Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

Authors: Ehteda, Anahid, Simon, Sandy, Franshaw, Laura, Giorgi, Federico M., Liu, Jie, Joshi, Swapna, Rouaen, Jourdin R.C., Pang, Chi Nam Ignatius, Pandher, Ruby, Mayoh, Chelsea, Tang, Yujie, Khan, Aaminah, Ung, Caitlin, Tolhurst, Ornella, Kankean, Anne, Hayden, Elisha, Lehmann, Rebecca, Shen, Sylvie, Gopalakrishnan, Anjana, Trebilcock, Peter, Gurova, Katerina, Gudkov, Andrei V., Norris, Murray D., Haber, Michelle, Vittorio, Orazio, Tsoli, Maria, Ziegler, David S.

Source: In Cell Reports 13 April 2021 35(2)

In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer

Authors: Lau, Loretta M S, Mayoh, Chelsea, Xie, Jinhan, Barahona, Paulette, MacKenzie, Karen L, Wong, Marie, Kamili, Alvin, Tsoli, Maria, Failes, Tim W, Kumar, Amit, Mould, Emily V A, Gifford, Andrew, Chow, Shu‐Oi, Pinese, Mark, Fletcher, Jamie I, Arndt, Greg M, Khuong‐Quang, Dong‐Anh, Wadham, Carol, Batey, Daniel, Eden, Georgina, Trebilcock, Peter, Joshi, Swapna, Alfred, Stephanie, Gopalakrishnan, Anjana, Khan, Aaminah, Grebert Wade, Dylan, Strong, Patrick A, Manouvrier, Elodie, Morgan, Lisa T, Span, Miriam, Lim, Jin Yi, Cadiz, Roxanne, Ung, Caitlin, Thomas, David M, Tucker, Katherine M, Warby, Meera, McCowage, Geoffrey B, Dalla‐Pozza, Luciano, Byrne, Jennifer A, Saletta, Federica, Fellowes, Andrew, Fox, Stephen B, Norris, Murray D, Tyrrell, Vanessa, Trahair, Toby N, Lock, Richard B, Cowley, Mark J, Ekert, Paul G, Haber, Michelle, Ziegler, David S, Marshall, Glenn M

Source: EMBO molecular medicine. 14(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100146289876.0x000001&indx=1&recIds=ETOCvdc_100146289876.0x000001

HGG-09. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION IN DIPG

Authors: Ehteda, Anahid, Simon, Sandy, Franshaw, Laura, Giorgi, Federico M, Liu, Jie, Hayden, Elisha, Rouaen, Jourdin, Pang, Chi Nam Ignatius, Pandher, Ruby, Mayoh, Chelsea, Tang, Yujie, Khan, Aaminah, Ung, Caitlin, Kankean, Anne, Lehmann, Rebecca, Shen, Sylvie, Gopalakrishnan, Anjana, Trebilcock, Peter, Gurova, Katerina, Gudkov, Andrei, Norris, Murray D, Haber, Michelle, Vittorio, Orazio, Tsoli, Maria, Ziegler, David S

Source: Neuro-oncology. 23(Supplement 1):i18-i19

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125173836.0x000001&indx=1&recIds=ETOCvdc_100125173836.0x000001

RARE-08. POTENTIAL NEW THERAPIES FOR DIFFUSE INTRINSIC PONTINE GLIOMAS IDENTIFIED THROUGH HIGH THROUGHPUT DRUG SCREENING

Authors: Upton, Dannielle, Valvi, Santosh, Liu, Jie, Yeung, Nicole, George, Sandra, Ung, Caitlin, Khan, Aaminah, Franshaw, Laura, Ehteda, Anahid, Shen, Han, Orienti, Isabella, Farruggia, Giovanna, Reynolds, Patrick, Tsoli, Maria, Ziegler, David

Source: Neuro-oncology. 23(Supplement 1):i42-i42

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125174588.0x000001&indx=1&recIds=ETOCvdc_100125174588.0x000001

HGG-10. THE BLOOD-BRAIN BARRIER IN DIPG: INVESTIGATING REGION-SPECIFIC DIFFERENCES IN PERMEABILITY

Authors: Ung, Caitlin, Upton, Dannielle, Tsoli, Maria, Ziegler, David

Source: Neuro-oncology. 23(Supplement 1):i19-i19

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125173870.0x000001&indx=1&recIds=ETOCvdc_100125173870.0x000001

Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy.

Authors: Upton, Dannielle H., Ung, Caitlin, George, Sandra M., Tsoli, Maria, Kavallaris, Maria, Ziegler, David S.

Source: Theranostics; 2022, Vol. 12 Issue 10, p4734-4752, 19p

DIPG-07. HIGH THROUGHPUT DRUG SCREENING IDENTIFIES POTENTIAL NEW THERAPIES FOR DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs)

Authors: Upton, Dannielle, Valvi, Santosh, Liu, Jie, Yeung, Nicole, George, Sandra, Ung, Caitlin, Khan, Aaminah, Franshaw, Laura, Ehteda, Anahid, Shen, Han, Orienti, Isabella, Farruggia, Giovanna, Nath, Christa, Reynolds, Patrick, Tsoli, Maria, Ziegler, David

Source: Neuro-oncology. 22(Supplement 3):iii288-iii288

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112155767.0x000001&indx=1&recIds=ETOCvdc_100112155767.0x000001

DIPG-27. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION

Authors: Ehteda, Anahid, Franshaw, Laura, Liu, Jie, Joshi, Swapna, Simon, Sandy, Pang, Chi Nam Ignatius, Giorgi, Federico, Pandher, Ruby, Ung, Caitlin, Tolhurst, Ornella, Mayoh, Chelsea, Khan, Aaminah, Hayden, Elisha, Gopalakrishnan, Anjana, Trebilcock, Peter, Upton, Dannielle, Lehmann, Rebecca, George, Sandra, Vittorio, Orazio, Tsoli, Maria, Gurova, Katerina, Gudkov, Andrei Gudkov, Norris, Murray D, Haber, Michelle, Ziegler, David S

Source: Neuro-oncology. 22(Supplement 3):iii292-iii292

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112156079.0x000001&indx=1&recIds=ETOCvdc_100112156079.0x000001

DDEL-12. NANOPARTICLE DELIVERY OF DOXORUBICIN FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Authors: Ung, Caitlin, Tsoli, Maria, Liu, Jie, Cassano, Domenico, Upton, Dannielle, Ehteda, Anahid, Mansfield, Friederike, Failes, Tim, Kavallaris, Maria, Arndt, Greg, Vittorio, Orazio, Voliani, Valerio, Cirilo, Giuseppe, Ziegler, David S

Source: Neuro-oncology. 22(Supplement 3):iii286-iii286

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112155624.0x000001&indx=1&recIds=ETOCvdc_100112155624.0x000001

Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas.

Authors: Khan, Aaminah, Gamble, Laura D., Upton, Dannielle H., Ung, Caitlin, Yu, Denise M. T., Ehteda, Anahid, Pandher, Ruby, Mayoh, Chelsea, Hébert, Steven, Jabado, Nada, Kleinman, Claudia L., Burns, Mark R., Norris, Murray D., Haber, Michelle, Tsoli, Maria, Ziegler, David S.

Source: Nature Communications; 2/12/2021, Vol. 12 Issue 1, p1-13, 13p

Subject Terms: POLYAMINES, GLIOMAS, ORNITHINE decarboxylase, BRAIN tumors, DNA replication, SURVIVAL analysis (Biometry)

Doxorubicin-Loaded Gold Nanoarchitectures as a Therapeutic Strategy against Diffuse Intrinsic Pontine Glioma.

Authors: Ung, Caitlin¹ (AUTHOR) cung@ccia.org.au, Tsoli, Maria^1,2 (AUTHOR) mtsoli@ccia.org.au, Liu, Jie¹ (AUTHOR) dupton@ccia.org.au, Cassano, Domenico³ (AUTHOR) domenico.cassano@sns.it, Pocoví-Martínez, Salvador³ (AUTHOR) spocovi@aidimme.es, Upton, Dannielle H.^1,2 (AUTHOR) AEhteda@ccia.org.au, Ehteda, Anahid¹ (AUTHOR) fmansfeld@ccia.org.au, Mansfeld, Friederike M.^1,2,4,5 (AUTHOR) ckatsinas@ccia.org.au, Failes, Timothy W.⁶ (AUTHOR) tfailes@ccia.org.au, Farfalla, Annafranca⁷ (AUTHOR) annafranca.farfalla@gmail.com, Katsinas, Christopher¹ (AUTHOR) mkavallaris@ccia.org.au, Kavallaris, Maria^1,2,4 (AUTHOR) ovittorio@ccia.org.au, Arndt, Greg M.⁶ (AUTHOR) garndt@ccia.org.au, Vittorio, Orazio^1,2,4 (AUTHOR), Cirillo, Giuseppe⁷ (AUTHOR) giuseppe.cirillo@unical.it, Voliani, Valerio³ (AUTHOR) valerio.voliani@iit.it, Ziegler, David S.^1,2,8 (AUTHOR) mtsoli@ccia.org.au, Hoskins, Clare (AUTHOR)

Source: Cancers. Mar2021, Vol. 13 Issue 6, p1278. 1p.

Subject Terms: *DOXORUBICIN, *WESTERN immunoblotting, *GOLD, *GLIOMAS, *APOPTOSIS, *PASSIFLORA, *SERUM albumin, *CELL proliferation, *NANOPARTICLES

THER-23. RESULTS OF THE ZERO CHILDHOOD CANCER INTEGRATED PRECISION MEDICINE PLATFORM FOR PAEDIATRIC HIGH-RISK BRAIN TUMOURS.

Authors: Tsoli, Maria, Lau, Loretta, Barahona, Paulette, Mayoh, Chelsea, Failes, Tim, Wong, Marie, Sherstyuk, Alexandra, Gifford, Andrew J, Kumar, Amit, Mould, Emily, Ung, Caitlin, Tolhurst, Ornella, Gopalakrishnan, Anjana, Grebert-Wade, Dylan, Strong, Patrick, Trebilcock, Peter, Lock, Richard, Tyrrell, Vanessa, Trahair, Toby, Tucker, Katherine

Source: Neuro-Oncology; 2019 Supplement, Vol. 21, pii118-ii118, 1p