The application of Bayesian forecasting to explore the effects of sex and high-fat diet on the pharmacokinetics of ropivacaine in the rat

Authors: Parvin, Shamima, Al Nebaihi, Hamdah M., Ussher, John R., Brocks, Dion R. ^⁎

Source: In Journal of Pharmacological and Toxicological Methods March 2025 132

Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis

Authors: Gopal, Keshav, Abdualkader, Abdualrahman Mohammed, Li, Xiaobei, Greenwell, Amanda A., Karwi, Qutuba G., Altamimi, Tariq R., Saed, Christina, Uddin, Golam M., Darwesh, Ahmed M., Jamieson, K. Lockhart, Kim, Ryekjang, Eaton, Farah, Seubert, John M., Lopaschuk, Gary D., Ussher, John R., Al Batran, Rami

Source: In Journal of Biological Chemistry December 2023 299(12)

Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease

Authors: Chen, Jerry, Farraj, Rabih Abou, Limonta, Daniel, Tabatabaei Dakhili, Seyed Amir, Kerek, Evan M., Bhattacharya, Ashim, Reformat, Filip M., Mabrouk, Ola M., Brigant, Benjamin, Pfeifer, Tom A., McDermott, Mark T., Ussher, John R., Hobman, Tom C., Glover, J.N. Mark, Hubbard, Basil P.

Source: In Journal of Biological Chemistry November 2023 299(11)

The antianginal ranolazine fails to improve glycaemia in obese liver‐specific pyruvate dehydrogenase deficient male mice

Authors: Saed, Christina T., Tabatabaei Dakhili, Seyed Amirhossein, Greenwell, Amanda A., Chan, Jordan S. F., Yang, Kunyan, Gopal, Keshav, Eaton, Farah, Al Batran, Rami, Ussher, John R.

Source: Basic & clinical pharmacology & toxicology. 133(2):194-201

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186830226.0x000001&indx=1&recIds=ETOCvdc_100186830226.0x000001

Exogenous ketone ester administration attenuates systemic inflammation and reduces organ damage in a lipopolysaccharide model of sepsis

Authors: Soni, Shubham, Martens, Matthew D., Takahara, Shingo, Silver, Heidi L., Maayah, Zaid H., Ussher, John R., Ferdaoussi, Mourad, Dyck, Jason R.B.

Source: In BBA - Molecular Basis of Disease 1 November 2022 1868(11)

Deletion of BCATm increases insulin-stimulated glucose oxidation in the heart

Authors: Uddin, Golam M., Karwi, Qutuba G., Pherwani, Simran, Gopal, Keshav, Wagg, Cory S., Biswas, Dipsikha, Atnasious, Mariam, Wu, Yikuan, Wu, Guoqing, Zhang, Liyan, Ho, Kim L., Pulinilkunnil, Thomas, Ussher, John R., Lopaschuk, Gary D.

Source: In Metabolism November 2021 124

The GLP-1 Receptor Agonist Liraglutide Increases Myocardial Glucose Oxidation Rates via Indirect Mechanisms and Mitigates Experimental Diabetic Cardiomyopathy

Authors: Almutairi, Malak, Gopal, Keshav, Greenwell, Amanda A., Young, Adrian, Gill, Robert, Aburasayn, Hanin, Al Batran, Rami, Chahade, Jadin J., Gandhi, Manoj, Eaton, Farah, Mailloux, Ryan J., Ussher, John R.

Source: In Canadian Journal of Cardiology January 2021 37(1):140-150

SP1-independent inhibition of FOXM1 by modified thiazolidinediones

Authors: Tabatabaei Dakhili, Seyed Amirhossein, Pérez, David J., Gopal, Keshav, Haque, Moinul, Ussher, John R., Kashfi, Khosrow, Velázquez-Martínez, Carlos A.

Source: In European Journal of Medicinal Chemistry 1 January 2021 209

Cardiovascular outcome trials in Type 2 diabetes: food for thought

Authors: Chahade, Jadin J, Kim, Ryekjang, Ussher, John R

Source: Future cardiology. 17(3):407-410

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187210547.0x000001&indx=1&recIds=ETOCvdc_100187210547.0x000001

Pimozide Alleviates Hyperglycemia in Diet-Induced Obesity by Inhibiting Skeletal Muscle Ketone Oxidation

Authors: Al Batran, Rami, Gopal, Keshav, Capozzi, Megan E., Chahade, Jadin J., Saleme, Bruno, Tabatabaei-Dakhili, S. Amirhossein, Greenwell, Amanda A., Niu, Jingjing, Almutairi, Malak, Byrne, Nikole J., Masson, Grant, Kim, Ryekjang, Eaton, Farah, Mulvihill, Erin E., Garneau, Léa, Masters, Andrea R., Desta, Zeruesenay, Velázquez-Martínez, Carlos A., Aguer, Céline, Crawford, Peter A., Sutendra, Gopinath, Campbell, Jonathan E., Dyck, Jason R.B., Ussher, John R.

Source: In Cell Metabolism 5 May 2020 31(5):909-919

Cardiovascular biology of the GIP receptor

Authors: Greenwell, Amanda A., Chahade, Jadin J., Ussher, John R. ^*

Source: In Peptides March 2020 125

Dietary-Induced Obesity, Hepatic Cytochrome P450, and Lidocaine Metabolism: Comparative Effects of High-Fat Diets in Mice and Rats and Reversibility of Effects With Normalization of Diet

Authors: Al Nebaihi, Hamdah M., Al Batran, Rami, Ussher, John R., Maayah, Zaid H., El-Kadi, Ayman O.S., Brocks, Dion R.

Source: In Journal of Pharmaceutical Sciences February 2020 109(2):1199-1210

A structure-activity relationship study of Forkhead Domain Inhibitors (FDI): The importance of halogen binding interactions

Authors: Tabatabaei Dakhili, Seyed Amirhossein, Pérez, David J., Gopal, Keshav, Tabatabaei Dakhili, Seyed Yasin, Ussher, John R., Velázquez-Martínez, Carlos A.

Source: In Bioorganic Chemistry December 2019 93

Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction

Authors: Wang, Wei, Zhang, Liyan, Battiprolu, Pavan K., Fukushima, Arata, Nguyen, Khanh, Milner, Kenneth, Gupta, Abhishek, Altamimi, Tariq, Byrne, Nikole, Mori, Jun, Alrob, Osama Abo, Wagg, Cory, Fillmore, Natasha, Wang, Shao-hua, Liu, Dongming M., Fu, Angela, Lu, Jenny Yinglin, Chaves, Mary, Motani, Alykhan, Ussher, John R., Reagan, Jeff D., Dyck, Jason R.B., Lopaschuk, Gary D.

Source: In JACC: Basic to Translational Science June 2019 4(3):385-400

L‐Citrulline supplementation improves glucose and exercise tolerance in obese male mice

Authors: Eshreif, Amina, Al Batran, Rami, Jamieson, K. Lockhart, Darwesh, Ahmed M., Gopal, Keshav, Greenwell, Amanda A., Zlobine, Igor, Aburasayn, Hanin, Eaton, Farah, Mulvihill, Erin E., Campbell, Jonathan E., Seubert, John M., Ussher, John R.

Source: Experimental physiology. 105(2):270-281

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100099798885.0x000001&indx=1&recIds=ETOCvdc_100099798885.0x000001

Ketones can become the major fuel source for the heart but do not increase cardiac efficiency

Authors: Ho, Kim L, Karwi, Qutuba G, Wagg, Cory, Zhang, Liyan, Vo, Katherina, Altamimi, Tariq, Uddin, Golam M, Ussher, John R, Lopaschuk, Gary D

Source: Cardiovascular research. 117(4):1178-1187

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130287168.0x000001&indx=1&recIds=ETOCvdc_100130287168.0x000001

Incretin-mediated control of cardiac energy metabolism.

Authors: Chan, Jordan S. F., Shafaati, Tanin, Ussher, John R.

Source: Journal of Endocrinology; Oct2024, Vol. 263 Issue 1, p1-10, 10p

Subject Terms: GLUCAGON-like peptide 1, GLUCAGON-like peptide-1 receptor, MAJOR adverse cardiovascular events, HEART metabolism, GLYCEMIC control

The Relationship Between Cardiac Energy Metabolism and Cardiac Function in Obesity and Type 2 Diabetes: Revisiting a 2003 Diabetes Classic by Aasum et al.

Authors: Ussher, John R.^1,2,3 (AUTHOR) jussher@ualberta.ca, Aasum, Ellen⁴ (AUTHOR)

Source: Diabetes. Sep2024, Vol. 73 Issue 9, p1373-1376. 4p.

Subject Terms: *FATTY acid oxidation, *HEART metabolism, *GLUCAGON-like peptide-1 receptor, *LABORATORY rats, *OXIDATION of glucose, *DIASTOLE (Cardiac cycle), *LEPTIN, *LACTATES

Liraglutide alleviates experimental diabetic cardiomyopathy in a PDH-dependent manner.

Authors: Chan, Jordan S. F., Greenwell, Amanda A., Saed, Christina T., Stenlund, Magnus J., Mangra-Bala, Indiresh A., Tabatabaei Dakhili, Seyed Amirhossein, Kunyan Yang, Ferrari, Sally R., Eaton, Farah, Gopal, Keshav, Ussher, John R.

Source: Journal of Endocrinology; Aug2024, Vol. 262 Issue 2, p1-12, 12p

Glucagon-like peptide-1 receptor action in the vasculature

Authors: Almutairi, Malak, Al Batran, Rami, Ussher, John R.

Source: In Peptides January 2019 111:26-32