Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

Authors: Zhang, Si Min ^{1, ∗}, Paulin, Cynthia B.J. ^{1, 4}, Shu, Huazhang ¹, Yagüe-Capilla, Miriam ¹, Michel, Maurice ¹, Marttila, Petra ¹, Ortis, Florian ¹, Bwanika, Henri Colyn ¹, Dirks, Christopher ¹, Venkatram, Rajagopal Papagudi ^{1, 5}, Wiita, Elisée ¹, Jemth, Ann-Sofie ¹, Almlöf, Ingrid ¹, Loseva, Olga ¹, Hormann, Femke M. ¹, Koolmeister, Tobias ¹, Linde, Erika ^{1, 6}, Lee, Sun ^{1, 7}, Llona-Minguez, Sabin ^{1, 8}, Haraldsson, Martin ², Axelsson, Hanna ², Strömberg, Kia ^{1, 9}, Homan, Evert J. ¹, Scobie, Martin ¹, Lundbäck, Thomas ^{2, 10}, Helleday, Thomas ^{1, 3}, Rudd, Sean G. ^{1, 11, ∗∗}

Source: In iScience 16 February 2024 27(2)