Effect of Hepatic Impairment on OATP1B Activity: Quantitative Pharmacokinetic Analysis of Endogenous Biomarker and Substrate Drugs

Authors: Lin, Jian, Kimoto, Emi, Yamazaki, Shinji, Vourvahis, Manoli, Bergman, Arthur, Rodrigues, A. David, Costales, Chester, Li, Rui, Varma, Manthena V. S.

Source: Clinical pharmacology & therapeutics. 113(5):1058-1069

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189922696.0x000001&indx=1&recIds=ETOCvdc_100189922696.0x000001

Genetic variation in organic cation transporters and considerations in drug development

Authors: Varma, Manthena V. S.

Source: Expert opinion on drug metabolism and toxicology. 19(3):149-164

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181120668.0x000001&indx=1&recIds=ETOCvdc_100181120668.0x000001

Biomarker‐Informed Model‐Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug‐Drug Interactions

Authors: Kimoto, Emi, Costales, Chester, West, Mark A., Bi, Yi‐an, Vourvahis, Manoli, David Rodrigues, A., Varma, Manthena V. S.

Source: Clinical pharmacology & therapeutics. 111(2):404-415

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138901352.0x000001&indx=1&recIds=ETOCvdc_100138901352.0x000001

Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective

Authors: Chu, Xiaoyan, Prasad, Bhagwat, Neuhoff, Sibylle, Yoshida, Kenta, Leeder, James Steven, Mukherjee, Dwaipayan, Taskar, Kunal, Varma, Manthena V. S., Zhang, Xinyuan, Yang, Xinning, Galetin, Aleksandra

Source: Clinical pharmacology & therapeutics. 112(3):501-526

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158381831.0x000001&indx=1&recIds=ETOCvdc_100158381831.0x000001

Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance

Authors: Zamek‐Gliszczynski, Maciej J., Sangha, Vishal, Shen, Hong, Feng, Bo, Wittwer, Matthias B., Varma, Manthena V. S., Liang, Xiaomin, Sugiyama, Yuichi, Zhang, Lei, Bendayan, Reina

Source: Clinical pharmacology & therapeutics. 112(3):485-500

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158381812.0x000001&indx=1&recIds=ETOCvdc_100158381812.0x000001

Effect of a Ketohexokinase Inhibitor (PF‐06835919) on In Vivo OATP1B Activity: Integrative Risk Assessment Using Endogenous Biomarker and a Probe Drug

Authors: Tess, David A., Kimoto, Emi, King‐Ahmad, Amanda, Vourvahis, Manoli, Rodrigues, A. David, Bergman, Arthur, Qui, Ruolun, Somayaji, Veena, Weng, Yan, Fonseca, Kari R., Litchfield, John, Varma, Manthena V. S.

Source: Clinical pharmacology & therapeutics. 112(3):605-614

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158381697.0x000001&indx=1&recIds=ETOCvdc_100158381697.0x000001

Positioning Enzyme- and Transporter-Based Precipitant Drug–Drug Interaction Studies in Drug Design.

Authors: Schroeter, Thomas, Lapham, Kimberly, Varma, Manthena V. S., Obach, R. Scott

Source: Journal of Medicinal Chemistry; 1/23/2025, Vol. 68 Issue 2, p1021-1032, 12p

Quantitative prediction of breast cancer resistant protein mediated drug‐drug interactions using physiologically‐based pharmacokinetic modeling

Authors: Costales, Chester, Lin, Jian, Kimoto, Emi, Yamazaki, Shinji, Gosset, James R., Rodrigues, A. David, Lazzaro, Sarah, West, Mark A., West, Michael, Varma, Manthena V. S.

Source: CPT: pharmacometrics & systems pharmacology. 10(9):1018-1031

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131136253.0x000001&indx=1&recIds=ETOCvdc_100131136253.0x000001

Drug‐Drug Interactions Involving Renal OCT2/MATE Transporters: Clinical Risk Assessment May Require Endogenous Biomarker‐Informed Approach

Authors: Mathialagan, Sumathy, Feng, Bo, Rodrigues, A. David, Varma, Manthena V. S.

Source: Clinical pharmacology & therapeutics. 110(4):855-859

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130127327.0x000001&indx=1&recIds=ETOCvdc_100130127327.0x000001

Cytochrome-P450-Mediated Drug—Drug Interactions of Substrate Drugs: Assessing Clinical Risk Based on Molecular Properties and an Extended Clearance Classification System

Authors: Steyn, Stefanus J., Varma, Manthena V. S.

Source: Molecular pharmaceutics. 17(8):3024-3032

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624441357&indx=1&recIds=ETOCRN624441357

Transporter–enzyme interplay and the hepatic drug clearance: what have we learned so far?

Authors: Alluri, Ravindra V., Li, Rui, Varma, Manthena V. S.

Source: Expert opinion on drug metabolism and toxicology. 16(5):387-401

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110699954.0x000001&indx=1&recIds=ETOCvdc_100110699954.0x000001

Physiologically Based Pharmacokinetic Model of OATP1B Substrates with a Nonlinear Mixed Effect Approach: Estimating Empirical In Vitro-to-In Vivo Scaling Factors.

Authors: Li, Rui, Kimoto, Emi, Bi, Yi-An, Tess, David, Varma, Manthena V. S.

Source: Clinical Pharmacokinetics; Aug2024, Vol. 63 Issue 8, p1177-1189, 13p

Subject Terms: PARAMETER identification, GENETIC translation, PHARMACOKINETICS, SAMPLE size (Statistics), INDEPENDENT sets

Mechanistic Determinants of Daprodustat Drug–Drug Interactions and Pharmacokinetics in Hepatic Dysfunction and Chronic Kidney Disease: Significance of OATP1B‐CYP2C8 Interplay.

Authors: Bi, Yi‐An, Jordan, Samantha, King‐Ahmad, Amanda, West, Mark A., Varma, Manthena V. S.

Source: Clinical Pharmacology & Therapeutics; Jun2024, Vol. 115 Issue 6, p1336-1345, 10p

Subject Terms: CHRONIC kidney failure, DRUG interactions, RIFAMPIN, PHARMACOKINETICS, KRA, HYPOXIA-inducible factors, ERYTHROPOIETIN receptors

Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes

Authors: Vildhede, Anna, Kimoto, Emi, Rodrigues, A. David, Varma, Manthena V. S.

Source: Molecular pharmaceutics. 15(8):3227-3235

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617048435&indx=1&recIds=ETOCRN617048435

Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S-Warfarin: In Vitro Studies and Mechanistic Evaluation

Authors: Bi, Yi-an, Lin, Jian, Mathialagan, Sumathy, Tylaska, Laurie, Callegari, Ernesto, Rodrigues, A. David, Varma, Manthena V. S.

Source: Molecular pharmaceutics. 15(3):1284-1295

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615152717&indx=1&recIds=ETOCRN615152717

Membrane transporters in drug development and as determinants of precision medicine

Authors: Galetin, Aleksandra, Brouwer, Kim L. R., Tweedie, Donald, Yoshida, Kenta, Sjöstedt, Noora, Aleksunes, Lauren, Chu, Xiaoyan, Evers, Raymond, Hafey, Michael J., Lai, Yurong, Matsson, Pär, Riselli, Andrew, Shen, Hong, Sparreboom, Alex, Varma, Manthena V. S., Yang, Jia, Yang, Xinning, Yee, Sook Wah, Zamek-Gliszczynski, Maciej J., Zhang, Lei, Giacomini, Kathleen M.

Source: Nature Reviews Drug Discovery; 20240101, Issue: Preprints p1-26, 26p

Hepatic Disposition of Gemfibrozil and Its Major Metabolite Gemfibrozil 1-O-β-Glucuronide

Authors: Kimoto, Emi, Li, Rui, Scialis, Renato J., Lai, Yurong, Varma, Manthena V. S.

Source: Molecular pharmaceutics. 12(11):3943-3952

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN603644394&indx=1&recIds=ETOCRN603644394

Identification of Organic Anion Transporter 2 Inhibitors: Screening, Structure-Based Analysis, and Clinical Drug Interaction Risk Assessment.

Authors: Ryu, Sangwoo, Woody, Nathaniel, Chang, George, Mathialagan, Sumathy, Varma, Manthena V. S.

Source: Journal of Medicinal Chemistry; 11/10/2022, Vol. 65 Issue 21, p14578-14588, 11p

Recent advances in drug transporter sciences: highlights from the year 2020.

Authors: Chothe, Paresh P., Nakakariya, Masanori, Rotter, Charles J., Sandoval, Philip, Tohyama, Kimio, Bi, Yi-An, Ryu, Sangwoo, Tess, David A., Rodrigues, A. David, Varma, Manthena V. S., Mathialagan, Sumathy, Feng, Bo, Luo, Lina, Ramanathan, Ragu, Horlbogen, Lauren, Costales, Chester, Vourvahis, Manoli, Holliman, Christopher L., Chen, Yuan, Ma, Fang

Source: Drug Metabolism Reviews; Aug 2021, Vol. 53 Issue 3, p321-349, 29p

Subject Terms: DRUG absorption, DRUG metabolism, BIOCONVERSION, ESSENTIAL drugs, GOVERNMENT agencies, PHARMACOKINETICS

Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, a First-In-Class Ketohexokinase Inhibitor for Metabolic Disorders and Nonalcoholic Fatty Liver Disease

Authors: Weng, Yan, Fonseca, Kari R., Bi, Yi-an, Mathialagan, Sumathy, Riccardi, Keith, Tseng, Elaine, Bessire, Andrew J., Cerny, Mathew A., Tess, David A., Rodrigues, A. David, Kalgutkar, Amit S., Litchfield, John, Di, Li, Varma, Manthena V. S.

Source: Drug Metabolism and Disposition; 2022, Vol. 50 Issue: 9 p1312-1321, 10p