Thiomorpholino oligonucleotides as a robust class of next generation platforms for alternate mRNA splicing

Authors: Le, Bao T., Paul, Sibasish, Jastrzebska, Katarzyna, Langer, Heera, Caruthers, Marvin H., Veedu, Rakesh N.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Sep 01. 119(36), 1-8.

Access URL: https://www.jstor.org/stable/27206953

Nanoparticles-assisted aptamer biosensing for the detection of environmental pathogens

Authors: Rahimizadeh, Kamal ^{a, b, 1}, Zahra, Qurat ul ain ^{a, 1}, Chen, Suxiang ^{a, b}, Le, Bao T. ^{a, b}, Ullah, Ismat ^c, Veedu, Rakesh N. ^{a, b, ∗}

Source: In Environmental Research 1 December 2023 238 Part 1

DNAzymes: Expanding the Potential of Nucleic Acid Therapeutics

Authors: Larcher, Leon M., Pitout, Ianthe L., Keegan, Niall P., Veedu, Rakesh N., Fletcher, Sue

Source: Nucleic acid therapeutics. 33(3):178-192

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184624781.0x000001&indx=1&recIds=ETOCvdc_100184624781.0x000001

Oligonucleotides containing 2′-O-methyl-5-(1-phenyl-1,2,3-triazol-4-yl)uridines demonstrate increased affinity for RNA and induce exon-skipping in vitro

Authors: Gimenez Molina, Alejandro, Raguraman, Prithi, Delcomyn, Line, Veedu, Rakesh N., Nielsen, Poul

Source: In Bioorganic & Medicinal Chemistry 1 February 2022 55

Novel 3′-[4-fluoroaryl-(1, 2, 3-triazol-1-yl)]-3′-deoxythymidine analogues: Design, synthesis, characterization and their potential as anticancer agents

Authors: Kumar, Ritik, Wang, Tao, Veedu, Rakesh N, Kumar, Surender

Source: Nucleosides, nucleotides & nucleic acids. 41(4):343-360

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153589257.0x000001&indx=1&recIds=ETOCvdc_100153589257.0x000001

Phosphorothioate modification improves exon-skipping of antisense oligonucleotides based on sulfonyl phosphoramidates in mdx mouse myotubesElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2ob00304j

Authors: Su, Yongdong, Raguraman, Prithi, Veedu, Rakesh N., Filichev, Vyacheslav V.

Source: Organic & biomolecular chemistry. 20(18):3790-3797

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149707389.0x000001&indx=1&recIds=ETOCvdc_100149707389.0x000001

Evaluation of DNA segments in 2′-modified RNA sequences in designing efficient splice switching antisense oligonucleotidesElectronic supplementary information (ESI) available: Tm curves, EC50 data and MS and HPLC analysis data of the ASOs. See DOI: 10.1039/d1ra00878a

Authors: Le, Bao T., Agarwal, Sudhir, Veedu, Rakesh N.

Source: RSC advances. 11(23):14029-14035

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100122621634.0x000001&indx=1&recIds=ETOCvdc_100122621634.0x000001

How to Develop and Prove High-Efficiency Selection of Ligands from Oligonucleotide Libraries: A Universal Framework for Aptamers and DNA-Encoded Small-Molecule Ligands

Authors: Le, An T. H., Krylova, Svetlana M., Beloborodov, Stanislav S., Wang, Tong Y., Hili, Ryan, Johnson, Philip E., Li, Feng, Veedu, Rakesh N., Belyanskaya, Svetlana, Krylov, Sergey N.

Source: Analytical chemistry. 93(13):5343-5354

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626218800&indx=1&recIds=ETOCRN626218800

Antisense Oligonucleotides as Potential Therapeutics for Type 2 Diabetes

Authors: Chen, Suxiang, Sbuh, Nabayet, Veedu, Rakesh N.

Source: Nucleic acid therapeutics. 31(1):39-57

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153501265.0x000001&indx=1&recIds=ETOCvdc_100153501265.0x000001

Antisense Oligonucleotide Modified with Disulfide Units Induces Efficient Exon Skipping in mdx Myotubes through Enhanced Membrane Permeability and Nucleus Internalization

Authors: Hiraoka, Haruka, Shu, Zhaoma, Tri Le, Bao, Masuda, Keiko, Nakamoto, Kosuke, Fangjie, Lyu, Abe, Naoko, Hashiya, Fumitaka, Kimura, Yasuaki, Shimizu, Yoshihiro, Veedu, Rakesh N., Abe, Hiroshi

Source: Chembiochem. 22(24):3437-3442

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100148312221.0x000001&indx=1&recIds=ETOCvdc_100148312221.0x000001

Development of a Novel DNA Oligonucleotide Targeting Low-Density Lipoprotein Receptor

Authors: Wang, Tao, Rahimizadeh, Kamal, Veedu, Rakesh N.

Source: In Molecular Therapy - Nucleic Acids 6 March 2020 19:190-198

A systematic investigation of key factors of nucleic acid precipitation toward optimized DNA/RNA isolation

Authors: Li, Yalin, Chen, Suxiang, Liu, Nan, Ma, Lixia, Wang, Tao, Veedu, Rakesh N, Li, Tao, Zhang, Fengqiu, Zhou, Huiyue, Cheng, Xiang, Jing, Xumiao

Source: Biotechniques. 68(4):191-199

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186566674.0x000001&indx=1&recIds=ETOCvdc_100186566674.0x000001

Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer Therapeutics

Authors: Le, Bao T., Raguraman, Prithi, Kosbar, Tamer R., Fletcher, Susan, Wilton, Steve D., Veedu, Rakesh N.

Source: In Molecular Therapy - Nucleic Acids 1 March 2019 14:142-157

Rational Design of Short Locked Nucleic Acid-Modified 2′-O-Methyl Antisense Oligonucleotides for Efficient Exon-Skipping In Vitro

Authors: Le, Bao T., Adams, Abbie M., Fletcher, Susan, Wilton, Stephen D., Veedu, Rakesh N.

Source: In Molecular Therapy - Nucleic Acids 15 December 2017 9:155-161

Rational Design of Chimeric Antisense Oligonucleotides on a Mixed PO–PS Backbone for Splice-Switching Applications.

Authors: Le, Bao T., Chen, Suxiang, Veedu, Rakesh N.

Source: Biomolecules (2218-273X); Jul2024, Vol. 14 Issue 7, p883, 10p

Subject Terms: RIBONUCLEASE H, BASE pairs, GENE expression, CELL nuclei, OLIGONUCLEOTIDE synthesis

Inhibition of survivin by 2'-O-methyl phosphorothioate-modified steric-blocking antisense oligonucleotides.

Authors: Yalin Li, Suxiang Chen, Rahimizadeh, Kamal, Zhen Zhang, Veedu, Rakesh N.

Source: RSC Advances; 2024, Vol. 14 Issue 19, p13336-13341, 6p

Oligonucleotides containing 2′-O-methyl-5-(1-phenyl-1, 2, 3-triazol-4-yl)uridines demonstrate increased affinity for RNA and induce exon-skipping in vitro

Authors: Gimenez Molina, Alejandro, Raguraman, Prithi, Delcomyn, Line, Veedu, Rakesh N., Nielsen, Poul

Source: Bioorganic & medicinal chemistry. 55

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152870983.0x000001&indx=1&recIds=ETOCvdc_100152870983.0x000001

Splice-Modulating Antisense Oligonucleotides as Therapeutics for Inherited Metabolic Diseases.

Authors: Chen, Suxiang, Heendeniya, Saumya Nishanga, Le, Bao T., Rahimizadeh, Kamal, Rabiee, Navid, Zahra, Qurat ul ain, Veedu, Rakesh N.

Source: BioDrugs; Mar2024, Vol. 38 Issue 2, p177-203, 27p

Subject Terms: GENETIC disorders, INBORN errors of metabolism, OLIGONUCLEOTIDES, THERAPEUTICS, INVESTIGATIONAL drugs, METABOLIC disorders

Company/Entity: UNITED States. Food & Drug Administration

Metallic nanostructure-based aptasensors for robust detection of proteins.

Authors: Rabiee, Navid, Ahmadi, Sepideh, Rahimizadeh, Kamal, Suxiang Chena, Veedu, Rakesh N.

Source: Nanoscale Advances; 2/7/2024, Vol. 6 Issue 3, p747-776, 30p

Smart functional nucleic acid chimeras: Enabling tissue specific RNA targeting therapy

Authors: Aaldering, Lukas J, Tayeb, Hossam, Krishnan, Shilpa, Fletcher, Susan, Wilton, Stephen D, Veedu, Rakesh N

Source: RNA biology. 12(4):412-425

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100029010192.0x000001&indx=1&recIds=ETOCETOCvdc_100029010192.0x000001