Sustained antiviral response against in vitro HIV-1 infection in peripheral blood mononuclear cells from people with chronic myeloid leukemia treated with ponatinib

Authors: Mario Manzanares, Fernando Ramos-Martín, Sara Rodríguez-Mora, Guiomar Casado-Fernández, Clara Sánchez-Menéndez, Alicia Simón-Rueda, Elena Mateos, Miguel Cervero, Adam M. Spivak, Vicente Planelles, Montserrat Torres, Valentín García-Gutiérrez, Mayte Coiras

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: HIV-1, ponatinib, cytotoxic immunity, antiviral response, chronic myeloid leukemia, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1426974/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/9854eb1f037746858c873d3668929237

The HIV-1 vpr R77Q Mutant Induces Apoptosis, G2 Cell Cycle Arrest, and Lower Production of Pro-Inflammatory Cytokines in Human CD4+ T Cells

Authors: Antonio Solis-Leal, Dalton C. Karlinsey, Sidney T. Sithole, Jack Brandon Lopez, Amanda Carlson, Vicente Planelles, Brian D. Poole, Bradford K. Berges

Source: Viruses, Vol 16, Iss 10, p 1642 (2024)

Subject Terms: HIV, AIDS, vpr, apoptosis, necrosis, inflammation, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/10/1642; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/81f1dcbbe6704fa3a7c9abb435451295

Reduced monocyte proportions and responsiveness in convalescent COVID-19 patients

Authors: Eugene V. Ravkov, Elizabeth S. C. P. Williams, Marc Elgort, Adam P. Barker, Vicente Planelles, Adam M. Spivak, Julio C. Delgado, Leo Lin, Timothy M. Hanley

Source: Frontiers in Immunology, Vol 14 (2024)

Subject Terms: monocytes, COVID-19, SARS-CoV-2, tissue factor, TNF-α, IL-6 69, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1329026/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c52ac4d8929e452ab412db6de5ac603e

HIV-1 provirus transcription and translation in macrophages differs from pre-integrated cDNA complexes and requires E2F transcriptional programs

Authors: Albebson L. Lim, Philip Moos, Christopher D. Pond, Erica C. Larson, Laura J. Martins, Matthew A. Szaniawski, Vicente Planelles, Louis R. Barrows

Source: Virulence, Vol 13, Iss 1, Pp 386-413 (2022)

Subject Terms: hiv-1, macrophages, single cell rna sequencing, infection, pre-integrated cdna complex transcription, provirus transcription, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/2150-5594; https://doaj.org/toc/2150-5608

Access URL: https://doaj.org/article/d117a10300674c17bc372d36e1db60f3

ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis

Authors: Nora-Guadalupe P. Ramirez, Jeon Lee, Yue Zheng, Lianbo Li, Bryce Dennis, Didi Chen, Ashwini Challa, Vicente Planelles, Kenneth D. Westover, Neal M. Alto, Iván D’Orso

Source: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/533a78919ec24b05aadddaaaa2df40d0

A rapid and affordable point of care test for antibodies against SARS-CoV-2 based on hemagglutination and artificial intelligence interpretation

Authors: Vanessa Redecke, Kazuki Tawaratsumida, Erin T. Larragoite, Elizabeth S. C. P. Williams, Vicente Planelles, Adam M. Spivak, Lincoln Hirayama, Marc Elgort, Shane Swenson, Rick Smith, Bryan Worthen, Russ Zimmerman, Patricia Slev, Ben Cahoon, Mark Astill, Hans Häcker

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/1655f619167244489c5e59a7785e3869

Broadly active zinc finger protein-guided transcriptional activation of HIV-1

Authors: Tristan A. Scott, Denis O’Meally, Nicole Anne Grepo, Citradewi Soemardy, Daniel C. Lazar, Yue Zheng, Marc S. Weinberg, Vicente Planelles, Kevin V. Morris

Source: Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 18-29 (2021)

Subject Terms: HIV-1, transcription, zinc finger protein, ZFN-362-VPR, activation, latency, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050120302229; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/1f554cb5e02940e1a1a103dbbd42a73a

Neutralization assay with SARS-CoV-1 and SARS-CoV-2 spike pseudotyped murine leukemia virions

Authors: Yue Zheng, Erin T. Larragoite, Elizabeth S. C. P. Williams, Juan Lama, Isabel Cisneros, Julio C. Delgado, Patricia Slev, Jenna Rychert, Emily A. Innis, Mayte Coiras, Matthew T. Rondina, Adam M. Spivak, Vicente Planelles

Source: Virology Journal, Vol 18, Iss 1, Pp 1-6 (2021)

Subject Terms: COVID-19, Coronavirus, SARS, SARS-CoV-2, Neutralization assay, Pseudotyped virus, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1743-422X

Access URL: https://doaj.org/article/23bf90048a4649b098183e1247d1a8c6

The landscape of alternative splicing in HIV-1 infected CD4 T-cells

Authors: Seyoun Byun, Seonggyun Han, Yue Zheng, Vicente Planelles, Younghee Lee

Source: BMC Medical Genomics, Vol 13, Iss S5, Pp 1-10 (2020)

Subject Terms: Alternative splicing, CCNT1, HIV-1, CD46, CD4 T-cell, Internal medicine, RC31-1245, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12920-020-0680-7; https://doaj.org/toc/1755-8794

Access URL: https://doaj.org/article/497542e115914c6688313705964e7506

Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers

Authors: Miguel Galán, Lorena Vigón, Daniel Fuertes, María Aránzazu Murciano-Antón, Guiomar Casado-Fernández, Susana Domínguez-Mateos, Elena Mateos, Fernando Ramos-Martín, Vicente Planelles, Montserrat Torres, Sara Rodríguez-Mora, María Rosa López-Huertas, Mayte Coiras

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: Long-COVID, cytotoxic immune response, immune exhaustion, CD8+ T cells, NK cells, Random Forest algorithm, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.848886/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/891cb4db0f1a4db881b5d1dea54e275e

Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort.

Authors: Lorena Vigón, Miguel Galán, Montserrat Torres, Antonio J Martín-Galiano, Sara Rodríguez-Mora, Elena Mateos, Magdalena Corona, Rosa Malo, Cristina Navarro, María Aránzazu Murciano-Antón, Valentín García-Gutiérrez, Vicente Planelles, Jorge Martínez-Laso, María Rosa López-Huertas, Mayte Coiras, Multidisciplinary Group of Study of COVID-19 (MGS-COVID)

Source: PLoS ONE, Vol 17, Iss 8, p e0272867 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a6e79f2f7bf54d219aca5dd06710b817

Interferon α-induced SAMHD1 regulates human cultured megakaryocyte apoptosis and proplatelet formation

Authors: Seema Bhatlekar, Shancy Jacob, Emilia Tugolukova, Bhanu K. Manne, Yasuhiro Kosaka, Phillipe Loher, Ryan M. O’Connell, Vicente Planelles, Matthew T. Rondina, Isidore Rigoutsos, Paul F. Bray

Source: Haematologica, Vol 107, Iss 2 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10448; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/776c2e22372247eb9d8d925e4c500b13

Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity

Authors: Emily Cruz-Lorenzo, Nora-Guadalupe P. Ramirez, Jeon Lee, Sonali Pandhe, Lei Wang, Juan Hernandez-Doria, Adam M. Spivak, Vicente Planelles, Tianna Petersen, Mamta K. Jain, Elisabeth D. Martinez, Iván D’Orso

Source: Viruses, Vol 14, Iss 10, p 2288 (2022)

Subject Terms: HIV-1, transcription factors, cell signaling, latency, reactivation, latency reversing agents, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/14/10/2288; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/c7a4d40bbedc40dd9dbcbd1dc2a1f3a3

Impaired Antibody-Dependent Cellular Cytotoxicity in a Spanish Cohort of Patients With COVID-19 Admitted to the ICU

Authors: Lorena Vigón, Javier García-Pérez, Sara Rodríguez-Mora, Montserrat Torres, Elena Mateos, María Castillo de la Osa, Miguel Cervero, Rosa Malo De Molina, Cristina Navarro, María Aránzazu Murciano-Antón, Valentín García-Gutiérrez, Vicente Planelles, José Alcamí, Mayte Pérez-Olmeda, Mayte Coiras, María Rosa López-Huertas

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: COVID-19 severity, SARS-CoV-2 neutralizing antibodies, humoral response, antibody-dependent cellular cytotoxicity (ADCC), CMV reactivation, EBV reactivation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.742631/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/182dfa925ac14f30b6cadc556ce86d6e

Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS

Authors: Indra Sarabia, Camille L. Novis, Amanda B. Macedo, Hiroshi Takata, Racheal Nell, Juyeon C. Kakazu, Robert L. Furler, Binita Shakya, Heidi L. Schubert, Christopher P. Hill, Ana Beatriz DePaula-Silva, Adam M. Spivak, Lydie Trautmann, Vicente Planelles, Alberto Bosque

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: Dynasore, HIV-1, shock and kill, latency, latency-reversal agents, MAVS, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.682182/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/2d9d89e2d68d41a7894a9b45ae46dc68

Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal

Authors: Yue Zheng, Heidi L. Schubert, Parmit K. Singh, Laura J. Martins, Alan N. Engelman, Iván D’Orso, Christopher P. Hill, Vicente Planelles

Source: mBio, Vol 12, Iss 3 (2021)

Subject Terms: Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/d7c36d3d4feb42ee994b4fd477199f64

Impaired Cytotoxic Response in PBMCs From Patients With COVID-19 Admitted to the ICU: Biomarkers to Predict Disease Severity

Authors: Lorena Vigón, Daniel Fuertes, Javier García-Pérez, Montserrat Torres, Sara Rodríguez-Mora, Elena Mateos, Magdalena Corona, Adolfo J. Saez-Marín, Rosa Malo, Cristina Navarro, María Aranzazu Murciano-Antón, Miguel Cervero, José Alcamí, Valentín García-Gutiérrez, Vicente Planelles, María Rosa López-Huertas, Mayte Coiras

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: SARS-CoV-2, COVID-19, cytotoxic response, NK and NKT cells, CD8 lymphocytes +, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.665329/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ae1f410a65c9480d984cb999f484bf76

Pharmacological Activation of Non-canonical NF-κB Signaling Activates Latent HIV-1 Reservoirs In Vivo

Authors: Lars Pache, Matthew D. Marsden, Peter Teriete, Alex J. Portillo, Dominik Heimann, Jocelyn T. Kim, Mohamed S.A. Soliman, Melanie Dimapasoc, Camille Carmona, Maria Celeridad, Adam M. Spivak, Vicente Planelles, Nicholas D.P. Cosford, Jerome A. Zack, Sumit K. Chanda

Source: Cell Reports Medicine, Vol 1, Iss 3, Pp 100037- (2020)

Subject Terms: HIV, latency, Smac mimetics, latency reversal agents, LRA, non-canonical NF-κB, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379120300495; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/844b2284d4654ae7b526e217e79fb151

HIV-1 Accessory Proteins Impart a Modest Interferon Response and Upregulate Cell Cycle-Related Genes in Macrophages

Authors: Laura J. Martins, Matthew A. Szaniawski, Elizabeth S. C. P. Williams, Mayte Coiras, Timothy M. Hanley, Vicente Planelles

Source: Pathogens, Vol 11, Iss 2, p 163 (2022)

Subject Terms: HIV-1, interferon, cell cycle, innate immune, transcriptome, accessory proteins, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-0817/11/2/163; https://doaj.org/toc/2076-0817

Access URL: https://doaj.org/article/3d842d7222654701b250f160f66930eb

CD4 T cells from patients with chronic myeloid leukemia are resistant to HIV-1 proviral integration and transcription after prolonged withdrawal of treatment with tyrosine kinase inhibitors

Authors: Lorena Vigón, Sara Rodríguez-Mora, Elena Mateos, Valentín García, Juan Ambrosioni, Nuria Climent, Guiomar Bautista, José Alcamí, Juan Luis Steegmann, Montserrat Plana, José M. Miró, Vicente Planelles, María Rosa López Huertas, Mayte Coiras

Source: Journal of Virus Eradication, Vol 5, Iss , Pp 53- (2019)

Subject Terms: Microbiology, QR1-502, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2055664020302144; https://doaj.org/toc/2055-6640

Access URL: https://doaj.org/article/87afa0e299bc4dc2a08967af5f2f9447