Annexin A8 deficiency delays atherosclerosis progression

Authors: Carmen Gutiérrez‐Muñoz, Rafael Blázquez‐Serra, Irene San Sebastian‐Jaraba, Sandra Sanz‐Andrea, Maria J. Fernández‐Gómez, Gonzalo Nuñez‐Moreno, Pablo Mínguez, Joan Carles Escolá‐Gil, Paula Nogales, Veronique Ollivier, Jose L. Martín‐Ventura, Benoit Ho‐Tin Noe, Ursula Rescher, Nerea Méndez‐Barbero, Luis M. Blanco‐Colio

Source: Clinical and Translational Medicine, Vol 15, Iss 1, Pp n/a-n/a (2025)

Subject Terms: AnxA8, atherosclerosis, inflammation, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/9e63958f007e4a0797c1405762a31340

Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics

Authors: Volker Gerke, Felicity N. E. Gavins, Michael Geisow, Thomas Grewal, Jyoti K. Jaiswal, Jesper Nylandsted, Ursula Rescher

Source: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0372b0d39f0048d4a7ebd22615898ab9

P-selectin-dependent leukocyte adhesion is governed by endolysosomal two-pore channel 2

Authors: Jonas Goretzko, Inga Pauels, Nicole Heitzig, Katharina Thomas, Marina Kardell, Johannes Naß, Einar Kleinhans Krogsaeter, Sebastian Schloer, Barbara Spix, Anna Lívia Linard Matos, Charlotte Leser, Tristan Wegner, Frank Glorius, Franz Bracher, Volker Gerke, Jan Rossaint, Christian Grimm, Ursula Rescher

Source: Cell Reports, Vol 42, Iss 12, Pp 113501- (2023)

Subject Terms: CP: Immunology, CP: Cell biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124723015139; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/743e166b584b4ba9a9ee505a123e92b3

3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseases

Authors: Sebastian Schloer, Daniel Treuherz, Aileen Faist, Marlous de Witt, Katharina Wunderlich, Rainer Wiewrodt, Karsten Wiebe, Peter Barth, Joo-Hee Wälzlein, Susann Kummer, Anne Balkema-Buschmann, Stephan Ludwig, Linda Brunotte, Ursula Rescher

Source: Emerging Microbes and Infections, Vol 11, Iss 1, Pp 2160-2175 (2022)

Subject Terms: Ex vivo infection model, influenza, SARS-CoV-2, drug repurposing, innate immunity, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/66fca9e1b656421f99cfdbe67a0b48d8

Pharmacologically induced endolysosomal cholesterol imbalance through clinically licensed drugs itraconazole and fluoxetine impairs Ebola virus infection in vitro

Authors: Susann Kummer, Angelika Lander, Jonas Goretzko, Norman Kirchoff, Ursula Rescher, Sebastian Schloer

Source: Emerging Microbes and Infections, Vol 11, Iss 1, Pp 195-207 (2022)

Subject Terms: ebola virus, niemann-pick c1, itraconazole, fiasma, fluoxetine, viral entry, endolysosomal interference, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/673fa9eaf29b4e8e97536ec71e50e379

Importance of ACE2 for SARS-CoV-2 Infection of Kidney Cells

Authors: Marie-Kristin Kroll, Sebastian Schloer, Peynaz Candan, Nadia Korthals, Christoph Wenzel, Hannah Ihle, Kevin Gilhaus, Kim Rouven Liedtke, Michael Schöfbänker, Beate Surmann, Rita Schröter, Ute Neugebauer, Gita Mall, Stefan Oswald, Stephan Ludwig, Ursula Rescher, Beate Vollenbröker, Giuliano Ciarimboli

Source: Biomolecules, Vol 13, Iss 3, p 472 (2023)

Subject Terms: SARS-CoV-2, kidneys, ACE2, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/13/3/472; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/e71fdfe8fe194d379460a457b03f96f0

Pathophysiological Mechanisms of Cardiac Dysfunction in Transgenic Mice with Viral Myocarditis

Authors: Matthias Rohrbeck, Verena Hoerr, Ilaria Piccini, Boris Greber, Jan Sebastian Schulte, Sara-Sophie Hübner, Elena Jeworutzki, Carsten Theiss, Veronika Matschke, Jörg Stypmann, Andreas Unger, Huyen Tran Ho, Paul Disse, Nathalie Strutz-Seebohm, Cornelius Faber, Frank Ulrich Müller, Stephan Ludwig, Ursula Rescher, Wolfgang A. Linke, Karin Klingel, Karin Busch, Stefan Peischard, Guiscard Seebohm

Source: Cells, Vol 12, Iss 4, p 550 (2023)

Subject Terms: CVB3, myocarditis, contractility, cardiac dysfunction, calcium homeostasis, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/4/550; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/db7af84332ff43d5847796a3095ebeff

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine

Authors: Sebastian Schloer, Linda Brunotte, Jonas Goretzko, Angeles Mecate-Zambrano, Nadia Korthals, Volker Gerke, Stephan Ludwig, Ursula Rescher

Source: Emerging Microbes and Infections, Vol 9, Iss 1, Pp 2245-2255 (2020)

Subject Terms: SARS-CoV-2, IAV, FIASMA, fluoxetine, viral entry, endolysosomal interference, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/bcf82b4bf73a42dcb504646c60eb279b

The MEK1/2 Inhibitor ATR-002 (Zapnometinib) Synergistically Potentiates the Antiviral Effect of Direct-Acting Anti-SARS-CoV-2 Drugs

Authors: André Schreiber, Benjamin Ambrosy, Oliver Planz, Sebastian Schloer, Ursula Rescher, Stephan Ludwig

Source: Pharmaceutics, Vol 14, Iss 9, p 1776 (2022)

Subject Terms: SARS-CoV-2, COVID-19, antiviral drug, MEK1/2 inhibitor, ATR-002, drug synergy, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/9/1776; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/21a8b64110ad42aebe8d6b5f58aaea74

Characterization of the Atl-mediated staphylococcal internalization mechanism

Authors: Tim Schlesier, Anke Siegmund, Ursula Rescher, Christine Heilmann

Source: International Journal of Medical Microbiology, Vol 310, Iss 8, Pp 151463- (2020)

Subject Terms: Staphylococcus, Internalization, Atl, α5β1 integrin, Fibronectin, Hsc70, Microbiology, QR1-502, Other systems of medicine, RZ201-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1438422120300734; https://doaj.org/toc/1438-4221

Access URL: https://doaj.org/article/23cb59a67fc045d280fd90b32580a664

Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities

Authors: Aline da Rocha Matos, Katharina Wunderlich, Sebastian Schloer, Klaus Schughart, Robert Geffers, Martine Seders, Marlous de Witt, Anmari Christersson, Rainer Wiewrodt, Karsten Wiebe, Peter Barth, Andreas Hocke, Stefan Hippenstiel, Katja Hönzke, Ulf Dittmer, Kathrin Sutter, Ursula Rescher, Svetlana Rodionycheva, Nicoletta Matera, Stephan Ludwig, Linda Brunotte

Source: Emerging Microbes and Infections, Vol 8, Iss 1, Pp 1763-1776 (2019)

Subject Terms: Human lung explant, influenza, antiviral, IFN-α subtype, ISG induction, MxA, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/846368ab325d404ba94cc3b595911cc2

The clinically licensed antifungal drug itraconazole inhibits influenza virus in vitro and in vivo

Authors: Sebastian Schloer, Jonas Goretzko, Alexander Kühnl, Linda Brunotte, Stephan Ludwig, Ursula Rescher

Source: Emerging Microbes and Infections, Vol 8, Iss 1, Pp 80-93 (2019)

Subject Terms: Influenza A virus, posaconazole, itraconazole, interferon response, cellular cholesterol, host cell factors, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/30def7bef94a4af185c7a339cd4abadd

Repurposing Antifungals for Host-Directed Antiviral Therapy?

Authors: Sebastian Schloer, Jonas Goretzko, Ursula Rescher

Source: Pharmaceuticals, Vol 15, Iss 2, p 212 (2022)

Subject Terms: antifungals, host-directed drug therapy, drug repurposing, azoles, polyenes, echinocandins, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/15/2/212; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/d4d37ee2f94a41cc83fe5b372f987012

Regulation of retinal pigment epithelial cell phenotype by Annexin A8

Authors: Katharina Lueck, Amanda-Jayne F. Carr, Dimitrios Stampoulis, Volker Gerke, Ursula Rescher, John Greenwood, Stephen E. Moss

Source: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/51d55e5e3165498991da240361a0634b

High Nuclease Activity of Long Persisting Staphylococcus aureus Isolates Within the Airways of Cystic Fibrosis Patients Protects Against NET-Mediated Killing

Authors: Susann Herzog, Felix Dach, Nicole de Buhr, Silke Niemann, Jannik Schlagowski, Diego Chaves-Moreno, Claudia Neumann, Jonas Goretzko, Vera Schwierzeck, Alexander Mellmann, Angelika Dübbers, Peter Küster, Holger Schültingkemper, Ursula Rescher, Dietmar H. Pieper, Maren von Köckritz-Blickwede, Barbara C. Kahl

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: Cystic fibrosis, Staphylococcus aureus, neutrophil extracellular traps, nuclease, adaptation, NET-mediated killing, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02552/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/d2bcd5f29662432aad134ee62a51d8fe

Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro

Authors: Linda Brunotte, Shuyu Zheng, Angeles Mecate-Zambrano, Jing Tang, Stephan Ludwig, Ursula Rescher, Sebastian Schloer

Source: Pharmaceutics, Vol 13, Iss 9, p 1400 (2021)

Subject Terms: combination therapy, SARS-CoV-2, nucleoside GS-441524, fluoxetine, synergy, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/9/1400; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/f0fff4fd462e4475bfbb1431db4ed90d

Special Issue 'Recent Developments in Annexin Biology'

Authors: Ursula Rescher, Volker Gerke, Lina Hsiu Kim Lim, Jyoti K. Jaiswal

Source: Cells, Vol 9, Iss 11, p 2477 (2020)

Subject Terms: Annexin, inflammation, membrane, injury, exocytosis, membrane repair, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/11/2477; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/e382f9b7b3224056860aa3399e1f5e6c

Combinatory Treatment with Oseltamivir and Itraconazole Targeting Both Virus and Host Factors in Influenza A Virus Infection

Authors: Sebastian Schloer, Jonas Goretzko, Stephan Pleschka, Stephan Ludwig, Ursula Rescher

Source: Viruses, Vol 12, Iss 7, p 703 (2020)

Subject Terms: influenza A virus, oseltamivir, itraconazole, host-directed therapy, drug repurposing, combination therapy, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/12/7/703; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/62f9580c45304b9bbf68cacee7b704da

Exploring Biased Agonism at FPR1 as a Means to Encode Danger Sensing

Authors: Jieny Gröper, Gabriele M. König, Evi Kostenis, Volker Gerke, Carsten A. Raabe, Ursula Rescher

Source: Cells, Vol 9, Iss 4, p 1054 (2020)

Subject Terms: bias analysis, G protein-coupled receptor (GPCR), formyl peptide receptor 1, danger-associated molecular pattern (DAMP), pathogen-associated molecular pattern (PAMP), annexin A1 peptide Ac2-26, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/4/1054; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/b490862b80de49e185a5bcd5fc1e34ae

Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus

Authors: Alexander Kühnl, Agnes Musiol, Nicole Heitzig, Danielle E. Johnson, Christina Ehrhardt, Thomas Grewal, Volker Gerke, Stephan Ludwig, Ursula Rescher

Source: mBio, Vol 9, Iss 4 (2018)

Subject Terms: IFITM3, influenza A virus, annexin A6, interferon, late endosomal cholesterol content, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2150-7511

Access URL: https://doaj.org/article/6c3d712588c4446f9847a58b5227d3c0