VEGF-B is a novel mediator of ER stress which induces cardiac angiogenesis via RGD-binding integrins independent of VEGFR1/NRP activities

Authors: Mallick, Rahul ¹, Montaser, Ahmed B. ², Komi, Henna ¹, Juusola, Greta ^{1, 3}, Tirronen, Annakaisa ¹, Gurzeler, Erika ¹, Barbiera, Maria ¹, Korpisalo, Petra ³, Terasaki, Tetsuya ², Nieminen, Tiina ^{1, 4}, Ylä-Herttuala, Seppo ^{1, 3, 4, ∗}

Source: In Molecular Therapy March 2025

Melatonin attenuates diabetic cardiomyopathy by increasing autophagy of cardiomyocytes via regulation of VEGF-B/GRP78/PERK signaling pathway

Authors: Shengzheng Zhang, Wencong Tian, Xianxian Duan, Qian Zhang, Lei Cao, Chunlei Liu, Guangru Li, Ziwei Wang, Junwei Zhang, Jing Li, Liang Yang, Yang Gao, Yang Xu, Jie Liu, Jie Yan, Jianlin Cui, Lifeng Feng, Chang Liu, Yanna Shen, Zhi Qi

Source: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-18 (2024)

Subject Terms: Melatonin, Diabetic cardiomyopathy, VEGF-B, Autophagy, Endoplasmic reticulum stress, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2840

Access URL: https://doaj.org/article/0f365877786543b2be1401a563fb80ac

Novel Applications and Technologies for the Industrial Exploitation of Algal Derived Marine Bioactives as Nutraceuticals or Pharmaceuticals

Contributors: García-Vaquero, Marco, Tiwari, Brijesh K.

Subject Terms: seaweed, innovative technology, extraction, polyphenol, nutraceuticals, Sargassum fusiforme polysaccharides, high-fat diet, cecal microbiota, fecal microbiota, 16S rRNA gene sequencing, fucosterol, algae, toxicity, in vivo, in vitro, adaptive laboratory evolution, microalgal production, environmental tolerance, ceramides, MCF-7, Ehrlich ascites carcinoma, VEGF-B, TNF-α, midkine, apoptosis, p53, LC-ESI-HRMS, Hypnea musciformis, Cystoseira compressa, microwave-assisted extraction, green extraction, biological activity, seasonal variations, fatty acids, marine biome, marine bioactive peptides, natural resources, bioactivities, pharmacology, biomedical, therapeutic attributes, in silico, biotechnology, cryptides, anti-hypertensive, antioxidant, anti-cancer, biopharmaceuticals, recombinant proteins, transient expression, viral vectors, Medicine and Nursing, Manufacturing industries

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/98971
https://mdpi.com/books/pdfview/book/7031

Advancing temporal sepsis biomarking: Covariate vascular endothelial growth factor A and B gene expression profiling in a murine model of SARS-CoV infection

Authors: Asrar Rashid, Feras Al-Obeidat, Kesava Ramakrishnan, Wael Hafez, Nouran Hamza, Zainab A. Malik, Raziya Kadwa, Muneir Gador, Govind Benakatti, Rayaz A Malik, Ibrahim Elbialy, Hekmieh Manad, Guftar Shaikh, Ahmed Al-Dubai, Amir Hussain

Source: Informatics in Medicine Unlocked, Vol 47, Iss , Pp 101474- (2024)

Subject Terms: Temporal sepsis biomarking, Kawasaki disease, Gene-expression, VEGF-A, VEGF-B, TNF, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352914824000303; https://doaj.org/toc/2352-9148

Access URL: https://doaj.org/article/b93f785ba53f4b35af732524ce63b4c2

Determination of Vascular Endothelial Growth Factor-B Concentrations in Aqueous Humor and Plasma of Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy Patients Before and After Anti-VEGF Therapy

Authors: Huiying Zhou, Xinyu Zhao, Shuran Wang, Youxin Chen

Source: Ophthalmology and Therapy, Vol 12, Iss 2, Pp 827-837 (2022)

Subject Terms: Polypoidal choroidal vasculopathy, Neovascular age-related macular degeneration, VEGF-B, Plasma, Aqueous humor, Anti-VEGF therapy, Ophthalmology, RE1-994

File Description: electronic resource

Relation: https://doaj.org/toc/2193-8245; https://doaj.org/toc/2193-6528

Access URL: https://doaj.org/article/ee4bab85a7d44de4b492a23c43e92941

Age-Related Macular Degeneration and Diabetic Retinopathy

Contributors: Westenskow, Peter D., Ebneter, Andreas

Subject Terms: subthreshold micropulse laser, 577-nm laser, laser fixed parameters, diabetic retinopathy, diabetic macular edema, optical coherence tomography, autofluorescence, real-life, diabetic macular oedema, visual prognosis, indicators, personalized medicine, age-related macular degeneration, choroidal neovascularization, classification, machine learning, type 2 diabetes, retinopathy, ethnicity, general practice, risk factors, progression, glycemic gap, glucose variability, ETDRS classification, biomarkers, phenotypes, anti-vascular endothelial growth factor, diabetic retinopathy severity scale, panretinal leakage index, neovascular age-related macular degeneration, anti-VEGF therapy, retinal thickness, visual acuity, variability, leakage index, microaneurysms, intravitreal aflibercept, neovascularization, ultra-widefield fluorescein angiography, retinal imaging, quantitative biomarkers, precision medicine, autoantibodies, AT1-receptor, PAR1, VEGF-A, VEGF-B, VEGF-receptor 2, AMD, complement system, semi-quantitative multiplex profilin, mass spectrometry, C4, vitronectin, factor I, genetic variants, metabolites, HDL, central area thickness, biomarker, microRNA, anti-VEGF, retina, edema, OCT, tomography, microphysiological systems, blood-neural barriers, neurovascular unit, disease modeling, 3D models, organ-on-a-chip, inner blood-retinal barrier, Research and information: general, Biology, life sciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/84510
https://mdpi.com/books/pdfview/book/5494

VEGF-B targeting by aryl hydrocarbon receptor mediates the migration and invasion of choriocarcinoma stem-like cells

Authors: Qianxia Tan, Jingting Cai, Jingping Peng, Cui Hu, ChenChun Wu, Huining Liu

Source: Cancer Cell International, Vol 22, Iss 1, Pp 1-14 (2022)

Subject Terms: Choriocarcinoma, VEGF-B, Migration, Invasion, Cancer stem cell, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/37b7377f3b0a47949aa5f44ebec9c06d

Proteases—From Basic Structure to Function to Drug Design as Targeted Therapy

Contributors: Kwok, Hang Fai, Shaw, Christopher, Walker, Brian

Subject Terms: MMP, MMP2, MMP9, MMP7, MMP14, matrix metalloproteases, PDAC, pancreatic cancer, Bowman–Birk inhibitor, ranacyclin, trypsin inhibitor, structure–activity relationship, synergistic effect, Gentamicin, matrix metalloproteinase, extracellular matrix, nuclei, cancer, apoptosis, immune response, cysteine protease inhibitor, stefin, signal peptide, parasite, phylogenetic analysis, diversification, protein structure, vascular endothelial growth factors (VEGFs), VEGF-A, PlGF, VEGF-B, VEGF-C, VEGF-D, angiogenesis, lymphangiogenesis, CCBE1, proteases, ADAMTS3, plasmin, cathepsin D, KLK3, prostate-specific antigen (PSA), thrombin, wound healing, metastasis, proteolytic activation, vascular biology, lymphedema, Research and information: general

File Description: image/jpeg

Access URL: https://directory.doabooks.org/handle/20.500.12854/77096
https://mdpi.com/books/pdfview/book/4715

Corrigendum: Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy

Authors: Reetta A. E. Eriksson, Tiina Nieminen, Lionel Galibert, Sanna K. Peltola, Petra Tikkanen, Piia Käyhty, Hanna M. Leinonen, Igor Oruetxebarria, Saana Lepola, Anniina J. Valkama, Eevi M. Lipponen, Hanna P. Lesch, Seppo Ylä-Herttuala, Kari J. Airenne

Source: Frontiers in Medicine, Vol 10 (2023)

Subject Terms: riboswitch, ON-switch, gene therapy, AAV (adeno-associated virus), VEGF-B, tetracycline, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2023.1143748/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/577226a018c4442398fc2f758afd0a1c

A dual covariant biomarker approach to Kawasaki disease, using vascular endothelial growth factor A and B gene expression; implications for coronary pathogenesis

Authors: Asrar Rashid, Govind Benakatti, Feras Al-Obeidat, Rajesh Phatak, Zainab A. Malik, Javed Sharief, Raziya Kadwa, Wael Hafez, Mohammed Toufiq, Damien Chaussabel, Rayaz Malik, Nasir Quraishi, Syed Ahmed Zaki, Guftar Shaikh, Amir Hussain

Source: Informatics in Medicine Unlocked, Vol 43, Iss , Pp 101384- (2023)

Subject Terms: Temporal, Kawasaki disease, Gene-expression, VEGF-A, VEGF-B, TNF, Computer applications to medicine. Medical informatics, R858-859.7

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352914823002307; https://doaj.org/toc/2352-9148

Access URL: https://doaj.org/article/1f81859349614a23ba01a98f5f8fe9d4

Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy

Authors: Reetta A. E. Eriksson, Tiina Nieminen, Lionel Galibert, Sanna K. Peltola, Petra Tikkanen, Piia Käyhty, Hanna M. Leinonen, Igor Oruetxebarria, Saana Lepola, Anniina J. Valkama, Eevi M. Lipponen, Hanna P. Lesch, Seppo Ylä-Herttuala, Kari J. Airenne

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: riboswitch, ON-switch, gene therapy, AAV (adeno-associated virus), VEGF-B, tetracycline, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.1052318/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/bac6cbe4bcff4b7981f043f3a2f22c28

Novel Designed Proteolytically Resistant VEGF-B186R127S Promotes Angiogenesis in Mouse Heart by Recruiting Endothelial Progenitor Cells

Authors: Rahul Mallick, Erika Gurzeler, Pyry I. Toivanen, Tiina Nieminen, Seppo Ylä-Herttuala

Source: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Subject Terms: angiogenesis, endothelial progenitor cell (EPC), gene therapy, inflammation, VEGF-B, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2022.907538/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/f86914d9ec104ff798544c8450dc46ba

VEGF-B is a potent antioxidant

Authors: Arjunan, Pachiappan, Lin, Xianchai, Tang, Zhongshu, Du, Yuxiang, Kumar, Anil, Liu, Lixian, Yin, Xiangke, Huang, Lijuan, Chen, Wei, Chen, Qishan, Ye, Zhimin, Wang, Shasha, Kuang, Haiqing, Zhou, Linbin, Xu, Kai, Chen, Xue, Zeng, Haitao, Lu, Weisi, Cao, Yihai, Liu, Yizhi, Zhao, Chen, Li, Xuri

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Oct 01. 115(41), 10351-10356.

Access URL: https://www.jstor.org/stable/26532182

Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?

Authors: Rahul Mallick, Seppo Ylä-Herttuala

Source: Cells, Vol 11, Iss 24, p 4134 (2022)

Subject Terms: angiogenesis, CHD, gene therapy, VEGF-A, VEGF-B, VEGF-R1, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/24/4134; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/cf21748733794babbeb1ef60102b4df4

The effects of mid and long-term endurance exercise on heart angiogenesis and oxidative stress

Authors: Maliheh Ardakanizade

Source: Iranian Journal of Basic Medical Sciences, Vol 21, Iss 8, Pp 800-805 (2018)

Subject Terms: Angiopoietin-1, Endurance Exercise, HDAC4, MMP-2, VEGF-B, Medicine

File Description: electronic resource

Relation: http://ijbms.mums.ac.ir/article_11074_006d44807c4aaf4b98706af3376d9797.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874

Access URL: https://doaj.org/article/f5b14d057a3444e4a8dc9a6b6f8b76dd

VEGF-A and VEGF-B Coordinate the Arteriogenesis to Repair the Infarcted Heart with Vagus Nerve Stimulation

Authors: Yan-xia Lv, Sen Zhong, Hexin Tang, Bin Luo, Shao-Juan Chen, Long Chen, Fei Zheng, Lei Zhang, Lu Wang, Xing-yuan Li, Yu-wen Yan, Ya-mu Pan, Miao Jiang, You-en Zhang, Lei Wang, Jian-ye Yang, Ling-yun Guo, Shi-you Chen, Jia-ning Wang, Jun-ming Tang

Source: Cellular Physiology and Biochemistry, Vol 48, Iss 2, Pp 433-449 (2018)

Subject Terms: Myocardial infarction, Vagal nerve stimulation, Angiogenesis, VEGF-A, VEGF-B, Physiology, QP1-981, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://www.karger.com/Article/FullText/491775; https://doaj.org/toc/1015-8987; https://doaj.org/toc/1421-9778

Access URL: https://doaj.org/article/1bc30d71ec9443039a340d93f7dc88ca

Anticancer Effects of New Ceramides Isolated from the Red Sea Red Algae Hypnea musciformis in a Model of Ehrlich Ascites Carcinoma: LC-HRMS Analysis Profile and Molecular Modeling

Authors: Sameh S. Elhady, Eman S. Habib, Reda F. A. Abdelhameed, Marwa S. Goda, Reem M. Hazem, Eman T. Mehanna, Mohamed A. Helal, Khaled M. Hosny, Reem M. Diri, Hashim A. Hassanean, Amany K. Ibrahim, Enas E. Eltamany, Usama Ramadan Abdelmohsen, Safwat A. Ahmed

Source: Marine Drugs, Vol 20, Iss 1, p 63 (2022)

Subject Terms: ceramides, MCF-7, Ehrlich ascites carcinoma, VEGF-B, TNF-α, midkine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1660-3397/20/1/63; https://doaj.org/toc/1660-3397

Access URL: https://doaj.org/article/36065ef5943b47f5a09db56446380c64

VEGF-B, VEGF-A, FLT-1, KDR, ERBB2, EGFR, GRB2, RAC1, CDH1 and HYAL-1 Genes Expression Analysis in Canine Mammary Gland Tumors and the Association with Tumor ClinicoPathological Parameters and Dog Breed Assessment

Authors: Simona Sakalauskaitė, Violeta Šaltenienė, Darja Nikitina, Rasa Ugenskienė, Vita Riškevičienė, Birutė Karvelienė, Nomeda Juodžiukynienė

Source: Veterinary Sciences, Vol 8, Iss 10, p 212 (2021)

Subject Terms: canine mammary carcinoma, breed, gene expression, VEGF-B, EGFR, Veterinary medicine, SF600-1100

File Description: electronic resource

Relation: https://www.mdpi.com/2306-7381/8/10/212; https://doaj.org/toc/2306-7381

Access URL: https://doaj.org/article/2f50a2f3cb3a4ca89a905519073b4d0f

Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs

Authors: Jaana Künnapuu, Honey Bokharaie, Michael Jeltsch

Source: Biology, Vol 10, Iss 2, p 167 (2021)

Subject Terms: vascular endothelial growth factors (VEGFs), VEGF-A, PlGF, VEGF-B, VEGF-C, VEGF-D, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2079-7737/10/2/167; https://doaj.org/toc/2079-7737

Access URL: https://doaj.org/article/5b1fc0e69bca4a0dbb1eed41752180d2

VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish

Authors: Jensen, Lasse D., Nakamura, Masaki, Bräutigam, Lars, Li, Xuri, Liu, Yizhi, Samani, Nilesh J., Cao, Yihai

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Nov 01. 112(44), E5944-E5953.

Access URL: https://www.jstor.org/stable/26465691