ANG2 Blockade Diminishes Proangiogenic Cerebrovascular Defects Associated With Models of Hereditary Hemorrhagic Telangiectasia

Authors: Zhou, Xingyan, Pucel, Jenna C., Nomura-Kitabayashi, Aya, Chandakkar, Pallavi, Guidroz, Adella P., Jhangiani, Nikita L., Bao, Duran, Fan, Jia, Arthur, Helen M., Ullmer, Christoph, Klein, Christian, Marambaud, Philippe, Meadows, Stryder M.

Source: Arteriosclerosis, thrombosis, and vascular biology. 43(8):1384-1403

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Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells

Authors: Kosar, Miroslav, Sykes, David A., Viray, Alexander E. G., Vitale, Rosa Maria, Sarott, Roman C., Ganzoni, Rudolf L., Onion, David, Tobias, Janelle M., Leippe, Philipp, Ullmer, Christoph

Source: Journal of the American Chemical Society. 145(28):15094-15108

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Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probeElectronic supplementary information (ESI) available: Supplementary figures and tables; general synthetic methods; compound synthesis and characterization; molecular docking; in vitro pharmacology; fluorescence spectroscopy; TR-FRET kinetic CB2R binding assay; FACS analysis; time-lapse confocal imaging; in vivo zebrafish imaging; NMR spectra; and N-terminal SNAP-hCB2R sequence. CCDC 1923120. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d1sc06659e

Authors: Gazzi, Thais, Brennecke, Benjamin, Atz, Kenneth, Korn, Claudia, Sykes, David, Forn-Cuni, Gabriel, Pfaff, Patrick, Sarott, Roman C., Westphal, Matthias V., Mostinski, Yelena, Mach, Leonard, Wasinska-Kalwa, Malgorzata, Weise, Marie, Hoare, Bradley L., Miljuš, Tamara, Mexi, Maira, Roth, Nicolas, Koers, Eline J., Guba, Wolfgang, Alker, André, Rufer, Arne C., Kusznir, Eric A., Huber, Sylwia, Raposo, Catarina, Zirwes, Elisabeth A., Osterwald, Anja, Pavlovic, Anto, Moes, Svenja, Beck, Jennifer, Nettekoven, Matthias, Benito-Cuesta, Irene, Grande, Teresa, Drawnel, Faye, Widmer, Gabriella, Holzer, Daniela, van der Wel, Tom, Mandhair, Harpreet, Honer, Michael, Fingerle, Jürgen, Scheffel, Jörg, Broichhagen, Johannes, Gawrisch, Klaus, Romero, Julián, Hillard, Cecilia J., Varga, Zoltan V., van der Stelt, Mario, Pacher, Pal, Gertsch, Jürg, Ullmer, Christoph, McCormick, Peter J., Oddi, Sergio, Spaink, Herman P., Maccarrone, Mauro, Veprintsev, Dmitry B., Carreira, Erick M., Grether, Uwe, Nazaré, Marc

Source: Chemical science. 13(19):5539-5545

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TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload

Authors: Bidault-Jourdainne, Valeska, Merlen, Grégory, Glénisson, Mathilde, Doignon, Isabelle, Garcin, Isabelle, Péan, Noémie, Boisgard, Raphael, Ursic-Bedoya, José, Serino, Matteo, Ullmer, Christoph, Humbert, Lydie, Abdelrafee, Ahmed, Golse, Nicolas, Vibert, Eric, Duclos-Vallée, Jean-Charles, Rainteau, Dominique, Tordjmann, Thierry

Source: In JHEP Reports April 2021 3(2)

New Technologies in Clinical Trials in Corneal Diseases and Limbal Stem Cell Deficiency: Review from the European Vision Institute Special Interest Focus Group Meeting

Authors: Schlereth, Simona L., Hos, Deniz, Matthaei, Mario, Hamrah, Pedram, Schmetterer, Leopold, O'Leary, Olivia, Ullmer, Christoph, Horstmann, Jens, Bock, Felix, Wacker, Katrin, Schröder, Hannes, Notara, Maria, Haagdorens, Michel, Nuijts, Rudy M.M.A., Dunker, Suryan L., Dickman, Mor M., Fauser, Sascha, Scholl, Hendrik P.N., Wheeler-Schilling, Thomas, Cursiefen, Claus

Source: OPHTHALMIC RESEARCH. 64(2):145-167

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Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity

Authors: Ho, Leona T.Y., Osterwald, Anja, Ruf, Iris, Hunziker, Daniel, Mattei, Patrizio, Challa, Pratap, Vann, Robin, Ullmer, Christoph, Rao, Ponugoti Vasanth

Source: In BBA - Molecular Basis of Disease 1 January 2020 1866(1)

Highly Selective, Amine‐Derived Cannabinoid Receptor 2 Probes

Authors: Westphal, Matthias V., Sarott, Roman C., Zirwes, Elisabeth A., Osterwald, Anja, Guba, Wolfgang, Ullmer, Christoph, Grether, Uwe, Carreira, Erick M.

Source: Chemistry. 26(6):1380-1387

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Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis

Authors: Ninou, Ioanna, Kaffe, Eleanna, Müller, Stefan, Budd, David C., Stevenson, Christopher S., Ullmer, Christoph, Aidinis, Vassilis

Source: In Pulmonary Pharmacology & Therapeutics October 2018 52:32-40

Angiopoietin-2 Inhibition Rescues Arteriovenous Malformation in a Smad4 Hereditary Hemorrhagic Telangiectasia Mouse Model

Authors: Crist, Angela M., Zhou, Xingyan, Garai, Jone, Lee, Amanda R., Thoele, Janina, Ullmer, Christoph, Klein, Christian, Zabaleta, Jovanny, Meadows, Stryder M.

Source: Circulation. 139(17):2049-2063

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A Novel Selective Inverse Agonist of the CB2 Receptor as a Radiolabeled Tool Compound for Kinetic Binding Studies

Authors: Martella, Andrea, Sijben, Huub, Rufer, Arne C., Grether, Uwe, Fingerle, Juergen, Ullmer, Christoph, Hartung, Thomas, IJzerman, Adriaan P., van der Stelt, Mario, Heitman, Laura H. ^*

Source: In Molecular Pharmacology October 2017 92(4):389-400

Distinct Claudins and Associated PDZ Proteins form Different Autotypic Tight Junctions in Myelinating Schwann Cells

Authors: Poliak, Sebastian, Matlis, Sean, Ullmer, Christoph, Scherer, Steven S., Peles, Elior

Source: The Journal of Cell Biology, 2002 Oct . 159(2), 361-371.

Access URL: https://www.jstor.org/stable/1621301

Doxycycline-Mediated Quantitative and Tissue-Specific Control of Gene Expression in Transgenic Mice

Authors: Kistner, Andreas, Gossen, Manfred, Zimmermann, Frank, Jerecic, Jasna, Ullmer, Christoph, Lübbert, Hermann, Bujard, Hermann

Source: Proceedings of the National Academy of Sciences of the United States of America, 1996 Oct 01. 93(20), 10933-10938.

Access URL: https://www.jstor.org/stable/40260

Incretin-like effects of small molecule trace amine-associated receptor 1 agonists

Authors: Raab, Susanne, Wang, Haiyan, Uhles, Sabine, Cole, Nadine, Alvarez-Sanchez, Ruben, Künnecke, Basil, Ullmer, Christoph, Matile, Hugues, Bedoucha, Marc, Norcross, Roger D., Ottaway-Parker, Nickki, Perez-Tilve, Diego, Conde Knape, Karin, Tschöp, Matthias H., Hoener, Marius C., Sewing, Sabine

Source: In Molecular Metabolism January 2016 5(1):47-56

New data in a mouse model of spontaneous choroidal neovascularisation support the role of angiopoietin‐2 inhibition in driving sustained vascular stabilisation and reduced fibrosis progression

Authors: Canonica, Jérémie, Uhles, Sabine, Foxton, Richard, Revelant, Franco, Cole, Nadine, Westenkow, Peter, Scheidl, Stefan, Ullmer, Christoph

Source: Acta ophthalmologica. 99

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BF-1 – A novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs

Authors: Schmitz, Beate, Ullmer, Christoph, Segelcke, Daniel, Gwarek, Mirella, Zhu, Xin-Ran, Lübbert, Hermann

Source: In European Journal of Pharmacology 15 March 2015 751:73-80

From Structure—Activity Relationships on Thiazole Derivatives to the In Vivo Evaluation of a New Radiotracer for Cannabinoid Subtype 2 PET Imaging

Authors: Caillé, Fabien, Cacheux, Fanny, Peyronneau, Marie-Anne, Jego, Benoit, Jaumain, Emilie, Pottier, Géraldine, Ullmer, Christoph, Grether, Uwe, Winkeler, Alexandra, Dollé, Frédéric

Source: Molecular pharmaceutics. 14(11):4064-4078

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Lysophosphatidic Acids and Autotaxin in Retinal Vein Occlusion

Authors: Dacheva, Ivanka, Ullmer, Christoph, Ceglowska, Karolina, Nogoceke, Everson, Hartmann, Guido, Müller, Stephan, Rejdak, Robert, Nowomiejska, Katarzyna, Reich, Michael, Nobl, Matthias

Source: Retina. 36(12):2311-2318

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Investigations into mRNA Lipid Nanoparticles Shelf-Life Stability under Nonfrozen Conditions.

Authors: Reinhart, Anne-Gaëlle, Osterwald, Anja, Ringler, Philippe, Leiser, Yael, Lauer, Matthias E., Martin, Rainer E., Ullmer, Christoph, Schumacher, Felix, Korn, Claudia, Keller, Michael

Source: Molecular Pharmaceutics; 12/4/2023, Vol. 20 Issue 12, p6492-6503, 12p

Pyridine derivatives as agonists of the CB2 receptor

ANG2 Blockade Diminishes Proangiogenic Cerebrovascular Defects Associated With Models of Hereditary Hemorrhagic Telangiectasia.

Authors: Xingyan Zhou, Pucel, Jenna C., Nomura-Kitabayashi, Aya, Chandakkar, Pallavi, Guidroz, Adella P., Jhangiani, Nikita L., Bao, Duran, Fan, Jia, Arthur, Helen M., Ullmer, Christoph, Klein, Christian, Marambaud, Philippe, Meadows, Stryder M.

Source: Arteriosclerosis, Thrombosis & Vascular Biology; Aug2023, Vol. 43 Issue 8, p1384-1403, 20p