Molecular profiling of metastatic breast cancer and target-based therapeutic matching in an Asian tertiary phase I oncology unit

Authors: Robert John Walsh, Rebecca Ong, Seng Wee Cheo, Peter Q.J. Low, Aishwarya Jayagopal, Matilda Lee, Natalie Ngoi, Samuel G. Ow, Andrea L.A. Wong, Siew Eng Lim, Yi Wan Lim, Valerie Heong, Raghav Sundar, Ross A. Soo, Cheng Ean Chee, Wei Peng Yong, Boon Cher Goh, Soo Chin Lee, David S.P. Tan, Joline S.J. Lim

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: breast cancer, precision oncology, molecular profiling, next-generation sequencing (NGS), phase I, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1342346/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/98dbdbab3f7349b688320adc069900de

The microtubule inhibitor eribulin demonstrates efficacy in platinum-resistant and refractory high-grade serous ovarian cancer patient-derived xenograft models

Authors: Gwo Yaw Ho, Cassandra J. Vandenberg, Ratana Lim, Elizabeth L. Christie, Dale W. Garsed, Elizabeth Lieschke, Ksenija Nesic, Olga Kondrashova, Gayanie Ratnayake, Marc Radke, Jocelyn S. Penington, Amandine Carmagnac, Valerie Heong, Elizabeth L. Kyran, Fan Zhang, Nadia Traficante, Ruby Huang, Alexander Dobrovic, Elizabeth M. Swisher, Orla McNally, Damien Kee, Matthew J. Wakefield, Anthony T. Papenfuss, David D. L. Bowtell, Holly E. Barker, Clare L. Scott

Source: Therapeutic Advances in Medical Oncology, Vol 15 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1758-8359

Access URL: https://doaj.org/article/acfd52763fdb4a6092abd9806478e071

A phase 1 study of the safety, pharmacokinetics and pharmacodynamics of escalating doses followed by dose expansion of the selective inhibitor of nuclear export (SINE) selinexor in Asian patients with advanced or metastatic malignancies

Authors: Jingshan Ho, Valerie Heong, Wei Peng Yong, Ross Soo, Cheng Ean Chee, Andrea Wong, Raghav Sundar, Yee Liang Thian, Anil Gopinathan, Mei Yan Pang, Priscillia Koe, Santhiay Nathan Jeraj, Phyu Pyar Soe, Mu Yar Soe, Tiffany Tang, Matthew C.H. Ng, David W.M. Tai, Tira J.Y. Tan, Hongmei Xu, Hua Chang, Yosef Landesman, Jatin Shah, Sharon Shacham, Soo Chin Lee, Daniel S.W. Tan, Boon Cher Goh, David S.P. Tan

Source: Therapeutic Advances in Medical Oncology, Vol 14 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1758-8359

Access URL: https://doaj.org/article/c79a3aab5cd24242a6a55312f1cb0bbf

The FZD7‐TWIST1 axis is responsible for anoikis resistance and tumorigenesis in ovarian carcinoma

Authors: Ming Tan, Mohammad Asad, Valerie Heong, Meng Kang Wong, Tuan Zea Tan, Jieru Ye, Kuee Theng Kuay, Jean Paul Thiery, Clare Scott, Ruby Yun‐Ju Huang

Source: Molecular Oncology, Vol 13, Iss 4, Pp 757-780 (2019)

Subject Terms: anoikis, BCL2, FZD7, ovarian carcinoma, tumorigenesis, TWIST1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/627ec59c33f042d7ac79b4f714ad778a

Statistical Process Control Charts for Monitoring Next-Generation Sequencing and Bioinformatics Turnaround in Precision Medicine Initiatives

Authors: Sneha Rajiv Jain, Wilson Sim, Cheng Han Ng, Yip Han Chin, Wen Hui Lim, Nicholas L. Syn, Nur Haidah Bte Ahmad Kamal, Mehek Gupta, Valerie Heong, Xiao Wen Lee, Nur Sabrina Sapari, Xue Qing Koh, Zul Fazreen Adam Isa, Lucius Ho, Caitlin O’Hara, Arvindh Ulagapan, Shi Yu Gu, Kashyap Shroff, Rei Chern Weng, Joey S. Y. Lim, Diana Lim, Brendan Pang, Lai Kuan Ng, Andrea Wong, Ross Andrew Soo, Wei Peng Yong, Cheng Ean Chee, Soo-Chin Lee, Boon-Cher Goh, Richie Soong, David S.P. Tan

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: precision medicine, computational biology, next generation sequencing, precision oncology, bioinformatics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.736265/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/480d74809a6444808db8f8d1fd0737bc

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Authors: Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann, Kevin K. Lin, Thomas C. Harding, Nadia Traficante, Australian Ovarian Cancer Study (AOCS), Anna deFazio, Iain A. McNeish, David D. Bowtell, Elizabeth M. Swisher, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott

Source: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/daa72fc740814394b7993401524f3f72