Light weight Real Time Indian Sign Language Symbol Recognition with Captioning and Speech Output

Authors: Varma, Manthena M., Kashinath, Tejas, Jain, Twisha, Pai, Smitha N

Source: 2022 International Conference on Smart Generation Computing, Communication and Networking (SMART GENCON) Smart Generation Computing, Communication and Networking (SMART GENCON), 2022 International Conference on. :1-8 Dec, 2022

Relation: 2022 International Conference on Smart Generation Computing, Communication and Networking (SMART GENCON)

Significance of gut breast cancer resistance protein versus organic anion transporting polypeptide 2B1 inhibition on rosuvastatin clinical drug-drug interactions

Authors: West, Mark A., Lazzaro, Sarah, Morrow, Riley, Costales, Chester, Yee, Sook Wah, Varma, Manthena V.S. ^∗

Source: In Drug Metabolism and Disposition February 2025

Low Molecular Weight Acids and Organic Anion Transporting Polypeptide (OATP1B)-Mediated Hepatic Clearance: In Vitro and In Vivo Evaluation Using Novel Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (Dustats)

Authors: Bi, Yi-An, Jordan, Samantha, King-Ahmad, Amanda, West, Mark A., Yamaguchi, Emi, Ryu, Sangwoo, Mathialagan, Sumathy, Tess, David A., Varma, Manthena V.S. ^*

Source: In Drug Metabolism and Disposition May 2024 52(5):399-407

Significance of Organic Anion Transporter 2 and Organic Cation Transporter 2 in Creatinine Clearance: Mechanistic Evaluation Using Freshly Prepared Human Primary Renal Proximal Tubule Cells

Authors: Mathialagan, Sumathy, Chung, Git, Pye, Keith, Rodrigues, A. David, Varma, Manthena V.S., Brown, Colin ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics January 2024 388(1):201-208

Translatability of in vitro Inhibition Potency to in vivo P-Glycoprotein Mediated Drug Interaction Risk

Authors: Lazzaro, Sarah, West, Mark A., Eatemadpour, Soraya, Feng, Bo, Varma, Manthena V.S., Rodrigues, A. David, Temesszentandrási-Ambrus, Csilla, Kovács-Hajdu, Péter, Nerada, Zsuzsanna, Gáborik, Zsuzsanna, Costales, Chester

Source: Journal of pharmaceutical sciences. 112(6):1715-1723

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190201783.0x000001&indx=1&recIds=ETOCvdc_100190201783.0x000001

Effect of Hepatic Impairment on OATP1B Activity: Quantitative Pharmacokinetic Analysis of Endogenous Biomarker and Substrate Drugs

Authors: Lin, Jian, Kimoto, Emi, Yamazaki, Shinji, Vourvahis, Manoli, Bergman, Arthur, Rodrigues, A. David, Costales, Chester, Li, Rui, Varma, Manthena V. S.

Source: Clinical pharmacology & therapeutics. 113(5):1058-1069

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189922696.0x000001&indx=1&recIds=ETOCvdc_100189922696.0x000001

Genetic variation in organic cation transporters and considerations in drug development

Authors: Varma, Manthena V. S.

Source: Expert opinion on drug metabolism and toxicology. 19(3):149-164

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Analysis of the interplay of physiological response to food intake and drug properties in food-drug interactions

Authors: Sharma, Sheena, Kogan, Clark, Varma, Manthena V.S., Prasad, Bhagwat

Source: In Drug Metabolism and Pharmacokinetics December 2023 53

Biomarker‐Informed Model‐Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug‐Drug Interactions

Authors: Kimoto, Emi, Costales, Chester, West, Mark A., Bi, Yi‐an, Vourvahis, Manoli, David Rodrigues, A., Varma, Manthena V. S.

Source: Clinical pharmacology & therapeutics. 111(2):404-415

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Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective

Authors: Chu, Xiaoyan, Prasad, Bhagwat, Neuhoff, Sibylle, Yoshida, Kenta, Leeder, James Steven, Mukherjee, Dwaipayan, Taskar, Kunal, Varma, Manthena V. S., Zhang, Xinyuan, Yang, Xinning, Galetin, Aleksandra

Source: Clinical pharmacology & therapeutics. 112(3):501-526

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Clinical Relevance of Organic Anion Transporting Polypeptide 1B–Mediated Hepatic Uptake for High‐Permeability Drugs: A Perspective

Authors: Varma, Manthena V.S.

Source: Clinical pharmacology & therapeutics. 112(3):446-449

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Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance

Authors: Zamek‐Gliszczynski, Maciej J., Sangha, Vishal, Shen, Hong, Feng, Bo, Wittwer, Matthias B., Varma, Manthena V. S., Liang, Xiaomin, Sugiyama, Yuichi, Zhang, Lei, Bendayan, Reina

Source: Clinical pharmacology & therapeutics. 112(3):485-500

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Effect of a Ketohexokinase Inhibitor (PF‐06835919) on In Vivo OATP1B Activity: Integrative Risk Assessment Using Endogenous Biomarker and a Probe Drug

Authors: Tess, David A., Kimoto, Emi, King‐Ahmad, Amanda, Vourvahis, Manoli, Rodrigues, A. David, Bergman, Arthur, Qui, Ruolun, Somayaji, Veena, Weng, Yan, Fonseca, Kari R., Litchfield, John, Varma, Manthena V. S.

Source: Clinical pharmacology & therapeutics. 112(3):605-614

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Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, a First-In-Class Ketohexokinase Inhibitor for Metabolic Disorders and Nonalcoholic Fatty Liver Disease

Authors: Weng, Yan, Fonseca, Kari R., Bi, Yi-an, Mathialagan, Sumathy, Riccardi, Keith, Tseng, Elaine, Bessire, Andrew J., Cerny, Mathew A., Tess, David A., Rodrigues, A. David, Kalgutkar, Amit S., Litchfield, John, Di, Li, Varma, Manthena V.S. ^*

Source: In Drug Metabolism and Disposition September 2022 50(9):1312-1321

Positioning Enzyme- and Transporter-Based Precipitant Drug–Drug Interaction Studies in Drug Design.

Authors: Schroeter, Thomas, Lapham, Kimberly, Varma, Manthena V. S., Obach, R. Scott

Source: Journal of Medicinal Chemistry; 1/23/2025, Vol. 68 Issue 2, p1021-1032, 12p

In Vitro–to–In Vivo Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach

Authors: Kumar, Aditya R., Prasad, Bhagwat, Bhatt, Deepak Kumar, Mathialagan, Sumathy, Varma, Manthena V.S., Unadkat, Jashvant D. ^*

Source: In Drug Metabolism and Disposition June 2021 49(6):470-478

Organic Anion–Transporting Polypeptide 1B1/1B3–Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro–In Vivo Evaluation in Cynomolgus Monkey

Authors: Eng, Heather, Bi, Yi-an, West, Mark A., Ryu, Sangwoo, Yamaguchi, Emi, Kosa, Rachel E., Tess, David A., Griffith, David A., Litchfield, John, Kalgutkar, Amit S., Varma, Manthena V.S. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics April 2021 377(1):169-180

Effect of Human Plasma on Hepatic Uptake of Organic Anion–Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes

Authors: Bi, Yi-an, Ryu, Sangwoo, Tess, David A., Rodrigues, A. David, Varma, Manthena V.S. ^*

Source: In Drug Metabolism and Disposition January 2021 49(1):72-83

Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes

Authors: Yoshikado, Takashi, Lee, Wooin, Toshimoto, Kota, Morita, Kiyoe, Kiriake, Aya, Chu, Xiaoyan, Lee, Nora, Kimoto, Emi, Varma, Manthena V.S., Kikuchi, Ryota, Scialis, Renato J., Shen, Hong, Ishiguro, Naoki, Lotz, Ralf, Li, Albert P., Maeda, Kazuya, Kusuhara, Hiroyuki, Sugiyama, Yuichi

Source: In Journal of Pharmaceutical Sciences January 2021 110(1):376-387

Quantitative prediction of breast cancer resistant protein mediated drug‐drug interactions using physiologically‐based pharmacokinetic modeling

Authors: Costales, Chester, Lin, Jian, Kimoto, Emi, Yamazaki, Shinji, Gosset, James R., Rodrigues, A. David, Lazzaro, Sarah, West, Mark A., West, Michael, Varma, Manthena V. S.

Source: CPT: pharmacometrics & systems pharmacology. 10(9):1018-1031

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131136253.0x000001&indx=1&recIds=ETOCvdc_100131136253.0x000001