Study protocol for locoregional precision treatment of hepatocellular carcinoma with transarterial chemoembolisation (TACTida), a clinical study: idarubicin dose selection, tissue response and survival

Authors: Fredrik Rorsman, Ulrika S H Simonsson, Håkan Ahlström, Sofi Sennefelt Nyman, Angeliki Dimopoulou Creusen, David Dahlgren, Mikael Hedeland, Femke Heindryckx, Ulf Johnson, Jaafar Khaled, Fredrik Kullenberg, Rickard Nyman, Reza Sheikhi, Erik Sjögren, Alkwin Wanders, Hans Lennernäs, Charlotte Ebeling Barbier

Source: BMJ Open, Vol 12, Iss 11 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/12/11/e065839.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/7c7c91e342a24d6c8b67d590e1e651b2

Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)

Authors: Mats Fredrikson, Jan-Willem C Alffenaar, Björn Carlsson, Katarina Niward, Jakob Paues, Ulrika S H Simonsson, David Ekqvist, Anna Bornefall, Daniel Augustinsson, Martina Sönnerbrandt, Michaela Jonsson Nordvall, Mårten Sandstedt

Source: BMJ Open, Vol 12, Iss 3 (2022)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://bmjopen.bmj.com/content/12/3/e054788.full; https://doaj.org/toc/2044-6055

Access URL: https://doaj.org/article/736a2080c7424baabb820e2ab4c131a2

Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing—Using Rifampicin as an Example

Authors: Lina Keutzer, Ulrika S. H. Simonsson

Source: Frontiers in Pharmacology, Vol 11 (2020)

Subject Terms: model-informed precision dosing, inter-occasion variability, tuberculosis, rifampicin, Bayesian forecasting, precision dosing, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2020.00794/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/153adfa1498a43adb428aa2e12cef6fd

A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions

Authors: Sebastian G. Wicha, Chunli Chen, Oskar Clewe, Ulrika S. H. Simonsson

Source: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/11acac90593d417596ce8ff040aeaa85

Seasonal influence on respiratory tract infection severity including COVID‐19 quantified through Markov Chain modeling

Authors: Rob C. vanWijk, Laurynas Mockeliunas, Caryn M. Upton, Jonathan Peter, Andreas H. Diacon, Ulrika S. H. Simonsson

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 9, Pp 1250-1261 (2023)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2163-8306

Access URL: https://doaj.org/article/990494102e934b25ad6b9c6a0f758109

Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19

Authors: Rob C. van Wijk, Laurynas Mockeliunas, Gerben van den Hoogen, Caryn M. Upton, Andreas H. Diacon, Ulrika S. H. Simonsson

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/023c5617c71b47638f55d07767493179

Model‐informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy

Authors: Alan Faraj, Rob C. vanWijk, Linda Neuman, Shraddha Desai, Grant E. Blouse, Tom Knudsen, Ulrika S. H. Simonsson

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 7, Pp 977-987 (2023)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2163-8306

Access URL: https://doaj.org/article/b6c9055674264f649750f35d1fd75d0f

Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug

Authors: Alan Faraj, Tom Knudsen, Shraddha Desai, Linda Neuman, Grant E. Blouse, Ulrika S. H. Simonsson

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 12, Pp 1628-1637 (2022)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2163-8306

Access URL: https://doaj.org/article/ce8d06664ffc40fd91a8527d8fc691ac

Finding the right hazard function for time‐to‐event modeling: A tutorial and Shiny application

Authors: Rob C. VanWijk, Ulrika S. H. Simonsson

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 8, Pp 991-1001 (2022)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2163-8306

Access URL: https://doaj.org/article/04915790ebaf4b64bc597d1e23aa096d

Risk Factors for COVID-19 and Respiratory Tract Infections during the Coronavirus Pandemic

Authors: Laurynas Mockeliunas, Rob C. van Wijk, Caryn M. Upton, Jonathan Peter, Andreas H. Diacon, Ulrika S. H. Simonsson

Source: Vaccines, Vol 12, Iss 3, p 329 (2024)

Subject Terms: risk factors, respiratory tract infections, COVID-19, time-to-event analysis, pharmacometrics, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/12/3/329; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/0c7e1a101744446f977319a9da3048a5

A modeling‐based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study

Authors: Lina Keutzer, Yasamin Akhondipour Salehabad, Lina Davies Forsman, Ulrika S. H. Simonsson

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 5, Pp 628-639 (2022)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2163-8306

Access URL: https://doaj.org/article/b4eba42d95c34d55b5c8ee2136f4c7fa

Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development

Authors: Laurynas Mockeliunas, Alan Faraj, Rob C. van Wijk, Caryn M. Upton, Gerben van den Hoogen, Andreas H. Diacon, Ulrika S. H. Simonsson

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: tuberculosis, early bactericidal activity, sample size, pharmacometrics, model-based analysis, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1150243/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/0a767df0e5414983ab94bc69ae08d21a

Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development

Authors: Rami Ayoun Alsoud, Robin J. Svensson, Elin M. Svensson, Stephen H. Gillespie, Martin J. Boeree, Andreas H. Diacon, Rodney Dawson, Rob E. Aarnoutse, Ulrika S. H. Simonsson

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: rifampicin, TTP, CFU, tuberculosis, biomarker, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1067295/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/1e7e34c9287b4aedb8b78bb3b1c57875

Derivation and Clinical Utility of Safety Targets for Linezolid-Related Adverse Events in Drug-Resistant Tuberculosis Treatment

Authors: Lina Keutzer, Laurynas Mockeliunas, Marieke G. G. Sturkenboom, Mathieu S. Bolhuis, Onno W. Akkerman, Ulrika S. H. Simonsson

Source: Pharmaceuticals, Vol 16, Iss 11, p 1575 (2023)

Subject Terms: tuberculosis, pharmacokinetics, linezolid, Monte Carlo simulation, indirect response modelling, time-to-event analysis, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/16/11/1575; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/141df131ff23475eb08c004706589575

Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies

Authors: Jan-Willem C. Alffenaar, Jurriaan E. M. de Steenwinkel, Andreas H. Diacon, Ulrika S. H. Simonsson, Shashikant Srivastava, Sebastian G. Wicha

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: tuberculosis, pharmacokinetics, pharmacodynamics, modeling and simulation, dose optimization, anti-TB drugs, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.1063453/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/e4542944f8a243b7ad22068ab5e9346d

Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin

Authors: Lina Keutzer, Huifang You, Ali Farnoud, Joakim Nyberg, Sebastian G. Wicha, Gareth Maher-Edwards, Georgios Vlasakakis, Gita Khalili Moghaddam, Elin M. Svensson, Michael P. Menden, Ulrika S. H. Simonsson, on behalf of the UNITE4TB Consortium

Source: Pharmaceutics, Vol 14, Iss 8, p 1530 (2022)

Subject Terms: machine learning, pharmacometrics, population pharmacokinetics, rifampicin, pharmacokinetics, simulation, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/8/1530; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/25a790d93aeb473e9a0152c76324f8f0

Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis

Authors: Laurynas Mockeliunas, Lina Keutzer, Marieke G. G. Sturkenboom, Mathieu S. Bolhuis, Lotte M. G. Hulskotte, Onno W. Akkerman, Ulrika S. H. Simonsson

Source: Pharmaceutics, Vol 14, Iss 4, p 753 (2022)

Subject Terms: tuberculosis, population pharmacokinetics, linezolid, auto-inhibition of linezolid elimination, model-informed precision dosing, simulation, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/4/753; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/610cde62416941eb9c0f796f9ffdb1e0

Model-Informed Drug Discovery and Development Strategy for the Rapid Development of Anti-Tuberculosis Drug Combinations

Authors: Rob C. van Wijk, Rami Ayoun Alsoud, Hans Lennernäs, Ulrika S. H. Simonsson

Source: Applied Sciences, Vol 10, Iss 7, p 2376 (2020)

Subject Terms: tuberculosis, MID3, pharmacokinetics, pharmacodynamics, drug-drug interactions, in vitro, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3417/10/7/2376; https://doaj.org/toc/2076-3417

Access URL: https://doaj.org/article/4f6603353ccd42d3b06b4d5b97312586