782 TransCon TLR7/8 agonist induces sustained local and systemic immune activation in patients with solid tumors

Authors: David Bajor, Nashat Gabrail, Alain Algazi, Diwakar Davar, Douglas Laux, Morteza Aghmesheh, Joan Morris, Vinod Ganju, Vibeke Miller Breinholt, Mette Kriegbaum, Alexander I Spira, Christian Krapp, Telma Lança, Stina Singel, Thomas Tuxen Poulsen

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/69f075075b164ef298aa8033a3763d55

Intratumoral delivery of TransCon™ TLR7/8 Agonist promotes sustained anti-tumor activity and local immune cell activation while minimizing systemic cytokine induction

Authors: Luis Alejandro Zúñiga, Torben Leßmann, Karan Uppal, Nicola Bisek, Enping Hong, Caroline E. Rasmussen, Jens-Jakob Karlsson, Joachim Zettler, Lars Holten-Andersen, Kathy Bang, Dhruv Thakar, Yu-Chi Lee, Salomon Martinez, Simran Singh Sabharwal, Sebastian Stark, Frank Faltinger, Oliver Kracker, Samuel Weisbrod, Robin Müller, Tobias Voigt, Kornelia Bigott, Mohammad Tabrizifard, Vibeke Miller Breinholt, Amer M. Mirza, David B. Rosen, Kennett Sprogøe, Juha Punnonen

Source: Cancer Cell International, Vol 22, Iss 1, Pp 1-17 (2022)

Subject Terms: Toll-like receptor, Tumor microenvironment, Innate immunity, Adaptive immunity, Intratumoral treatment, Intratumoral injection, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/9c07ff8778c14891ac4c75977cba6fba

TransCon IL-2 β/γ: a novel long-acting prodrug with sustained release of an IL-2Rβ/γ-selective IL-2 variant with improved pharmacokinetics and potent activation of cytotoxic immune cells for the treatment of cancer

Authors: Anne Månsson Kvarnhammar, Juha Punnonen, Enping Hong, Diana Reich, Karan Uppal, Kathy Bang, David B Rosen, Burkhardt Laufer, Thomas Knappe, Jens Jakob Karlsson, Yu-Chi Lee, Dhruv Thakar, Luis Alejandro Zúñiga, Simran Singh Sabharwal, Janne Damm Olling, Kristian Kjaergaard, Thomas Kurpiers, Meike Schnabel, Philipp Glock, Joachim Zettler, Mathias Krusch, Ana Bernhard, Stefan Heinig, Valentino Konjik, Thomas Wegge, Yvonne Hehn, Steffen Killian, Laura Viet, Josefine Runz, Frank Faltinger, Mohammad Tabrizi, Kristin Laura Abel, Vibeke Miller Breinholt, Stina M Singel, Kennett Sprogøe

Source: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/10/7/e004991.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/c5975468cd0f4febb405f737118e732f