Methods to identify and optimize small molecules interacting with RNA (SMIRNAs)

Authors: Ursu, Andrei, Vézina-Dawod, Simon, Disney, Matthew D. ^⁎

Source: In Drug Discovery Today October 2019 24(10):2002-2016

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD

Authors: Ursu, Andrei, Wang, Kye Won, Bush, Jessica A., Choudhary, Shruti, Chen, Jonathan L., Baisden, Jared T., Zhang, Yong-Jie, Gendron, Tania F., Petrucelli, Leonard, Yildirim, Ilyas

Source: ACS chemical biology. 15(12):3112-3123

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN625735188&indx=1&recIds=ETOCRN625735188

Design of small molecules targeting RNA structure from sequenceElectronic supplementary information (ESI) available. See DOI: 10.1039/d0cs00455c

Authors: Ursu, Andrei, Childs-Disney, Jessica L., Andrews, Ryan J., O'Leary, Collin A., Meyer, Samantha M., Angelbello, Alicia J., Moss, Walter N., Disney, Matthew D.

Source: Chemical Society reviews. 49(20):7252-7270

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110402859.0x000001&indx=1&recIds=ETOCvdc_100110402859.0x000001

Gini Coefficients as a Single Value Metric to Define Chemical Probe Selectivity

Authors: Ursu, Andrei, Childs-Disney, Jessica L., Angelbello, Alicia J., Costales, Matthew G., Meyer, Samantha M., Disney, Matthew D.

Source: ACS chemical biology. 15(8):2031-2040

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624552647&indx=1&recIds=ETOCRN624552647

Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß

Authors: Kremer, Lea, Hennes, Elisabeth, Brause, Alexandra, Ursu, Andrei, Robke, Lucas, Matsubayashi, Hideaki T., Nihongaki, Yuta, Flegel, Jana, Mejdrová, Ivana, Eickhoff, Jan, Baumann, Matthias, Nencka, Radim, Janning, Petra, Kordes, Susanne, Schöler, Hans R., Sterneckert, Jared, Inoue, Takanari, Ziegler, Slava, Waldmann, Herbert

Source: Angewandte Chemie international edition. 58(46):16617-16628

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135379611.0x000001&indx=1&recIds=ETOCvdc_100135379611.0x000001

The Convergence of Stem Cell Technologies and Phenotypic Drug Discovery

Authors: Friese, Alexandra, Ursu, Andrei, Hochheimer, Andreas, Schöler, Hans R., Waldmann, Herbert, Bruder, Jan M.

Source: Cell chemical biology. 26(8):1050-1066

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087360088.0x000001&indx=1&recIds=ETOCvdc_100087360088.0x000001

Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs

Authors: Illich, Damir Jacob, Zhang, Miao, Ursu, Andrei, Osorno, Rodrigo, Kim, Kee-Pyo, Yoon, Juyong, Araúzo-Bravo, Marcos J., Wu, Guangming, Esch, Daniel, Sabour, Davood, Colby, Douglas, Grassme, Kathrin S., Chen, Jiayu, Greber, Boris, Höing, Susanne, Herzog, Wiebke, Ziegler, Slava, Chambers, Ian, Gao, Shaorong, Waldmann, Herbert, Schöler, Hans R.

Source: In Cell Reports 26 April 2016 15(4):787-800

Hide and seek: Identification and confirmation of small molecule protein targets

Authors: Ursu, Andrei, Waldmann, Herbert

Source: In Bioorganic & Medicinal Chemistry Letters 15 August 2015 25(16):3079-3086

Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1

Authors: Ursu, Andrei, Illich, Damir J., Takemoto, Yasushi, Porfetye, Arthur T., Zhang, Miao, Brockmeyer, Andreas, Janning, Petra, Watanabe, Nobumoto, Osada, Hiroyuki, Vetter, Ingrid R., Ziegler, Slava, Schöler, Hans R., Waldmann, Herbert

Source: Cell chemical biology. 23(4):494-507

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100042754566.0x000001&indx=1&recIds=ETOCvdc_100042754566.0x000001

Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair.

Authors: Corkery, Dale, Ursu, Andrei, Lucas, Belén, Grigalunas, Michael, Kriegler, Simon, Oliva, Rosario, Dec, Robert, Koska, Sandra, Pahl, Axel, Sievers, Sonja, Ziegler, Slava, Winter, Roland, Wu, Yao‐Wen, Waldmann, Herbert

Source: ChemBioChem; 12/14/2023, Vol. 24 Issue 24, p1-11, 11p

The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules

Authors: Wang, Zi-Fu, Ursu, Andrei, Childs-Disney, Jessica L., Guertler, Rea, Yang, Wang-Yong, Bernat, Viachaslau, Rzuczek, Suzanne G., Fuerst, Rita, Zhang, Yong-Jie, Gendron, Tania F., Yildirim, Ilyas, Dwyer, Brendan G., Rice, Joseph E., Petrucelli, Leonard, Disney, Matthew D.

Source: Cell chemical biology. 26(2):179-190.e12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100076779301.0x000001&indx=1&recIds=ETOCvdc_100076779301.0x000001

Development of small molecule modulators of stem cell reprogramming

Authors: Ursu, Andrei

Contributors: Waldmann, Herbert, Schöler, Hans Robert

Availability: http://data.europeana.eu/aggregation/europeana/2048441/item_ND734HCEFWYOMHNQOXKCIALKD43NQH4L

Decembrie 1989: Revoluție sau loviluție? (Romanian)

Authors: ARMANCA, Brînduşa, BACONSCHI, Teodor, BĂNICĂ, Mirel, CORNEA, Andrei, GUSSI, Alexandru, HULBER, Maria, STANOMIR, Ioan, URSU, Andrei, VASILE, Cristian

Source: Orizont; dec2024, Vol. 36 Issue 12, p14-15, 2p

A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks.

Authors: Ursu, Andrei, Baisden, Jared T., Bush, Jessica A., Taghavi, Amirhossein, Choudhary, Shruti, Zhang, Yong-Jie, Gendron, Tania F., Petrucelli, Leonard, Yildirim, Ilyas, Disney, Matthew D.

Source: ACS Chemical Neuroscience; 11/3/2021, Vol. 12 Issue 21, p4076-4089, 14p

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models.

Authors: Bush, Jessica A., Aikawa, Haruo, Fuerst, Rita, Li, Yue, Ursu, Andrei, Meyer, Samantha M., Benhamou, Raphael I., Chen, Jonathan L., Khan, Tanya, Wagner-Griffin, Sarah, Van Meter, Montina J., Tong, Yuquan, Olafson, Hailey, McKee, Kendra K., Childs-Disney, Jessica L., Gendron, Tania F., Zhang, Yongjie, Coyne, Alyssa N., Wang, Eric T., Yildirim, Ilyas

Source: Science Translational Medicine; 10/27/2021, Vol. 13 Issue 617, p1-13, 13p

Subject Terms: SMALL molecules, RIBONUCLEASES, AMYOTROPHIC lateral sclerosis, ENDONUCLEASES, LABORATORY mice, FRONTOTEMPORAL dementia, TANDEM repeats

People: BUSH, George W. (George Walker), 1946-

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Tabuul totalitar. (Romanian)

Authors: URSU, Andrei

Source: Orizont; dec2023, Vol. 35 Issue 12, p4-5, 2p

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