ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease and has High Oral Bioavailability in Humans

Authors: Kempf, Dale J., Marsh, Kennan C., Denissen, Jon F., McDonald, Edith, Vasavanonda, Sudthida, Flentge, Charles A., Green, Brian E., Fino, Lynnmarie, Park, Chang H., Kong, Xiang-Peng, Wideburg, Norman E., Saldivar, Ayda, Ruiz, Lisa, Kati, Warren M., Sham, Hing L., Robins, Terry, Stewart, Kent D., Hsu, Ann, Plattner, Jacob J., Leonard, John M., Norbeck, Daniel W.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1995 Mar . 92(7), 2484-2488.

Access URL: https://www.jstor.org/stable/2367144

Ordered accumulation of mutations in HIV protease confers resistance to ritonavir

Authors: Molla, Akhteruzzaman, Korneyeva, Marina, Gao, Qing, Vasavanonda, Sudthida, Schipper, Paaline J., Mo, Hong-Mei, Markowitz, Martin, Chernyavskiy, Tatyana, Niu, Ping, Lyons, Nicholas, Hsu, Ann, Granneman, G. Richard, Ho, David D., Boucher, Charles A.B., Leonard, John M., Norbeck, Daniel W., Kempf, Dale J.

Source: Nature medicine. 2(7):760-766

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191244674.0x000001&indx=1&recIds=ETOCvdc_100191244674.0x000001

Human serum attenuates the activity of protease inhibitors toward wild-type and mutant human immunodeficiency virus.

Authors: Molla, Akhteruzzaman, Vasavanonda, Sudthida, Kumar, Gondi

Source: Virology; October 25 1998, Vol. 250 Issue 2, p255-262, 8p

Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains

Authors: Zhao, Chen, Sham, Hing L., Sun, Minghua, Stoll, Vincent S., Stewart, Kent D., Lin, Shuqun, Mo, Hongmei, Vasavanonda, Sudthida, Saldivar, Ayda, Park, Chang, McDonald, Edith J., Marsh, Kennan C., Klein, Larry L., Kempf, Dale J., Norbeck, Daniel W.

Source: In Bioorganic & Medicinal Chemistry Letters 2005 15(24):5499-5503

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Synthesis and antiviral activity of P1′ arylsulfonamide azacyclic urea HIV protease inhibitors

Authors: Huang, Peggy P, Randolph, John T, Klein, Larry L, Vasavanonda, Sudthida, Dekhtyar, Tatyana, Stoll, Vincent S, Kempf, Dale J

Source: In Bioorganic & Medicinal Chemistry Letters 2004 14(15):4075-4078

Novel lopinavir analogues incorporating heterocyclic replacements of six-member cyclic urea––synthesis and structure–activity relationships

Authors: Sham, Hing L., Betebenner, David A., Rosenbrook, William, Herrin, Thomas, Saldivar, Ayda, Vasavanonda, Sudthida, Plattner, Jacob J., Norbeck, Daniel W.

Source: In Bioorganic & Medicinal Chemistry Letters 2004 14(10):2643-2645

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands

Authors: Chen, Xiaoqi, Kempf, Dale J., Li, Lin, Sham, Hing L., Vasavanonda, Sudthida, Wideburg, Norman E., Saldivar, Ayda, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.

Source: In Bioorganic & Medicinal Chemistry Letters 3 November 2003 13(21):3657-3660

Mechanistic Study of HCV Polymerase Inhibitors at Individual Steps of the Polymerization Reaction.

Authors: Yaya Liu, Jiang, Wen W., Pratt, John, Rockway, Todd, Harris, Kevin, Vasavanonda, Sudthida, Tripathi, Rakesh, Pithawalla, Ron, Kati, Warren M.

Source: Biochemistry; 9/26/2006, Vol. 45 Issue 38, p11312-11323, 12p, 4 Diagrams, 1 Chart, 7 Graphs

Synthesis and structure–activity relationships of a novel series of HIV-1 protease inhibitors encompassing ABT-378 (Lopinavir)

Authors: Sham, Hing L., Betebenner, David A., Chen, Xiaoqi, Saldivar, Ayda, Vasavanonda, Sudthida, Kempf, Dale J., Plattner, Jacob J., Norbeck, Daniel W.

Source: In Bioorganic & Medicinal Chemistry Letters 22 April 2002 12(8):1185-1187

Novel lopinavir analogues incorporating non-Aromatic P-1 side chains—Synthesis and structure–Activity relationships

Authors: Sham, Hing L, Zhao, Chen, Li, Leping, Betebenner, David A, Saldivar, Ayda, Vasavanonda, Sudthida, Kempf, Dale J, Plattner, Jacob J, Norbeck, Daniel W

Source: In Bioorganic & Medicinal Chemistry Letters 2002 12(21):3101-3103

Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir)

Authors: Sham, Hing L, Betebenner, David A, Herrin, Thomas, Kumar, Gondi, Saldivar, Ayda, Vasavanonda, Sudthida, Molla, Akhter, Kempf, Dale J, Plattner, Jacob J, Norbeck, Daniel W

Source: In Bioorganic & Medicinal Chemistry Letters 2001 11(11):1351-1353

Estimation of Serum-Free 50-Percent Inhibitory Concentrations for Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir

Authors: Hickman, Dean, Vasavanonda, Sudthida, Nequist, George, Colletti, Lynn, Kati, Warren M., Bertz, Richard, Hsu, Ann, Kempf, Dale J.

Source: Antimicrobial Agents and Chemotherapy; August 2004, Vol. 48 Issue: 8 p2911-2917, 7p

In Vitro Antiviral Interaction of Lopinavir with Other Protease Inhibitors

Authors: Molla, Akhteruzzaman, Mo, Hongmei, Vasavanonda, Sudthida, Han, Lixin, Lin, C. Thomas, Hsu, Ann, Kempf, Dale J.

Source: Antimicrobial Agents and Chemotherapy; July 2002, Vol. 46 Issue: 7 p2249-2253, 5p

Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel P3 ligands

Authors: Chen, Xiaoqi, Kempf, Dale J., Sham, Hing L., Green, Brian E., Molla, Akhteruzaman, Korneyeva, Marina, Vasavanonda, Sudthida, Wideburg, Norman E., Saldivar, Ayda, Marsh, Kennan C., McDonald, Edith, Norbeck, Daniel W.

Source: Bioorganic & Medicinal Chemistry Letters; 1998, Vol. 8 Issue: 24 p3531-3536, 6p

ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

Authors: Sham, Hing L., Kempf, Dale J., Molla, Akhteruzammen, Marsh, Kennan C., Kumar, Gondi N., Chen, Chih-Ming, Kati, Warren, Stewart, Kent, Lal, Ritu, Hsu, Ann, Betebenner, David, Korneyeva, Marina, Vasavanonda, Sudthida, McDonald, Edith, Saldivar, Ayda, Wideburg, Norm, Chen, Xiaoqi, Niu, Ping, Park, Chang, Jayanti, Venkata, Grabowski, Brian, Granneman, G. Richard, Sun, Eugene, Japour, Anthony J., Leonard, John M., Plattner, Jacob J., Norbeck, Daniel W.

Source: Antimicrobial Agents and Chemotherapy; December 1998, Vol. 42 Issue: 12 p3218-3224, 7p

Lack of stereospecificity in the binding of the P2 amino acid of ritonavir to HIV protease

Authors: Kempf, Dale J., Molla, Akhteruzzaman, Marsh, Kennan C., Park, Chang, Rodrigues, A.David, Korneyeva, Marina, Vasavanonda, Sudthida, McDonald, Edith, Flentge, Charles A., Muchmore, Steven, Wideburg, Norman E., Saldivar, Ayda, Cooper, Art, Kati, Warren M., Stewart, Kent D., Norbeck, Daniel W.

Source: Bioorganic & Medicinal Chemistry Letters; March 1997, Vol. 7 Issue: 6 p699-704, 6p

Corrigendum to “Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir)”: [Bioorg. Med. Chem. Lett. 11 (2001) 1351]

Authors: Sham, Hing L., Betebenner, David A., Herrin, Thomas, Kumar, Gondi, Saldivar, Ayda, Vasavanonda, Sudthida, Molla, Akhter, Kempf, Dale J., Plattner, Jacob J., Norbeck, Daniel W.

Source: In Bioorganic & Medicinal Chemistry Letters 2004 14(10):2695-2695

Pseudo‐symmetrical difluoroketones

Authors: Sham, Hing L., Betebenner, David A., Wideburg, Norman, Saldivar, Ayda C., Kohlbrenner, William E., Craig-Kennard, Adrienne, Vasavanonda, Sudthida, Kempf, Dale J., Clement, Jacob J., Erickson, John E., Plattner, Jacob J., Norbeck, Daniel W.

Source: FEBS Letters; August 1993, Vol. 329 Issue: 1-2 p144-146, 3p

Synthesis and Antiviral Activity of P1′ Arylsulfonamide Azacyclic Urea HIV Protease Inhibitors.

Authors: Huang, Peggy P., Randolph, John T., Klein, Larry L., Vasavanonda, Sudthida, Dekhtyar, Tatyana, Stoll, Vincent S., Kempf, Dale J.

Source: ChemInform; Dec2004, Vol. 35 Issue 49, pno-no, 1p