Islet cell stress induced by insulin-degrading enzyme deficiency promotes regeneration and protection from autoimmune diabetes

Authors: Zhu, Shuaishuai ^{1, 8}, Waeckel-Énée, Emmanuelle ¹, Oshima, Masaya ², Moser, Anna ¹, Bessard, Marie-Andrée ¹, Gdoura, Abdelaziz ¹, Roger, Kevin ³, Mode, Nina ², Lipecka, Joanna ³, Yilmaz, Ayse ¹, Bertocci, Barbara ¹, Diana, Julien ¹, Saintpierre, Benjamin ⁴, Guerrera, Ida Chiara ³, Scharfmann, Raphael ², Francesconi, Stefania ⁵, Mauvais, François-Xavier ^{1, 6}, van Endert, Peter ^{1, 7, 9, ∗}

Source: In iScience 21 June 2024 27(6)

Hydroxychloroquine sulfate: A novel treatment for lipin-1 deficiency?

Authors: Renard, Perrine, Caccavelli, Laure, Legendre, Antoine, Tuchmann-Durand, Caroline, Balakirouchenane, David, Blanchet, Benoit, Narjoz, Céline, Straube, Marjolène, Hubas, Arnaud, Garros, Alexa, Mention, Karine, Bednarek, Nathalie, Goudin, Nicolas, Broissand, Christine, Schlatter, Joel, Cisternino, Salvatore, Cagnard, Nicolas, van Endert, Peter, Diana, Julien, de Calbiac, Hortense, de Lonlay, Pascale

Source: In Biomedicine & Pharmacotherapy July 2023 163

Mast cell–mediated inflammation relies on insulin-regulated aminopeptidase controlling cytokine export from the Golgi

Authors: Weimershaus, Mirjana, Carvalho, Caroline, Rignault, Rachel, Waeckel-Enee, Emmanuelle, Dussiot, Michael, van Endert, Peter, Maciel, Thiago Trovati, Hermine, Olivier

Source: In The Journal of Allergy and Clinical Immunology June 2023 151(6):1595-1608

Cross-presentation by the others

Authors: Mauvais, François-Xavier, van Endert, Peter

Source: In Seminars in Immunology May 2023 67

Uncovering the genomic toll of the Black Death

Authors: Kuiper, Jonas, van Endert, Peter

Source: Trends in immunology. 44(2):90-92

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179821747.0x000001&indx=1&recIds=ETOCvdc_100179821747.0x000001

Discovery of New Nanomolar Selective IRAP Inhibitors.

Authors: He, Ben, Karroum, Nour Bou, Gealageas, Ronan, Mauvais, François-Xavier, Warenghem, Sandrine, Roignant, Matthieu, Kraupner, Nicolas, Lam, Bao Vy, Azaroual, Nathalie, Ultré, Vincent, Rech, Alexandre, Lesire, Laetitia, Couturier, Cyril, Leroux, Florence, van Endert, Peter, Deprez, Benoit, Deprez-Poulain, Rebecca

Source: Journal of Medicinal Chemistry; 2/27/2025, Vol. 68 Issue 4, p4168-4195, 28p

Epitope length variants balance protective immune responses and viral escape in HIV-1 infection

Authors: Pymm, Phillip, Tenzer, Stefan, Wee, Edmund, Weimershaus, Mirjana, Burgevin, Anne, Kollnberger, Simon, Gerstoft, Jan, Josephs, Tracy M., Ladell, Kristin, McLaren, James E., Appay, Victor, Price, David A., Fugger, Lars, Bell, John I., Schild, Hansjörg, van Endert, Peter, Harkiolaki, Maria, Iversen, Astrid K.N.

Source: In Cell Reports 1 March 2022 38(9)

Compromised mitochondrial quality control triggers lipin1-related rhabdomyolysis

Authors: Hamel, Yamina, Mauvais, François-Xavier, Madrange, Marine, Renard, Perrine, Lebreton, Corinne, Nemazanyy, Ivan, Pellé, Olivier, Goudin, Nicolas, Tang, Xiaoyun, Rodero, Mathieu P., Tuchmann-Durand, Caroline, Nusbaum, Patrick, Brindley, David N., van Endert, Peter, de Lonlay, Pascale

Source: In Cell Reports Medicine 17 August 2021 2(8)

Modulators of hERAP2 discovered by high-throughput screening

Authors: Medve, Laura, Gealageas, Ronan, Lam, Bao Vy, Guillaume, Valentin, Castillo-Aguilera, Omar, Camberlein, Virgyl, Piveteau, Catherine, Rosell, Melissa, Fleau, Charlotte, Warenghem, Sandrine, Charton, Julie, Dumont-Ryckembusch, Julie, Bosc, Damien, Leroux, Florence, van Endert, Peter, Deprez, Benoit, Deprez-Poulain, Rebecca

Source: In European Journal of Medicinal Chemistry 5 February 2021 211

Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes.

Authors: Bessard, Marie-Andrée, Moser, Anna, Waeckel-Énée, Emmanuelle, Lindo, Vivian, Gdoura, Abdelaziz, You, Sylvaine, Wong, F. Susan, Greer, Fiona, van Endert, Peter

Source: Frontiers in Immunology; 2024, p1-13, 13p

Subject Terms: PANCREATIC beta cells, TYPE 1 diabetes, T cells, ISLANDS of Langerhans, ENZYME deficiency

Sex- and time-dependent role of insulin regulated aminopeptidase in lipopolysaccharideinduced inflammation.

Authors: Vear, Anika, Chakraborty, Amlan, Fahimi, Farnaz, Ferens, Dorota, Widdop, Robert, Samuel, Chrishan S., Gaspari, Tracey, van Endert, Peter M., Chai, Siew Yeen

Source: Frontiers in Immunology; 2024, p1-18, 18p

Subject Terms: CELL populations, SEPTIC shock, DENDRITIC cells, T cells, KNOCKOUT mice

Insulin‐degrading enzyme inhibition increases the unfolded protein response and favours lipid accumulation in the liver.

Authors: Andres, Marine, Hennuyer, Nathalie, Zibar, Khamis, Bicharel‐Leconte, Marie, Duplan, Isabelle, Enée, Emmanuelle, Vallez, Emmanuelle, Herledan, Adrien, Loyens, Anne, Staels, Bart, Deprez, Benoit, van Endert, Peter, Deprez‐Poulain, Rebecca, Lancel, Steve

Source: British Journal of Pharmacology; Oct2024, Vol. 181 Issue 19, p3610-3626, 17p

Subject Terms: NON-alcoholic fatty liver disease, UNFOLDED protein response, FATTY liver, LIVER proteins, LIVER enzymes

Immunosuppression by Mutated Calreticulin Released from Malignant Cells

Authors: Liu, Peng, Zhao, Liwei, Loos, Friedemann, Marty, Caroline, Xie, Wei, Martins, Isabelle, Lachkar, Sylvie, Qu, Bo, Waeckel-Énée, Emmanuelle, Plo, Isabelle, Vainchenker, William, Perez, Franck, Rodriguez, David, López-Otin, Carlos, van Endert, Peter, Zitvogel, Laurence, Kepp, Oliver, Kroemer, Guido

Source: In Molecular Cell 20 February 2020 77(4):748-760

Impact of the TAP-like transporter in antigen presentation and phagosome maturation

Authors: Lawand, Myriam, Evnouchidou, Irini, Baranek, Thomas, Montealegre, Sebastian, Tao, Sha, Drexler, Ingo, Saveanu, Loredana, Si-Tahar, Mustapha, van Endert, Peter

Source: In Molecular Immunology September 2019 113:75-86

Peptide trimming by endoplasmic reticulum aminopeptidases: Role of MHC class I binding and ERAP dimerization

Authors: Evnouchidou, Irini, van Endert, Peter

Source: In Human Immunology May 2019 80(5):290-295

Stabilization of the open conformation οf insulin‐regulated aminopeptidase by a novel substrate‐selective small‐molecule inhibitor.

Authors: Mpakali, Anastasia, Georgaki, Galateia, Buson, Alberto, Findlay, Alison D., Foot, Jonathan S., Mauvais, Francois‐Xavier, van Endert, Peter, Giastas, Petros, Hamprecht, Dieter W., Stratikos, Efstratios

Source: Protein Science: A Publication of the Protein Society; Sep2024, Vol. 33 Issue 9, p1-18, 18p

Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes

Authors: Miani, Michela, Le Naour, Julie, Waeckel-Enée, Emmanuelle, Verma, Subash chand, Straube, Marjolène, Emond, Patrick, Ryffel, Bernhard, van Endert, Peter, Sokol, Harry, Diana, Julien

Source: In Cell Metabolism 2 October 2018 28(4):557-572

Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation

Authors: Weimershaus, Mirjana, Mauvais, François-Xavier, Saveanu, Loredana, Adiko, Cézaire, Babdor, Joël, Abramova, Anastasia, Montealegre, Sebastian, Lawand, Myriam, Evnouchidou, Irini, Huber, Katharina Julia, Chadt, Alexandra, Zwick, Markus, Vargas, Pablo, Dussiot, Michael, Lennon-Dumenil, Ana Maria, Brocker, Thomas, Al-Hasani, Hadi, van Endert, Peter

Source: In Cell Reports 25 September 2018 24(13):3568-3581

microRNA 125a Regulates MHC-I Expression on Esophageal Adenocarcinoma Cells, Associated With Suppression of Antitumor Immune Response and Poor Outcomes of Patients

Authors: Mari, Luigi, Hoefnagel, Sanne J.M., Zito, Domenico, van de Meent, Marian, van Endert, Peter, Calpe, Silvia, Sancho Serra, Maria del Carmen, Heemskerk, Mirjam H.M., van Laarhoven, Hanneke W.M., Hulshof, Maarten C.C.M., Gisbertz, Susanne S., Medema, Jan Paul, van Berge Henegouwen, Mark I., Meijer, Sybren L., Bergman, Jacques J.G.H.M., Milano, Francesca, Krishnadath, Kausilia K.

Source: In Gastroenterology September 2018 155(3):784-798

Trimming of MHC Class I Ligands by ERAP Aminopeptidases

Authors: Weimershaus, Mirjana, Evnouchidou, Irini, Li, Lenong, van Endert, Peter, Bouvier, Marlene

Source: Methods in molecular biology. 1988:31-44

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620394762&indx=1&recIds=ETOCRN620394762