Neutralization diversity of HIV-1 Indian subtype C envelopes obtained from cross sectional and followed up individuals against broadly neutralizing monoclonal antibodies having distinct gp120 specificities

Authors: Ranajoy Mullick, Jyoti Sutar, Nitin Hingankar, Suprit Deshpande, Madhuri Thakar, Seema Sahay, Rajesh P. Ringe, Sampurna Mukhopadhyay, Ajit Patil, Shubhangi Bichare, Kailapuri G. Murugavel, Aylur K. Srikrishnan, Rajat Goyal, Devin Sok, Jayanta Bhattacharya

Source: Retrovirology, Vol 18, Iss 1, Pp 1-13 (2021)

Subject Terms: HIV-1, Clade C, Neutralizing antibodies, Envelope, VRC01, CAP256-VRC26.25, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1742-4690

Access URL: https://doaj.org/article/99653c24e0ee4fc79b2ce85aad8fba26

Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor

Contributors: Shao, Yiming [Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing (China); Peking Univ., Beijing (China); Nankai Univ., Tainjin (China)]

Source: Immunity; 44; 4

File Description: Medium: ED; Size: p. 939-950

Access URL: http://www.osti.gov/scitech/servlets/purl/1252759

Structure-Based Identification of Natural-Product-Derived Compounds with Potential to Inhibit HIV-1 Entry

Authors: Nneka Ugwu-Korie, Osbourne Quaye, Edward Wright, Sylvester Languon, Odame Agyapong, Emmanuel Broni, Yash Gupta, Prakasha Kempaiah, Samuel K. Kwofie

Source: Molecules, Vol 28, Iss 2, p 474 (2023)

Subject Terms: HIV-1 entry, inhibition, CD4-binding site, VRC01, gp120, virtual screening, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/2/474; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/54c299fa218b4cbeae41fef4fbceed89

Modeling HIV-1 Within-Host Dynamics After Passive Infusion of the Broadly Neutralizing Antibody VRC01

Authors: E. Fabian Cardozo-Ojeda, Alan S. Perelson

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: virus dynamics, HIV-1, VRC01, mathematical modeling, ODE, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.710012/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4fea6d4ec5e34bc3ae62cceba36b7800

Pharmacokinetics and predicted neutralisation coverage of VRC01 in HIV-uninfected participants of the Antibody Mediated Prevention (AMP) trials

Authors: Yunda Huang, Logashvari Naidoo, Lily Zhang, Lindsay N. Carpp, Erika Rudnicki, April Randhawa, Pedro Gonzales, Adrian McDermott, Julie Ledgerwood, Margarita M.Gomez Lorenzo, David Burns, Allan DeCamp, Michal Juraska, John Mascola, Srilatha Edupuganti, Nyaradzo Mgodi, Myron Cohen, Lawrence Corey, Philip Andrew, Shelly Karuna, Peter B. Gilbert, Kathryn Mngadi, Erica Lazarus

Source: EBioMedicine, Vol 64, Iss , Pp 103203- (2021)

Subject Terms: Antibody mediated prevention trials, Population pharmacokinetics, VRC01, Broadly neutralising antibodies, HIV-1, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S235239642030579X; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/46ca6747a177430f915ba48c115dcd47

A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention

Authors: Young D. Kwon, Mangaiarkarasi Asokan, Jason Gorman, Baoshan Zhang, Qingbo Liu, Mark K. Louder, Bob C. Lin, Krisha McKee, Amarendra Pegu, Raffaello Verardi, Eun Sung Yang, VRC Production Program, Kevin Carlton, Nicole A. Doria-Rose, Paolo Lusso, John R. Mascola, Peter D. Kwong

Source: mAbs, Vol 13, Iss 1 (2021)

Subject Terms: Antibody VRC01, broadly neutralizing antibody, HIV-1 envelope trimer, matrix-based design, polyreactivity, prophylaxis, Therapeutics. Pharmacology, RM1-950, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/1942-0862; https://doaj.org/toc/1942-0870

Access URL: https://doaj.org/article/fd7ff32ab1e546deaa0798bcdf196936

Modeling cumulative overall prevention efficacy for the VRC01 phase 2b efficacy trials

Authors: Yunda Huang, Shelly Karuna, Lindsay N. Carpp, Daniel Reeves, Amarendra Pegu, Kelly Seaton, Kenneth Mayer, Joshua Schiffer, John Mascola, Peter B. Gilbert

Source: Human Vaccines & Immunotherapeutics, Vol 14, Iss 9, Pp 2116-2127 (2018)

Subject Terms: antibody mediated prevention trial, broadly neutralizing antibody, non-human primate challenge study, population pharmacokinetics, statistical modeling of hiv prevention efficacy, vrc01, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X

Access URL: https://doaj.org/article/14375d417ee24111baa289d8eaaa14dd

Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FIT45

Authors: Alexander Falkenhagen, Sadhna Joshi

Source: Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 387-395 (2017)

Subject Terms: bifunctional antiviral proteins, entry inhibitor, fusion inhibitor, sCD4, VRC01, sCD4-FIT45, gene therapy, HIV, entry, cell fusion, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253117301683; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/23a8eef9e49846afbe082b2d607f65d6

Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors

Authors: Christina Yacoob, Marie Pancera, Vladimir Vigdorovich, Brian G. Oliver, Jolene A. Glenn, Junli Feng, D. Noah Sather, Andrew T. McGuire, Leonidas Stamatatos

Source: Cell Reports, Vol 17, Iss 6, Pp 1560-1570 (2016)

Subject Terms: HIV, VRC01, broadly neutralizing antibodies, human alleles, CDRH3, germline, human antibodies, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716314036; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/89b0691fe5784d43ad3379ed62d6fd1e

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

Authors: Andrew J Borst, Connor E Weidle, Matthew D Gray, Brandon Frenz, Joost Snijder, M Gordon Joyce, Ivelin S Georgiev, Guillaume BE Stewart-Jones, Peter D Kwong, Andrew T McGuire, Frank DiMaio, Leonidas Stamatatos, Marie Pancera, David Veesler

Source: eLife, Vol 7 (2018)

Subject Terms: HIV, HIV envelope, VRC01, cryoEM, crystallography, glycan shield, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/37688; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/a11468bd4dce41cdae2356acea7e4869

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Mouse Models Expresssing Precursors of Broadly Neutralizing Antibodies Against HIV

Authors: Dao, Mai

Source: Dao, Mai. 2019. Mouse Models Expresssing Precursors of Broadly Neutralizing Antibodies Against HIV. Doctoral dissertation, Harvard Medical School.

Subject Terms: HIV vaccine, broadly neutralizing antibodies, mouse models, VRC01, vaccine

File Description: application/pdf; application/pdf

Access URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42063326

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