Research Priorities for Atrial Fibrillation in Australia: A Statement From the Australian Cardiovascular Alliance Clinical Arrhythmia Theme

Authors: Abhayaratna, Walter, Al-Falahi, Zaidon, Bell, James, Burrell, Louise, Delbridge, Lea, Elliott, Adrian, Fatkin, Diane, Ganesan, Anand, Hall, Tanya, Hendriks, Jeroen, Hill, Adam, Hsu, Meng, Jenkins, Alicia, Kalman, Jonathan, Kilkenny, Monique, Kizana, Eddy, La Gerche, Andre, McMullen, Julie, Middeldorp, Melissa, Olaiya, Muideen, Ritchie, Rebecca, Sanders, Prash, Shang, Catherine, Thijs, Vincent, Thomas, Liza, Vandenberg, Jamie, Elliott, Adrian D., Middeldorp, Melissa E., McMullen, Julie R., Gwynne, Kylie, Hill, Adam P., Hsu, Meng-Ping, Vandenberg, Jamie I., Kalman, Jonathan M., Sanders, Prashanthan

Source: In Heart, Lung and Circulation November 2024 33(11):1523-1532

Cardiovascular Workforce Sustainability Sector Consultation: Recommendations From an Australian Stakeholder Summit

Authors: Santiago, Celine F. ^{a, b, 1}, Blekkenhorst, Lauren C. ^{c, d, 1}, Hsu, Meng-Ping ^e, Mirabito Colafella, Katrina M. ^{f, g}, Calkin, Anna C. ^h, Nicholls, Stephen J. ^{i, j}, Doyle, Kerry C. ^e, Vandenberg, Jamie I. ^{a, b}, Thomas, Emma E. ^{k, l, 2}, Chapman, Niamh ^{m, ∗, 2}

Source: In Heart, Lung and Circulation January 2025 34(1):95-101

Mechanistic Insights and Knowledge Gaps in the Effects of Radiation Therapy on Cardiac Arrhythmias

Authors: Balaji, Poornima ^{*, †}, Liulu, Xingzhou ^{*, †, ‡}, Sivakumar, Sonaali ^{*, †}, Chong, James J.H. ^{*, †, ‡, §}, Kizana, Eddy ^{*, †, ‡, §}, Vandenberg, Jamie I. ^‖, Hill, Adam P. ^‖, Hau, Eric ^{‡, ¶, #, ⁎⁎}, Qian, Pierre C. ^{*, †, ‡, 1}

Source: In International Journal of Radiation Oncology, Biology, Physics 1 January 2025 121(1):75-89

A Call to Action to Improve Cardiac Arrest Outcomes: A Report From the National Summit for Cardiac Arrest

Authors: La Gerche, Andre, Paratz, Elizabeth D., Bray, Janet E., Jennings, Garry, Page, Greg, Timbs, Susan, Vandenberg, Jamie I., Abhayaratna, Walter, Chow, Clara K., Dennis, Mark, Figtree, Gemma A., Kovacic, Jason C., Maris, Jessica, Nehme, Ziad, Parsons, Sarah, Pflaumer, Andreas, Puranik, Rajesh, Stub, Dion, Freitas, Edwin, Zecchin, Robert, Cartledge, Susie, Haskins, Brian, Ingles, Jodie

Source: In Heart, Lung and Circulation November 2024 33(11):1507-1522

A multitiered analysis platform for genome sequencing: Design and initial findings of the Australian Genomics Cardiovascular Disorders Flagship

Authors: Ades, Lesley, Enriquez, Annabel, McLean, Alison, Smyth, Renee, Alankarage, Dimithu, Fatkin, Diane, McNamara, James, Soka, Magdalena, Morgan almog, Fear, Vanessa, Medi, Caroline, Stark, Zornitza, Al-Shinnag, Mohammad, Fine, Miriam, Metke, Alejandro, Sy, Raymond, Atherton, John J., Finlay, Keri, Milnes, Di, Tang, Dotti, Austin, Rachel, Garza, Denisse, Milward, Michael, Taylor, Jessica, Bagnall, Richard D., Giannoulatou, Eleni, Morrish, Ansley, Taylor, Shelby, Barnett, Chris, Gongolidis, Laura, Morwood, Jim, Tchan, Michel, Blue, Gillian M., Gray, Belinda, Mountain, Helen, Thompson, Tina, Bodek, Simon, Greer, Cassie, Mowat, David, Thorpe, Jordan, Boggs, Kirsten, Haan, Eric, Ng, Chai-Ann, Trainer, Alison, Bogwitz, Michael, Haas, Mathilda, Nowak, Natalie, Trivedi, Gunjan, Boughtwood, Tiffany, Hanna, Bernadette, Martinez, Noelia Nunez, Valente, Giulia, Bray, Alessandra, Harvey, Richard, Ohanian, Monique, van Spaendonck-Zwarts, Karin, Brion, Marie-Jo, Hayward, Janette, O’Sullivan, Sinead, Vandenberg, Jamie, Brown, Jaye, Herrera, Carmen, Overkov, Angela, Verma, Kunal, Richardson, Rob Bryson, Hill, Adam, Pachter, Nicholas, Vidgen, Miranda, Burnett, Leslie, Hollingsworth, Georgie, Patel, Chirag, Vohra, Jitendra, Burns, Charlotte, Hollway, Georgina, Perrin, Mark, Waddel-Smith, Kathryn, Cao, Michelle, Horton, Ari E., Perry, Matthew, Wallis, Mathew, Carr, Will, Howting, Denise, Pflaumer, Andreas, Weintraub, Robert G., Casauria, Sarah, Ingles, Jodie, Phillips, Peta, Wilson, Meredith, Chalinor, Heather, Isbister, Joanne, Phuong, Thuan, Winlaw, David, Chang, Yuchen, Jackson, Matilda, Pope-Couston, Rachel, Worgan, Lisa, Chapman, Gavin, James, Paul, Poplawski, Nicola K., Wornham, Linda, Charitou, Theosodia, Jane-Pantaleo, Sarah, Punni, Preeti, Wu, Kathy, Chong, Belinda, Johnson, Renee, Quinn, Michael C.J., Yeates, Laura, Collins, Felicity, Kelly, Andrew, Quinn, Michael, Zentner, Dominica, Correnti, Gemma, King-Smith, Sarah, Rajagopalan, Sulekha, Cox, Kathy, Kirk, Edwin, Raju, Hariharan, Cunningham, Fiona, Kummerfeld, Sarah, Rath, Emma M., Das, Debjani, Lassman, Timo, Regan, Matthew, Davis, Jason, Lipton, Jonathon, Rogers, Jonathan, Davis, Andrew, Lunke, Sebastian, Ryan, Mark, De Fazio, Paul, Macciocca, Ivan, Sandaradura, Sarah, de Silva, Michelle, MacIntyre, Paul, Schonrock, Nicole, Den Elzen, Nicola, Madelli, Evanthia O., Scuffham, Paul, Devery, Sophie, Mallawaarachchi, Amali, Semsarian, Chris, Dobbins, Julia, Mansour, Julia, Sherburn, Isabella, Dunwoodie, Sally L., Martin, Ellenore, Sherlock, Mary-Clare, Dwyer, Nathan, Mathew, Jacob, Singer, Emma, Elbracht-Leong, Stefanie, Mattiske, Tessa, Smerdon, Carla, Elliott, David, McGaughran, Julie, Smith, Janine, Brown, Jaye S., Haas, Matilda, Pantaleo, Sarah-Jane

Source: In Genetics in Medicine Open 2024 2

Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs With Potential to Prolong Cardiac Repolarization

Authors: Lee, William, Ng, Ben, Mangala, Melissa M., Perry, Matthew D., Subbiah, Rajesh N., Vandenberg, Jamie I., Hill, Adam P.

Source: Circulation.Arrhythmia and electrophysiology. 16(7):399-410

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193348104.0x000001&indx=1&recIds=ETOCvdc_100193348104.0x000001

Don’t Turn Off the Tap! The Importance of Discovery Science to the Australian Cardiovascular Sector and Improving Clinical Outcomes Into the Future

Authors: Bursill, Christina A., Smith, Nicola J., Palpant, Nathan, Tan, Isabella, Sunde, Margaret, Harvey, Richard P., Lewis, Benjamin, Figtree, Gemma A., Vandenberg, Jamie I.

Source: In Heart, Lung and Circulation October 2022 31(10):1321-1332

A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome

Authors: Jiang, Connie, Richardson, Ebony, Farr, Jessica, Hill, Adam P., Ullah, Rizwan, Kroncke, Brett M., Harrison, Steven M., Thomson, Kate L., Ingles, Jodie, Vandenberg, Jamie I., Ng, Chai-Ann

Source: American journal of human genetics. 109(7):1199-1207

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167273256.0x000001&indx=1&recIds=ETOCvdc_100167273256.0x000001

A massively parallel assay accurately discriminates between functionally normal and abnormal variants in a hotspot domain of KCNH2

Authors: Ng, Chai-Ann, Ullah, Rizwan, Farr, Jessica, Hill, Adam P., Kozek, Krystian A., Vanags, Loren R., Mitchell, Devyn W., Kroncke, Brett M., Vandenberg, Jamie I.

Source: American journal of human genetics. 109(7):1208-1216

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167273260.0x000001&indx=1&recIds=ETOCvdc_100167273260.0x000001

Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation

Authors: TeBay, Clifford, McArthur, Jeffrey R., Mangala, Melissa, Kerr, Nicholas, Heitmann, Stewart, Perry, Matthew D., Windley, Monique J., Vandenberg, Jamie I., Hill, Adam P.

Source: British journal of pharmacology. 179(11):2631-2646

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149851384.0x000001&indx=1&recIds=ETOCvdc_100149851384.0x000001

High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol

Authors: Windley, Monique J., Farr, Jessica, TeBay, Clifford, Vandenberg, Jamie I., Hill, Adam P.

Source: In Journal of Pharmacological and Toxicological Methods September-October 2022 117

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1

Authors: Kozek, Krystian A., Glazer, Andrew M., Ng, Chai-Ann, Blackwell, Daniel, Egly, Christian L., Vanags, Loren R., Blair, Marcia, Mitchell, Devyn, Matreyek, Kenneth A., Fowler, Douglas M., Knollmann, Bjorn C., Vandenberg, Jamie I., Roden, Dan M., Kroncke, Brett M.

Source: In Heart Rhythm December 2020 17(12):2180-2189

The diagnostic role of T wave morphology biomarkers in congenital and acquired long QT syndrome: A systematic review

Authors: Tardo, Daniel T., Peck, Matthew, Subbiah, Rajesh N., Vandenberg, Jamie I., Hill, Adam. P.

Source: Annals of noninvasive electrocardiology. 28(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170805532.0x000001&indx=1&recIds=ETOCvdc_100170805532.0x000001

The yin and yang of Tbx5 variant effects on sodium channel function

Authors: Kerr, Nicholas P, Vandenberg, Jamie I

Source: Cardiovascular research. 118(4):929-931

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152803645.0x000001&indx=1&recIds=ETOCvdc_100152803645.0x000001

High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants

Authors: Ng, Chai-Ann, Perry, Matthew D., Liang, Whitney, Smith, Nicola J., Foo, Brian, Shrier, Alvin, Lukacs, Gergely L., Hill, Adam P., Vandenberg, Jamie I.

Source: In Heart Rhythm March 2020 17(3):492-500

Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go–Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding

Authors: Lee, William, Windley, Monique J., Perry, Matthew D., Vandenberg, Jamie I., Hill, Adam P. ^*

Source: In Molecular Pharmacology May 2019 95(5):537-550

Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events

Authors: Ballouz, Sara, Mangala, Melissa M, Perry, Matthew D, Heitmann, Stewart, Gillis, Jesse A, Hill, Adam P, Vandenberg, Jamie I

Source: Cardiovascular research. 117(10):2216-2227

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135662357.0x000001&indx=1&recIds=ETOCvdc_100135662357.0x000001

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

Authors: Li, Zhihua, Mirams, Gary R., Yoshinaga, Takashi, Ridder, Bradley J., Han, Xiaomei, Chen, Janell E., Stockbridge, Norman L., Wisialowski, Todd A., Damiano, Bruce, Severi, Stefano, Morissette, Pierre, Kowey, Peter R., Holbrook, Mark, Smith, Godfrey, Rasmusson, Randall L., Liu, Michael, Song, Zhen, Qu, Zhilin, Leishman, Derek J., Steidl‐Nichols, Jill, Rodriguez, Blanca, Bueno‐Orovio, Alfonso, Zhou, Xin, Passini, Elisa, Edwards, Andrew G., Morotti, Stefano, Ni, Haibo, Grandi, Eleonora, Clancy, Colleen E., Vandenberg, Jamie, Hill, Adam, Nakamura, Mikiko, Singer, Thomas, Polonchuk, Liudmila, Greiter‐Wilke, Andrea, Wang, Ken, Nave, Stephane, Fullerton, Aaron, Sobie, Eric A., Paci, Michelangelo, Musuamba Tshinanu, Flora, Strauss, David G.

Source: Clinical pharmacology & therapeutics. 107(1):102-111

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100095987299.0x000001&indx=1&recIds=ETOCvdc_100095987299.0x000001

The Temperature Dependence of Kinetics Associated with Drug Block of hERG Channels Is Compound-Specific and an Important Factor for Proarrhythmic Risk Prediction

Authors: Windley, Monique J., Lee, William, Vandenberg, Jamie I., Hill, Adam P. ^*

Source: In Molecular Pharmacology July 2018 94(1):760-769

Towards a Structural View of Drug Binding to hERG K+ Channels

Authors: Vandenberg, Jamie I., Perozo, Eduardo, Allen, Toby W.

Source: In Trends in Pharmacological Sciences October 2017 38(10):899-907