Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging

Authors: Jakobsen, Niels Asger, Turkalj, Sven, Zeng, Andy G.X., Stoilova, Bilyana, Metzner, Marlen, Rahmig, Susann, Nagree, Murtaza S., Shah, Sayyam, Moore, Rachel, Usukhbayar, Batchimeg, Angulo Salazar, Mirian, Gafencu, Grigore-Aristide, Kennedy, Alison, Newman, Simon, Kendrick, Benjamin J.L., Taylor, Adrian H., Afinowi-Luitz, Rasheed, Gundle, Roger, Watkins, Bridget, Wheway, Kim, Beazley, Debra, Murison, Alex, Aguilar-Navarro, Alicia G., Flores-Figueroa, Eugenia, Dakin, Stephanie G., Carr, Andrew J., Nerlov, Claus, Dick, John E., Xie, Stephanie Z., Vyas, Paresh

Source: In Cell Stem Cell 1 August 2024 31(8):1127-1144

GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells

Authors: Turkalj, Sven, Jakobsen, Niels Asger, Groom, Angus, Metzner, Marlen, Riva, Simone G., Gür, E. Ravza, Usukhbayar, Batchimeg, Salazar, Mirian Angulo, Hentges, Lance D., Mickute, Gerda, Clark, Kevin, Sopp, Paul, Davies, James O.J., Hughes, Jim R., Vyas, Paresh

Source: In Cell Stem Cell 4 May 2023 30(5):722-740

Heterogeneous genetic and non‐genetic mechanisms contribute to response and resistance to azacitidine monotherapy

Authors: Symeonidou, Vasiliki, Metzner, Marlen, Usukhbayar, Batchimeg, Jackson, Aimee E., Fox, Sonia, Craddock, Charles F., Vyas, Paresh

Source: EJHaem. 3(3):794-803

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182035440.0x000001&indx=1&recIds=ETOCvdc_100182035440.0x000001

Mongol Familiarisation with European Medical Practices in the Nineteenth–Twentieth Centuries

Authors: Norov, Batsaikhan, Batsaikhan, Binderiya, Usukhbayar, Batchimeg

Source: Inner Asia, 2020 Jan 01. 22(2), 299-319.

Access URL: https://www.jstor.org/stable/27139831

Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome

Authors: Hernandez, David Cruz, Metzner, Marlen, de Groot, Anne Pieta, Usukhbayar, Batchimeg, Elliott, Natalina, Roberts, Irene, Vyas, Paresh

Source: Blood. 136(12):1460-1465

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624598477&indx=1&recIds=ETOCRN624598477

Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells

Authors: Karamitros, Dimitris, Stoilova, Bilyana, Aboukhalil, Zahra, Hamey, Fiona, Reinisch, Andreas, Samitsch, Marina, Quek, Lynn, Otto, Georg, Repapi, Emmanouela, Doondeea, Jessica, Usukhbayar, Batchimeg, Calvo, Julien, Taylor, Stephen, Goardon, Nicolas, Six, Emmanuelle, Pflumio, Francoise, Porcher, Catherine, Majeti, Ravindra, Göttgens, Berthold, Vyas, Paresh

Source: Nature immunology. 19(1):85-97

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132383571.0x000001&indx=1&recIds=ETOCvdc_100132383571.0x000001

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

Authors: Mettananda, Sachith, Fisher, Chris, Hay, Deborah, Badat, Mohsin, Quek, Lynn, Clark, Kevin, Hublitz, Philip, Downes, Damien, Kerry, Jon, Gosden, Matthew, Telenius, Jelena, Sloane-Stanley, Jackie, Faustino, Paula, Coelho, Andreia, Doondeea, Jessica, Usukhbayar, Batchimeg, Sopp, Paul, Sharpe, Jacqueline, Hughes, Jim, Vyas, Paresh, Gibbons, Richard, Higgs, Douglas

Source: Nature communications. 8(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178443671.0x000001&indx=1&recIds=ETOCvdc_100178443671.0x000001

Genetically distinct leukemic stem cells in human CD34^- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage

Authors: Quek, Lynn, Otto, Georg W., Garnett, Catherine, Lhermitte, Ludovic, Karamitros, Dimitris, Stoilova, Bilyana, Lau, I-Jun, Doondeea, Jessica, Usukhbayar, Batchimeg, Kennedy, Alison

Source: Journal of experimental medicine. 213(8):1513-1536

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN607394543&indx=1&recIds=ETOCRN607394543

Graft Versus Leukaemia (GvL): Identification & Characterisation of Alloreactive Antigens and Cognate T Cell Responses in Acute Myeloid Leukemia

Authors: Sweeney, Connor ^*, Mickute, Gerda ^*, Gupta, Kinam ^*, Metzner, Marlen ^*, Usukhbayar, Batchimeg ^*, Barbanti, Maria Chiara ^*, Sangha, Gavinda ^*, Chakraverty, Ronjon ^*, Borrow, Persephone ^*, Ternette, Nicola ^*, Ogbe, Ane ^*, Aggelakopoulou, Maria ^*, Vyas, Paresh ^*

Source: In Blood 15 November 2022 140 Supplement 1:1576-1578

Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome

Authors: Cruz Hernandez, David ^{1, 2, *}, Metzner, Marlen ^{1, 2, *}, de Groot, Anne Pieta ^{1, 2}, Usukhbayar, Batchimeg ^{1, 2}, Elliott, Natalina ^{1, 3}, Roberts, Irene ^{1, 2, 3}, Vyas, Paresh ^{1, 1, 2}

Source: In Blood 17 September 2020 136(12):1460-1465

GATA1 Target Gene CSF2RB Is Functionally Coupled to MPL and Marks a TPO-Dependent Preleukemic TAM Cell Population Sustained By the Fetal Liver but Not Bone Marrow

Authors: Cruz Hernandez, David, Papadopoulos, Nicolas, Sepulchre, Elise, Metzner, Marlen, Usukhbayar, Batchimeg, Angulo Salazar, Mirian, Varghese, Leila, Levy, Gabriel, Roberts, Irene, Constantinescu, Stefan N, Vyas, Paresh

Source: In Blood 28 November 2023 142 Supplement 1:404-404

Dysregulation of Stem-Progenitor and Differentiation Programmes through Modulation of Bivalent Chromatin Drives Leukemogenesis in Mutant IDH2 Acute Myeloid Leukaemia

Authors: Silveira, Douglas RA RA ^*, Chatzikyriakou, Prodromos ^*, Casares Alaez, Maria del Pilar ^*, Mackie, Sarah ^*, Hulks, Roan ^*, Yavorska, Olena ^*, Siejka-Zielinska, Paulina ^*, Metzner, Marlen ^*, Smith, Alastair ^*, Usukhbayar, Batchimeg ^*, Penard-Lacronique, Virginie ^*, Song, Chunxiao ^*, Gandhi, Anita K., Hasan, Maroof ^*, Vyas, Paresh, Milne, Thomas A., Kriaucionis, Skirmantas ^*, Quek, Lynn ^*

Source: In Blood 15 November 2022 140 Supplement 1:8698-8699

Dynamics of Clonal Hematopoiesis Inferred By Modelling Deep Bulk Whole-Genome Sequencing Data at a Single Time Point

Authors: Ansari-Pour, Naser ^*, Körber, Verena ^*, Jakobsen, Niels Asger ^*, Moore, Rachel ^*, Claudino, Nina ^*, Metzner, Marlen ^*, Usukhbayar, Batchimeg ^*, Salazar, Mirian Angulo ^*, Newman, Simon ^*, Kendrick, Benjamin ^*, Taylor, Adrian ^*, Afinowi-Luitz, Rasheed ^*, Gundle, Roger ^*, Watkins, Bridget ^*, Wheway, Kim ^*, Beazley, Debra ^*, Carr, Andrew ^*, Vyas, Paresh, Höfer, Thomas ^*

Source: In Blood 15 November 2022 140 Supplement 1:5753-5754

Single Cell Characterisation of Transcriptional Programmes of Responsive and Resistant Leukaemic Progenitors in IDH2-Mutant Acute Myeloid Leukaemia in the AG221-AML-005 Study

Authors: Chatzikyriakou, Prodromos ^*, Silveira, Douglas RA ^*, Casares Aláez, Maria del Pilar ^*, Usukhbayar, Batchimeg ^*, Metzner, Marlen ^*, Vyas, Paresh, Gandhi, Anita K., Risueño, Alberto ^*, Hasan, Maroof ^*, Quek, Lynn ^*

Source: In Blood 15 November 2022 140 Supplement 1:3414-3415

Single-Cell Analysis of Human Clonal Hematopoiesis Identifies Distinct Impact of DNMT3A and TET2 mutations on Hematopoietic Differentiation

Authors: Jakobsen, Niels Asger ^*, Turkalj, Sven ^*, Stoilova, Bilyana ^*, Metzner, Marlen ^*, Moore, Rachel ^*, Usukhbayar, Batchimeg ^*, Salazar, Mirian Angulo ^*, Kennedy, Alison ^*, Newman, Simon ^*, Kendrick, Benjamin ^*, Taylor, Adrian ^*, Afinowi-Luitz, Rasheed ^*, Gundle, Roger ^*, Watkins, Bridget ^*, Wheway, Kim ^*, Beazley, Debra ^*, Carr, Andrew ^*, Vyas, Paresh

Source: In Blood 15 November 2022 140 Supplement 1:2227-2228

Genotyping of Multiple Genomic Loci with Chromatin Accessibility Profiling in Single Cells Links Clonal Hierarchy with Epigenetic Variation in Acute Myeloid Leukemia

Authors: Turkalj, Sven ^*, Jakobsen, Niels Asger ^*, Groom, Angus ^*, Metzner, Marlen ^*, Usukhbayar, Batchimeg ^*, Angulo Salazar, Mirian ^*, Clark, Kevin ^*, Gür, E. Ravza ^*, Hentges, Lance D. ^*, Sopp, Paul ^*, Davies, James O.J. ^*, Hughes, Jim R. ^*, Vyas, Paresh

Source: In Blood 15 November 2022 140 Supplement 1:1193-1194

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A Novel Model of Human Hemopoiesis Based on Single Cell Functional and Transcriptional Analysis of Lympho-Myeloid Progenitors

Authors: Stoilova, Bilyana ^*, Karamitros, Dimitris ^*, Aboukhalil, Zahra ^*, Hamey, Fiona ^*, Reinisch, Andreas ^*, Samitsch, Marina ^*, Quek, Lynn ^*, Otto, Georg ^*, Repapi, Emmanouela ^*, Doondeea, Jessica ^*, Usukhbayar, Batchimeg ^*, Calvo, Julien ^*, Taylor, Stephen ^*, Goardon, Nicolas ^*, Six, Emmanuelle ^*, Pflumio, Francoise ^*, Porcher, Catherine ^*, Majeti, Ravi, Gottgens, Berthold ^*, Vyas, Paresh

Source: In Blood 8 December 2017 130 Supplement 1:2413-2413

Single cell assays unveil functional and transcriptional heterogeneity of human hemopoietic lympho-myeloid progenitors

Authors: Stoilova, Bilyana, Karamitros, Dimitris, Aboukhalil, Zahra, Reinisch, Andreas, Hamey, Fiona, Samitsch, Marina, Quek, Lynn, Otto, Georg, Repapi, Emmanouela, Doondeea, Jessica, Usukhbayar, Batchimeg, Calvo, Julien, Taylor, Stephen, Goardon, Nicolas, Six, Emmanuelle, Pflumio, Francoise, Porcher, Catherine, Majeti, Ravindra, Gottgens, Berthold, Vyas, Paresh

Source: In Experimental Hematology September 2017 53 Supplement:S50-S50