The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes

Authors: Bowen, Margot E., McClendon, Jacob, Long, Hannah K., Sorayya, Aryo, Van Nostrand, Jeanine L., Wysocka, Joanna, Attardi, Laura D.

Source: In Developmental Cell 22 July 2019 50(2):212-228

AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation

Authors: Van Nostrand, Jeanine L., Hellberg, Kristina, Luo, En-Ching, Van Nostrand, Eric L., Dayn, Alina, Yu, Jingting, Shokhirev, Maxim N., Dayn, Yelena, Yeo, Gene W., Shaw, Reuben J.

Source: Genes & development. 34(19/20):1330-1344

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624881458&indx=1&recIds=ETOCRN624881458

Siva plays a critical role in mouse embryonic development

Authors: Jacobs, Suzanne B. R., Van Nostrand, Jeanine L., Bowen, Margot E., Baker, Julie C., Attardi, Laura D.

Source: Cell death and differentiation. 27(1):297-309

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193385640.0x000001&indx=1&recIds=ETOCvdc_100193385640.0x000001

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

Authors: Young, Nathan P., Kamireddy, Anwesh, Van Nostrand, Jeanine L., Eichner, Lillian J., Shokhirev, Maxim Nikolaievich, Dayn, Yelena, Shaw, Reuben J.

Source: Genes & development. 30(5):535-552

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN605520417&indx=1&recIds=ETOCRN605520417

Guilty as CHARGED: p53's expanding role in disease

Authors: Van Nostrand, Jeanine L, Attardi, Laura D

Source: Cell cycle. 13(24):3798-3807

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110828866.0x000001&indx=1&recIds=ETOCvdc_100110828866.0x000001

Inappropriate p53 activation during development induces features of CHARGE syndrome.

Authors: Van Nostrand, Jeanine L.¹, Jung, Heiyoun¹, Wysocka, Joanna², Martin, Donna M.³, Attardi, Laura D.⁴, Brady, Colleen A.⁵, Kozak, Margaret M.⁵, Johnson, Thomas M.⁵, Fuentes, Daniel R.⁵, Lin, Chieh-Yu⁵, Vogel, Hannes⁵, Lin, Chien-Jung⁵, Swiderski, Donald L.⁵, Bernstein, Jonathan A.⁵, Attié-Bitach, Tania⁵, Chang, Ching-Pin⁵

Source: Nature. 10/9/2014, Vol. 514 Issue 7521, p228-232. 5p.

Subject Terms: *CHARGE syndrome, *P53 protein, *COLOBOMA, *APOPTOSIS, *PHENOTYPES, *EAR abnormalities

Fine-tuning AMPK in physiology and disease using point-mutant mouse models

Authors: Ashraf, Naghmana, Van Nostrand, Jeanine L.

Source: Disease Models and Mechanisms; August 2024, Vol. 17 Issue: 8 pdmm050798-dmm050798, 1p

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Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.

Authors: Oravecz-Wilson, Katherine, Lauder, Emma, Taylor, Austin, Maneix, Laure, Van Nostrand, Jeanine L., Yaping Sun, Lu Li, Dongchang Zhao, Chen Liu, Reddy, Pavan

Source: Journal of Clinical Investigation. 3/1/2024, Vol. 134 Issue 5, p1-14. 14p.

Subjects: GRAFT versus host reaction, GRAFT versus host disease, HEMATOPOIETIC stem cell transplantation, AUTOPHAGY

AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy.

Authors: Chien-Min Hung¹, Lombardo, Portia S.¹, Malik, Nazma¹, Brun, Sonja N.¹, Hellberg, Kristina¹, Van Nostrand, Jeanine L.¹, Garcia, Daniel¹, Baumgart, Joshua¹, Diffenderfer, Ken², Asara, John M.³, Shaw, Reuben J.¹ shaw@salk.edu

Source: Science Advances. 4/7/2021, Vol. 7 Issue 15, p1-14. 14p.

Subject Terms: *PHOSPHORYLATION, *GLIAL cell line-derived neurotrophic factor, *LYSOSOMES