Safety, clinical activity, pharmacodynamics, and pharmacokinetics of IMU-856, a SIRT6 modulator, in coeliac disease: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial

Authors: Daveson, A James M, Stubbs, Richard, Polasek, Thomas M, Isola, Jorma, Anderson, Robert, Tye-Din, Jason A, Schoeman, Mark, Lionnet, Claudette, Mei, Swee Lin Chen Yi, Mihajlović, Jelena, Wirth, Martina, Peelen, Evelyn, Schreieck, Amelie, Kohlhof, Hella, Vitt, Daniel, Muehler, Andreas ^*, Buriánek, Franziska

Source: In The Lancet Gastroenterology & Hepatology January 2025 10(1):44-54

Past, Present, and Future of Noninvasive Tests to Assess Gluten Exposure, Celiac Disease Activity, and End-Organ Damage

Authors: Silvester, Jocelyn A., Elli, Luca, Khosla, Chaitan, Tye-Din, Jason A.

Source: In Gastroenterology June 2024 167(1):159-171

Clinical Presentation and Spectrum of Gluten Symptomatology in Celiac Disease

Authors: Adams, Dawn W., Moleski, Stephanie, Jossen, Jacqueline, Tye-Din, Jason A.

Source: In Gastroenterology June 2024 167(1):51-63

A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes

Authors: Harrison, Leonard C, Bandala‐Sanchez, Esther, Oakey, Helena, Colman, Peter G, Watson, Kelly, Kim, Ki Wook, Wu, Roy, Hamilton‐Williams, Emma E, Stone, Natalie L, Haynes, Aveni, Thomson, Rebecca L, Vuillermin, Peter J, Soldatos, Georgia, Rawlinson, William D, McGorm, Kelly J, Morahan, Grant, Barry, Simon C, Sinnott, Richard O, Wentworth, John M, Couper, Jennifer J, Penno, Megan AS, Craig, Maria E, Davis, Elizabeth A, Hamilton‐Williams, Emma, Harris, Mark, Penno, Megan A S, Anderson, Amanda J, Ashwood, Pat, Brown, James D, Hu, William, Huynh, Dao, Tye‐Din, Jason, Huynh, Tony, Morbey, Claire, Lopez, Prudence, Beresford, Sarah, Bertram, Samantha, Bezuidenhout, Debra, Brandrick, Susan, Butterworth, Carlie, Catteau, Jacki, Clements, Nakita, Gartrell, Kyana, Gilbert, Abbey, Griffiths, Helen, Gwiazdzinski, Alison, Hall, Candice, Harper, Gail, Hulley, Amanda, Hoffman, Mikayla, Kludas, Renee, Moore, Belinda, Ramoso, Benjamin, Roberts, Alison, Tully, Alexandra, Vicary, Isabelle, Wood, Rosemary, Battersby, Rachel, Hope, Chris, Sadlon, Tim, Roth‐Schulze, Alexandra, Wong, Ying‐Ying, Zozaya‐Valdes, Enrique, Binkowski, Sabrina, Brittain, Bek, Bui, Minh, Minhaj, Asma, Naselli, Gaetano, Ngui, Katrina, Nguyen, Trung, Stone, Natalie, Ward, Emily, Xu, Yan, Yau, Cynthia

Source: Journal of diabetes investigation. 14(9):1092-1100

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191174818.0x000001&indx=1&recIds=ETOCvdc_100191174818.0x000001

Deteriorating Sprue: A New Frontier for Gastrointestinal Ultrasound

Authors: Elford, Alexander T., Tye-Din, Jason A., Christensen, Britt

Source: Gastroenterology. 164(6):876-879

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188043931.0x000001&indx=1&recIds=ETOCvdc_100188043931.0x000001

Efficacy and safety of gluten peptide-based antigen-specific immunotherapy (Nexvax2) in adults with coeliac disease after bolus exposure to gluten (RESET CeD): an interim analysis of a terminated randomised, double-blind, placebo-controlled phase 2 study

Authors: Adams, Atoya, Andrews, Jane M, Behrend, Clint E, Brown, Gregor J E, Chen Yi Mei, Swee Lin, Coates, Allan G, DiMarino, Anthony J, Ee, Hooi, Elliott, David E, Epstein, Roger M, Feyen, Bryan John, Fogel, Ronald P, Friedenberg, Keith Alan, Gearry, Richard B, Gerdis, Michael S, Goldstein, Michael J, Gupta, Vipin K, Holmes, Robert John, Holtmann, Gerald J, Idarraga, Samuel H, James, George W, King, Tim, Klein, Terry D, Kupfer, Sonia S, Lebwohl, Benjamin, Lowe, Matthew John, Murray, Joseph A, Newton, Eric B, Quinn, Dean, Radin, David M, Ritter, Timothy E, Stacey, Helen Lee, Strout, Cynthia B, Stubbs, Richard S, Thackwray, Susan Lynn, Trivedi, Vivek M, Weber, John R, Wilson, Scott A, Tye-Din, Jason A, Daveson, A James M, Goel, Gautam, Goldstein, Kaela E, Hand, Holly L, Neff, Kristin M, Popp, Alina, Taavela, Juha, Maki, Markku, Isola, Jorma, Williams, Leslie J, Truitt, Kenneth E, Anderson, Robert P ^*

Source: In The Lancet Gastroenterology & Hepatology May 2023 8(5):446-457

Undiagnosed coeliac disease identified by active case finding in first degree relatives of people with coeliac disease in Australia: a prospective observational study

Authors: Muir, Richard, Sehgal, Anuj, Tye‐Din, Jason A, Daveson, A James M

Source: Medical journal of Australia. 219(8):371-373

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195874416.0x000001&indx=1&recIds=ETOCvdc_100195874416.0x000001

Coeliac disease - optimising long-term management

Authors: Saitta, Daniel, Tye-Din, Jason A.

Source: Medicine today. 23(11):26-36

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630489312&indx=1&recIds=ETOCRN630489312

BASTA, a simple whole-blood assay for measuring β cell antigen–specific CD4⁺ T cell responses in type 1 diabetes.

Authors: Lacorcia, Matthew, Bhattacharjee, Pushpak, Foster, Abby, Hardy, Melinda Y., Tye-Din, Jason A., Karas, John A., Wentworth, John M., Cameron, Fergus J., Mannering, Stuart I.

Source: Science Translational Medicine; 3/19/2025, Vol. 17 Issue 790, p1-12, 12p

Longitudinal assessment of the common sense model before and during the COVID-19 pandemic: A large coeliac disease cohort study

Authors: Möller, Stephan P., Apputhurai, Pragalathan, Tye-Din, Jason A., Knowles, Simon R.

Source: In Journal of Psychosomatic Research February 2022 153

Hydroxychloroquine inhibits the mitochondrial antioxidant system in activated T cells

Authors: Kim, Man Lyang, Hardy, Melinda Y., Edgington-Mitchell, Laura E., Ramarathinam, Sri H., Chung, Shan Zou, Russell, Amy K., Currie, Iain, Sleebs, Brad E., Purcell, Anthony W., Tye-Din, Jason A., Wicks, Ian P.

Source: In iScience 17 December 2021 24(12)

Quality of life in coeliac disease: relationship between psychosocial processes and quality of life in a sample of 1697 adults living with coeliac disease

Authors: Möller, Stephan P., Apputhurai, Pragalathan, Tye-Din, Jason A., Knowles, Simon R.

Source: In Journal of Psychosomatic Research December 2021 151

Systematic review: Exploration of the impact of psychosocial factors on quality of life in adults living with coeliac disease

Authors: Möller, Stephan P., Hayes, Bree, Wilding, Helen, Apputhurai, Pragalathan, Tye-Din, Jason A., Knowles, Simon R.

Source: In Journal of Psychosomatic Research August 2021 147

The Risk of Contracting COVID-19 Is Not Increased in Patients With Celiac Disease

Authors: Zhen, Jamie, Stefanolo, Juan Pablo, Temprano, Maria de la Paz, Tedesco, Sebastian, Seiler, Caroline, Caminero, Alberto Fernandez, de-Madaria, Enrique, Huguet, Miguel Montoro, Vivas, Santiago, Niveloni, Sonia Isabel, Bercik, Premysl, Smecuol, Edgardo, Uscanga, Luis, Trucco, Elena, Lopez, Virginia, Olano, Carolina, Mansueto, Pasquale, Carroccio, Antonio, Green, Peter H.R., Day, Andrew, Tye-Din, Jason, Bai, Julio Cesar, Ciacci, Carolina, Verdu, Elena F., Lebwohl, Benjamin, Pinto-Sanchez, Maria Ines

Source: In Clinical Gastroenterology and Hepatology February 2021 19(2):391-393

Iron deficiency

Authors: Pasricha, Sant-Rayn ^*, Tye-Din, Jason, Muckenthaler, Martina U, Swinkels, Dorine W

Source: In The Lancet 16-22 January 2021 397(10270):233-248

18 A BISPECIFIC ANTIBODY TARGETING HLA-DQ2.5-GLUTEN PEPTIDES POTENTLY BLOCKS GLUTEN-SPECIFIC T CELLS INDUCED BY GLUTEN INGESTION IN PATIENTS WITH CELIAC DISEASE

Authors: Hardy, Melinda Y., Henneken, Lee, Russell, Amy, Mizoroki, Akihiko, Ozono, Yui, Okura, Yuu, Murakami, Yosuke, Kobayashi, Shinta, Tye-Din, Jason A.

Source: Gastroenterology. 164(6):S-6-S-6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194436790.0x000001&indx=1&recIds=ETOCvdc_100194436790.0x000001

Tu1902 STOOL GLUTEN IMMUNOGENIC PEPTIDE DETECTION IS HIGHLY SENSITIVE AFTER LOW-DOSE GLUTEN CHALLENGE AND REVEALS A HIGH BACKGROUND RATE OF UNINTENDED GLUTEN INTAKE IN TREATED CELIAC DISEASE

Authors: Russell, Amy, Lucas, Erin C., Henneken, Lee, Pizzey, Catherine, Moscatelli, Olivia, Apputhurai, Pragalathan, Halmos, Emma P., Myleus, Anna, Tye-Din, Jason A.

Source: Gastroenterology. 164(6):S-1155-S-1155

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194457447.0x000001&indx=1&recIds=ETOCvdc_100194457447.0x000001

Tu1369 THE RATE OF ADVERSE EVENTS AFTER COVID-19 VACCINATION IS SIMILAR IN PATIENTS WITH CELIAC DISEASE AND NON-CELIAC POPULATION: RESULTS OF A LARGE INTERNATIONAL CROSS-SECTIONAL STUDY

Authors: Tandon, Shilpa, Stefanolo, Juan P., Russell, Lindsey, Temprano, Paz, Niveloni, Sonia I., Verdu, Elena F., Armstrong, David, Lebwohl, Benjamin, Leffler, Daniel A., Tye-Din, Jason A., Day, Andrew S., Ciacci, Carolina, Carraccio, Antonio, Mansueto, Pasquale, Olano, Carolina, Lopez, Virginia, Uscanga, Luis F., Valerio, Fernando, Montoro, Miguel A., de-Madaria, Enrique, Vivas, Santiago, Rodriguez-Herrera, Alfonso, Schuppan, Detlef, Mulder, Chris, Makharia, Govind K., Sanders, David, Zeitz, Jonas, Aziz, Imran, Sanchez, María Inés Pinto

Source: Gastroenterology. 164(6):S-1034-S-1034

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194460379.0x000001&indx=1&recIds=ETOCvdc_100194460379.0x000001

Accurate and robust genomic prediction of celiac disease using statistical learning

Authors: Abraham, Gad, Tye-Din, Jason A., Bhalala, Oneil G., Kowalczyk, Adam, Zobel, Justin, Inouye, Michael

Subject Terms: Quantitative Biology - Genomics, Statistics - Applications

Access URL: http://arxiv.org/abs/1301.5948

Cytokine release after gluten ingestion differentiates coeliac disease from self‐reported gluten sensitivity

Authors: Tye‐Din, Jason A, Skodje, Gry I, Sarna, Vikas K, Dzuris, John L, Russell, Amy K, Goel, Gautam, Wang, Suyue, Goldstein, Kaela E, Williams, Leslie J, Sollid, Ludvig M, Lundin, Knut EA, Anderson, Robert P

Source: United European Gastroenterology journal. 8(1):108-118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112784791.0x000001&indx=1&recIds=ETOCvdc_100112784791.0x000001