Investigating Neurons and Heads in Transformer-based LLMs for Typographical Errors

Authors: Tsuji, Kohei, Hiraoka, Tatsuya, Cheng, Yuchang, Aramaki, Eiji, Iwakura, Tomoya

Subject Terms: Computer Science - Computation and Language

Access URL: http://arxiv.org/abs/2502.19669

SubRegWeigh: Effective and Efficient Annotation Weighing with Subword Regularization

Authors: Tsuji, Kohei, Hiraoka, Tatsuya, Cheng, Yuchang, Iwakura, Tomoya

Subject Terms: Computer Science - Computation and Language

Access URL: http://arxiv.org/abs/2409.06216

Optical hyperdimensional soft sensing: Speckle-based touch interface and tactile sensor

Authors: Kitagawa, Kei, Tsuji, Kohei, Sagehashi, Koyo, Niiyama, Tomoaki, Sunada, Satoshi

Source: Optics Express Vol. 32, Issue 3, pp. 3209-3220 (2024)

Subject Terms: Electrical Engineering and Systems Science - Signal Processing, Physics - Optics

Access URL: http://arxiv.org/abs/2401.05435

Fine-tuning probes for fluorescence polarization binding assays of bivalent ligands against polo-like kinase 1 using full-length protein

Authors: Tsuji, Kohei ^{a, b, ⁎}, Tamamura, Hirokazu ^a, Burke, Terrence R. ^b

Source: In Bioorganic & Medicinal Chemistry 1 March 2025 119

Naphthalen-1-ylethanamine–containing small molecule inhibitors of the papain-like protease of SARS-CoV-2

Authors: Shinohara, Kouki, Kobayakawa, Takuya, Tsuji, Kohei, Takamatsu, Yuki, Mitsuya, Hiroaki, Tamamura, Hirokazu

Source: In European Journal of Medicinal Chemistry 15 December 2024 280

Design, synthesis and evaluation of bioactivity of peptidomimetics based on chloroalkene dipeptide isosteres

Authors: Kobayakawa, Takuya, Tsuji, Kohei, Tamamura, Hirokazu

Source: In Bioorganic & Medicinal Chemistry 1 August 2024 110

Development of anti-HBV agents targeting HBV capsid proteinsElectronic supplementary information (ESI) available: Experimental procedures including characterization data of novel synthetic compounds. See DOI: https://doi.org/10.1039/d3md00258f

Authors: Kobayakawa, Takuya, Amano, Masayuki, Nakayama, Miyuki, Tsuji, Kohei, Ishii, Takahiro, Miura, Yutaro, Shinohara, Kouki, Yamamoto, Kenichi, Matsuoka, Masao, Tamamura, Hirokazu

Source: RSC medicinal chemistry. 14(10):1973-1980

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196339112.0x000001&indx=1&recIds=ETOCvdc_100196339112.0x000001

Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C

Authors: Matsuura, Kanako, Yamaura, Mizuki, Sakawaki, Hiromi, Himeno, Ai, Pisil, Yalcin, Kobayakawa, Takuya, Tsuji, Kohei, Tamamura, Hirokazu, Matsushita, Shuzo, Miura, Tomoyuki

Source: Virology. 578:171-179

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178471120.0x000001&indx=1&recIds=ETOCvdc_100178471120.0x000001

Dimerized fusion inhibitor peptides targeting the HR1–HR2 interaction of SARS-CoV-2Electronic supplementary information (ESI) available: General information, details of synthesis of the compounds, characterization data of the compounds including MS and analytical HPLC charts to check the purity of the compounds, and data of their biological evaluation. See DOI: https://doi.org/10.1039/d2ra07356k

Authors: Tsuji, Kohei, Baffour-Awuah Owusu, Kofi, Miura, Yutaro, Ishii, Takahiro, Shinohara, Kouki, Kobayakawa, Takuya, Emi, Akino, Nakano, Takashi, Suzuki, Youichi, Tamamura, Hirokazu

Source: RSC advances. 13(13):8779-8793

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178409955.0x000001&indx=1&recIds=ETOCvdc_100178409955.0x000001

Low-molecular-weight anti-HIV-1 agents targeting HIV-1 capsid proteinsElectronic supplementary information (ESI) available: Experimental procedures including characterization data of novel synthetic compounds. See DOI: https://doi.org/10.1039/d2ra06837k

Authors: Kobayakawa, Takuya, Yokoyama, Masaru, Tsuji, Kohei, Fujino, Masayuki, Kurakami, Masaki, Onishi, Takato, Boku, Sayaka, Ishii, Takahiro, Miura, Yutaro, Shinohara, Kouki, Kishihara, Yuki, Ohashi, Nami, Kotani, Osamu, Murakami, Tsutomu, Sato, Hironori, Tamamura, Hirokazu

Source: RSC advances. 13(3):2156-2167

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173556559.0x000001&indx=1&recIds=ETOCvdc_100173556559.0x000001

Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity

Authors: Ishii, Takahiro, Kobayakawa, Takuya, Matsuda, Kouki, Tsuji, Kohei, Ohashi, Nami, Nakahata, Shingo, Noborio, Airi, Yoshimura, Kazuhisa, Mitsuya, Hiroaki, Maeda, Kenji, Tamamura, Hirokazu

Source: In European Journal of Medicinal Chemistry 5 August 2023 256

Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors

Authors: Wang, Rongyi, Tsuji, Kohei, Kobayakawa, Takuya, Liu, Yishan, Yoshimura, Kazuhisa, Matsushita, Shuzo, Harada, Shigeyoshi, Tamamura, Hirokazu

Source: In Bioorganic & Medicinal Chemistry 15 December 2022 76

Potent and biostable inhibitors of the main protease of SARS-CoV-2

Authors: Tsuji, Kohei, Ishii, Takahiro, Kobayakawa, Takuya, Higashi-Kuwata, Nobuyo, Azuma, Chika, Nakayama, Miyuki, Onishi, Takato, Nakano, Hiroki, Wada, Naoya, Hori, Miki, Shinohara, Kouki, Miura, Yutaro, Kawada, Takuma, Hayashi, Hironori, Hattori, Shin-ichiro, Bulut, Haydar, Das, Debananda, Takamune, Nobutoki, Kishimoto, Naoki, Saruwatari, Junji, Okamura, Tadashi, Nakano, Kenta, Misumi, Shogo, Mitsuya, Hiroaki, Tamamura, Hirokazu

Source: In iScience 18 November 2022 25(11)

Development of ultra-high affinity bivalent ligands targeting the polo-like kinase 1Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2cb00153ePreliminary accounts of the work has been reported: Tsuji, K.; Hymel, D.; Burke, T. R., Jr. Exploration of inhibitors targeting intramolecular protein–protein interaction.' 25th American Peptide Symposium, Whistler, Canada (June 17-22, 2017) poster P229 and Tsuji, K.; Hymel, D.; Ma, B.; Nussinov, R.; T. R. Burke, J. Unexpected findings in the development of bivalent polo-like kinase 1-binding ligands with potentially important implications. 26th American Peptide Symposium, Monterey, CA (June 22–27, 2019) poster YI-P261.

Authors: Tsuji, Kohei, Hymel, David, Ma, Buyong, Tamamura, Hirokazu, Nussinov, Ruth, Burke, Terrence R.

Source: RSC chemical biology. 3(9):1111-1120

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100159062490.0x000001&indx=1&recIds=ETOCvdc_100159062490.0x000001

Suppression of non‐small‐cell lung cancer A549 tumor growth by an mtDNA mutation‐targeting pyrrole‐imidazole polyamide‐triphenylphosphonium and a senolytic drug

Authors: Tsuji, Kohei, Kida, Yuki, Koshikawa, Nobuko, Yamamoto, Seigi, Shinozaki, Yoshinao, Watanabe, Takayoshi, Lin, Jason, Nagase, Hiroki, Takenaga, Keizo

Source: Cancer science. 113(4):1321-1337

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100146272759.0x000001&indx=1&recIds=ETOCvdc_100146272759.0x000001

Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors

Authors: Tsuji, Kohei, Kobayakawa, Takuya, Konno, Kiju, Masuda, Ami, Takahashi, Kohei, Ohashi, Nami, Yoshimura, Kazuhisa, Kuwata, Takeo, Matsushita, Shuzo, Harada, Shigeyoshi, Tamamura, Hirokazu

Source: In Bioorganic & Medicinal Chemistry 15 February 2022 56

Potent leads based on CA-19L, an anti-HIV active HIV-1 capsid fragment

Authors: Tsuji, Kohei, Wang, Rongyi, Kobayakawa, Takuya, Owusu, Kofi Baffour-Awuah, Fujino, Masayuki, Kaneko, Moemi, Yamamoto, Naoki, Murakami, Tsutomu, Tamamura, Hirokazu

Source: In Bioorganic & Medicinal Chemistry 15 January 2021 30

A linear five-ring pyrrole-imidazole polyamide-triphenylphosphonium conjugate targeting a mitochondrial DNA mutation efficiently induces apoptosis of HeLa cybrid cells carrying the mutation

Authors: Koshikawa, Nobuko, Kida, Yuki, Yasui, Nanami, Shinozaki, Yoshinao, Tsuji, Kohei, Watanabe, Takayoshi, Lin, Jason, Yamamoto, Seigi, Takenaga, Keizo, Nagase, Hiroki

Source: Biochemical and biophysical research communications. 576:93-99

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138945579.0x000001&indx=1&recIds=ETOCvdc_100138945579.0x000001

Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1, 2-diacylglycerol-lactonesElectronic supplementary information (ESI) available. See DOI: 10.1039/d1ob00814e

Authors: Tsuji, Kohei, Ishii, Takahiro, Kobayakawa, Takuya, Ohashi, Nami, Nomura, Wataru, Tamamura, Hirokazu

Source: Organic & biomolecular chemistry. 19(38):8264-8271

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131619956.0x000001&indx=1&recIds=ETOCvdc_100131619956.0x000001

Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain – binding peptide macrocyclesElectronic supplementary information (ESI) available. See DOI: 10.1039/d1ob01120k

Authors: Hymel, David, Tsuji, Kohei, Grant, Robert A., Chingle, Ramesh M., Kunciw, Dominique L., Yaffe, Michael B., Burke, Terrence R.

Source: Organic & biomolecular chemistry. 19(36):7843-7854

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130208472.0x000001&indx=1&recIds=ETOCvdc_100130208472.0x000001