Tumor-derived G-CSF induces an immunosuppressive microenvironment in an osteosarcoma model, reducing response to CAR.GD2 T-cells

Authors: Michele Pezzella, Concetta Quintarelli, Maria C. Quadraccia, Andrea Sarcinelli, Simona Manni, Laura Iaffaldano, Alessio Ottaviani, Roselia Ciccone, Antonio Camera, Maria L. D’Amore, Stefano Di Cecca, Matilde Sinibaldi, Marika Guercio, Mariasole Aurigemma, Pamela De Falco, Valentina Fustaino, Rossella Rota, Silvia Pomella, Matteo Cassandri, Angela Di Giannatale, Chiara Agrati, Veronica Bordoni, Federica Guarracino, Michele Massa, Giada Del Baldo, Marco Becilli, Giuseppe M. Milano, Francesca Del Bufalo, Franco Locatelli, Biagio De Angelis

Source: Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-23 (2024)

Subject Terms: GD2, Chimeric antigen receptor (CAR), Sarcoma, ICasp9.2A.GD2.CAR-CD28.4–1BBζ, CAR.GD2 T-cells, EZH2 inhibitor, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/d31ce40cc6e6413095e8c1ada8b07976

Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress

Authors: Silvia Cardarelli, Martina Biglietto, Tiziana Orsini, Valentina Fustaino, Lucia Monaco, Ana Gabriela de Oliveira do Rêgo, Francesca Liccardo, Silvia Masciarelli, Francesco Fazi, Fabio Naro, Luciana De Angelis, Manuela Pellegrini

Source: Cell Death and Disease, Vol 15, Iss 2, Pp 1-13 (2024)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/9e92047c17d740e299d954bf14c8d523

The activity of a PI3K δ-sparing inhibitor, MEN1611, in non-small cell lung cancer cells with constitutive activation of the PI3K/AKT/mTOR pathway

Authors: Giuliana Papoff, Dario Presutti, Valentina Fustaino, Andrea Parente, Clelia Calandriello, Stefano Alemà, Ferdinando Scavizzi, Marcello Raspa, Giuseppe Merlino, Massimiliano Salerno, Mario Bigioni, Monica Binaschi, Giovina Ruberti

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: NSCLC, PI3K inhibitor, EGFR-TKIs, drug-resistance, combination therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1283951/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/280dc1bb29754467928f7742e2628ec3

Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by 1H-NMR spectroscopy.

Authors: Alessandra Guidi, Greta Petrella, Valentina Fustaino, Fulvio Saccoccia, Sara Lentini, Roberto Gimmelli, Giulia Di Pietro, Alberto Bresciani, Daniel Oscar Cicero, Giovina Ruberti

Source: PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008767 (2020)

Subject Terms: Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735

Access URL: https://doaj.org/article/9de522a703934102aba12d64e4e2443f

MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells.

Authors: Dario Presutti, Simonetta Santini, Beatrice Cardinali, Giuliana Papoff, Cristiana Lalli, Simone Samperna, Valentina Fustaino, Giuseppe Giannini, Giovina Ruberti

Source: PLoS ONE, Vol 10, Iss 11, p e0143333 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4651538?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6a8affea9d934b048239ca508fb43c89