Insights from explainable AI in oesophageal cancer team decisions

Authors: Thavanesan, Navamayooran, Farahi, Arya, Parfitt, Charlotte, Belkhatir, Zehor, Azim, Tayyaba, Vallejos, Elvira Perez, Walters, Zoë, Ramchurn, Sarvapali, Underwood, Timothy J., Vigneswaran, Ganesh

Source: In Computers in Biology and Medicine September 2024 180

Cardiopulmonary exercise variables and their association with postoperative morbidity and mortality after major oesophagogastric cancer surgery—a multicentre observational study

Authors: West, Malcolm A., Rahman, Saqib, Jack, Sandy, Grocott, Michael P.W., Levett, Denny Z.H., Rashid, Yasir, Griffiths, John, Ezra, Martin, Ayres, Lyndsay, Neville-Webbe, Helen, Javed, Muhammad Shafiq, Shrotri, Milind, Khan, Iftikhar, Whitmore, David, Prabhu, Pradeep, Timbrell, David, Allen, Sophie, Packham, Andrew O., Sharpe, David, Anderson, Helen, Minto, Gary, McAleer, Samuel, McPhail, Stuart, Alasmar, Mohamed, Hartley, Robert A., Sultan, Javed, Grace, Ben, Underwood, Timothy J., Byrne, James, Noble, Fergus, Kelly, Jamie, Ansell, Gillian, Edwards, Mark

Source: In BJA Open June 2024 10

Multi-Omic Analysis of Esophageal Adenocarcinoma Uncovers Candidate Therapeutic Targets and Cancer-Selective Posttranscriptional Regulation

Authors: Fitzgerald, Rebecca C., Edwards, Paul A.W., Grehan, Nicola, Nutzinger, Barbara, Loreno, Christine, Redmond, Aisling M., Abbas, Sujath, Freeman, Adam, Smyth, Elizabeth C., O'Donovan, Maria, Miremadi, Ahmad, Malhotra, Shalini, Tripathi, Monika, Cheah, Calvin, Coles, Hannah, Millington, Curtis, Devonshire, Ginny, Eldridge, Matthew, Secrier, Maria, Jammula, Sriganesh, Davies, Jim, Crichton, Charles, Carroll, Nick, Hardwick, Richard H., Safranek, Peter, Hindmarsh, Andrew, Sujendran, Vijayendran, Hayes, Stephen J., Ang, Yeng, Sharrocks, Andrew, Preston, Shaun R., Bagwan, Izhar, Save, Vicki, Skipworth, Richard J.E., Hupp, Ted R., O'Neill, J Robert, Tucker, Olga, Beggs, Andrew, Taniere, Philippe, Puig, Sonia, Contino, Gianmarco, Underwood, Timothy J., Walker, Robert C., Grace, Ben L., Lagergren, Jesper, Gossage, James, Davies, Andrew, Chang, Fuju, Mahadeva, Ula, Goh, Vicky, Ciccarelli, Francesca D., Sanders, Grant, Berrisford, Richard, Chan, David, Cheong, Ed, Kumar, Bhaskar, Sreedharan, L., Parsons, Simon L., Soomro, Irshad, Kaye, Philip, Saunders, John, Lovat, Laurence, Haidry, Rehan, Scott, Michael, Sothi, Sharmila, Lishman, Suzy, Hanna, George B., Peters, Christopher J., Moorthy, Krishna, Grabowska, Anna, Turkington, Richard, McManus, Damian, Coleman, Helen, Petty, Russell D., Bartlet, Freddie, O'Neill, J. Robert ^{1, 2, ‡, ∗}, Yébenes Mayordomo, Marcos ^{2, 3, ‡, ∗}, Mitulović, Goran ^{4, 5}, Al Shboul, Sofian ⁶, Bedran, Georges ³, Faktor, Jakub ³, Hernychova, Lenka ⁷, Uhrik, Lukas ⁷, Gómez-Herranz, Maria ³, Kocikowski, Mikołaj ³, Vojtěšek, Bořivoj ⁷, Arends, Mark J. ⁹, Hupp, Ted ^{2, 3}, Alfaro, Javier Antonio ^{3, 10, 11, 12, 13, ∗}

Source: In Molecular & Cellular Proteomics June 2024 23(6)

The AUGIS Survival Predictor: Prediction of Long-Term and Conditional Survival After Esophagectomy Using Random Survival Forests

Authors: Rahman, Saqib A., Walker, Robert C., Maynard, Nick, Crosby, Tom, Cromwell, David A., Underwood, Timothy J.

Source: Annals of surgery. 277(2):267-274

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186826891.0x000001&indx=1&recIds=ETOCvdc_100186826891.0x000001

Review: Targeting EZH2 in neuroblastoma

Authors: Gao, Jinhui, Fosbrook, Claire, Gibson, Jane, Underwood, Timothy J., Gray, Juliet C., Walters, Zoë S.

Source: In Cancer Treatment Reviews September 2023 119

The Oesophageal Cancer Multidisciplinary Team: Can Machine Learning Assist Decision-Making?

Authors: Thavanesan, Navamayooran, Vigneswaran, Ganesh, Bodala, Indu, Underwood, Timothy J.

Source: In Journal of Gastrointestinal Surgery April 2023 27(4):807-822

Impact of an unannounced standardized veteran program on access to community-based services for veterans experiencing homelessness

Authors: Weiner, Saul J, Schwartz, Alan, Binns-Calvey, Amy, Kass, Benjamin, Underwood, Timothy D, Kane, Vincent

Source: Journal of public health. 44(1):207-213

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159697737.0x000001&indx=1&recIds=ETOCvdc_100159697737.0x000001

Prevalence and Risk Factors for Malignant Nodal Involvement in Early Esophago-Gastric Adenocarcinoma: Results From the Multicenter Retrospective Congress Study (endosCopic resectiON, esophaGectomy or Gastrectomy for Early Esophagogastric Cancers).

Authors: Pucher, Philip H., Rahman, Saqib A., Bhandari, Pradeep, Blencowe, Natalie, Chidambaram, Swathikan, Crosby, Tom, Evans, Richard P.T., Griffiths, Ewen A., Kamarajah, Sivesh K., Markar, Sheraz R., Trudgill, Nigel, Underwood, Timothy J., Gossage, James A., Abdelrahman, Tarig, Akbari, Khalid, Alexandre, Leo, Ali, Hasan, Alkhafaff, Bilal, Alwis, Anuradaha, Athanasiou, Antonios

Source: Annals of Surgery; Mar2025, Vol. 281 Issue 3, p363-370, 8p

Cardiopulmonary exercise testing has greater prognostic value than sarcopenia in oesophago‐gastric cancer patients undergoing neoadjuvant therapy and surgical resection

Authors: West, Malcolm A, Baker, William CA, Rahman, Saqib, Munro, Alicia, Jack, Sandy, Grocott, Michael PW, Underwood, Timothy J, Levett, Denny ZH

Source: Journal of surgical oncology. 124(8):1306-1316

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134623385.0x000001&indx=1&recIds=ETOCvdc_100134623385.0x000001

Thinking through the multimodal treatment of localized oesophageal cancer: the point of view of the surgeon

Authors: Pucher, Philip H., Wijnhoven, Bas P.L., Underwood, Timothy J., Reynolds, John V., Davies, Andrew R.

Source: Current opinion in oncology. 33(4):353-361

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121662969.0x000001&indx=1&recIds=ETOCvdc_100121662969.0x000001

Minimally Invasive Approach in Boerhaave's Syndrome: Case Series and Systematic Review

Authors: Pickering, Oliver, Pucher, Philip H., De'Ath, Henry, Abuawwad, Mahmoud, Kelly, Jamie, Underwood, Timothy J., Noble, Fergus, Byrne, James P.

Source: Journal of laparoendoscopic & advanced surgical techniques. 31(11):1254-1261

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133471832.0x000001&indx=1&recIds=ETOCvdc_100133471832.0x000001

High proportion of PD-1 and CD39 positive CD8+ tissue resident T lymphocytes correlates with better clinical outcome in resected human oesophageal adenocarcinoma.

Authors: Hill, Samuel L., Sugiyarto, Gessa, Harrington, Jack, James, Edward, Underwood, Timothy J., Elliott, Tim

Source: Cancer Immunology, Immunotherapy; Nov2024, Vol. 73 Issue 11, p1-8, 8p

Subject Terms: TUMOR-infiltrating immune cells, T cells, TREATMENT effectiveness, FATIGUE (Physiology), PROGRAMMED cell death 1 receptors

Oesophageal cancer

Authors: Walker, Robert C., Underwood, Timothy J.

Source: In Surgery (Oxford) November 2020 38(11):702-710

Identification of Subtypes of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data

Authors: Fitzgerald, Rebecca C., Noorani, Ayesha, Edwards, Paul A.W., Grehan, Nicola, Nutzinger, Barbara, Hughes, Caitriona, Fidziukiewicz, Elwira, Bornschein, Jan, MacRae, Shona, Crawte, Jason, Northrop, Alex, Contino, Gianmarco, Li, Xiaodun, de la Rue, Rachel, O’Donovan, Maria, Miremadi, Ahmad, Malhotra, Shalini, Tripathi, Monika, Tavaré, Simon, Lynch, Andy G., Eldridge, Matthew, Secrier, Maria, Bower, Lawrence, Devonshire, Ginny, Perner, Juliane, Jammula, Sriganesh, Davies, Jim, Crichton, Charles, Carroll, Nick, Safranek, Peter, Hindmarsh, Andrew, Sujendran, Vijayendran, Hayes, Stephen J., Ang, Yeng, Preston, Shaun R., Oakes, Sarah, Bagwan, Izhar, Save, Vicki, Skipworth, Richard J.E., Hupp, Ted R., O’Neill, J. Robert, Tucker, Olga, Beggs, Andrew, Taniere, Philippe, Puig, Sonia, Underwood, Timothy J., Noble, Fergus, Owsley, Jack, Barr, Hugh, Shepherd, Neil, Old, Oliver, Lagergren, Jesper, Gossage, James, Davies, Andrew, Chang, Fuju, Zylstra, Janine, Mahadeva, Ula, Goh, Vicky, Ciccarelli, Francesca D., Sanders, Grant, Berrisford, Richard, Harden, Catherine, Lewis, Mike, Cheong, Ed, Kumar, Bhaskar, Parsons, Simon L., Soomro, Irshad, Kaye, Philip, Saunders, John, Lovat, Laurence, Haidry, Rehan, Igali, Laszlo, Scott, Michael, Sothi, Sharmila, Suortamo, Sari, Lishman, Suzy, Hanna, George B., Moorthy, Krishna, Peters, Christopher J., Grabowska, Anna, Turkington, Richard, Jammula, SriGanesh, Katz-Summercorn, Annalise C., Linossi, Constanza, Smyth, Elizabeth, Killcoyne, Sarah, Biasci, Daniele, Subash, Vinod V., Abbas, Sujath, Blasko, Adrienn, Grantham, Amber, Wronowski, Filip, Eldridge, Matthew D.

Source: In Gastroenterology May 2020 158(6):1682-1697

Tu1280 GLAND PHENOTYPIC DIVERSITY OVER TIME AND SPACE AS A PREDICTOR OF PROGRESSION TO DYSPLASIA IN BARRETT'S ESOPHAGUS

Authors: Carlotti, Emanuela, Passman, Adam M., Lin, Meng-Lay, Devkumar, Shruthi, Hackett, Richard J., McLean, Mairi, Aleong, Jo-Anne Chin, Underwood, Timothy, Rodriguez-Justo, Manuel, Novelli, Marco, Wright, Nicholas A., Jansen, Marnix, McDonald, Stuart A.

Source: Gastroenterology. 164(6):S-1018-S-1018

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194461036.0x000001&indx=1&recIds=ETOCvdc_100194461036.0x000001

Tu1269 DEEP GLAND PHENOTYPING IN BARRETT'S ESOPHAGUS GLANDS REVEALS POTENTIAL BIOMARKERS OF CANCER RISK

Authors: Passman, Adam M., Carlotti, Emanuela, Lin, Meng-Lay, Devkumar, Shruthi, Hackett, Richard J., McLean, Mairi, Underwood, Timothy, Chin-Aleong, Joanne, Rodriguez-Justo, Manuel, Novelli, Marco, Wright, Nicholas A., Jansen, Marnix, McDonald, Stuart A.

Source: Gastroenterology. 164(6):S-1011-S-1011

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194461245.0x000001&indx=1&recIds=ETOCvdc_100194461245.0x000001

Outcomes and survival following neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for cancer of the esophagus: Inverse propensity score weighted analysis

Authors: Pucher, Philip H., Rahman, Saqib A., Walker, Robert C., Grace, Ben L., Bateman, Andrew, Iveson, Tim, Jackson, Andrew, Rees, Charlotte, Byrne, James P., Kelly, Jamie J., Noble, Fergus, Underwood, Timothy J.

Source: European journal of surgical oncology. 46(12):2248-2256

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138404767.0x000001&indx=1&recIds=ETOCvdc_100138404767.0x000001

Utilising anatase nano-seeds coupled with a visible-light antennae system (Cu–Pd–N) for effective photo-organic transformationsElectronic supplementary information (ESI) available. See DOI: 10.1039/c9nj05034e

Authors: Underwood, Timothy M., Robinson, Ross S.

Source: New journal of chemistry. 44(44):19201-19211

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100110479141.0x000001&indx=1&recIds=ETOCvdc_100110479141.0x000001

Machine learning to predict early recurrence after oesophageal cancer surgery

Authors: Rahman, S. A., Walker, R. C., Lloyd, M. A., Grace, B. L., van Boxel, G. I., Kingma, B. F., Ruurda, J. P., van Hillegersberg, R., Harris, S., Parsons, S., Mercer, S., Griffiths, E. A., O'Neill, J. R., Turkington, R., Fitzgerald, R. C., Underwood, T. J., Noorani, Ayesha, Elliott, Rachael Fels, Edwards, Paul A.W., Grehan, Nicola, Nutzinger, Barbara, Crawte, Jason, Chettouh, Hamza, Contino, Gianmarco, Li, Xiaodun, Gregson, Eleanor, Zeki, Sebastian, de la Rue, Rachel, Malhotra, Shalini, Tavaré, Simon, Lynch, Andy G., Smith, Mike L., Davies, Jim, Crichton, Charles, Carroll, Nick, Safranek, Peter, Hindmarsh, Andrew, Sujendran, Vijayendran, Hayes, Stephen J., Ang, Yeng, Preston, Shaun R., Oakes, Sarah, Bagwan, Izhar, Save, Vicki, Skipworth, Richard J.E., Hupp, Ted R., O'Neill, J. Robert, Tucker, Olga, Beggs, Andrew, Taniere, Philippe, Puig, Sonia, Underwood, Timothy J., Noble, Fergus, Byrne, James P., Kelly, Jamie J., Owsley, Jack, Barr, Hugh, Shepherd, Neil, Old, Oliver, Lagergren, Jesper, Gossage, James, Chang, Andrew Davies Fuju, Zylstra, Janine, Goh, Vicky, Ciccarelli, Francesca D., Sanders, Grant, Berrisford, Richard, Harden, Catherine, Bunting, David, Lewis, Mike, Cheong, Ed, Kumar, Bhaskar, Parsons, Simon L., Soomro, Irshad, Kaye, Philip, Saunders, John, Lovat, Laurence, Haidry, Rehan, Eneh, Victor, Igali, Laszlo, Scott, Michael, Sothi, Shamila, Suortamo, Sari, Lishman, Suzy, Hanna, George B., Peters, Christopher J., Grabowska, Anna

Source: British journal of surgery. 107(8):1042-1052

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107408970.0x000001&indx=1&recIds=ETOCvdc_100107408970.0x000001

Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts

Authors: Noorani, Ayesha, Edwards, Paul A.W., Grehan, Nicola, Nutzinger, Barbara, Hughes, Caitriona, Fidziukiewicz, Elwira, Bornschein, Jan, MacRae, Shona, Crawte, Jason, Contino, Gianmarco, Li, Xiaodun, Rue, Rachel de la, O’Donovan, Maria, Miremad, Ahmad, Malhotra, Shalini, Tripathi, Monika, Tavaré, Simon, Lynch, Andy G., Eldridge, Matthew, Secrier, Maria, Bower, Lawrence, Devonshire, Ginny, Perner, Juliane, Jammula, Sriganesh, Davies, Jim, Crichton, Charles, Carroll, Nick, Safranek, Peter, Hindmarsh, Andrew, Sujendran, Vijayendran, Hayes, Stephen J., Ang, Yeng, Preston, Shaun R., Oakes, Sarah, Bagwan, Izhar, Save, Vicki, Skipworth, Richard J.E., Hupp, Ted R., O’Neill, J. Robert, Tucker, Olga, Beggs, Andrew, Taniere, Philippe, Puig, Sonia, Underwood, Timothy J., Noble, Fergus, Owsley, Jack, Barr, Hugh, Shepherd, Neil, Old, Oliver, Lagergren, Jesper, Gossage, James, Davies, Andrew, Chang, Fuju, Zylstra, Janine, Mahadeva, Ula, Goh, Vicky, Ciccarelli, Francesca D., Sanders, Grant, Berrisford, Richard, Harden, Catherine, Bunting, David, Lewis, Mike, Cheong, Ed, Kumar, Bhaskar, Parsons, Simon L., Soomro, Irshad, Kaye, Philip, Saunders, John, Lovat, Laurence, Haidry, Rehan, Eneh, Victor, Igali, Laszlo, Scott, Michael, Sothi, Sharmila, Suortamo, Sari, Lishman, Suzy, Hanna, George B., Peters, Christopher J., Grabowska, Anna, Turkington, Richard, Sawas, Tarek, Killcoyne, Sarah, Iyer, Prasad G., Wang, Kenneth K., Smyrk, Thomas C., Kisiel, John B., Qin, Yi, Ahlquist, David A., Rustgi, Anil K., Costa, Rui J., Gerstung, Moritz, Fitzgerald, Rebecca C., Katzka, David A.

Source: In Gastroenterology December 2018 155(6):1720-1728