Stapled ACE2 peptidomimetics designed to target the SARS‐CoV‐2 spike protein do not prevent virus internalization

Authors: Morgan, Danielle C., Morris, Caroline, Mahindra, Amit, Blair, Connor M., Tejeda, Gonzalo, Herbert, Imogen, Turnbull, Matthew L., Lieber, Gauthier, Willett, Brian J., Logan, Nicola, Smith, Brian, Tobin, Andrew B., Bhella, David, Baillie, George, Jamieson, Andrew G.

Source: Peptide science. 113(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123868498.0x000001&indx=1&recIds=ETOCvdc_100123868498.0x000001

BTN3A3 evasion promotes the zoonotic potential of influenza A viruses.

Authors: Pinto, Rute Maria, Bakshi, Siddharth, Lytras, Spyros, Zakaria, Mohammad Khalid, Swingler, Simon, Worrell, Julie C., Herder, Vanessa, Hargrave, Kerrie E., Varjak, Margus, Cameron-Ruiz, Natalia, Collados Rodriguez, Mila, Varela, Mariana, Wickenhagen, Arthur, Loney, Colin, Pei, Yanlong, Hughes, Joseph, Valette, Elise, Turnbull, Matthew L., Furnon, Wilhelm, Gu, Quan

Source: Nature; Jul2023, Vol. 619 Issue 7969, p338-347, 10p

In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2.

Authors: Szemiel, Agnieszka M.¹, Merits, Andres², Orton, Richard J.¹, MacLean, Oscar A.¹, Pinto, Rute Maria¹, Wickenhagen, Arthur¹, Lieber, Gauthier¹, Turnbull, Matthew L.¹, Wang, Sainan², Furnon, Wilhelm¹, Suarez, Nicolas M.¹, Mair, Daniel¹, da Silva Filipe, Ana¹, Willett, Brian J.¹, Wilson, Sam J.¹, Patel, Arvind H.¹, Thomson, Emma C.¹, Palmarini, Massimo¹, Kohl, Alain¹, Stewart, Meredith E.¹, Meredith.Stewart@glasgow.ac.uk

Source: PLoS Pathogens; 9/17/2021, Vol. 17 Issue 9, p1-24, 24p

The antiviral state has shaped the CpG composition of the vertebrate interferome to avoid self-targeting.

Authors: Shaw, Andrew E.^1,2, Rihn, Suzannah J.¹, Mollentze, Nardus^1,3, Wickenhagen, Arthur¹, Stewart, Douglas G.¹, Orton, Richard J.¹, Kuchi, Srikeerthana¹, Bakshi, Siddharth¹, Collados, Mila Rodriguez¹, Turnbull, Matthew L.¹, Busby, Joseph¹, Gu, Quan¹, Smollett, Katherine¹, Bamford, Connor G. G.¹, Sugrue, Elena¹, Johnson, Paul C. D.^1,3, Da Silva, Ana Filipe¹, Castello, Alfredo¹, Streicker, Daniel G.^1,3, Robertson, David L.¹

Source: PLoS Biology; 9/7/2021, Vol. 19 Issue 9, p1-25, 25p, 5 Graphs

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research.

Authors: Rihn, Suzannah J.¹, Merits, Andres², Bakshi, Siddharth¹, Turnbull, Matthew L.¹, Wickenhagen, Arthur¹, Alexander, Akira J. T.¹, Baillie, Carla³, Brennan, Benjamin¹, Brown, Fiona³, Brunker, Kirstyn⁴, Bryden, Steven R.¹, Burness, Kerry A.³, Carmichael, Stephen¹, Cole, Sarah J.¹, Cowton, Vanessa M.¹, Davies, Paul³, Davis, Chris¹, De Lorenzo, Giuditta¹, Donald, Claire L.¹, Dorward, Mark³

Source: PLoS Biology; 2/25/2021, Vol. 19 Issue 2, p1-22, 22p, 3 Diagrams, 3 Graphs

A chicken bioreactor for efficient production of functional cytokines

Authors: Herron, Lissa R., Pridans, Clare, Turnbull, Matthew L., Smith, Nikki, Lillico, Simon, Sherman, Adrian, Gilhooley, Hazel J., Wear, Martin, Kurian, Dominic, Papadakos, Grigorios, Digard, Paul, Hume, David A., Gill, Andrew C., Sang, Helen M.

Source: BMC biotechnology. 18(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127246293.0x000001&indx=1&recIds=ETOCvdc_100127246293.0x000001

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Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruses.

Authors: Hussain, Saira¹, Turnbull, Matthew L.¹, Wise, Helen M.¹, Jagger, Brett W.^2,3, Beard, Philippa M.^1,4, Kovacikova, Kristina¹, Taubenberger, Jeffery K.³, Vervelde, Lonneke¹, Engelhardt, Othmar G.⁵, Digarda, Paul¹

Source: Journal of Virology. Jan2019, Vol. 93 Issue 2, p1-33. 41p.

Subject Terms: *INFLUENZA A virus, *VIRAL mutation, *CHICKEN embryos, *INFLUENZA vaccines, *GENE expression in viruses, *EMBRYO mortality in livestock, *VIRUS diseases in poultry

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A prenylated dsRNA sensor protects against severe COVID-19.

Authors: Wickenhagen, Arthur, Sugrue, Elena, Lytras, Spyros, Kuchi, Srikeerthana, Noerenberg, Marko, Turnbull, Matthew L., Loney, Colin, Herder, Vanessa, Allan, Jay, Jarmson, Innes, Cameron-Ruiz, Natalia, Varjak, Margus, Pinto, Rute M., Lee, Jeffrey Y., Iselin, Louisa, Palmalux, Natasha, Stewart, Douglas G., Swingler, Simon, Greenwood, Edward J. D., Crozier, Thomas W. M.

Source: Science; 10/29/2021, Vol. 374 Issue 6567, p579-579, 1p, 1 Color Photograph

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Stapled ACE2peptidomimetics designed to target the SARS‐CoV‐2 spike protein do not prevent virus internalization

Authors: Morgan, Danielle C., Morris, Caroline, Mahindra, Amit, Blair, Connor M., Tejeda, Gonzalo, Herbert, Imogen, Turnbull, Matthew L., Lieber, Gauthier, Willett, Brian J., Logan, Nicola, Smith, Brian, Tobin, Andrew B., Bhella, David, Baillie, George, Jamieson, Andrew G.

Source: Peptide Science; July 2021, Vol. 113 Issue: 4

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A chicken bioreactor for efficient production of functional cytokines.

Authors: Smith, Nikki, Lillico, Simon, Sherman, Adrian, Gilhooley, Hazel J., Kurian, Dominic, Digard, Paul, Sang, Helen M., Herron, Lissa R., Pridans, Clare, Hume, David A., Turnbull, Matthew L., Gill, Andrew C., Papadakos, Grigorios, Wear, Martin

Source: BMC Biotechnology; 12/29/2018, Vol. 18 Issue 1, pN.PAG-N.PAG, 1p

Subject Terms: BIOREACTORS, CYTOKINES, TRANSGENIC animals, RECOMBINANT proteins, ANIMAL biotechnology

TRIM69 Inhibits Vesicular Stomatitis Indiana Virus.

Authors: Rihn, Suzannah J.¹, Aziz, Muhamad Afiq¹, Stewart, Douglas G.¹, Hughes, Joseph¹, Turnbull, Matthew L.¹, Varela, Mariana¹, Sugrue, Elena¹, Herd, Christie S.¹, Stanifer, Megan², Sinkins, Steven P.¹, Palmarini, Massimo¹, Wilson, Sam J.¹ Sam.Wilson@glasgow.ac.uk

Source: Journal of Virology. Oct2019, Vol. 93 Issue 20, p1-21. 21p.

Subject Terms: *VESICULAR stomatitis, *RIFT Valley fever, *VIRAL transmission, *POPULATION, *INFLUENZA viruses, *INTERFERON receptors, *ARBOVIRUS diseases

Geographic Terms: INDIANA