Activity of tarloxotinib‐E in cells with EGFR exon‐20 insertion mutations and mechanisms of acquired resistance

Authors: Nishino, Masaya, Suda, Kenichi, Koga, Takamasa, Ohara, Shuta, Fujino, Toshio, Soh, Junichi, Tirunagaru, Vijaya, Vellanki, Avanish, Doebele, Robert C., Mitsudomi, Tetsuya

Source: Thoracic cancer. 12(10):1511-1516

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120687246.0x000001&indx=1&recIds=ETOCvdc_100120687246.0x000001

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Inhibition of c-Myc By Apto-253 As an Innovative Therapeutic Approach to Induce Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukemia

Authors: Zhang, Hongying ^*, Local, Andrea ^*, Benbatoul, Khalid ^*, Folger, Peter ^*, Sheng, Susan ^*, Esquivies, Luis ^*, Lightfoot, Jeff ^*, Vellanki, Avanish ^*, Rice, William G.

Source: In Blood 2 December 2016 128(22):1716-1716

Clinical Pharmacokinetics of Apto-253 Support Its Use As a Novel Agent for the Treatment of Relapsed or Refractory Hematologic Malignancies

Authors: Rice, William G., Lightfoot, Jeff ^*, Zhang, Hongying ^*, Cheng, Tiffany ^*, Vellanki, Avanish ^*, Peralta, Robert ^*, Howell, Stephen B ^*, Local, Andrea ^*, Chau, Fannie ^*, Esquivies, Luis ^*

Source: In Blood 3 December 2015 126(23):4934-4934

Broad Activity of Apto-253 in AML and Other Hematologic Malignancies Correlates with KLF4 Expression Level

Authors: Kurtz, Stephen E. ^*, Bottomly, Daniel ^*, Wilmot, Beth ^*, McWeeney, Shannon K. ^*, Rice, William ^*, Howell, Stephen B ^*, Vellanki, Avanish ^*, Druker, Brian J., Tyner, Jeffrey W.

Source: In Blood 3 December 2015 126(23):1358-1358

APTO-253 Induces KLF4 to Promote Potent in Vitro Pro-Apoptotic Activity in Hematologic Cancer Cell Lines and Antitumor Efficacy As a Single Agent and in Combination with Azacitidine in Animal Models of Acute Myelogenous Leukemia (AML)

Authors: Rice, William G ^*, Vellanki, Avanish ^*, Lee, Yoon ^*, Lightfoot, Jeff ^*, Peralta, Robert ^*, Jamerlan, Mona ^*, Jin, Hongnan ^*, Lum, Ronnie ^*, Cheng, Tiffany ^*

Source: In Blood 6 December 2014 124(21):4813-4813

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