Dense Collagen I as a Biomimetic Material to Track Matrix Remodelling in Renal Carcinomas

Authors: Anuja Upadhyay, Deniz Bakkalci, Auxtine Micalet, Matt Butler, Marianne Bergin, Emad Moeendarbary, Marilena Loizidou, Umber Cheema

Source: ACS Omega, Vol 9, Iss 40, Pp 41419-41432 (2024)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/a3eb5d5153f441f2ac150ff1a9d4ca0d

Patient-specific colorectal-cancer-associated fibroblasts modulate tumor microenvironment mechanics

Authors: Auxtine Micalet, Anuja Upadhyay, Yousef Javanmardi, Camila Gabriela de Brito, Emad Moeendarbary, Umber Cheema

Source: iScience, Vol 27, Iss 6, Pp 110060- (2024)

Subject Terms: cell biology, stem cells research, biomechanics, cancer, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224012859; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/dd1f97b365824046b776ccf6d7b9ba3e

Spatial transcriptomic interrogation of the tumour-stroma boundary in a 3D engineered model of ameloblastoma

Authors: Deniz Bakkalci, Georgina Al-Badri, Wei Yang, Andy Nam, Yan Liang, Syed Ali Khurram, Susan Heavey, Stefano Fedele, Umber Cheema

Source: Materials Today Bio, Vol 24, Iss , Pp 100923- (2024)

Subject Terms: Spatial transcriptomics, 3D models, Tumour-stroma boundary, Tissue engineering, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590006423003836; https://doaj.org/toc/2590-0064

Access URL: https://doaj.org/article/977c36513ebd473c84c94da9666fe446

Stromal cells regulate mechanics of tumour spheroid

Authors: Ayushi Agrawal, Soufian Lasli, Yousef Javanmardi, Diane Coursier, Auxtine Micalet, Sara Watson, Somayeh Shahreza, Bianca Serwinski, Boris Djordjevic, Nicolas Szita, Umber Cheema, Sergio Bertazzo, Fernando Calvo, Emad Moeendarbary

Source: Materials Today Bio, Vol 23, Iss , Pp 100821- (2023)

Subject Terms: Traction forces, Contractility, Stromal cells, Cancer spheroids, Mechanobiology, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590006423002818; https://doaj.org/toc/2590-0064

Access URL: https://doaj.org/article/7925c79384624c1a8b3c8097324bebae

Urokinase-type plasminogen activator (uPA) regulates invasion and matrix remodelling in colorectal cancer

Authors: Auxtine Micalet, Luke J. Tappouni, Katarzyna Peszko, Despoina Karagianni, Ashley Lam, John R. Counsell, Sergio A. Quezada, Emad Moeendarbary, Umber Cheema

Source: Matrix Biology Plus, Vol 19, Iss , Pp 100137- (2023)

Subject Terms: 3D models, Tumour microenvironment, CRISPR-Cas9, Urokinase-type plasminogen activator, uPA, Cancer invasion, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590028523000108; https://doaj.org/toc/2590-0285

Access URL: https://doaj.org/article/d717ce246c6c4b19a2effb52e7212958

Associated changes in stiffness of collagen scaffolds during osteoblast mineralisation and bone formation

Authors: Deniz Bakkalci, Auxtine Micalet, Rawiya Al Hosni, Emad Moeendarbary, Umber Cheema

Source: BMC Research Notes, Vol 15, Iss 1, Pp 1-7 (2022)

Subject Terms: AFM, 3D models, Bone, Tissue engineering, Stiffness, ECM, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

File Description: electronic resource

Relation: https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/7a4226da8eb743da9f8c60acd399ae0c

Position Paper Progress in the development of biomimetic engineered human tissues

Authors: Umber Cheema

Source: Journal of Tissue Engineering, Vol 14 (2023)

Subject Terms: Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2041-7314

Access URL: https://doaj.org/article/6a7a2299c0c642a1af912abb71194d78

Bioengineering the ameloblastoma tumour to study its effect on bone nodule formation

Authors: Deniz Bakkalci, Amrita Jay, Azadeh Rezaei, Christopher A. Howard, Håvard Jostein Haugen, Judith Pape, Shosei Kishida, Michiko Kishida, Gavin Jell, Timothy R. Arnett, Stefano Fedele, Umber Cheema

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/19972648a94d4c56988f99a00e43b716

Modelling stromal compartments to recapitulate the ameloblastoma tumour microenvironment

Authors: Deniz Bakkalci, Amir Zaki Abdullah Zubir, Syed Ali Khurram, Judith Pape, Kristiina Heikinheimo, Stefano Fedele, Umber Cheema

Source: Matrix Biology Plus, Vol 16, Iss , Pp 100125- (2022)

Subject Terms: Fibroblasts, 3D models, IHC, RANKL, Tumour microenvironment, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590028522000254; https://doaj.org/toc/2590-0285

Access URL: https://doaj.org/article/98aed28f53ae416fb0594835c6925e2d

RANKL neutralisation prevents osteoclast activation in a human ameloblastoma-bone model

Authors: Judith Pape, Deniz Bakkalci, Rawiya Al Hosni, Benjamin S Simpson, Kristiina Heikinheimo, Stefano Fedele, Umber Cheema

Source: Journal of Tissue Engineering, Vol 13 (2022)

Subject Terms: Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2041-7314

Access URL: https://doaj.org/article/0912d38704924aa687d75d318345cf66

Reprogramming bone progenitor identity and potency through control of collagen density and oxygen tension

Authors: Rawiya Al Hosni, Laurent Bozec, Scott J. Roberts, Umber Cheema

Source: iScience, Vol 25, Iss 4, Pp 104059- (2022)

Subject Terms: Cell biology, Stem cells research, Developmental biology, Biophysics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222003297; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/7f644a9b753d40b0bfab1a678ac78312

3D Cancer Models: The Need for a Complex Stroma, Compartmentalization and Stiffness

Authors: Judith Pape, Mark Emberton, Umber Cheema

Source: Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)

Subject Terms: 3D models, tissue-engineering, tumor stroma, compartmentalization, stiffness, collagen density, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2021.660502/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/6737d4b52504403fab0ab607b5e8e713

The anti-angiogenic tyrosine kinase inhibitor Pazopanib kills cancer cells and disrupts endothelial networks in biomimetic three-dimensional renal tumouroids

Authors: Katerina Stamati, Patricia A Redondo, Agata Nyga, Joana B Neves, Maxine GB Tran, Mark Emberton, Umber Cheema, Marilena Loizidou

Source: Journal of Tissue Engineering, Vol 11 (2020)

Subject Terms: Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2041-7314

Access URL: https://doaj.org/article/ee3795e876754f4fa91d5b941fc49b03

Elements of the niche for adult stem cell expansion

Authors: Patricia A Redondo, Marina Pavlou, Marilena Loizidou, Umber Cheema

Source: Journal of Tissue Engineering, Vol 8 (2017)

Subject Terms: Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2041-7314

Access URL: https://doaj.org/article/ea1147e89ec5492d91262def40715325

The efficacy of cetuximab in a tissue-engineered three-dimensional in vitro model of colorectal cancer

Authors: Tarig Magdeldin, Víctor López-Dávila, Cecile Villemant, Grant Cameron, Rosemary Drake, Umber Cheema, Marilena Loizidou

Source: Journal of Tissue Engineering, Vol 5 (2014)

Subject Terms: Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2041-7314

Access URL: https://doaj.org/article/440ad9f1b7e8457699003fcd2663753c

Evolution of oxygen utilization in multicellular organisms and implications for cell signalling in tissue engineering

Authors: Katerina Stamati, Vivek Mudera, Umber Cheema

Source: Journal of Tissue Engineering, Vol 2 (2011)

Subject Terms: Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/2041-7314

Access URL: https://doaj.org/article/2ddd956120f84ec09374576485587b15

Oxygen consumption rate of cells in 3D culture: The use of experiment and simulation to measure kinetic parameters and optimise culture conditions.

Authors: Ian Streeter^1,2, Umber Cheema¹

Source: Analyst. Sep2011, Vol. 136 Issue 19, p4013-4019. 7p.

Subject Terms: *OXYGEN consumption, *CELL culture, *TISSUE scaffolds, *MATHEMATICAL models, *MESENCHYMAL stem cells, *FIBROBLASTS, *CHEMICAL kinetics

Needle enzyme electrode based glucose diffusive transport measurement in a collagen gel and validation of a simulation model.

Authors: Zimei Rong, Umber Cheema, Pankaj Vadgama

Source: Analyst; Jun2006, Vol. 131 Issue 7, p816-821, 6p

Mechanical signals and IGF-I gene splicing in vitro in relation to development of skeletal muscle.

Authors: Umber Cheema¹, Robert Brown¹, Vivek Mudera¹, Shi Yu Yang², Gus McGrouther³, Geoffrey Goldspink²

Source: Journal of Cellular Physiology. Jan2005, Vol. 202 Issue 1, p67-75. 9p.

Subject Terms: *MYOBLASTS, *CYTOKINES, *PROINSULIN, *GENES