Responses in Blood Pressure and Kidney Function to Soluble Guanylyl Cyclase Stimulation or Activation in Normal and Diabetic Rats

Authors: Patel, Rohit, Fu, Yiling, Khang, Ser, Benardeau, Agnes M., Thomson, Scott C., Vallon, Volker

Source: Nephron journals. 147(5):281-300

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SGLT2 Inhibition and Uric Acid Excretion in Patients with Type 2 Diabetes and Normal Kidney Function

Authors: Suijk, Danii L.S., van Baar, Michaël J.B., van Bommel, Erik J.M., Iqbal, Zainab, Krebber, Merle M., Vallon, Volker, Touw, Daan, Hoorn, Ewout J., Nieuwdorp, Max, Kramer, Mark M.H., Joles, Jaap A., Bjornstad, Petter, van Raalte, Daniël H.

Source: Clinical journal of the American Society of Nephrology. 17(5):663-671

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Renal Clearance of Fibroblast Growth Factor‐23 (FGF23) and its Fragments in Humans

Authors: Sharma, Shilpa, Katz, Ronit, Ginsberg, Charles, Bullen, Alexander, Vallon, Volker, Thomson, Scott, Moe, Orson W., Hoofnagle, Andrew N., Leeuw, Peter W., Kroon, Abraham A., Houben, Alfons J.H.M., Ix, Joachim H.

Source: Journal of bone and mineral research. 37(6):1170-1178

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Protecting the Kidney: The Unexpected Logic of Inhibiting a Glucose Transporter

Authors: Vallon, Volker, Kim, Young Chul

Source: Clinical pharmacology & therapeutics. 112(3):434-438

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Role of the macula densa sodium glucose cotransporter type 1-neuronal nitric oxide synthase-tubuloglomerular feedback pathway in diabetic hyperfiltration

Authors: Zhang, Jie, Cai, Jing, Cui, Yu, Jiang, Shan, Wei, Jin, Kim, Young Chul, Chan, Jenna, Thalakola, Anish, Le, Thanh, Xu, Lan, Wang, Lei, Jiang, Kun, Wang, Ximing, Wang, Haibo, Cheng, Feng, Buggs, Jacentha, Koepsell, Hermann, Vallon, Volker, Liu, Ruisheng

Source: Kidney international. 101(3):541-550

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Western diet exacerbates a murine model of Balkan nephropathy.

Authors: Oe, Yuji, Kim, Young Chul, Kanoo, Sadhana, Goodluck, Helen A., Lopez, Natalia, Diedrich, Jolene, Pinto, Antonio Michel, Evensen, K. Garrett, Currais, Antonio Jose Martins, Maher, Pamela, Vallon, Volker

Source: American Journal of Physiology: Renal Physiology; Jan2025, Vol. 328 Issue 1, pF15-F28, 14p

Subject Terms: DNA repair, ORGANIC anion transporters, ION transport (Biology), RENAL fibrosis, WESTERN diet

Transcriptomics of SGLT2-positive early proximal tubule segments in mice: response to type 1 diabetes, SGLT1/2 inhibition, or GLP1 receptor agonism.

Authors: Kim, Young Chul, Das, Vivek, Kanoo, Sadhana, Yao, Huazhen, Stanford, Stephanie M., Bottini, Nunzio, Karihaloo, Anil, Vallon, Volker

Source: American Journal of Physiology: Renal Physiology; Jan2025, Vol. 328 Issue 1, pF68-F81, 14p

Subject Terms: GLUCAGON-like peptide-1 receptor, ION transport (Biology), TYPE 1 diabetes, GLUCAGON-like peptide-1 agonists, GENE expression profiling, DAPAGLIFLOZIN, ORGANIC anion transporters

SGLT2 Inhibition for CKD and Cardiovascular Disease in Type 2 Diabetes: Report of a Scientific Workshop Sponsored by the National Kidney Foundation

Authors: Tuttle, Katherine R., Brosius, Frank C., III, Cavender, Matthew A., Fioretto, Paola, Fowler, Kevin J., Heerspink, Hiddo J.L., Manley, Tom, McGuire, Darren K., Molitch, Mark E., Mottl, Amy K., Perreault, Leigh, Rosas, Sylvia E., Rossing, Peter, Sola, Laura, Vallon, Volker, Wanner, Christoph, Perkovic, Vlado

Source: In American Journal of Kidney Diseases January 2021 77(1):94-109

Knockout of Macula Densa Neuronal Nitric Oxide Synthase Increases Blood Pressure in db/db Mice

Authors: Zhang, Jie, Wang, Ximing, Cui, Yu, Jiang, Shan, Wei, Jin, Chan, Jenna, Thalakola, Anish, Le, Thanh, Xu, Lan, Zhao, Liang, Wang, Lei, Jiang, Kun, Cheng, Feng, Patel, Trushar, Buggs, Jacentha, Vallon, Volker, Liu, Ruisheng

Source: Hypertension. 78(6):1760-1770

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State-of-the-Art-Review: Mechanisms of Action of SGLT2 Inhibitors and Clinical Implications.

Authors: Vallon, Volker

Source: American Journal of Hypertension; Nov2024, Vol. 37 Issue 11, p841-852, 12p

Subject Terms: KIDNEY cortex, BLOOD volume, TYPE 2 diabetes, GLUCOSE transporters, OXYGEN in the blood, URATES

How can inhibition of glucose and sodium transport in the early proximal tubule protect the cardiorenal system?

Authors: Vallon, Volker^1,2,3 (AUTHOR) vvallon@health.ucsd.edu

Source: Nephrology Dialysis Transplantation. Oct2024, Vol. 39 Issue 10, p1565-1573. 9p.

Subject Terms: *PROXIMAL kidney tubules, *OXYGEN detectors, *TYPE 2 diabetes, *RF values (Chromatography), *GLOMERULAR filtration rate, *SODIUM-glucose cotransporters

The role of renal hypoxia in the pathogenesis of diabetic kidney disease: a promising target for newer renoprotective agents including SGLT2 inhibitors?

Authors: Hesp, Anne C., Schaub, Jennifer A., Prasad, Pottumarthi V., Vallon, Volker, Laverman, Gozewijn D., Bjornstad, Petter, van Raalte, Daniël H.

Source: In Kidney International September 2020 98(3):579-589

Did you know how SGLT2 inhibitors protect the kidney?

Authors: Layton, Anita T., Vallon, Volker

Source: Acta physiologica. 238(4)

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Renal Effects of Sodium-Glucose Co-Transporter Inhibitors

Authors: Thomson, Scott C., Vallon, Volker

Source: In The American Journal of Cardiology 15 December 2019 124 Supplement 1:S28-S35

Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alström Syndrome

Authors: Kim, Young Chul, Ganguly, Souradipta, Nespoux, Josselin, Freeman, Brent, Zhang, Haiyan, Brenner, David, Dhar, Debanjan, Vallon, Volker

Source: Nephron journals. 144(8):400-412

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Glucose transporters in the kidney in health and disease

Authors: Vallon, Volker

Source: Pflügers Archiv. 472(9):1345-1370

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Deletion, but Not Heterozygosity, of eNOS Raises Blood Pressure and Aggravates Nephropathy in BTBR ob/ob Mice.

Authors: Kanoo, Sadhana, Goodluck, Helen, Kim, Young Chul, Garrido, Aleix Navarro, Crespo-Masip, Maria, Lopez, Natalia, Zhang, Haiyan, Gonzalez-Villalobos, Romer A., Ma, Li-Jun, Vallon, Volker

Source: Nephron; 2024, Vol. 148 Issue 9, p631-642, 12p

How do Kidneys Adapt to a Deficit or Loss in Nephron Number?

Authors: Fattah, Hadi, Layton, Anita, Vallon, Volker

Source: Physiology. 34:189-197

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Systemic proteomic and metabolomic signature of the SGLT2 inhibitor dapagliflozin

Authors: Billing, Anja, Kim, Young‐Chul, Vallon, Volker, Rinschen, Markus

Source: FASEB journal. 36

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Sustained Exposure to the SGLT2 Inhibitor Ertugliflozin, But Not NHE‐1 Inhibition By Cariporide, Attenuates Adrenergic Stimulation of Cytosolic CA2+ Levels in Spontaneously Contracting Cardiac Myocytes

Authors: Alam, Sifat M., Gierden, Kyle J., Zhao, Tengteng, Lu, Sun S., Dixit, Mihir, Babicheva, Aleksandra, Yuan, Jason, Vallon, Volker, Zemljic‐Harpf, Alice E.

Source: FASEB journal. 36

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