Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation

Authors: Yu-Ting Tsai, Wei-Lun Lo, Pin-Yuan Chen, Chiung-Yuan Ko, Jian-Ying Chuang, Tzu-Jen Kao, Wen-Bing Yang, Kwang-Yu Chang, Chia-Yang Hung, Ushio Kikkawa, Wen-Chang Chang, Tsung-I. Hsu

Source: Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-17 (2022)

Subject Terms: TMZ-resistant GBM, Sp1, PGE2, Mitochondria, Fatty acid β-oxidation, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1423-0127

Access URL: https://doaj.org/article/41e5eb2931d64c3ea1398dfe091319be

HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells

Authors: An-Chih Wu, Wen-Bin Yang, Kwang-Yu Chang, Jung-Shun Lee, Jing-Ping Liou, Ruei-Yuan Su, Siao Muk Cheng, Daw-Yang Hwang, Ushio Kikkawa, Tsung-I Hsu, Chih-Yang Wang, Wen-Chang Chang, Pin-Yuan Chen, Jian-Ying Chuang

Source: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)

Subject Terms: Glioblastoma, Histone deacetylase 6, lncRNA LINC00461, RNA-binding proteins, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/d9672530025d48d3b6d942240400f4bd

Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells

Authors: Wen-Bin Yang, An-Chih Wu, Tsung-I Hsu, Jing-Ping Liou, Wei-Lun Lo, Kwang-Yu Chang, Pin-Yuan Chen, Ushio Kikkawa, Shung-Tai Yang, Tzu-Jen Kao, Ruei-Ming Chen, Wen-Chang Chang, Chiung-Yuan Ko, Jian-Ying Chuang

Source: Cell Death and Disease, Vol 12, Iss 10, Pp 1-13 (2021)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/0550dd11627c4cb1b510f29cabb3b452

RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth

Authors: Takuya Kano, Ryosuke Tsumagari, Akio Nakashima, Ushio Kikkawa, Shuji Ueda, Minoru Yamanoue, Nobuyuki Takei, Yasuhito Shirai

Source: Biomolecules, Vol 11, Iss 12, p 1814 (2021)

Subject Terms: diacylglycerol kinase, phosphatidic acid, mammalian target of rapamycin, RalA, phospholipase D (PLD), neurite, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/11/12/1814; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/b3187720133b4b8e927a5c073e278f1e

The S. pombe CDK5 Orthologue Pef1 Cooperates with Three Cyclins, Clg1, Pas1 and Psl1, to Promote Pre-Meiotic DNA Replication

Authors: Shinya Matsuda, Ushio Kikkawa, Akio Nakashima

Source: Biomolecules, Vol 11, Iss 1, p 89 (2021)

Subject Terms: meiosis, Pef1, CDK5, Cdc2, pre-meiotic DNA replication, cyclin, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/11/1/89; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/f61c285e950c4802a710f5a264cc50a9

Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter

Authors: Akio Nakashima, Shinji Kamada, Fuyuhiko Tamanoi, Ushio Kikkawa

Source: Biology Open, Vol 3, Iss 6, Pp 542-552 (2014)

Subject Terms: Arrestin-related trafficking adaptor, ART, Arn1/Any1, Amino acid uptake, Endocytosis of transporter, Ubiquitination, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://bio.biologists.org/content/3/6/542; https://doaj.org/toc/2046-6390

Access URL: https://doaj.org/article/25d65b306dcc47bcbf7f1231c3b2dc30

The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast.

Authors: Ning Ma, Yan Ma, Akio Nakashima, Ushio Kikkawa, Tomoyuki Furuyashiki

Source: PLoS ONE, Vol 11, Iss 5, p e0156239 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4881991?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6b417209a78340ba82986d16086db554

Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex.

Authors: Arthur Jorge Santiago Lima, Marianne Hoogeveen-Westerveld, Akio Nakashima, Anneke Maat-Kievit, Ans van den Ouweland, Dicky Halley, Ushio Kikkawa, Mark Nellist

Source: PLoS ONE, Vol 9, Iss 4, p e93940 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093940&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/520b61817c1c4bdc812669da3bee6825

Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein.

Authors: Masayuki Nakano, Akio Nakashima, Taiki Nagano, Shintaro Ishikawa, Ushio Kikkawa, Shinji Kamada

Source: PLoS ONE, Vol 8, Iss 11, p e80411 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3819289?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e42ff7eee4094d95bab0ee587934ecc2

Contribution of caspase(s) to the cell cycle regulation at mitotic phase.

Authors: Toshiaki Hashimoto, Ushio Kikkawa, Shinji Kamada

Source: PLoS ONE, Vol 6, Iss 3, p e18449 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3068168?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c72b71b4789642a89ae725b79085a757

The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase.

Authors: Akio Nakashima, Yoshiko Maruki, Yuko Imamura, Chika Kondo, Tomoko Kawamata, Ippei Kawanishi, Hideki Takata, Akira Matsuura, Kyung S Lee, Ushio Kikkawa, Yoshinori Ohsumi, Kazuyoshi Yonezawa, Yoshiaki Kamada

Source: PLoS ONE, Vol 3, Iss 5, p e2223 (2008)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2375053?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/108ca55cecd243f88f3ebd8137374753

The S. pombe CDK5 ortholog Pef1 regulates sexual differentiation through control of the TORC1 pathway and autophagy.

Authors: Shinya Matsuda^1,2 s-matsuda@u-shizuoka-ken.ac.jp, Ushio Kikkawa^1,3, Haruka Uda³, Akio Nakashima^1,3 anakashima@person.kobe-u.ac.jp

Source: Journal of Cell Science. 2020, Vol. 133 Issue 17, p1-16. 16p.

Subject Terms: *SEX differentiation (Embryology), *SCHIZOSACCHAROMYCES pombe, *CYCLINS, *AUTOPHAGY

Midostaurin preferentially attenuates proliferation of triple-negative breast cancer cell lines through inhibition of Aurora kinase family.

Authors: Masaaki Kawai, Akio Nakashima, Shinji Kamada, Ushio Kikkawa

Source: Journal of Biomedical Science; Jul2015, Vol. 22 Issue 1, p1-10, 10p, 1 Color Photograph, 2 Diagrams, 5 Graphs

Subject Terms: BREAST cancer, CANCER cell proliferation, BIOMARKERS, HORMONE receptors, EPIDERMAL growth factor receptors, PROTEIN kinase inhibitors, AURORA kinases

Cyclin I is involved in the regulation of cell cycle progression.

Authors: Taiki Nagano, Toshiaki Hashimoto, Akio Nakashima, Shin-Ichi Hisanaga, Ushio Kikkawa, Shinji Kamada

Source: Cell Cycle; 08/15/2013, Vol. 12 Issue 16, p2617-2724, 8p

Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor1.

Authors: Joseph Avruch, Xiaomeng Long, Yenshou Lin, Sara Ortiz-vega, Joseph Rapley, Angela Papageorgiou, Noriko Oshiro, Ushio Kikkawa

Source: Biochemical Society Transactions; 2009, Vol. 37 Issue 1, p223-226, 4p

Subject Terms: ENZYME activation, SERINE proteinases, GUANOSINE triphosphate, CELLULAR signal transduction, PROTEIN binding, PROTEIN kinases, CARRIER proteins, PHOSPHORYLATION

Protein kinase C in melanoma.

Authors: Masahiro Oka, Ushio Kikkawa

Source: Cancer & Metastasis Reviews; Jun2005, Vol. 24 Issue 2, p287-300, 14p

Subject Terms: PHOSPHOTRANSFERASES, PROTEIN kinase C, MELANOMA, COCARCINOGENS

Proline dehydrogenase promotes senescence through the generation of reactive oxygen species.

Authors: Taiki Nagano, Akio Nakashima, Kengo Onishi, Kosuke Kawai, Yuto Awai, Mizuki Kinugasa, Tetsushi Iwasaki, Ushio Kikkawa, Shinji Kamada

Source: Journal of Cell Science; 4/15/2017, Vol. 130 Issue 8, p1-1, 1p

Subject Terms: PROLINE, DEHYDROGENASES, CELLULAR aging

LY6D-induced macropinocytosis as a survival mechanism of senescent cells.

Authors: Taiki Nagano¹, Tetsushi Iwasaki^1,2,3, Kengo Onishi², Yuto Awai³, Anju Terachi², Shione Kuwaba³, Shota Asano², Ryoko Katasho², Kiyoko Nagai¹, Akio Nakashima^1,4, Ushio Kikkawa^1,4, Shinji Kamada^1,2,3 skamada@kobe-u.ac.jp

Source: Journal of Biological Chemistry. Jan-Jun2021, Vol. 296, p1-15. 15p.

Subject Terms: *LIPID rafts, *MEMBRANE lipids, *CELL membranes, *AMINO acids, *GLUTAMINE