Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase

Authors: Zhou, Jujun, Deng, Youchao, Iyamu, Iredia D., Horton, John R., Yu, Dan, Hajian, Taraneh, Vedadi, Masoud, Rotili, Dante, Mai, Antonello, Blumenthal, Robert M.

Source: ACS chemical biology. 18(4):734-745

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Design and synthesis of naturally-inspired SARS-CoV-2 inhibitorsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2md00149g

Authors: Hassan, Haitham, Chiavaralli, Jeanne, Hassan, Afnan, Bedda, Loay, Krischuns, Tim, Chen, Kuang-Yu, Li, Alice Shi Ming, Delpal, Adrien, Decroly, Etienne, Vedadi, Masoud, Naffakh, Nadia, Agou, Fabrice, Mallart, Sergio, Arafa, Reem K., Arimondo, Paola B.

Source: RSC medicinal chemistry. 14(3):507-519

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178445334.0x000001&indx=1&recIds=ETOCvdc_100178445334.0x000001

Development of selective class I protein arginine methyltransferase inhibitors through fragment-based drug design approach

Authors: Bhattacharya, Debomita, Shi Ming Li, Alice, Paul, Barnali, Ghosh Dastidar, Uddipta, Santhakumar, Vijayaratnam, Sarkar, Dipika, Chau, Irene, Li, Fengling, Ghosh, Trisha, Vedadi, Masoud, Talukdar, Arindam

Source: In European Journal of Medicinal Chemistry 15 November 2023 260

Histone H4K20 monomethylation enables recombinant nucleosome methylation by PRMT1 in vitro

Authors: Li, Alice Shi Ming, Homsi, Charles, Bonneil, Eric, Thibault, Pierre, Verreault, Alain, Vedadi, Masoud

Source: In BBA - Gene Regulatory Mechanisms June 2023 1866(2)

SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses

Authors: Li, Fengling ^{a, 1}, Ghiabi, Pegah ^{a, 1}, Hajian, Taraneh ^{a, b}, Klima, Martin ^c, Li, Alice Shi Ming ^{b, d}, Khalili Yazdi, Aliakbar ^a, Chau, Irene ^a, Loppnau, Peter ^a, Kutera, Maria ^a, Seitova, Almagul ^a, Bolotokova, Albina ^a, Hutchinson, Ashley ^a, Perveen, Sumera ^a, Boura, Evzen ^c, Vedadi, Masoud ^{a, b, d, e, ⁎}

Source: In BBA - General Subjects April 2023 1867(4)

Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library

Authors: Shell, Devan J., Rectenwald, Justin M., Buttery, Peter H., Johnson, Rebecca L., Foley, Caroline A., Guduru, Shiva K.R., Uguen, Mélanie, Rubiano, Juanita Sanchez, Zhang, Xindi, Li, Fengling, Norris-Drouin, Jacqueline L., Axtman, Matthew, Brian Hardy, P., Vedadi, Masoud, Frye, Stephen V., James, Lindsey I., Pearce, Kenneth H.

Source: In SLAS Discovery December 2022 27(8):428-439

Target 2035 – update on the quest for a probe for every protein

Authors: Müller, Susanne, Ackloo, Suzanne, Al Chawaf, Arij, Al-Lazikani, Bissan, Antolin, Albert, Baell, Jonathan B., Beck, Hartmut, Beedie, Shaunna, Betz, Ulrich A. K., Bezerra, Gustavo Arruda, Brennan, Paul E., Brown, David, Brown, Peter J., Bullock, Alex N., Carter, Adrian J., Chaikuad, Apirat, Chaineau, Mathilde, Ciulli, Alessio, Collins, Ian, Dreher, Jan, Drewry, David, Edfeldt, Kristina, Edwards, Aled M., Egner, Ursula, Frye, Stephen V., Fuchs, Stephen M., Hall, Matthew D., Hartung, Ingo V., Hillisch, Alexander, Hitchcock, Stephen H., Homan, Evert, Kannan, Natarajan, Kiefer, James R., Knapp, Stefan, Kostic, Milka, Kubicek, Stefan, Leach, Andrew R., Lindemann, Sven, Marsden, Brian D., Matsui, Hisanori, Meier, Jordan L., Merk, Daniel, Michel, Maurice, Morgan, Maxwell R., Mueller-Fahrnow, Anke, Owen, Dafydd R., Perry, Benjamin G., Rosenberg, Saul H., Saikatendu, Kumar Singh, Schapira, Matthieu, Scholten, Cora, Sharma, Sujata, Simeonov, Anton, Sundström, Michael, Superti-Furga, Giulio, Todd, Matthew H., Tredup, Claudia, Vedadi, Masoud, von Delft, Frank, Willson, Timothy M., Winter, Georg E., Workman, Paul, Arrowsmith, Cheryl H.

Source: RSC medicinal chemistry. 13(1):13-21

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140079916.0x000001&indx=1&recIds=ETOCvdc_100140079916.0x000001

Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro

Authors: Trush, Viacheslav V., Feller, Christian, Li, Alice Shi Ming, Allali-Hassani, Abdellah, Szewczyk, Magdalena M., Chau, Irene, Eram, Mohammad S., Jiang, Boya, Luu, Raymond, Zhang, Fangfei, Barsyte-Lovejoy, Dalia, Aebersold, Ruedi, Arrowsmith, Cheryl H., Vedadi, Masoud

Source: In BBA - Gene Regulatory Mechanisms July 2022 1865(5)

A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells

Authors: Xu, Chenxi, Meng, Fanye, Park, Kwang-Su, Storey, Aaron J., Gong, Weida, Tsai, Yi-Hsuan, Gibson, Elisa, Byrum, Stephanie D., Li, Dongxu, Edmondson, Rick D., Mackintosh, Samuel G., Vedadi, Masoud, Cai, Ling, Tackett, Alan J., Kaniskan, H. Ümit, Jin, Jian, Wang, Gang Greg

Source: In Cell Chemical Biology 17 March 2022 29(3):386-397

Chemical Genetics Screen Identifies COPB2 Tool Compounds That Alters ER Stress Response and Induces RTK Dysregulation in Lung Cancer Cells

Authors: Saraon, Punit, Snider, Jamie, Schormann, Wiebke, Rai, Ankit, Radulovich, Nikolina, Sánchez-Osuna, Maria, Coulombe-Huntington, Jasmin, Huard, Caroline, Mohammed, Mohammed, Lima-Fernandes, Evelyne, Thériault, Brigitte, Halabelian, Levon, Chan, Manuel, Joshi, Dhananjay, Drecun, Luka, Yao, Zhong, Pathmanathan, Shivanthy, Wong, Victoria, Lyakisheva, Anna, Aboualizadeh, Farzaneh, Niu, Li, Li, Fengling, Kiyota, Taira, Subramanian, Ratheesh, Joseph, Babu, Aman, Ahmed, Prakesch, Michael, Isaac, Methvin, Mamai, Ahmed, Poda, Gennady, Vedadi, Masoud, Marcellus, Richard, Uehling, David, Leighl, Natasha, Sacher, Adrian, Samaržija, Miroslav, Jakopović, Marko, Arrowsmith, Cheryl, Tyers, Mike, Tsao, Ming-Sound, Andrews, David, Al-awar, Rima, Stagljar, Igor

Source: In Journal of Molecular Biology 19 November 2021 433(23)

Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors

Authors: Devkota, Kanchan, Schapira, Matthieu, Perveen, Sumera, Khalili Yazdi, Aliakbar, Li, Fengling, Chau, Irene, Ghiabi, Pegah, Hajian, Taraneh, Loppnau, Peter, Bolotokova, Albina, Satchell, Karla J.F., Wang, Ke, Li, Deyao, Liu, Jing, Smil, David, Luo, Minkui, Jin, Jian, Fish, Paul V., Brown, Peter J., Vedadi, Masoud ^*

Source: In SLAS Discovery October 2021 26(9):1200-1211

Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening

Authors: Gradl, Stefan ^*, Steuber, Holger, Weiske, Joerg, Szewczyk, Magda M., Schmees, Norbert, Siegel, Stephan, Stoeckigt, Detlef, Christ, Clara D., Li, Fengling, Organ, Shawna, Abbey, Megha, Kennedy, Steven, Chau, Irene, Trush, Viacheslav, Barsyte-Lovejoy, Dalia, Brown, Peter J., Vedadi, Masoud, Arrowsmith, Cheryl, Husemann, Manfred, Badock, Volker, Bauser, Marcus, Haegebarth, Andrea, Hartung, Ingo V., Stresemann, Carlo ^**

Source: In SLAS Discovery September 2021 26(8):947-960

A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex

Authors: Khalili Yazdi, Aliakbar, Li, Fengling, Devkota, Kanchan, Perveen, Sumera, Ghiabi, Pegah, Hajian, Taraneh, Bolotokova, Albina, Vedadi, Masoud ^*

Source: In SLAS Discovery July 2021 26(6):757-765

A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19

Authors: Perveen, Sumera, Khalili Yazdi, Aliakbar, Devkota, Kanchan, Li, Fengling, Ghiabi, Pegah, Hajian, Taraneh, Loppnau, Peter, Bolotokova, Albina, Vedadi, Masoud ^*

Source: In SLAS Discovery June 2021 26(5):620-627

A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex

Authors: Yazdi, Aliakbar Khalili, Li, Fengling, Devkota, Kanchan, Perveen, Sumera, Ghiabi, Pegah, Hajian, Taraneh, Bolotokova, Albina, Vedadi, Masoud

Source: SLAS discovery. 26(6):757-765

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627051552&indx=1&recIds=ETOCRN627051552

Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**

Authors: Sutherland, Mathew, Li, Alice, Kaghad, Anissa, Panagopoulos, Dimitrios, Li, Fengling, Szewczyk, Magdalena, Smil, David, Scholten, Cora, Bouché, Léa, Stellfeld, Timo, Arrowsmith, Cheryl H., Barsyte, Dalia, Vedadi, Masoud, Hartung, Ingo V., Steuber, Holger, Britton, Robert, Santhakumar, Vijayaratnam

Source: ChemMedChem. 16(7):1116-1125

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100119180333.0x000001&indx=1&recIds=ETOCvdc_100119180333.0x000001

Development of LM98, a Small‐Molecule TEAD Inhibitor Derived from Flufenamic Acid

Authors: Mélin, Léa, Abdullayev, Shuay, Fnaiche, Ahmed, Vu, Victoria, González Suárez, Narjara, Zeng, Hong, Szewczyk, Magdalena M., Li, Fengling, Senisterra, Guillermo, Allali‐Hassani, Abdellah, Chau, Irene, Dong, Aiping, Woo, Simon, Annabi, Borhane, Halabelian, Levon, LaPlante, Steven R., Vedadi, Masoud, Barsyte‐Lovejoy, Dalia, Santhakumar, Vijayaratnam, Gagnon, Alexandre

Source: ChemMedChem. 16(19):2982-3002

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131840294.0x000001&indx=1&recIds=ETOCvdc_100131840294.0x000001

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells

Authors: Vilema-Enríquez, Gabriela, Quinlan, Robert, Kilfeather, Peter, Mazzone, Roberta, Saqlain, Saba, del Molino del Barrio, Irene, Donato, Annalidia, Corda, Gabriele, Li, Fengling, Vedadi, Masoud, Németh, Andrea H., Brennan, Paul E., Wade-Martins, Richard ^*

Source: In Journal of Biological Chemistry 25 December 2020 295(52):17973-17985

Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X

Authors: Paudel, Prajwal, Zhang, Qi, Leung, Charles, Greenberg, Harrison C., Guo, Yusong, Chern, Yi-Hsuan, Dong, Aiping, Li, Yanjun, Vedadi, Masoud, Zhuang, Zhihao, Tong, Yufeng

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Apr 01. 116(15), 7288-7297.

Access URL: https://www.jstor.org/stable/26701383

Chemical probes for protein arginine methyltransferases

Authors: Li, Alice Shi Ming, Li, Fengling, Eram, Mohammad S., Bolotokova, Albina, dela Seña, Carlo C., Vedadi, Masoud

Source: In Methods 15 March 2020 175:30-43