Adding checkpoint inhibitors to first-line chemotherapy for NUT carcinoma patients

Authors: Sarah Haebe, Gesa Schuebbe, Philipp Jurmeister, Michael von Bergwelt-Baildon, C. Benedikt Westphalen, Ulrich M. Lauer, Wolfgang G. Kunz, Marion Subklewe, Oliver Weigert

Source: npj Precision Oncology, Vol 9, Iss 1, Pp 1-6 (2025)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2397-768X

Access URL: https://doaj.org/article/f983ad34aec84644a35568bcf6f69bae

Case report: Pulmonary Ewing sarcoma disguised as non-small cell lung cancer

Authors: Mary E. Carter, Alessia Benegiamo-Chilla, Linus D. Kloker, Nikolas Paulsen, Vlatko Potkrajcic, Frank Paulsen, Attila Nemeth, Volker Steger, Martin Schulze, Saskia Biskup, Katrin Benzler, Stephan Singer, Ulrich M. Lauer, Lars Zender, Christoph K. W. Deinzer

Source: Frontiers in Oncology, Vol 14 (2024)

Subject Terms: case report, Ewing sarcoma, pulmonary Ewing sarcoma, chemotherapy, molecular pathology, EWSR1::FLI1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1449119/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/5dbcb53fcef34475aac759e77dd87a55

Analysis of High-Dose Ascorbate-Induced Cytotoxicity in Human Glioblastoma Cells and the Role of Dehydroascorbic Acid and Iron

Authors: Alban Piotrowsky, Markus Burkard, Katharina Hammerschmidt, Hannah K. Ruple, Pia Nonnenmacher, Monika Schumacher, Christian Leischner, Susanne Berchtold, Luigi Marongiu, Thomas A. Kufer, Ulrich M. Lauer, Olga Renner, Sascha Venturelli

Source: Antioxidants, Vol 13, Iss 9, p 1095 (2024)

Subject Terms: ascorbate, vitamin C, glioblastoma, cancer, iron, reactive oxygen species, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/13/9/1095; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/0e0ee2440fab426a82a3784ac1036db3

Treatment modalities favoring outcome in well-differentiated neuroendocrine tumors G3

Authors: Martina Hinterleitner, Ruben Pfeiffer, Nils F. Trautwein, Bence Sipos, Stephan Singer, Silvio Nadalin, Alfred Königsrainer, Ulrich M. Lauer, Christian la Fougère, Lars Zender, Clemens Hinterleitner

Source: Frontiers in Endocrinology, Vol 14 (2024)

Subject Terms: neuroendocrine tumor, grading, G3, somatostatin receptor, PET, treatment, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1285529/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/f776dfeedfdc46f3b01b72156cb56fc2

Multimodal Therapy Approaches for NUT Carcinoma by Dual Combination of Oncolytic Virus Talimogene Laherparepvec with Small Molecule Inhibitors

Authors: Stavros Sotiriadis, Julia Beil, Susanne Berchtold, Irina Smirnow, Andrea Schenk, Ulrich M. Lauer

Source: Viruses, Vol 16, Iss 5, p 775 (2024)

Subject Terms: NUT carcinoma, talimogene laherparepvec, T-VEC, virotherapy, small molecule inhibitors, combination therapy, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/5/775; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/e41cbb98ceae47299878f08069ea5cbd

Multiomics surface receptor profiling of the NCI-60 tumor cell panel uncovers novel theranostics for cancer immunotherapy

Authors: Simon Heumos, Sandra Dehn, Konstantin Bräutigam, Marius C. Codrea, Christian M. Schürch, Ulrich M. Lauer, Sven Nahnsen, Michael Schindler

Source: Cancer Cell International, Vol 22, Iss 1, Pp 1-14 (2022)

Subject Terms: Immunotherapy, cancer, Multiomics, Theranostics, Flow cytometry, FACS, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/8bb11c41994743a69f5a8ec609156a24

IgG-based B7-H3xCD3 bispecific antibody for treatment of pancreatic, hepatic and gastric cancer

Authors: Martina S. Lutz, Latifa Zekri, Laura Weßling, Susanne Berchtold, Jonas S. Heitmann, Ulrich M. Lauer, Gundram Jung, Helmut R. Salih

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: immunotherapy, pancreatic cancer, hepatic cancer, gastric cancer, B7-H3 (CD276), CD3, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1163136/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a9c1d07ea6db491a89f09555d59e60dd

Serendipitous synergism – an exceptional response to treatment with pembrolizumab in the course of a natural immunovirotherapy: a case report and review of the literature

Authors: Lara M. Khoury, Kimberly M. Burcher, Ronald T. Ng, Alexander H. Song, Mark J. Chang, Elena Gavrila, Chance H. Bloomer, Mac B. Robinson, Brian E. Kouri, Joshua D. Waltonen, Paul M. Bunch, Ulrich M. Lauer, Mercedes Porosnicu

Source: Therapeutic Advances in Medical Oncology, Vol 14 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1758-8359

Access URL: https://doaj.org/article/483654dff18f4ed9bb6231e345b4dea5

Determination of phage load and administration time in simulated occurrences of antibacterial treatments

Authors: Steffen Plunder, Markus Burkard, Ulrich M. Lauer, Sascha Venturelli, Luigi Marongiu

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: microbial ecology models, phage therapy, machine learning, Pareto optimization, antibacterial treatment, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.1040457/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/3ac786e08c5f4022b8e72e8232d8a316

Case report: Immunovirotherapy as a novel add-on treatment in a patient with thoracic NUT carcinoma

Authors: Linus D. Kloker, Branko Calukovic, Katrin Benzler, Alexander Golf, Sebastian Böhm, Sven Günther, Marius Horger, Simone Haas, Susanne Berchtold, Julia Beil, Mary E. Carter, Tina Ganzenmueller, Stephan Singer, Abbas Agaimy, Robert Stöhr, Arndt Hartmann, Thomas Duell, Sandra Mairhofer, Fabian Fohrer, Niels Reinmuth, Lars Zender, Ulrich M. Lauer

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: NUT carcinoma, virotherapy, immunotherapy, T-VEC, chemotherapy, NUTM1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.995744/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/937409fb0e814f379cae06b3619b90ce

NUT Carcinoma—An Underdiagnosed Malignancy

Authors: Ulrich M. Lauer, Martina Hinterleitner, Marius Horger, Paul V. Ohnesorge, Lars Zender

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: NUT carcinoma, NUTM1, NUT rearrangement, BET inhibitor, BRD4, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.914031/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/39734a5c312b4e5fbec029ccd60ad515

Long‐term remission of small cell lung cancer after reactivation of tuberculosis following immune‐checkpoint blockade: A case report

Authors: Mattia Sirgiovanni, Clemens Hinterleitner, Marius Horger, Naushad Bijoy Atique, Ulrich M. Lauer, Lars Zender, Martina Hinterleitner

Source: Thoracic Cancer, Vol 12, Iss 5, Pp 699-702 (2021)

Subject Terms: immune‐checkpoint inhibitors, lung cancer, PD‐L1, tuberculosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1759-7706; https://doaj.org/toc/1759-7714

Access URL: https://doaj.org/article/2c156fed30e849c2961ad2aac761a37e

Oncolytic vaccinia virus GLV-1h68 exhibits profound antitumoral activities in cell lines originating from neuroendocrine neoplasms

Authors: Linus D. Kloker, Susanne Berchtold, Irina Smirnow, Julia Beil, Andreas Krieg, Bence Sipos, Ulrich M. Lauer

Source: BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)

Subject Terms: Endocrine cancers, Virotherapy, Immunotherapy, Vaccinia virus, Neuroendocrine tumors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-020-07121-8; https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/7feb99fdfa9c48e58f33df3aadf9220f

A Three-Dimensional Organoid Model of Primary Breast Cancer to Investigate the Effects of Oncolytic Virotherapy

Authors: Mary E. Carter, Andreas D. Hartkopf, Anna Wagner, Léa L. Volmer, Sara Y. Brucker, Susanne Berchtold, Ulrich M. Lauer, André Koch

Source: Frontiers in Molecular Biosciences, Vol 9 (2022)

Subject Terms: oncolytic virus, virotherapy, breast cancer, measles virus, vaccinia virus, organoid cell culture, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2022.826302/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/d911baf1fff44c8087817ae0548efeb2

Establishing a New Platform to Investigate the Efficacy of Oncolytic Virotherapy in a Human Ex Vivo Peritoneal Carcinomatosis Model

Authors: Jana Koch, Julia Beil, Susanne Berchtold, Dina Mönch, Annika Maaß, Irina Smirnow, Andrea Schenk, Mary E. Carter, Linus D. Kloker, Tobias Leibold, Philipp Renner, Marc-H. Dahlke, Ulrich M. Lauer

Source: Viruses, Vol 15, Iss 2, p 363 (2023)

Subject Terms: peritoneal carcinomatosis, ex vivo peritoneal culture model, virotherapy, oncolytic measles vaccine virus, oncolytic vaccinia virus, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/15/2/363; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/822e82baacc441038ab92e364129dec5

High-Dose Ascorbate in Combination with Anti-PD1 Checkpoint Inhibition as Treatment Option for Malignant Melanoma

Authors: Markus Burkard, Heike Niessner, Christian Leischner, Alban Piotrowsky, Olga Renner, Luigi Marongiu, Ulrich M. Lauer, Christian Busch, Tobias Sinnberg, Sascha Venturelli

Source: Cells, Vol 12, Iss 2, p 254 (2023)

Subject Terms: malignant melanoma, cancer, ascorbate, vitamin C, immunotherapy, checkpoint blockade, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/2/254; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/748f1d6dd3e54c14b47d1ac01c5f0e50

Clinical Trials of Oncolytic Viruses in Breast Cancer

Authors: Mary E. Carter, André Koch, Ulrich M. Lauer, Andreas D. Hartkopf

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: oncolytic virus, virotherapy, breast cancer, clinical trials, review, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.803050/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/c1fb03e4b2c047f4b6cad71d3627401a

Biological treatment of pediatric sarcomas by combined virotherapy and NK cell therapy

Authors: Chihab Klose, Susanne Berchtold, Marina Schmidt, Julia Beil, Irina Smirnow, Sascha Venturelli, Markus Burkard, Rupert Handgretinger, Ulrich M. Lauer

Source: BMC Cancer, Vol 19, Iss 1, Pp 1-15 (2019)

Subject Terms: Virotherapy, Measles vaccine virus, NK cells, Immunotherapy, Pediatric sarcoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/6589fcdac91c4e748e005b5088b675fc

High-Affinity DARPin Allows Targeting of MeV to Glioblastoma Multiforme in Combination with Protease Targeting without Loss of Potency

Authors: Jan R.H. Hanauer, Vivian Koch, Ulrich M. Lauer, Michael D. Mühlebach

Source: Molecular Therapy: Oncolytics, Vol 15, Iss , Pp 186-200 (2019)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770519300944; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/8c68c3450c474b758f4a914f0657803a

Vitamin C Deficiency in Blood Samples of COVID-19 Patients

Authors: Tobias Sinnberg, Christa Lichtensteiger, Katharina Hill-Mündel, Christian Leischner, Heike Niessner, Christian Busch, Olga Renner, Nina Wyss, Lukas Flatz, Ulrich M. Lauer, Ludwig E. Hoelzle, Donatus Nohr, Markus Burkard, Luigi Marongiu, Sascha Venturelli

Source: Antioxidants, Vol 11, Iss 8, p 1580 (2022)

Subject Terms: COVID-19, vitamin plasma levels, ascorbate, calcidiol, retinol, α-tocopherol, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/11/8/1580; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/a03a10598ea946df810d82b974e25561