Enhancer-gene rewiring in the pathogenesis of Quebec platelet disorder

Authors: Liang, Minggao ^{1, 2}, Soomro, Asim ³, Tasneem, Subia ³, Abatti, Luis E. ⁴, Alizada, Azad ^{1, 2}, Yuan, Xuefei ^{1, 2}, Uusküla-Reimand, Liis ¹, Antounians, Lina ^{1, 2}, Alvi, Sana Akhtar ¹, Paterson, Andrew D. ^{1, 5}, Rivard, Georges-Étienne ⁶, Scott, Ian C. ^{1, 2}, Mitchell, Jennifer A. ⁴, Hayward, Catherine P.M. ^{3, 6, 7, *}, Wilson, Michael D. ^{1, 2, *}

Source: In Blood 3 December 2020 136(23):2679-2690

Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks

Authors: Zhu, Helen, Uusküla-Reimand, Liis, Isaev, Keren, Wadi, Lina, Alizada, Azad, Shuai, Shimin, Huang, Vincent, Aduluso-Nwaobasi, Dike, Paczkowska, Marta, Abd-Rabbo, Diala, Ocsenas, Oliver, Liang, Minggao, Thompson, J. Drew, Li, Yao, Ruan, Luyao, Krassowski, Michal, Dzneladze, Irakli, Simpson, Jared T., Lupien, Mathieu, Stein, Lincoln D., Boutros, Paul C., Wilson, Michael D., Reimand, Jüri

Source: In Molecular Cell 19 March 2020 77(6):1307-1321

Break Check: Transcription-Driven Topoisomerase II Collisions near Chromatin Loop Anchors Are Hotspots for DNA Damage and Translocations

Authors: Uusküla-Reimand, Liis, Wilson, Michael D.

Source: In Molecular Cell 25 July 2019 75(2):203-205

Age, sex, and cell type-resolved hypothalamic gene expression across the pubertal transition in mice.

Authors: Sokolowski, Dustin J., Hou, Huayun, Yuki, Kyoko E., Roy, Anna, Chan, Cadia, Choi, Wendy, Faykoo-Martinez, Mariela, Hudson, Matt, Corre, Christina, Uusküla-Reimand, Liis, Goldenberg, Anna, Palmert, Mark R., Wilson, Michael D.

Source: Biology of Sex Differences; 10/24/2024, Vol. 15 Issue 1, p1-22, 22p

Subject Terms: GENE regulatory networks, GENE expression, GENETIC regulation, GERMPLASM, RNA sequencing, PUBERTY

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

Authors: Lambert, Jean-Philippe, Picaud, Sarah, Fujisawa, Takao, Hou, Huayun, Savitsky, Pavel, Uusküla-Reimand, Liis, Gupta, Gagan D., Abdouni, Hala, Lin, Zhen-Yuan, Tucholska, Monika, Knight, James D.R., Gonzalez-Badillo, Beatriz, St-Denis, Nicole, Newman, Joseph A., Stucki, Manuel, Pelletier, Laurence, Bandeira, Nuno, Wilson, Michael D., Filippakopoulos, Panagis, Gingras, Anne-Claude

Source: In Molecular Cell 7 February 2019 73(3):621-638

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma

Authors: Yin, Wen-Chi, Satkunendran, Thevagi, Mo, Rong, Morrissy, Sorana, Zhang, Xiaoyun, Huang, Eunice Shiao, Uusküla-Reimand, Liis, Hou, Huayun, Son, Joe Eun, Liu, Weifan, Liu, Yulu C., Zhang, Jianing, Parker, Jessica, Wang, Xin, Farooq, Hamza, Selvadurai, Hayden, Chen, Xin, Ngan, Elly Sau-Wai, Cheng, Steven Y., Dirks, Peter B., Angers, Stephane, Wilson, Michael D., Taylor, Michael D., Hui, Chi-chung

Source: In Developmental Cell 28 January 2019 48(2):167-183

Untangling the roles of TOP2A and TOP2B in transcription and cancer.

Authors: Uusküla-Reimand, Liis¹ liis.uuskula-reimand@sickkids.ca, Wilson, Michael D.^1,2 michael.wilson@sickkids.ca

Source: Science Advances. 11/4/2022, Vol. 8 Issue 44, p1-16. 16p.

Subject Terms: *DNA topoisomerase I, *TRANSCRIPTION factors, *DOUBLE-strand DNA breaks, *DNA ligases, *MITOCHONDRIAL DNA, *DNA topoisomerase II, *DNA repair, *DNA structure

Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland.

Authors: Hou, Huayun, Chan, Cadia, Yuki, Kyoko E., Sokolowski, Dustin, Roy, Anna, Qu, Rihao, Uusküla-Reimand, Liis, Faykoo-Martinez, Mariela, Hudson, Matt, Corre, Christina, Goldenberg, Anna, Zhang, Zhaolei, Palmert, Mark R., Wilson, Michael D.

Source: Biology of Sex Differences; 10/11/2022, Vol. 13 Issue 1, p1-23, 23p

Subject Terms: PITUITARY gland, GENE expression, PUBERTY, GENE regulatory networks, ANIMAL offspring sex ratio, NON-coding RNA, GENETIC regulation, SEX (Biology)

X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition.

Authors: Volpatti, Jonathan R., Ghahramani-Seno, Mehdi M., Mansat, Mélanie, Sabha, Nesrin, Sarikaya, Ege, Goodman, Sarah J., Chater-Diehl, Eric, Celik, Alper, Pannia, Emanuela, Froment, Carine, Combes-Soia, Lucie, Maani, Nika, Yuki, Kyoko E., Chicanne, Gaëtan, Uusküla-Reimand, Liis, Monis, Simon, Alvi, Sana Akhtar, Genetti, Casie A., Payrastre, Bernard, Beggs, Alan H.

Source: Acta Neuropathologica; Sep2022, Vol. 144 Issue 3, p537-563, 27p

Subject Terms: NEUROMUSCULAR diseases, VALPROIC acid, MUSCLE diseases, EPIGENETICS, DNA methylation

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma

Authors: Yin, Wen-Chi, Satkunendran, Thevagi, Mo, Rong, Morrissy, Sorana, Zhang, Xiaoyun, Huang, Eunice Shiao, Uusküla-Reimand, Liis, Hou, Huayun, Son, Joe Eun, Liu, Weifan, Liu, Yulu C., Zhang, Jianing, Parker, Jessica, Wang, Xin, Farooq, Hamza, Selvadurai, Hayden, Chen, Xin, Sau-Wai Ngan, Elly, Cheng, Steven Y., Dirks, Peter B., Angers, Stephane, Wilson, Michael D., Taylor, Michael D., Hui, Chi-chung

Source: In Developmental Cell 6 January 2020 52(1):132-132

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