Cholesterol‐dependent cytolysins: The outstanding questions

Authors: Johnstone, Bronte A., Joseph, Riya, Christie, Michelle P., Morton, Craig J., McGuiness, Conall, Walsh, James C., Böcking, Till, Tweten, Rodney K., Parker, Michael W.

Source: IUBMB life. 74(12):1169-1179

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167025062.0x000001&indx=1&recIds=ETOCvdc_100167025062.0x000001

Preclinical in vitro and in vivo profile of a highly-attenuated, broadly efficacious pneumolysin genetic toxoid

Authors: Thanawastien, Ann, Joyce, Kelsey E., Cartee, Robert T., Haines, Laurel A., Pelton, Stephen I., Tweten, Rodney K., Killeen, Kevin P.

Source: Vaccine. 39(11):1652-1660

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136661291.0x000001&indx=1&recIds=ETOCvdc_100136661291.0x000001

Pneumolysin Induces 12-Lipoxygenase—Dependent Neutrophil Migration during Streptococcus pneumoniae Infection

Authors: Adams, Walter, Bhowmick, Rudra, Ghanem, Elsa N. Bou, Wade, Kristin, Shchepetov, Mikhail, Weiser, Jeffrey N., McCormick, Beth A., Tweten, Rodney K., Leong, John M.

Source: Journal of immunology. 204(1):101-111

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN622549254&indx=1&recIds=ETOCRN622549254

Molecular Basis of Listeriolysin O pH Dependence

Authors: Schuerch, Daniel W., Wilson-Kubalek, Elizabeth M., Tweten, Rodney K., Collier, R. John

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Aug . 102(35), 12537-12542.

Access URL: https://www.jstor.org/stable/3376613

The Domains of a Cholesterol-Dependent Cytolysin Undergo a Major FRET-Detected Rearrangement during Pore Formation

Authors: Ramachandran, Rajesh, Tweten, Rodney K., Johnson, Arthur E., Collier, R. John

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 May . 102(20), 7139-7144.

Access URL: https://www.jstor.org/stable/3375498

Insights into the Action of the Superfamily of Cholesterol-Dependent Cytolysins from Studies of Intermedilysin

Authors: Polekhina, Galina, Giddings, Kara Sue, Tweten, Rodney K., Parker, Michael W., Taylor, Susan S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Jan . 102(3), 600-605.

Access URL: https://www.jstor.org/stable/3374294

Mapping Dominant-Negative Mutations of Anthrax Protective Antigen by Scanning Mutagenesis

Authors: Mourez, Michael, Yan, Ming, Lacy, D. Borden, Dillon, Lisa, Bentsen, Lori, Marpoe, Amy, Maurin, Clémence, Hotze, Eileen, Wigelsworth, Darran, Pimental, Ruth-Anne, Ballard, Jimmy D., Collier, R. John, Tweten, Rodney K.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 Nov . 100(24), 13803-13808.

Access URL: https://www.jstor.org/stable/3148868

Redefining Cholesterol's Role in the Mechanism of the Cholesterol-Dependent Cytolysins

Authors: Giddings, Kara S., Johnson, Arthur E., Tweten, Rodney K.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2003 Sep . 100(20), 11315-11320.

Access URL: https://www.jstor.org/stable/3147788

Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria.

Authors: Abrahamsen, Hunter L., Sanford, Tristan C., Collamore, Casie E., Johnstone, Bronte A., Coyne, Michael J., García-Bayona, Leonor, Christie, Michelle P., Evans, Jordan C., Farrand, Allison J., Flores, Katia, Morton, Craig J., Parker, Michael W., Comstock, Laurie E., Tweten, Rodney K.

Source: Nature Communications; 6/12/2024, Vol. 15 Issue 1, p1-15, 15p

Subject Terms: ANTIBIOSIS, TOXINS, GRAM-positive bacteria, PATHOGENIC bacteria, RELATIVES, COMPLEMENT receptors, ENTEROTYPES, EUKARYOTIC cells

Bacterial cholesterol-dependent cytolysins and their interaction with the human immune response.

Authors: Sanford, Tristan C., Tweten, Rodney K., Abrahamsen, Hunter L.

Source: Current Opinion in Infectious Diseases; Jun2024, Vol. 37 Issue 3, p164-169, 6p

Cholesterol-dependent cytolysins: from water-soluble state to membrane pore

Authors: Christie, Michelle P., Johnstone, Bronte A., Tweten, Rodney K., Parker, Michael W., Morton, Craig J.

Source: Biophysical reviews. 10(5):1337-1348

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127133243.0x000001&indx=1&recIds=ETOCvdc_100127133243.0x000001

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins

Authors: Lawrence, Sara L., Gorman, Michael A., Feil, Susanne C., Mulhern, Terrence D., Kuiper, Michael J., Ratner, Adam J., Tweten, Rodney K., Morton, Craig J., Parker, Michael W.

Source: In Structure 6 September 2016 24(9):1488-1498

The Apicomplexan CDC/MACPF-like pore-forming proteins

Authors: Wade, Kristin R, Tweten, Rodney K

Source: In Current Opinion in Microbiology August 2015 26:48-52

The Cholesterol-dependent Cytolysin Membrane-binding Interface Discriminates Lipid Environments of Cholesterol to Support β-Barrel Pore Insertion

Authors: Farrand, Allison J., Hotze, Eileen M., Sato, Takehiro K., Wade, Kristin R., Wimley, William C., Johnson, Arthur E., Tweten, Rodney K.

Source: In Journal of Biological Chemistry 17 July 2015 290(29):17733-17744

Stonefish toxin defines an ancient branch of the perforin-like superfamily

Authors: Ellisdon, Andrew M., Reboul, Cyril F., Panjikar, Santosh, Huynh, Kitmun, Oellig, Christine A., Winter, Kelly L., Dunstone, Michelle A., Hodgson, Wayne C., Seymour, Jamie, Dearden, Peter K., Tweten, Rodney K., Whisstock, James C., McGowan, Sheena

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Dec . 112(50), 15360-15365.

Access URL: https://www.jstor.org/stable/26466601

An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin

Authors: Wade, Kristin R., Hotze, Eileen M., Kuiper, Michael J., Morton, Craig J., Parker, Michael W., Tweten, Rodney K.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Feb . 112(7), 2204-2209.

Access URL: https://www.jstor.org/stable/26461612

Broadly Protective Protein-Based Pneumococcal Vaccine Composed of Pneumolysin Toxoid—CbpA Peptide Recombinant Fusion Protein

Authors: Mann, Beth, Thornton, Justin, Heath, Richard, Wade, Kristin R., Tweten, Rodney K., Gao, Geli, Kasmi, Karim El, Jordan, John B., Mitrea, Diana M., Kriwacki, Richard, Maisonneuve, Jeff, Alderson, Mark, Tuomanen, Elaine I.

Source: The Journal of Infectious Diseases, 2014 Apr 01. 209(7), 1116-1125.

Access URL: http://www.jstor.org/stable/43708436

Cardiac Myocyte Dysfunction Induced by Streptolysin O Is Membrane Pore and Calcium Dependent

Authors: Bolz, Devin D., Li, Zhi, McIndoo, Eric R., Tweten, Rodney K., Bryant, Amy E., Stevens, Dennis L.

Source: Shock. 43(2):178-184

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100034338009.0x000001&indx=1&recIds=ETOCvdc_100034338009.0x000001

The Unique Molecular Choreography of Giant Pore Formation by the Cholesterol-Dependent Cytolysins of Gram-Positive Bacteria

Authors: Tweten, Rodney K., Hotze, Eileen M., Wade, Kristin R.

Source: Annual review of microbiology. 69:323-340

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN604303599&indx=1&recIds=ETOCRN604303599

Monomer-Monomer Interactions Propagate Structural Transitions Necessary for Pore Formation by the Cholesterol-dependent Cytolysins

Authors: Hotze, Eileen M., Wilson-Kubalek, Elizabeth, Farrand, Allison J., Bentsen, Lori, Parker, Michael W., Johnson, Arthur E. ^**, Tweten, Rodney K.

Source: In Journal of Biological Chemistry July 2012 287(29):24534-24543