Specific activity of mouse liver desaturases and elongases: Time course effects using n-3 and n-6 PUFA substrates and inhibitory responses of delta-6 desaturase

Authors: Valenzuela, Rodrigo ^{a, b, ⁎}, Metherel, Adam H. ^b, Cisbani, Giulia ^b, Smith, Mackenzie E. ^b, Chouinard-Watkins, Raphaël ^b, Klievik, Brinley J. ^b, Farias, Camila ^b, Videla, Luis A. ^c, Bazinet, Richard P. ^b

Source: In BBA - Molecular and Cell Biology of Lipids March 2025 1870(2)

Modulation of Δ5- and Δ6-desaturases in the brain-liver axis

Authors: Zúñiga-Hernández, Jessica ^a, Farias, Camila ^b, Espinosa, Alejandra ^{c, d}, Mercado, Lorena ^{b, e}, Dagnino-Subiabre, Alexies ^f, Campo, Andrea del ^g, Illesca, Paola ^{h, i}, Videla, Luis A. ^j, Valenzuela, Rodrigo ^{b, ⁎}

Source: In Nutrition March 2025 131

Cellular Functional, Protective or Damaging Responses Associated with Different Redox Imbalance Intensities: A Comprehensive Review

Authors: del Campo, Andrea, Valenzuela, Rodrigo, Videla, Luis Alberto, Zúñiga-Hernandez, Jessica

Source: Current medicinal chemistry. 30(34):3927-3939

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186303246.0x000001&indx=1&recIds=ETOCvdc_100186303246.0x000001

Standpoints in mitochondrial dysfunction: Underlying mechanisms in search of therapeutic strategies

Authors: Videla, Luis A., Marimán, Andrea, Ramos, Bastián, José Silva, María, del Campo, Andrea

Source: MITOCHONDRION -AMSTERDAM. 63:9-22

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171319675.0x000001&indx=1&recIds=ETOCvdc_100171319675.0x000001

Beneficial Effects of Dietary Polyphenols in the Prevention and Treatmentof NAFLD: Cell-Signaling Pathways Underlying Health Effects

Authors: Echeverría, Francisca, Bustamante, Andrés, Sambra, Verónica, Álvarez, Daniela, Videla, Luis, Valenzuela, Rodrigo

Source: Current medicinal chemistry. 29(2):299-328

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140374189.0x000001&indx=1&recIds=ETOCvdc_100140374189.0x000001

Perspectives in liver redox imbalance: Toxicological and pharmacological aspects underlying iron overloading, nonalcoholic fatty liver disease, and thyroid hormone action

Authors: Videla, Luis A., Valenzuela, Rodrigo

Source: BioFactors. 48(2):400-415

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149780721.0x000001&indx=1&recIds=ETOCvdc_100149780721.0x000001

N-3 PUFAs and their specialized pro-resolving lipid mediators on airway inflammatory response: beneficial effects in the prevention and treatment of respiratory diseases

Authors: Zúñiga-Hernández, Jessica, Sambra, Verónica, Echeverría, Francisca, Videla, Luis A., Valenzuela, Rodrigo

Source: Food & function. 13(8):4260-4272

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149413847.0x000001&indx=1&recIds=ETOCvdc_100149413847.0x000001

Influence of the nutritional status and oxidative stress in the desaturation and elongation of n-3 and n-6 polyunsaturated fatty acids: Impact on non-alcoholic fatty liver disease

Authors: Videla, Luis A., Hernandez-Rodas, Maria Catalina, Metherel, Adam H., Valenzuela, Rodrigo

Source: In Prostaglandins, Leukotrienes and Essential Fatty Acids June 2022 181

Omega-3 Lipid Mediators: Modulation of the M1/M2 Macrophage Phenotype and Its Protective Role in Chronic Liver Diseases.

Authors: Videla, Luis Alberto¹ (AUTHOR) lvidela1944@gmail.com, Valenzuela, Rodrigo² (AUTHOR) rvalenzuelab@uchile.cl, Del Campo, Andrea³ (AUTHOR) andreadelcamposfeir@gmail.com, Zúñiga-Hernández, Jessica⁴ (AUTHOR) jezuniga@utalca.cl

Source: International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 21, p15528. 17p.

Subject Terms: *PHAGOCYTOSIS, *LIVER diseases, *OMEGA-3 fatty acids, *NON-alcoholic fatty liver disease, *MACROPHAGES, *EICOSAPENTAENOIC acid, *LIPIDS

Beneficial effects of natural compounds on experimental liver ischemia-reperfusion injury

Authors: Dossi, Camila G., Vargas, Romina G., Valenzuela, Rodrigo, Videla, Luis A.

Source: Food & function. 12(9):3787-3798

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120384391.0x000001&indx=1&recIds=ETOCvdc_100120384391.0x000001

Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration

Authors: Ortiz, Macarena, Soto-Alarcón, Sandra A., Orellana, Paula, Espinosa, Alejandra, Campos, Cristian, López-Arana, Sandra, Rincón, Miguel A., Illesca, Paola, Valenzuela, Rodrigo, Videla, Luis A.

Source: In Digestive and Liver Disease August 2020 52(8):895-904

Iron-induced derangement in hepatic Δ-5 and Δ-6 desaturation capacity and fatty acid profile leading to steatosis: Impact on extrahepatic tissues and prevention by antioxidant-rich extra virgin olive oil

Authors: Barrera, Cynthia, Valenzuela, Rodrigo, Rincón, Miguel A., Espinosa, Alejandra, López-Arana, Sandra, González-Mañan, Daniel, Romero, Nalda, Vargas, Romina, Videla, Luis A.

Source: In Prostaglandins, Leukotrienes and Essential Fatty Acids February 2020 153

The metabolic dysfunction of white adipose tissue induced in mice by a high-fat diet is abrogated by co-administration of docosahexaenoic acid and hydroxytyrosol

Authors: Illesca, Paola, Valenzuela, Rodrigo, Espinosa, Alejandra, Echeverría, Francisca, Soto-Alarcón, Sandra, Ortiz, Macarena, Campos, Cristian, Vargas, Romina, Videla, Luis A.

Source: Food & function. 11(10):9086-9102

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110408961.0x000001&indx=1&recIds=ETOCvdc_100110408961.0x000001

Targeting n-3 Polyunsaturated Fatty Acids in Non-Alcoholic Fatty Liver Disease

Authors: Valenzuela, Rodrigo, Ortiz, Macarena, Hernández-Rodas, María Catalina, Echeverría, Francisca, Videla, Luis Alberto

Source: Current medicinal chemistry. 27(31):5250-5272

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100109405543.0x000001&indx=1&recIds=ETOCvdc_100109405543.0x000001

Combined administration of docosahexaenoic acid and thyroid hormone synergistically enhances rat liver levels of resolvins RvD1 and RvD2

Authors: Videla, Luis A., Vargas, Romina, Valenzuela, Rodrigo, Muñoz, Patricio, Corbari, Alicia, Hernandez-Rodas, María C.

Source: In Prostaglandins, Leukotrienes and Essential Fatty Acids January 2019 140:42-46

Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB

Authors: Illesca, Paola, Valenzuela, Rodrigo, Espinosa, Alejandra, Echeverría, Francisca, Soto-Alarcon, Sandra, Ortiz, Macarena, Videla, Luis A.

Source: In Biomedicine & Pharmacotherapy January 2019 109:2472-2481

Molecular mechanisms related to the hepatoprotective effects of antioxidant-rich extra virgin olive oil supplementation in rats subjected to short-term iron administration

Authors: Barrera, Cynthia, Valenzuela, Rodrigo, Rincón, Miguel Ángel, Espinosa, Alejandra, Echeverria, Francisca, Romero, Nalda, Gonzalez-Mañan, Daniel, Videla, Luis A.

Source: In Free Radical Biology and Medicine October 2018 126:313-321

Crosstalk mechanisms in hepatoprotection: Thyroid hormone-docosahexaenoic acid (DHA) and DHA-extra virgin olive oil combined protocols

Authors: Valenzuela, Rodrigo, Videla, Luis A.

Source: In Pharmacological Research June 2018 132:168-175

Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues

Authors: Valenzuela, Rodrigo, Rincón-Cervera, Miguel Ángel, Echeverría, Francisca, Barrera, Cynthia, Espinosa, Alejandra, Hernández-Rodas, María Catalina, Ortiz, Macarena, Valenzuela, Alfonso, Videla, Luis A.

Source: In Nutrition January 2018 45:49-58

High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administrationElectronic supplementary information (ESI) available. See DOI: 10.1039/c9fo01373c

Authors: Echeverría, Francisca, Valenzuela, Rodrigo, Bustamante, Andrés, Álvarez, Daniela, Ortiz, Macarena, Espinosa, Alejandra, Illesca, Paola, Gonzalez-Mañan, Daniel, Videla, Luis A.

Source: Food & function. 10(9):6170-6183

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100088811072.0x000001&indx=1&recIds=ETOCvdc_100088811072.0x000001