima, Atsunari, How, Nathan, Okello, John B, Guedes, Liana B, Ouellet, Veronique, Picanço, Clarissa, Koti, Madhuri, Reis, Rodolfo B, Saad, Fred, Mes-Masson, Anne-Marie, Lotan, Tamara L, Squire, Jeremy A, Peng, Yingwei P

Source: JNCI: Journal of the National Cancer Institute; Nov2020, Vol. 112 Issue 11, p1098-1104, 7p

Subject Terms: PROSTATE cancer, LOG-rank test, GLEASON grading system, PROSTATECTOMY, DISEASE management, CANCER cells, RISK assessment, RESEARCH, IMMUNOHISTOCHEMISTRY, RESEARCH methodology, PHOSPHATASES, RETROSPECTIVE studies, PROGNOSIS, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, KAPLAN-Meier estimator, RESEARCH funding, PROSTATE tumors, LONGITUDINAL method, PROPORTIONAL hazards models

Emerging role of PTEN loss in evasion of the immune response to tumours.

Authors: Vidotto, Thiago¹ (AUTHOR), Melo, Camila Morais¹ (AUTHOR), Castelli, Erick² (AUTHOR), Koti, Madhuri^3,4 (AUTHOR), dos Reis, Rodolfo Borges⁵ (AUTHOR), Squire, Jeremy A.^1,6 (AUTHOR) jsquireinsp@gmail.com

Source: British Journal of Cancer. Jun2020, Vol. 122 Issue 12, p1732-1743. 12p. 3 Diagrams, 3 Charts.

Subject Terms: *GENETIC mutation, *ANIMAL experimentation, *PHOSPHATASES, *RESEARCH funding, *TUMORS, *IMMUNOTHERAPY

The Role of Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer.

Authors: Melo, Camila Morais¹ (AUTHOR) camila.morais.melo@gmail.com, Vidotto, Thiago¹ (AUTHOR) thiagovidotto@gmail.com, Chaves, Luiz Paulo¹ (AUTHOR) luizpaulocds@usp.br, Lautert-Dutra, William¹ (AUTHOR) williamlautert@usp.br, Reis, Rodolfo Borges dos² (AUTHOR) rodolforeis@fmrp.usp.br, Squire, Jeremy Andrew^1,3 (AUTHOR) squirej@fmrp.usp.br

Source: International Journal of Molecular Sciences. Sep2021, Vol. 22 Issue 17, p9550. 1p.

Subject Terms: *GENETIC mutation, *SOMATIC mutation, *TUMOR microenvironment, *PROSTATE cancer, *IMMUNE response, *PROSTATE tumors

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Investigating the STING Pathway to Explain Mechanisms of BCG Failures in Non-Muscle Invasive Bladder Cancer: Prognostic and Therapeutic Implications

Authors: Koti, Madhuri, Chenard, Stephen, Nersesian, Sarah, Vidotto, Thiago, Morales, Alvaro, Siemens, D. Robert

Source: Bladder Cancer; November 2019, Vol. 5 Issue: 3 p225-234, 10p