Oxidized LDL receptors: a recent update

Authors: Khan, Mohd Azeem, Mohammad, Irshad, Banerjee, Sohom, Tomar, Akanksha, Varughese, Kottayil I, Mehta, Jawahar L, Chandele, Anmol, Arockiasamy, Arulandu

Source: Current opinion in lipidology. 34(4):147-155

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191823371.0x000001&indx=1&recIds=ETOCvdc_100191823371.0x000001

The structural basis of effective LOX-1 inhibition

Authors: Kore, Rajshekhar A, Bagchi, Ashim K, Varughese, Kottayil I, Mehta, Jawahar L

Source: Future medicinal chemistry. 14(10):731-743

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188671709.0x000001&indx=1&recIds=ETOCvdc_100188671709.0x000001

Exploring the druggability of oxidized low-density lipoprotein (ox-LDL) receptor, LOX-1, a proatherogenic drug target involved in atherosclerosis

Authors: Tomar, Akanksha, Sahoo, Sibasis, Aathi, Muthusankar, Kuila, Shobhan, Khan, Mohd Azeem, Ravi, Guru Raj Rao, Jeyaraman, Jeyakanthan, Mehta, Jawahar L., Varughese, Kottayil I., Arockiasamy, Arulandu

Source: Biochemical and biophysical research communications. 623:59-65

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168820124.0x000001&indx=1&recIds=ETOCvdc_100168820124.0x000001

FAM98 Family Proteins Play Distinct Roles in Osteoclastogenesis and Bone Resorption.

Authors: Wang, Lei, Minocha, Tarun, Das, Bhaba K., Kunika, Mikaela D., Kannan, Aarthi, Gao, Ling, Mohan, Subburaman, Xing, Weirong, Varughese, Kottayil I., Zhao, Haibo

Source: Biology (2079-7737); Jan2025, Vol. 14 Issue 1, p45, 18p

Subject Terms: COMPACT bone, CANCELLOUS bone, OSTEOCLASTOGENESIS, OSTEOCLASTS, BONE resorption, HOMEOSTASIS

Modulation of α-Thrombin Function by Distinct Interactions with Platelet Glycoprotein Ibα

Authors: Celikel, Reha, McClintock, Richard A., Roberts, James R., Mendolicchio, G. Loredana, Ware, Jerry, Varughese, Kottayil I., Ruggeri, Zaverio M.

Source: Science, 2003 Jul 01. 301(5630), 218-221.

Access URL: https://www.jstor.org/stable/3834792

Molecular and functional mapping of Plekhm1-Rab7 interaction in osteoclasts.

Authors: Das, Bhaba K, Minocha, Tarun, Kunika, Mikaela D, Kannan, Aarthi, Gao, Ling, Mohan, Subburaman, Xing, Weirong, Varughese, Kottayil I, Zhao, Haibo

Source: JBMR Plus; May2024, Vol. 8 Issue 5, p1-15, 15p

Subject Terms: GENE mapping, METABOLIC bone disorders, OSTEOCLASTS, BONE resorption, CANCELLOUS bone, PROTEIN stability

LOX-1 in Atherosclerosis and Myocardial Ischemia

Authors: Pothineni, Naga Venkata K., Karathanasis, Sotirios K., Ding, Zufeng, Arulandu, Arockiasamy, Varughese, Kottayil I., Mehta, Jawahar L.

Source: Journal of the American College of Cardiology. 69(22):2759-2768

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100045228106.0x000001&indx=1&recIds=ETOCvdc_100045228106.0x000001

Binding of α-thrombin to surface-anchored platelet glycoprotein Ibα sulfotyrosines through a two-site mechanism involving exosite I

Authors: Zarpellon, Alessandro, Celikel, Reha, Roberts, James R., McClintock, Richard A., Mendolicchio, G. Loredana, Moore, Kevin L., Jing, Hua, Varughese, Kottayil I., Ruggeri, Zaverio M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 May . 108(21), 8628-8633.

Access URL: https://www.jstor.org/stable/25831003

In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration.

Authors: Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Ayyadevara, Haarika, Kiaei, Lily, Shmookler Reis, Robert J., Varughese, Kottayil I., Kiaei, Mahmoud

Source: Scientific Reports; 2/6/2023, Vol. 13 Issue 1, p1-10, 10p

Subject Terms: AMYOTROPHIC lateral sclerosis, TUBULINS, MICROTUBULES, MOTOR neurons, CYTOSKELETAL proteins, NEURODEGENERATION, PROTEIN structure

Crystal Structure of Rat Liver Dihydropteridine Reductase

Authors: Varughese, Kottayil I., Skinner, Matthew M., Whiteley, John M., Matthews, David A., Xuong, Nguyen H.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1992 Jul 01. 89(13), 6080-6084.

Access URL: https://www.jstor.org/stable/2359496

Conformation of Cyclo(-L-Pro-Gly-) 3 and Its Ca 2+ and Mg 2+ Complexes

Authors: Kartha, Gopinath, Varughese, Kottayil I., Aimoto, Saburo

Source: Proceedings of the National Academy of Sciences of the United States of America, 1982 Jul . 79(14), 4519-4522.

Access URL: https://www.jstor.org/stable/12811

ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation

Authors: Kiaei, Mahmoud, Balasubramaniam, Meenakshisundaram, Govind Kumar, Vivek, Shmookler Reis, Robert J., Moradi, Mahmoud, Varughese, Kottayil I.

Source: Scientific reports. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131182840.0x000001&indx=1&recIds=ETOCvdc_100131182840.0x000001

Structure and Inhibitor Specificity of L, D-Transpeptidase (LdtMt2) from Mycobacterium tuberculosis and Antibiotic Resistance: Calcium Binding Promotes Dimer Formation

Authors: Gokulan, Kuppan, Khare, Sangeeta, Cerniglia, Carl E., Foley, Steven L., Varughese, Kottayil I.

Source: AAPS journal. 20(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128527471.0x000001&indx=1&recIds=ETOCvdc_100128527471.0x000001

Platelet Dysfunction and a High Bone Mass Phenotype in a Murine Model of Platelet-Type von Willebrand Disease

Authors: Suva, Larry J., Hartman, Eric, Dilley, Joshua D., Russell, Susan, Akel, Nisreen S., Skinner, Robert A., Hogue, William R., Budde, Ulrich, Varughese, Kottayil I., Kanaji, Taisuke, Ware, Jerry

Source: In The American Journal of Pathology 2008 172(2):430-439

Amino acid identity at one position within the α1 helix of both the histidine kinase and the response regulator of the WalRK and PhoPR two-component systems plays a crucial role in the specificity of phosphotransfer.

Authors: Jende, Inga, Varughese, Kottayil I., Devine, Kevin M.

Source: Microbiology (13500872); June 2010, Vol. 156 Issue 6, p1848-1859, 12p

The Crystal Structure of Beryllofluoride Spo0F in Complex with the Phosphotransferase Spo0B Represents a Phosphotransfer Pretransition State.

Authors: Varughese, Kottayil I., Tsigelny, Igor, Zhao, Haiyan

Source: Journal of Bacteriology; July 2006, Vol. 188 Issue 13, p4970-4977, 8p

Conformational Changes of Spo0F along the Phosphotransfer Pathway.

Authors: Varughese, Kottayil I.

Source: Journal of Bacteriology; December 2005, Vol. 187 Issue 24, p8221-8227, 7p

A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure

Authors: Vasudevan, Sona, Celikel, Reha, Ruggeri, Zaverio M, Varughese, Kottayil I, Kunicki, Thomas J ^*

Source: In Blood Cells, Molecules and Diseases 2004 32(1):176-181

Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia

Authors: Corrons, Joan-Lluis Vives ^*, Garcia, Estefania, Tusell, Joan J., Varughese, Kottayil I., West, Carol, Beutler, Ernest

Source: In Blood 1 June 2003 102(1):353-356

Crystal structure of an actinidin-E-64 complex.

Authors: Varughese, Kottayil I., Su, Ying, Cromwell, Dean

Source: Biochemistry; June 9 1992, Vol. 31, p5172-5176, 5p