A cytotoxic Petiveria alliacea dry extract induces ATP depletion and decreases β-F1-ATPase expression in breast cancer cells and promotes survival in tumor-bearing mice

Authors: Hernández, John F., Urueña, Claudia P., Sandoval, Tito A., Cifuentes, Maria C., Formentini, Laura, Cuezva, Jose M., Fiorentino, Susana

Source: Revista Brasileira de Farmacognosia. June 2017 27(3)

Subject Terms: Petiveria alliacea, Breast cancer, β-F1-ATPase, Respiration, ATP depletion

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Access URL: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000300306

Plant extracts modulate cellular stress to inhibit replication of mouse Coronavirus MHV-A59

Authors: Prieto, Karol ¹, Arévalo, Cindy ¹, Lasso, Paola, Carlosama, Carolina, Urueña, Claudia, Fiorentino, Susana, Barreto, Alfonso ^∗

Source: In Heliyon 15 January 2024 10(1)

Doxorubicin Activity Is Modulated by Traditional Herbal Extracts in a 2D and 3D Multicellular Sphere Model of Leukemia.

Authors: Corzo Parada, Laura¹ (AUTHOR), Urueña, Claudia¹ (AUTHOR), Leal-García, Efraín² (AUTHOR), Barreto, Alfonso¹ (AUTHOR), Ballesteros-Ramírez, Ricardo¹ (AUTHOR), Rodríguez-Pardo, Viviana¹ (AUTHOR), Fiorentino, Susana^1,2 (AUTHOR) susana.fiorentino@javeriana.edu.co

Source: Pharmaceutics. Jun2023, Vol. 15 Issue 6, p1690. 15p.

Subject Terms: *DOXORUBICIN, *FRACTIONS, *MESENCHYMAL stem cells, *MEDICAL botany, *PLANT extracts, *LEUKEMIA, *ENDOTHELIAL cells

Encapsulated Phytomedicines against Cancer: Overcoming the "Valley of Death".

Authors: Brotons-Canto, Ana¹ (AUTHOR) ana.brotons@nucapsnanotechnology.com, Urueña, Claudia P.^2,3 (AUTHOR), Imbuluzqueta, Izaskun¹ (AUTHOR), Luque-Michel, Edurne¹ (AUTHOR), Martinez-López, Ana Luisa¹ (AUTHOR), Ballesteros-Ramírez, Ricardo^2,3 (AUTHOR), Rojas, Laura² (AUTHOR), Fiorentino, Susana² (AUTHOR) ana.brotons@nucapsnanotechnology.com

Source: Pharmaceutics. Apr2023, Vol. 15 Issue 4, p1038. 13p.

Subject Terms: *ADJUVANT treatment of cancer, *ORAL drug administration, *TUMOR growth, *CAESALPINIA, *BIOAVAILABILITY, *TREATMENT effectiveness

The delay in cell death caused by the induction of autophagy by P2Et extract is essential for the generation of immunogenic signals in melanoma cells

Authors: Prieto, Karol, Lozano, Maria Paula, Urueña, Claudia, Alméciga-Díaz, Carlos Javier, Fiorentino, Susana, Barreto, Alfonso

Source: Apoptosis. 25(11-12):875-888

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187135059.0x000001&indx=1&recIds=ETOCvdc_100187135059.0x000001

Triple negative breast cancer migration is modified by mitochondrial metabolism alteration induced by natural extracts of C. spinosa and P. alliacea.

Authors: Carlosama, Carolina, Arévalo, Cindy, Jimenez, María Camila, Lasso, Paola, Urueña, Claudia, Fiorentino, Susana, Barreto, Alfonso

Source: Scientific Reports; 8/31/2024, Vol. 14 Issue 1, p1-15, 15p

Subject Terms: TRIPLE-negative breast cancer, OXYGEN consumption, CELL metabolism, METABOLISM, MITOCHONDRIA, NATURAL products, POTASSIUM channels

The breast cancer immune microenvironment is modified by neoadjuvant chemotherapy.

Authors: Urueña, Claudia¹ (AUTHOR) curuena@javeriana.edu.co, Lasso, Paola¹ (AUTHOR), Bernal-Estevez, David² (AUTHOR), Rubio, Diego³ (AUTHOR), Salazar, Ana Janeth³ (AUTHOR), Olaya, Mercedes³ (AUTHOR), Barreto, Alfonso¹ (AUTHOR), Tawil, Mauricio⁴ (AUTHOR), Torregrosa, Lilian⁴ (AUTHOR), Fiorentino, Susana¹ (AUTHOR) susana.fiorentino@javeriana.edu.co

Source: Scientific Reports. 5/13/2022, Vol. 12 Issue 1, p1-13. 13p.

Subject Terms: *TUMOR microenvironment, *NEOADJUVANT chemotherapy, *REGULATORY T cells, *MYELOID-derived suppressor cells, *BREAST cancer, *T cells

Assessment of Acute and Chronic Toxicity in Wistar Rats (Rattus norvegicus) and New Zealand Rabbits (Oryctolagus cuniculus) of an Enriched Polyphenol Extract Obtained from Caesalpinia spinosa.

Authors: Ballesteros-Ramírez, Ricardo, Lasso, Paola, Urueña, Claudia, Saturno, Jenny, Fiorentino, Susana

Source: Journal of Toxicology; 4/10/2024, Vol. 2024, p1-10, 10p

Subject Terms: RATS, RATTUS norvegicus, EUROPEAN rabbit, RABBITS, LABORATORY rats, CHRONIC toxicity testing, ACUTE toxicity testing

Geographic Terms: NEW Zealand

Standardized Extract from Caesalpinia spinosa is Cytotoxic Over Cancer Stem Cells and Enhance Anticancer Activity of Doxorubicin

Authors: Sandoval, Tito A., Urueña, Claudia P., Llano, Mónica, Gómez-Cadena, Alejandra, Hernández, John F., Sequeda, Luis Gonzalo, Loaiza, Alix E., Barreto, Alfonso, Li, Shaoping, Fiorentino, Susana

Source: American journal of Chinese medicine. 44(8):1693-1718

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN609336594&indx=1&recIds=ETOCRN609336594

Effect of Petiveria alliacea Extracts on Metabolism of K562 Myeloid Leukemia Cells.

Authors: Rojas, Laura, Pardo-Rodriguez, Daniel, Urueña, Claudia, Lasso, Paola, Arévalo, Cindy, Cala, Mónica P., Fiorentino, Susana

Source: International Journal of Molecular Sciences; Dec2023, Vol. 24 Issue 24, p17418, 14p

Subject Terms: MYELOID leukemia, METABOLOMICS, MYELOID cells, HEMATOPOIETIC stem cells, METABOLISM, AMINO acid metabolism, CELL cycle, OXYGEN consumption

Natural Products Induce Different Anti-Tumor Immune Responses in Murine Models of 4T1 Mammary Carcinoma and B16-F10 Melanoma.

Authors: Lasso, Paola, Rojas, Laura, Arévalo, Cindy, Urueña, Claudia, Murillo, Natalia, Fiorentino, Susana

Source: International Journal of Molecular Sciences; Dec2023, Vol. 24 Issue 23, p16698, 15p

Subject Terms: DOXORUBICIN, REGULATORY T cells, NATURAL products, TUMOR necrosis factors, IMMUNE response, T cells

Piper nigrum extract suppresses tumor growth and enhances the antitumor immune response in murine models of breast cancer and melanoma.

Authors: Lasso, Paola, Rojas, Laura, Arévalo, Cindy, Urueña, Claudia, Murillo, Natalia, Nossa, Paula, Sandoval, Tito, Chitiva, Luis Carlos, Barreto, Alfonso, Costa, Geison M., Fiorentino, Susana

Source: Cancer Immunology, Immunotherapy; Oct2023, Vol. 72 Issue 10, p3279-3292, 14p

Subject Terms: BLACK pepper (Plant), MYELOID-derived suppressor cells, TUMOR growth, BREAST cancer, IMMUNE response, CANCER cell growth

Evaluation of chemotherapy and P2Et extract combination in ex-vivo derived tumor mammospheres from breast cancer patients

Authors: Urueña, Claudia, Sandoval, Tito A., Lasso, Paola, Tawil, Mauricio, Barreto, Alfonso, Torregrosa, Lilian, Fiorentino, Susana

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187028568.0x000001&indx=1&recIds=ETOCvdc_100187028568.0x000001

Multifunctional T Lymphocytes Generated After Therapy With an Antitumor Gallotanin-Rich Normalized Fraction Are Related to Primary Tumor Size Reduction in a Breast Cancer Model

Authors: Urueña, Claudia, Gomez, Alejandra, Sandoval, Tito, Hernandez, John, Li, Shaoping, Barreto, Alfonso, Fiorentino, Susana

Source: Integrative cancer therapies. 14(5):468-483

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN602668093&indx=1&recIds=ETOCRN602668093

Safety and efficacy of P2Et extract from Caesalpinia spinosa in breast cancer patients: study protocol for a randomized double blind phase II clinical trial (CS003-BC).

Authors: Ballesteros-Ramírez, Ricardo, Pinilla, Paola, Sanchéz, Jesús, Torregrosa, Lilian, Aschner, Pablo, Urueña, Claudia, Fiorentino, Susana

Source: BMC Complementary Medicine & Therapies; 9/5/2023, Vol. 23 Issue 1, p1-12, 12p, 1 Diagram, 1 Chart

Subject Terms: PHYTOTHERAPY, WELL-being, ANTHRACYCLINES, CANCER chemotherapy, ANTINEOPLASTIC agents, IMMUNE system, CANCER patients, TREATMENT effectiveness, RANDOMIZED controlled trials, QUALITY of life, HUMAN microbiota, RESEARCH funding, PLANT extracts, COMBINED modality therapy, BREAST tumors, PATIENT safety

Petiveria alliacea Reduces Tumor Burden and Metastasis and Regulates the Peripheral Immune Response in a Murine Myeloid Leukemia Model.

Authors: Murillo, Natalia, Lasso, Paola, Urueña, Claudia, Pardo-Rodriguez, Daniel, Ballesteros-Ramírez, Ricardo, Betancourt, Giselle, Rojas, Laura, Cala, Mónica P., Fiorentino, Susana

Source: International Journal of Molecular Sciences; Aug2023, Vol. 24 Issue 16, p12972, 17p

Subject Terms: MOUSE leukemia, MYELOID leukemia, METASTASIS, ACUTE myeloid leukemia, IMMUNE response

Exploring the safety and efficacy of phytomedicine Petiveria alliacea extract (Esperanza) in patients with metastatic gastrointestinal tumors and acute leukemias: study protocol for a phase Ib/randomized double blind phase II trial (PA001).

Authors: Ballesteros-Ramírez, Ricardo, Pinilla, Paola, Sanchéz, Jesús, Arévalo, Mónica, Sanchez, Elio, Aschner, Pablo, Urueña, Claudia, Fiorentino, Susana

Source: BMC Complementary Medicine & Therapies; 8/10/2023, Vol. 23 Issue 1, p1-17, 17p, 1 Diagram, 5 Charts

Subject Terms: DRUG efficacy, MEDICINAL plants, METASTASIS, LEUKEMIA, GASTROINTESTINAL tumors, QUALITY of life, RESEARCH funding, PLANT extracts, PATIENT safety

Tillandsia usneoides Extract Decreases the Primary Tumor in a Murine Breast Cancer Model but Not in Melanoma.

Authors: Lasso, Paola, Rojas, Laura, Arévalo, Cindy, Urueña, Claudia, Murillo, Natalia, Barreto, Alfonso, Costa, Geison M., Fiorentino, Susana

Source: Cancers; Nov2022, Vol. 14 Issue 21, p5383, 17p

Subject Terms: IN vitro studies, MEDICINAL plants, IN vivo studies, ANIMAL experimentation, IMMUNOMODULATORS, APOPTOSIS, DISEASE relapse, QUALITY of life, PLANT extracts, ALTERNATIVE medicine, CELL lines, CELL surface antigens, BREAST tumors, MICE, IMMUNODIAGNOSIS

CAR-T Cell Performance: How to Improve Their Persistence?

Authors: López-Cantillo, Gina, Urueña, Claudia, Camacho, Bernardo Armando, Ramírez-Segura, Cesar

Source: Frontiers in Immunology; 4/28/2022, Vol. 13, p1-16, 16p

Subject Terms: T cells, CHIMERIC antigen receptors, IMMUNOLOGIC memory, CELL metabolism, CELLULAR therapy

A gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze displays cytotoxic activity and raises sensitivity to doxorubicin in a leukemia cell line

Authors: Castañeda Diana M, Pombo Luis, Urueña Claudia, Hernandez John, Fiorentino Susana

Source: BMC Complementary and Alternative Medicine, Vol 12, Iss 1, p 38 (2012)

Subject Terms: Adjuvants, Gallotannins, C.spinosa, Tumor, Leukemia, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: http://www.biomedcentral.com/1472-6882/12/38; https://doaj.org/toc/1472-6882

Access URL: https://doaj.org/article/da9ef8cd35a146bdabb5785c2e082167