The CHIP-clinic as the catalyst of preventive medicine

Authors: Hans Carl Hasselbalch, Vibe Skov, Lasse Kjaer, Trine Alma Knudsen, Christina Schjellerup Eickhardt-Dalbøge, Christina Ellervik, Sabrina Cordua, Anders Lindholm Sørensen, Sarah Friis Christensen, Marie Hvelplund Kristiansen, Jes Sanddal Lindholt, Mads Thomassen, Torben A. Kruse, Niels Eske Bruun, Matias Greve Lindholm, Claus Henrik Nielsen, Miklos Egyed, Winfried März, Morten Kranker Larsen, Troels Wienecke

Source: Frontiers in Hematology, Vol 3 (2024)

Subject Terms: JAK2V617F mutation, cardiovascular disease, stroke, myeloproliferative neoplasms (MPNs), CHIP-clinic, preventative medicine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/frhem.2024.1459154/full; https://doaj.org/toc/2813-3935

Access URL: https://doaj.org/article/b05ed2c1e5ac413eba6f1e617b161752

Neutrophil-to-lymphocyte ratio and all-cause mortality with and without myeloproliferative neoplasms—a Danish longitudinal study

Authors: Morten Kranker Larsen, Vibe Skov, Lasse Kjær, Christina Schjellerup Eickhardt-Dalbøge, Trine Alma Knudsen, Marie Hvelplund Kristiansen, Anders Lindholm Sørensen, Troels Wienecke, Morten Andersen, Johnny T. Ottesen, Johanne Gudmand-Høyer, Jordan Andrew Snyder, Mikkel Porsborg Andersen, Christian Torp-Pedersen, Henrik Enghusen Poulsen, Thomas Stiehl, Hans Carl Hasselbalch, Christina Ellervik

Source: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5385

Access URL: https://doaj.org/article/46ca4a43de774498aff8a1da1a776787

Mathematical modelling of stem and progenitor cell dynamics during ruxolitinib treatment of patients with myeloproliferative neoplasms

Authors: Tobias Idor Boklund, Jordan Snyder, Johanne Gudmand-Hoeyer, Morten Kranker Larsen, Trine Alma Knudsen, Christina Schjellerup Eickhardt-Dalbøge, Vibe Skov, Lasse Kjær, Hans C. Hasselbalch, Morten Andersen, Johnny T. Ottesen, Thomas Stiehl

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: mathematical modelling, ordinary differential equations, myeloproliferative neoplasms (MPN), parameter estimation, JAK2 V617F, ruxolitinib, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1384509/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/d2e7c2148e984299bb4c140c1200e5d0

Serum levels of IL-4, IL-13 and IL-33 in patients with age-related macular degeneration and myeloproliferative neoplasms

Authors: Kathrine Gotfredsen, Charlotte Liisborg, Vibe Skov, Lasse Kjær, Hans Carl Hasselbalch, Torben Lykke Sørensen

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/7748d9ed607e46248c6404734dc8220f

A novel integrated biomarker index for the assessment of hematological responses in MPNs during treatment with hydroxyurea and interferon‐alpha2

Authors: Marc J. B. Dam, Rasmus K. Pedersen, Trine A. Knudsen, Morten Andersen, Christina Ellervik, Morten Kranker Larsen, Lasse Kjær, Vibe Skov, Hans C. Hasselbalch, Johnny T. Ottesen

Source: Cancer Medicine, Vol 12, Iss 4, Pp 4218-4226 (2023)

Subject Terms: combination therapy, essential thrombocythemia, hydroxyurea, interferon‐alpha2, MPN, myelofibrosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/6d18381c628347d29d0da1bb87b5aa11

1138 TGFβ-specific T cells recognize megakaryocyte progenitors in patients with myeloproliferative neoplasms

Authors: Vibe Skov, Lasse Kjær, Hans Hasselbalch, Mads Andersen, Morten Orebo Holmström, Maria Perez Penco, Thomas Lisle, Josephine Hallundbæk Ruders, Jacob Handlos Grauslund

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/1fc7a6af3a214a96a3bcd8b2bf7dd201

Pronounced gut microbiota signatures in patients with JAK2V617F-positive essential thrombocythemia

Authors: Christina Schjellerup Eickhardt-Dalbøge, Anna Cäcilia Ingham, Henrik V. Nielsen, Kurt Fuursted, Christen Rune Stensvold, Lee O'Brien Andersen, Morten Kranker Larsen, Lasse Kjær, Sarah Friis Christensen, Trine Alma Knudsen, Vibe Skov, Christina Ellervik, Lars Rønn Olsen, Hans Carl Hasselbalch, Jens Jørgen Elmer Christensen, Xiaohui Chen Nielsen

Source: Microbiology Spectrum, Vol 11, Iss 5 (2023)

Subject Terms: gut microbiota, gut microbiome, essential thrombocythemia, myeloproliferative neoplasms, ET, polycythemia vera, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2165-0497

Access URL: https://doaj.org/article/b3609417a5e84dac83bf1109859a4035

Therapeutic cancer vaccination against mutant calreticulin in myeloproliferative neoplasms induces expansion of specific T cells in the periphery but specific T cells fail to enrich in the bone marrow

Authors: Morten Orebo Holmström, Morten Andersen, Sofie Traynor, Shamaila Munir Ahmad, Thomas Landkildehus Lisle, Jacob Handlos Grauslund, Vibe Skov, Lasse Kjær, Johnny T. Ottesen, Morten Frier Gjerstorff, Hans Carl Hasselbalch, Mads Hald Andersen

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: myeloproliferative neoplasms, calreticulin, cancer vaccines, immune escape, adaptive immunity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1240678/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ea1a4e7fa4a849529a58c4ed8bd4131d

Case Report: First longitudinal study of a patient with CALR positive clonal hematopoiesis of indeterminate potential developing into pre-fibrotic myelofibrosis

Authors: Lasse Kjær, Vibe Skov, Morten Kranker Larsen, Tobias Idor Boklund, Morten Andersen, Maria Kefala, Trine A. Knudsen, Christina Schjellerup Eickhardt-Dalbøge, Thomas Stiehl, Johanne Gudmand-Høyer, Jordan Snyder, Morten Holmström, Mads H. Andersen, Johnny T. Ottesen, Christina Ellervik, Hans C. Hasselbalch

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: case report, MPN, CALR, clonal hematopoiesis, myelofibrosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1176173/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/ee792f216b2a41bf8a7c41cd3ed8d0cd

An arginase1- and PD-L1-derived peptide-based vaccine for myeloproliferative neoplasms: A first-in-man clinical trial

Authors: Jacob Handlos Grauslund, Morten Orebo Holmström, Evelina Martinenaite, Thomas Landkildehus Lisle, Hannah Jorinde Glöckner, Daniel El Fassi, Uffe Klausen, Rasmus E. J. Mortensen, Nicolai Jørgensen, Lasse Kjær, Vibe Skov, Inge Marie Svane, Hans Carl Hasselbalch, Mads Hald Andersen

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: myeloproliferative neoplasms, cancer immune therapy, arginase-1, PD-L1, immune modulatory vaccines, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1117466/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5bb1896ca9234691adc0750d751600e6

Corrigendum: Patients with myeloproliferative neoplasms harbor high frequencies of CD8 T cell-platelet aggregates associated with T cell suppression

Authors: Ana Micaela Carnaz Simões, Morten Orebo Holmström, Pia Aehnlich, Anne Rahbech, Marlies J. W. Peeters, Aneta Radziwon-Balicka, Carlos Zamora, Tobias Wirenfeldt Klausen, Vibe Skov, Lasse Kjær, Christina Ellervik, Daniel El Fassi, Silvia Vidal, Hans Carl Hasselbalch, Mads Hald Andersen, Per thor Straten

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: platelets, platelet-bound T cells, platelet-T cell aggregates, Myeloproliferative Neoplasms (MPN), CALR mutation, JAK2 mutation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.970322/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/593b961b919e482caa28a6ae47f86f5f

Dynamics of competing heterogeneous clones in blood cancers explains multiple observations - a mathematical modeling approach

Authors: Katrine O. Bangsgaard, Morten Andersen, Vibe Skov, Lasse Kjær, Hans C. Hasselbalch, Johnny T. Ottesen

Source: Mathematical Biosciences and Engineering, Vol 17, Iss 6, Pp 7645-7670 (2020)

Subject Terms: hematopoiesis, blood cancer, mathematical modeling, stem cell dynamics, competition dynamics, inflammation, Biotechnology, TP248.13-248.65, Mathematics, QA1-939

File Description: electronic resource

Relation: https://doaj.org/toc/1551-0018

Access URL: https://doaj.org/article/cc35487e572b4add9d1c02985a112f10

Myeloproliferative blood cancers as a human neuroinflammation model for development of Alzheimer’s disease: evidences and perspectives

Authors: Hans C. Hasselbalch, Vibe Skov, Lasse Kjær, Torben L. Sørensen, Christina Ellervik, Troels Wienecke

Source: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-13 (2020)

Subject Terms: Alzheimer’s disease, Myeloproliferative neoplasms, Essential thrombocythemia, Polycythemia vera, Myelofibrosis, Blood cancer mutations, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-020-01877-3; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/5507c948fdcf4ec591250bf03bc8cc03

Patients With Myeloproliferative Neoplasms Harbor High Frequencies of CD8 T Cell-Platelet Aggregates Associated With T Cell Suppression

Authors: Ana Micaela Carnaz Simões, Morten Orebo Holmström, Pia Aehnlich, Anne Rahbech, Marlies J. W. Peeters, Aneta Radziwon-Balicka, Carlos Zamora, Tobias Wirenfeldt Klausen, Vibe Skov, Lasse Kjær, Christina Ellervik, Daniel El Fassi, Silvia Vidal, Hans Carl Hasselbalch, Mads Hald Andersen, Per thor Straten

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: platelets, platelet-bound T cells, platelet-T cell aggregates, Myeloproliferative Neoplasms (MPN), CALR mutation, JAK2 mutation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.866610/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4d831d41a2bb43238209bbff284b2564

Patients with MPNs and retinal drusen show signs of complement system dysregulation and a high degree of chronic low-grade inflammation

Authors: Charlotte Liisborg, Vibe Skov, Lasse Kjær, Hans Carl Hasselbalch, Torben Lykke Sørensen

Source: EClinicalMedicine, Vol 43, Iss , Pp 101248- (2022)

Subject Terms: Myeloproliferative neoplasms, “Human inflammation model”, Biological continuum, Age-related macular degeneration, Chronic low-grade inflammation, Complement dysregulation, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537021005290; https://doaj.org/toc/2589-5370

Access URL: https://doaj.org/article/b5e15a84c2a5409691d4a96b7441b473

Lower CXCR3 expression in both patients with neovascular AMD and advanced stages of chronic myeloproliferative blood cancers

Authors: Charlotte Liisborg, Vibe Skov, Lasse Kjær, Hans Carl Hasselbalch, Torben Lykke Sørensen

Source: PLoS ONE, Vol 17, Iss 6 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202899/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/446f44e8d8af483db6b0b0b0dfd4bec7

Lower CXCR3 expression in both patients with neovascular AMD and advanced stages of chronic myeloproliferative blood cancers.

Authors: Charlotte Liisborg, Vibe Skov, Lasse Kjær, Hans Carl Hasselbalch, Torben Lykke Sørensen

Source: PLoS ONE, Vol 17, Iss 6, p e0269960 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/16b8d39ae0f843599f2bab48deba1aa9

Interferon-alpha2 treatment of patients with polycythemia vera and related neoplasms favorably impacts deregulation of oxidative stress genes and antioxidative defense mechanisms.

Authors: Vibe Skov, Mads Thomassen, Lasse Kjær, Christina Ellervik, Morten Kranker Larsen, Trine Alma Knudsen, Torben A Kruse, Hans C Hasselbalch

Source: PLoS ONE, Vol 17, Iss 6, p e0270669 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/aceab8411aa04d0da74a523ba9142672

Dose‐dependent mathematical modeling of interferon‐α‐treatment for personalized treatment of myeloproliferative neoplasms

Authors: Rasmus K. Pedersen, Morten Andersen, Trine A. Knudsen, Vibe Skov, Lasse Kjær, Hans C. Hasselbalch, Johnny T. Ottesen

Source: Computational and Systems Oncology, Vol 1, Iss 4, Pp n/a-n/a (2021)

Subject Terms: interferon, mathematical modeling, myeloproliferative neoplasms, personalized treatment, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: https://doaj.org/toc/2689-9655

Access URL: https://doaj.org/article/9f8b8cb17edf4ff18f6229b3819ecb2f

Data‐driven analysis of JAK2V617F kinetics during interferon‐alpha2 treatment of patients with polycythemia vera and related neoplasms

Authors: Rasmus K. Pedersen, Morten Andersen, Trine A. Knudsen, Zamra Sajid, Johanne Gudmand‐Hoeyer, Marc J. B. Dam, Vibe Skov, Lasse Kjær, Christina Ellervik, Thomas S. Larsen, Dennis Hansen, Niels Pallisgaard, Hans C. Hasselbalch, Johnny T. Ottesen

Source: Cancer Medicine, Vol 9, Iss 6, Pp 2039-2051 (2020)

Subject Terms: early treatment, essential thrombocythemia, interferon‐alpha2, JAK2V617F kinetics, myeloproliferative neoplasms, polycythemia vera, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/131ca176f70243be969c1f07922ecf78