Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study)

Authors: Julian Reza Kretschmer, Daria Tkachenko, Tania Kümpfel, Joachim Havla, Daniel Engels, Friedemann Paul, Patrick Schindler, Judith Bellmann-Strobl, Achim Berthele, Katrin Giglhuber, Clarissa Zappe, Luisa Klotz, Lisa Revie, Eva Dawin, Makbule Senel, Hayrettin Tumani, Florian Then Bergh, Clemens Warnke, Markus Kraemer, Annette Walter, Antonios Bayas, Uwe K. Zettl, Ann-Sophie Lauenstein, Yavor Yalachkov, Thorleif Etgen, Matthias Kaste, Felix Luessi, Stefan Gingele, Sarah Passoke, Martin S. Weber, Jörn Peter Sieb, Axel Haarmann, Patrick Oschmann, Veit Rothhammer, Christian Geis, Markus C. Kowarik, Peter Kern, Matthias Grothe, Heike Stephanik, Klemens Angstwurm, Frank Hoffmann, Ulrike Wallwitz, Brigitte Wildemann, Sven Jarius, Jan-Patrick Stellmann, Thivya Pakeerathan, Carolin Schwake, Ilya Ayzenberg, Ingo Kleiter, Katinka Fischer, Orhan Aktas, Marius Ringelstein, Vivien Häußler, Corinna Trebst, Martin W. Hümmert

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: NMOSD = neuromyelitis optica spectrum disorder, aging, late onset, immunoscenecence, myelitis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575613/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/826eb6bcf0f245db97dfdf5d082aadec

Apheresis for the treatment of relapses in MS and NMOSD: reduced antibody reactivities, gene expression changes and potential clinical response indicators

Authors: Michael Hecker, Brit Fitzner, Isis Ludwig-Portugall, Friederike Bohne, Edmar Heyland, Juliane Klehmet, Matthias Grothe, Matthias Schwab, Alexander Winkelmann, Stefanie Meister, Ales Dudesek, Hannah Wurm, Ilya Ayzenberg, Ingo Kleiter, Corinna Trebst, Martin W. Hümmert, Bernhard Neumann, Klaus Eulitz, Dirk Koczan, Uwe K. Zettl

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: multiple sclerosis, neuromyelitis optica spectrum disorder, acute relapse, apheresis, glucocorticoids, antibodies, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531447/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/be579a60752843e68003a335c7099c58

Serum glial fibrillary acidic protein and disability progression in progressive multiple sclerosis

Authors: Ahmed Abdelhak, Kai Antweiler, Markus C. Kowarik, Makbule Senel, Joachim Havla, Uwe K. Zettl, Ingo Kleiter, Thomas Skripuletz, Axel Haarmann, Alexander Stahmann, Andre Huss, Stefan Gingele, Markus Krumbholz, Pascal Benkert, Jens Kuhle, Tim Friede, Albert C. Ludolph, Ulf Ziemann, Tania Kümpfel, Hayrettin Tumani

Source: Annals of Clinical and Translational Neurology, Vol 11, Iss 2, Pp 477-485 (2024)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/017baefb71394890b530b34dca8c17fc

Side effects following vaccination in multiple sclerosis: a prospective, multi-centre cohort study

Authors: Alexander Winkelmann, Christoph Metze, Uwe K. Zettl, Micha Loebermann

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c919d8cebaa0409eb018a36af2a21a0e

Treatment switches of disease-modifying therapies in people with multiple sclerosis: long-term experience from the German MS Registry

Authors: Niklas Frahm, David Ellenberger, Alexander Stahmann, Firas Fneish, Daniel Lüftenegger, Hans C. Salmen, Ksenija Schirduan, Tom P. A. Schaak, Peter Flachenecker, Christoph Kleinschnitz, Friedemann Paul, Dagmar Krefting, Uwe K. Zettl, Melanie Peters, Clemens Warnke

Source: Therapeutic Advances in Neurological Disorders, Vol 17 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-2864

Access URL: https://doaj.org/article/c8eeaeea69924efc9284aba8da3cbdca

Polypharmacy in patients with multiple sclerosis and the impact on levels of care and therapy units

Authors: Finn Brüggemann, Stefan Gross, Marie Süße, Pavel Hok, Sebastian Strauss, Tjalf Ziemssen, Niklas Frahm, Uwe K. Zettl, Matthias Grothe

Source: Frontiers in Neurology, Vol 14 (2023)

Subject Terms: multiple sclerosis, polypharmacy, health costs, level of care, comorbidity, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2023.1330066/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/05b8d56e231e41828fa276df7ca2598b

Epileptic seizures at multiple sclerosis onset and their role in disease progression

Authors: Matthias Grothe, David Ellenberger, Paulus S. Rommer, Alexander Stahmann, Uwe K. Zettl

Source: Therapeutic Advances in Neurological Disorders, Vol 16 (2023)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-2864

Access URL: https://doaj.org/article/840158c596c944f99abb9da57908da3f

Occurrence and Risk Factors of Relapse Activity after Vaccination against COVID-19 in People with Multiple Sclerosis: 1-Year Follow-Up Results from a Nationwide Longitudinal Observational Study

Authors: Firas Fneish, Niklas Frahm, Melanie Peters, David Ellenberger, Judith Haas, Micha Löbermann, Dieter Pöhlau, Anna-Lena Röper, Sarah Schilling, Alexander Stahmann, Herbert Temmes, Friedemann Paul, Uwe K. Zettl

Source: Vaccines, Vol 11, Iss 12, p 1859 (2023)

Subject Terms: SARS-CoV-2, vaccination, multiple sclerosis, relapse, side effects, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/11/12/1859; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/fd7179958544494b9322499460d272e4

Chances and challenges of a long-term data repository in multiple sclerosis: 20th birthday of the German MS registry

Authors: Lisa-Marie Ohle, David Ellenberger, Peter Flachenecker, Tim Friede, Judith Haas, Kerstin Hellwig, Tina Parciak, Clemens Warnke, Friedemann Paul, Uwe K. Zettl, Alexander Stahmann

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/3654845ac2f64275b780abb489f96ac1

SARS-CoV-2 vaccination in patients with multiple sclerosis in Germany and the United Kingdom: Gender-specific results from a longitudinal observational study

Authors: Niklas Frahm, Firas Fneish, David Ellenberger, Judith Haas, Micha Loebermann, Tina Parciak, Melanie Peters, Dieter Pöhlau, Jeff Rodgers, Anna-Lena Röper, Sarah Schilling, Alexander Stahmann, Herbert Temmes, Uwe K. Zettl, Rodden M. Middleton

Source: The Lancet Regional Health. Europe, Vol 22, Iss , Pp 100502- (2022)

Subject Terms: SARS-CoV-2, COVID-19, Vaccination, Vaccination reaction, Multiple sclerosis, Gender, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666776222001983; https://doaj.org/toc/2666-7762

Access URL: https://doaj.org/article/9a6b3486974f4051a56463f363e21125

The pathophysiology of motor fatigue and fatigability in multiple sclerosis

Authors: Robert Patejdl, Uwe K. Zettl

Source: Frontiers in Neurology, Vol 13 (2022)

Subject Terms: multiple sclerosis, motor fatigue, aerobic capacity, detraining, autonomic dysfunction, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2022.891415/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/fc4a181905a24901af19e83ceb47725a

Treatment patterns in pediatric patients with multiple sclerosis in Germany—a nationwide claim-based analysis

Authors: Niklas Frahm, Melanie Peters, Jörg Bätzing, David Ellenberger, Manas K. Akmatov, Judith Haas, Paulus S. Rommer, Alexander Stahmann, Uwe K. Zettl, Jakob Holstiege

Source: Therapeutic Advances in Neurological Disorders, Vol 14 (2021)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-2864

Access URL: https://doaj.org/article/5aa4ca49ffe54e85a974a9dbbd0a8893

Multiple Sclerosis Therapy Consensus Group (MSTCG): position statement on disease-modifying therapies for multiple sclerosis (white paper)

Authors: Heinz Wiendl, Ralf Gold, Thomas Berger, Tobias Derfuss, Ralf Linker, Mathias Mäurer, Orhan Aktas, Karl Baum, Martin Berghoff, Stefan Bittner, Andrew Chan, Adam Czaplinski, Florian Deisenhammer, Franziska Di Pauli, Renaud Du Pasquier, Christian Enzinger, Elisabeth Fertl, Achim Gass, Klaus Gehring, Claudio Gobbi, Norbert Goebels, Michael Guger, Aiden Haghikia, Hans-Peter Hartung, Fedor Heidenreich, Olaf Hoffmann, Boris Kallmann, Christoph Kleinschnitz, Luisa Klotz, Verena I. Leussink, Fritz Leutmezer, Volker Limmroth, Jan D. Lünemann, Andreas Lutterotti, Sven G. Meuth, Uta Meyding-Lamadé, Michael Platten, Peter Rieckmann, Stephan Schmidt, Hayrettin Tumani, Frank Weber, Martin S. Weber, Uwe K. Zettl, Tjalf Ziemssen, Frauke Zipp

Source: Therapeutic Advances in Neurological Disorders, Vol 14 (2021)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-2864

Access URL: https://doaj.org/article/cee55fa870514dd8bb41f4326e4ce63e

Vaccination in multiple sclerosis patients treated with highly effective disease-modifying drugs: an overview with consideration of cladribine tablets

Authors: Ralf Gold, Gerd Fätkenheuer, Hans-Peter Hartung, Christoph Kleinschnitz, Reinhard Marks, Matthias Maschke, Antonios Bayas, Micha Löbermann, Uwe K. Zettl, Heinz Wiendl

Source: Therapeutic Advances in Neurological Disorders, Vol 14 (2021)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-2864

Access URL: https://doaj.org/article/df0fbbc16fae47b5b0109543bae2232c

Correspondence: Humoral immune response to COVID-19 mRNA vaccine in patients with multiple sclerosis treated with high-efficacy disease-modifying therapies

Authors: Hela-Felicitas Petereit, Hayrettin Tumani, Uwe K. Zettl

Source: Therapeutic Advances in Neurological Disorders, Vol 14 (2021)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1756-2864

Access URL: https://doaj.org/article/585b1ac23d99468db38876f1a7432c66

Management of MS Patients Treated With Daclizumab – a Case Series of 267 Patients

Authors: Paulus S. Rommer, Klaus Berger, David Ellenberger, Firas Fneish, Alexandra Simbrich, Alexander Stahmann, Uwe K. Zettl

Source: Frontiers in Neurology, Vol 11 (2020)

Subject Terms: multiple sclerosis, multiple sclerosis—drug therapy, daclizumab, side effects, registers, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2020.00996/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/e6c33d9b2b4b49d19dcdf78faaefe9d2

Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study

Authors: Stefan Bittner, Falk Steffen, Timo Uphaus, Muthuraman Muthuraman, Vinzenz Fleischer, Anke Salmen, Felix Luessi, Achim Berthele, Luisa Klotz, Sven G. Meuth, Antonios Bayas, Friedemann Paul, Hans-Peter Hartung, Ralf Linker, Christoph Heesen, Martin Stangel, Brigitte Wildemann, Florian Then Bergh, Björn Tackenberg, Tania Kuempfel, Frank Weber, Uwe K. Zettl, Ulf Ziemann, Hayrettin Tumani, Sergiu Groppa, Mark Mühlau, Carsten Lukas, Bernhard Hemmer, Heinz Wiendl, Ralf Gold, Frauke Zipp

Source: EBioMedicine, Vol 56, Iss , Pp 102807- (2020)

Subject Terms: Neurofilament light chain, sNfL, Multiple sclerosis, Prediction, Biomarker, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396420301821; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/98657026f6cc4acd9432c67dabb1f2fa

Explorative study of emerging blood biomarkers in progressive multiple sclerosis (EmBioProMS): Design of a prospective observational multicentre pilot study

Authors: Ahmed Abdelhak, Andre Huss, Alexander Stahmann, Makbule Senel, Markus Krumbholz, Markus C. Kowarik, Joachim Havla, Tania Kümpfel, Ingo Kleiter, Isabella Wüstinger, Uwe K. Zettl, Margit Schwartz, Romy Roesler, Tim Friede, Albert C. Ludolph, Ulf Ziemann, Hayrettin Tumani

Source: Contemporary Clinical Trials Communications, Vol 18, Iss , Pp 100574- (2020)

Subject Terms: Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2451865420300582; https://doaj.org/toc/2451-8654

Access URL: https://doaj.org/article/46666c1d554343f685ebfa50cc99b728

Merits and culprits of immunotherapies for neurological diseases in times of COVID-19

Authors: Marc Pawlitzki, Uwe K. Zettl, Tobias Ruck, Leoni Rolfes, Hans-Peter Hartung, Sven G. Meuth

Source: EBioMedicine, Vol 56, Iss , Pp 102822- (2020)

Subject Terms: COVID-19, Multiple sclerosis, Immunotherapies, Infections risk, Disease modifying therapies, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396420301973; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/7c00727e934a4427855d500f40b75779

Central Suppression of the GH/IGF Axis and Abrogation of Exercise-Related mTORC1/2 Activation in the Muscle of Phenotype-Selected Male Marathon Mice (DUhTP)

Authors: Julia Brenmoehl, Christina Walz, Caroline Caffier, Elli Brosig, Michael Walz, Daniela Ohde, Nares Trakooljul, Martina Langhammer, Siriluck Ponsuksili, Klaus Wimmers, Uwe K. Zettl, Andreas Hoeflich

Source: Cells, Vol 10, Iss 12, p 3418 (2021)

Subject Terms: endurance exercise, energy metabolism, pituitary gland, muscle, growth hormone, insulin-like growth factor, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/12/3418; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/fd3dd789b7b24d959c756b74fa623db1