Cdk6’s functions are critically regulated by its unique C-terminus

Authors: Alessia Schirripa, Helge Schöppe, Sofie Nebenfuehr, Markus Zojer, Thorsten Klampfl, Valentina Kugler, Belinda S. Maw, Huriye Ceylan, Iris Z. Uras, Lisa Scheiblecker, Elisabeth Gamper, Ulrich Stelzl, Eduard Stefan, Teresa Kaserer, Veronika Sexl, Karoline Kollmann

Source: iScience, Vol 28, Iss 2, Pp 111697- (2025)

Subject Terms: Biochemistry, Molecular Structure, Structural biology, Cancer, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224029249; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/50f9aaca33e34a8e823674aad486339c

Impact of protein and small molecule interactions on kinase conformations

Authors: Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair, Veronika Sexl, Pascal Meier, Teresa Kaserer, Eduard Stefan

Source: eLife, Vol 13 (2024)

Subject Terms: kinase conformation, target engagement, drug interactions, kinase scaffolding function, kinase complex formation, cell-based reporter assay, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/94755; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/71c92e4b1a0b490fa5cb3387e2ae8a9c

Disruptor: Computational identification of oncogenic mutants disrupting protein-protein and protein-DNA interactions

Authors: Valentina Kugler, Andreas Lieb, Nathan Guerin, Bruce R. Donald, Eduard Stefan, Teresa Kaserer

Source: Communications Biology, Vol 6, Iss 1, Pp 1-6 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/44c54c3e1e4348bb8e98e527dd1bde73

Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico

Authors: Jakob Fleischmann, Andreas Feichtner, Louis DeFalco, Valentina Kugler, Selina Schwaighofer, Roland G Huber, Eduard Stefan

Source: Biomolecules, Vol 11, Iss 4, p 518 (2021)

Subject Terms: RAF, RAS, ERK, kinase inhibitor, allosteric inhibitor, cancer mutations, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/11/4/518; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/6411160c8b174af68957ffdf8eb8a5b7