Emodin disrupts the KITENIN oncogenic complex by binding ErbB4 and suppresses colorectal cancer progression in dual blockade with KSRP-binding compound

Authors: Varlı, Mücahit ^a, Ji, Moongi ^a, Kim, Eunae ^b, Kim, Sung Jin ^c, Choi, Byeongchan ^a, Ha, Hyung-Ho ^a, Kim, Kyung Keun ^c, Paik, Man-Jeong ^a, Kim, Hangun ^{a, ⁎}

Source: In Phytomedicine January 2025 136

Unveiling the antimetastatic activity of monoterpene indole alkaloids targeting MMP9 in cancer cells, with a focus on pharmacokinetic and cellular insights

Authors: Varlı, Mücahit ¹, Lee, Kyungha ², Kang, Kyo Bin ², Kim, Hangun ^{1, ⁎}

Source: In Molecules and Cells December 2024 47(12)

Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex.

Authors: Varlı, Mücahit¹ (AUTHOR), Kim, Eunae² (AUTHOR), Oh, Songjin¹ (AUTHOR), Pulat, Sultan¹ (AUTHOR), Zhou, Rui¹ (AUTHOR), Gamage, Chathurika D. B.¹ (AUTHOR), Gökalsın, Barış³ (AUTHOR), Sesal, Nüzhet Cenk³ (AUTHOR), Kim, Kyung Keun⁴ (AUTHOR), Paik, Man-Jeong¹ (AUTHOR), Kim, Hangun¹ (AUTHOR) hangunkim@scnu.ac.kr

Source: Cancer Cell International. 7/19/2024, Vol. 24 Issue 1, p1-17. 17p.

Subject Terms: *CANCER cell motility, *COLORECTAL cancer, *ENERGY metabolism, *CELL motility, *MOLECULAR docking

A fatty acid-rich fraction of an endolichenic fungus Phoma sp. suppresses immune checkpoint markers via AhR/ARNT and ESR1

Authors: Varlı, Mücahit ^a, Ngo, Men Thi ^b, Kim, Seong-Min ^a, Taş, İsa ^a, Zhou, Rui ^a, Gamage, Chathurika D.B. ^a, Pulat, Sultan ^a, Park, So-Yeon ^a, Sesal, Nüzhet Cenk ^c, Hur, Jae-Seoun ^d, Kang, Kyo Bin ^b, Kim, Hangun ^{a, ∗}

Source: In Heliyon September 2023 9(9)

Atraric Acid Induces Hair Growth through the Stimulation of Sonic Hedgehog/GLI1 in Human Dermal Papilla Cells.

Authors: Pulat, Sultan, Kim, Wonyong, Hwang, Jee-Hyun, Zhou, Rui, Gamage, Chathurika D. B., Varlı, Mücahit, Taş, İsa, Yang, Yi, Park, So-Yeon, Lim, Kyung-Min, Hur, Jae-Seoun, Kim, Hangun

Source: Stem Cell Reviews & Reports; Jan2025, Vol. 21 Issue 1, p283-286, 4p

Subject Terms: HAIR growth, HAIR follicles, TISSUE viability, GENE expression, MEMBRANE proteins

Physciosporin suppresses mitochondrial respiration, aerobic glycolysis, and tumorigenesis in breast cancer

Authors: Taş, İsa, Varlı, Mücahit, Son, Yeseon, Han, Jin, Kwak, Dahye, Yang, Yi, Zhou, Rui, Gamage, Chathurika D.B., Pulat, Sultan, Park, So-Yeon, Yu, Young Hyun, Moon, Kyung-Sub, Lee, Kyung-Hwa, Ha, Hyung-Ho, Hur, Jae-Seoun, Kim, Hangun

Source: In Phytomedicine October 2021 91

TDO2 inhibition counters Benzo[a]pyrene-induced immune evasion and suppresses tumorigenesis in lung adenocarcinoma.

Authors: Taş, İsa, Varlı, Mücahit, Pulat, Sultan, Sim, Hyun Bo, Kim, Jong-Jin, Kim, Hangun

Source: Cancer & Metabolism; 11/26/2024, Vol. 12 Issue 1, p1-17, 17p

Subject Terms: IMMUNE checkpoint proteins, ARYL hydrocarbon receptors, POLYCYCLIC aromatic hydrocarbons, GENE expression, ENZYME metabolism, TRP channels

Usnic Acid Targets 14-3-3 Proteins and Suppresses Cancer Progression by Blocking Substrate Interaction

Authors: Varlı, Mücahit, Bhosle, Suresh R., Kim, Eunae, Yang, Yi, Taş, İsa, Zhou, Rui, Pulat, Sultan, Gamage, Chathurika D. B., Park, So-Yeon, Ha, Hyung-Ho, Kim, Hangun

Source: JACS Au; April 2024, Vol. 4 Issue: 4 p1521-1537, 17p

Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells.

Authors: Pulat, Sultan, Yang, Inho, Lee, Jihye, Hwang, Sunghoon, Zhou, Rui, Gamage, Chathurika D. B., Varlı, Mücahit, Taş, İsa, Yang, Yi, Park, So-Yeon, Hong, Ahreum, Kim, Jeong-Hyeon, Oh, Dong-Chan, Kim, Hangun, Nam, Sang-Jip, Kang, Heonjoong

Source: Marine Drugs; Feb2024, Vol. 22 Issue 2, p88, 13p

KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer.

Authors: Varlı, Mücahit¹ (AUTHOR), Kim, Sung Jin^1,2 (AUTHOR), Noh, Myung-Giun³ (AUTHOR), Kim, Yoon Gyoon⁴ (AUTHOR), Ha, Hyung-Ho¹ (AUTHOR), Kim, Kyung Keun² (AUTHOR), Kim, Hangun¹ (AUTHOR) hangunkim@sunchon.ac.kr

Source: Cell & Bioscience. 8/8/2023, Vol. 13 Issue 1, p1-21. 21p.

Subject Terms: *GLYCOLYSIS, *COLORECTAL cancer, *CELL metabolism, *PYRUVATE kinase, *ENERGY metabolism, *COMPLEX compounds

Phthalides Isolated from the Endolichenic Arthrinium sp. EL000127 Exhibits Antiangiogenic Activity.

Authors: Gamage, Chathurika D. B., Lee, Kyungha, Park, So-Yeon, Varlı, Mücahit, Lee, Chang Wook, Kim, Seong-Min, Zhou, Rui, Pulat, Sultan, Yang, Yi, Taş, İsa, Hur, Jae-Seoun, Kang, Kyo Bin, Kim, Hangun

Source: ACS Omega; 4/4/2023, Vol. 8 Issue 13, p12548-12557, 10p

Marinobazzanan, a Bazzanane-Type Sesquiterpenoid, Suppresses the Cell Motility and Tumorigenesis in Cancer Cells.

Authors: Pulat, Sultan, Hillman, Prima F., Kim, Sojeong, Asolkar, Ratnakar N., Kim, Haerin, Zhou, Rui, Taş, İsa, Gamage, Chathurika D. B., Varlı, Mücahit, Park, So-Yeon, Park, Sung Chul, Yang, Inho, Shin, Jongheon, Oh, Dong-Chan, Kim, Hangun, Nam, Sang-Jip, Fenical, William

Source: Marine Drugs; Mar2023, Vol. 21 Issue 3, p153, 18p

Libertellenone T, a Novel Compound Isolated from Endolichenic Fungus, Induces G2/M Phase Arrest, Apoptosis, and Autophagy by Activating the ROS/JNK Pathway in Colorectal Cancer Cells.

Authors: Gamage, Chathurika D. B., Kim, Jeong-Hyeon, Yang, Yi, Taş, İsa, Park, So-Yeon, Zhou, Rui, Pulat, Sultan, Varlı, Mücahit, Hur, Jae-Seoun, Nam, Sang-Jip, Kim, Hangun

Source: Cancers; Jan2023, Vol. 15 Issue 2, p489, 24p

Subject Terms: REVERSE transcriptase polymerase chain reaction, AUTOPHAGY, FUNGI, APOPTOSIS, CELL cycle, CELLULAR signal transduction, COLORECTAL cancer, MOLECULAR biology, IMMUNOBLOTTING, RESEARCH funding, REACTIVE oxygen species, MOLECULAR structure, CYTOTOXINS

An acetonic extract and secondary metabolites from the endolichenic fungus Nemania sp. EL006872 exhibit immune checkpoint inhibitory activity in lung cancer cell.

Authors: Varlı, Mücahit, Pham, Huong T., Seong-Min Kim, Taş, İsa, Gamage, Chathurika D. B., Rui Zhou, Pulat, Sultan, So-Yeon Park, Sesal, Nüzhet Cenk, Jae-Seoun Hur, Kyo Bin Kang, Hangun Kim

Source: Frontiers in Pharmacology; 9/8/2022, Vol. 13, p1-13, 13p

Subject Terms: IMMUNE checkpoint proteins, IMMUNE checkpoint inhibitors, FUNGAL metabolites, LUNG cancer, CANCER cells, WESTERN immunoblotting, METABOLITES

Physical characteristics of black cumin oil emulsions compared to sunflower and corn oils emulsions.

Authors: Varlı, Mücahit, Solak, Rukiye, Turan, Semra, Ramadan, Mohamed Fawzy

Source: Journal of Food Measurement & Characterization; Aug2021, Vol. 15 Issue 4, p3207-3215, 9p

Subject Terms: BLACK cumin, SUNFLOWER seed oil, CORN oil, EMULSIONS, DROPLETS

INTENSIFICATION OF CELLULOSE ENZYMATIC HYDROLYSIS BY MICROWAVE PRETREATMENT.

Authors: Varlı, Mücahit, Ertuğral, Elif Gülin, Jákói, Zoltán, Hodúr, Cecilia, Beszédes, Sándor

Source: Analecta Technica Szegedinensia; 2020, Vol. 14 Issue 1, p89-99, 11p

Subject Terms: CELLULOSE, HYDROLYSIS, RAW materials, HEMICELLULOSE, FOOD industry

Plectalibertellenone A suppresses colorectal cancer cell motility and glucose metabolism by targeting TGF‐β/Smad and Wnt pathways.

Authors: Gamage, Chathurika D. B.¹ (AUTHOR) chathurika.gamage@gmail.com, Kim, Jeong‐Hyeon² (AUTHOR), Zhou, Rui¹ (AUTHOR), Park, So‐Yeon¹ (AUTHOR), Pulat, Sultan¹ (AUTHOR), Varlı, Mücahit¹ (AUTHOR), Nam, Sang‐Jip² (AUTHOR), Kim, Hangun¹ (AUTHOR) hangunkim@sunchon.ac.kr

Source: Biofactors. Sep2024, p1. 20p. 9 Illustrations.

Subject Terms: *CANCER cell motility, *EPITHELIAL-mesenchymal transition, *GLUCOSE metabolism, *GENETIC regulation, *OXIDATIVE phosphorylation, *GLYCOLYSIS