Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance

Authors: Goettel, Manuela ^{a, ⁎}, Werner, Christoph ^a, Honarvar, Naveed ^b, Gröters, Sibylle ^b, Fegert, Ivana ^a, Haines, Corinne ^{c, 1}, Chatham, Lynsey R. ^{c, 2}, Vardy, Audrey ^c, Lake, Brian G. ^d

Source: In Toxicology June 2024 505

Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance

Authors: Lake, Brian G. ^*, Price, Roger J., Scott, Mary P., Chatham, Lynsey R., Vardy, Audrey, Osimitz, Thomas G.

Source: In Toxicology June 2020 439

Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats

Authors: Goettel, Manuela ^*, Fegert, Ivana, Honarvar, Naveed, Vardy, Audrey, Haines, Corinne, Chatham, Lynsey R., Lake, Brian G.

Source: In Toxicology 30 March 2020 433-434

Metazachlor: Mode of action analysis for rat liver tumour formation and human relevance

Authors: Wiemann, Christiane, Goettel, Manuela, Vardy, Audrey, Elcombe, Barbara M., Elcombe, Clifford R., Chatham, Lynsey R., Wang, Hongbing, Li, Linhao, Buesen, Roland, Honarvar, Naveed, Treumann, Silke, Marxfeld, Heike, Groeters, Sibylle, Lake, Brian G.

Source: In Toxicology 1 October 2019 426

Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats

Authors: Haines, Corinne, Chatham, Lynsey R., Vardy, Audrey, Elcombe, Clifford R., Foster, John R., Lake, Brian G.

Source: In Toxicology 1 May 2018 400-401:20-27

Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes

Authors: Haines, Corinne, Elcombe, Barbara M., Chatham, Lynsey R., Vardy, Audrey, Higgins, Larry G., Elcombe, Clifford R., Lake, Brian G.

Source: In Toxicology 1 March 2018 396-397:23-32

Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes

Authors: Hedges, Laura, Brown, Susan, MacLeod, A. Kenneth, Vardy, Audrey, Doyle, Edward, Song, Gina, Moreau, Marjory, Yoon, Miyoung, Osimitz, Thomas G., Lake, Brian G.

Source: Xenobiotica. 49(5):521-527

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103790546.0x000001&indx=1&recIds=ETOCvdc_100103790546.0x000001

Metabolism of deltamethrin and cis- and trans-permethrin by rat and human liver microsomes, liver cytosol and plasma preparations

Authors: Hedges, Laura, Brown, Susan, Vardy, Audrey, Doyle, Edward, Yoon, Miyoung, Osimitz, Thomas G., Lake, Brian G.

Source: Xenobiotica. 49(4):388-396

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103790515.0x000001&indx=1&recIds=ETOCvdc_100103790515.0x000001

Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats

Authors: Haines, Corinne, Chatham, Lynsey R., Vardy, Audrey, Elcombe, Clifford R., Foster, John R., Lake, Brian G.

Source: Xenobiotica. 49(2):227-238

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103790469.0x000001&indx=1&recIds=ETOCvdc_100103790469.0x000001

Mode of action and human relevance of THF-induced mouse liver tumors

Authors: Choi, Christopher J., Rushton, Erik K., Vardy, Audrey, Higgins, Larry, Augello, Andrea, Parod, Ralph J.

Source: Toxicology letters. 276:138-143

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100045232148.0x000001&indx=1&recIds=ETOCvdc_100045232148.0x000001

An integrated approach for prospectively investigating a mode-of-action for rodent liver effects

Authors: LeBaron, Matthew J., Geter, David R., Rasoulpour, Reza J., Gollapudi, B. Bhaskar, Thomas, Johnson, Murray, Jennifer, Kan, H. Lynn, Wood, Amanda J., Elcombe, Cliff, Vardy, Audrey, McEwan, Jillian, Terry, Claire, Billington, Richard

Source: In Toxicology and Applied Pharmacology 15 July 2013 270(2):164-173

Neurosteroid modulation of GABA A receptors

Authors: Lambert, Jeremy J., Belelli, Delia, Peden, Dianne R., Vardy, Audrey W., Peters, John A.

Source: In Progress in Neurobiology 2003 71(1):67-80

Assembly and Cell Surface Expression of Homomeric and Heteromeric 5-HT3 Receptors: The Role of Oligomerization and Chaperone Proteins

Authors: Boyd, Gary W., Low, Pamela, Dunlop, James I., Robertson, Laura A., Vardy, Audrey, Lambert, Jeremy J., Peters, John A., Connolly, Christopher N.

Source: In Molecular and Cellular Neuroscience 2002 21(1):38-50

CAR-mediated tumor formation in rats induced by the herbicide metazachlor

Authors: Wiemann, Christiane, Goettel, Manuela, Honarvar, Naveed, Vardy, Audrey, Fegert, Ivana

Source: Toxicology letters. 280(1):S135-S136

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100061453113.0x000001&indx=1&recIds=ETOCvdc_100061453113.0x000001

Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator.

Authors: Nudischer, Ramona, Renggli, Kasper, Bertinetti-Lapatki, Cristina, Hoflack, Jean-Christophe, Flint, Nicholas, Sewing, Sabine, Pedersen, Lykke, Schadt, Simone, Higgins, Larry G, Vardy, Audrey, Lenz, Barbara, Gand, Laurent, Boess, Franziska, Elcombe, Barbara M, Hierlemann, Andreas, Roth, Adrian B

Source: Toxicological Sciences; Aug2020, Vol. 176 Issue 2, p329-342, 14p, 1 Diagram, 6 Charts, 7 Graphs

Subject Terms: PREGNANE X receptor, ANDROSTANE receptors, KRA, OLIGONUCLEOTIDES, LIVER analysis, HUMAN behavior

An in vitro model for the prediction of chemical metabolism and toxicity

Authors: Ding, Shaohong, Vardy, Audrey, Elcombe, Clifford R., Wolf, C. Roland

Source: In Toxicology 2009 262(1):23-23

Investigative toxicology: Mechanism-based problem solving.

Authors: Vardy, Audrey¹, Elcombe, Cliff¹

Source: Speciality Chemicals. Jan2011, Vol. 31 Issue 1, p44-46. 3p. 3 Diagrams.

Subject Terms: *Research, *Problem solving, *Chemical industry, Genetic toxicology, Carcinogenicity, Laboratory rodents

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