YTHDC1 cooperates with the THO complex to prevent RNA-damage-induced DNA breaks

Authors: Tsao, Ning ¹, Lombardi, Patrick M. ², Park, Ajin ³, Olabode, Jennifer ¹, Rodell, Rebecca ¹, Sun, Hua ¹, Padmanaban, Shilpa ⁴, Brickner, Joshua R. ¹, Tsai, Miaw-Sheue ⁵, Pollina, Elizabeth A. ⁴, Chen, Chun-Kan ³, Mosammaparast, Nima ^{1, 6, ∗}

Source: In Molecular Cell 20 March 2025 85(6):1085-1100

ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase

Authors: Chinnam, Naga babu, Thapar, Roopa, Arvai, Andrew S., Sarker, Altaf H., Soll, Jennifer M., Paul, Tanmoy, Syed, Aleem, Rosenberg, Daniel J., Hammel, Michal, Bacolla, Albino, Katsonis, Panagiotis, Asthana, Abhishek, Tsai, Miaw-Sheue, Ivanov, Ivaylo, Lichtarge, Olivier, Silverman, Robert H., Mosammaparast, Nima, Tsutakawa, Susan E., Tainer, John A.

Source: In Journal of Biological Chemistry June 2024 300(6)

Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair

Authors: Kim, Mihyun, Kim, Hyun-Suk, D’Souza, Areetha, Gallagher, Kaitlyn, Jeong, Eunwoo, Topolska-Woś, Agnieszka, Le Meur, Kateryna Ogorodnik, Tsai, Chi-Lin, Tsai, Miaw-Sheue, Kee, Minyong, Tainer, John A., Yeo, Jung-Eun, Chazin, Walter J., Schärer, Orlando D.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Aug . 119(34), 1-12.

Access URL: https://www.jstor.org/stable/27171537

A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy

Authors: Townley, Brittany A., Buerer, Luke, Tsao, Ning, Bacolla, Albino, Mansoori, Fadhel, Rusanov, Timur, Clark, Nathaniel E., Goodarzi, Negar, Schmidt, Nicolas, Srivatsan, Sridhar Nonavinkere, Sun, Hua, Sample, Reilly A., Brickner, Joshua R., McDonald, Drew, Tsai, Miaw-Sheue, Walter, Matthew J., Wozniak, David F., Holehouse, Alex S., Pena, Vladimir, Tainer, John A., Fairbrother, William G., Mosammaparast, Nima

Source: In Molecular Cell 6 July 2023 83(13):2258-2275

Purification and Characterization of Human DNA Ligase IIIα Complexes After Expression in Insect Cells

Authors: Rashid, Ishtiaque, Tsai, Miaw-Sheue, Sverzhinsky, Aleksandr, Hlaing, Aye Su, Shih, Brian, Thwin, Aye C., Lin, Judy G., Maw, Su S., Pascal, John M., Tomkinson, Alan E.

Source: Methods in molecular biology. 2444:243-270

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628969575&indx=1&recIds=ETOCRN628969575

Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations

Authors: Tsutakawa, Susan E., Sarker, Altaf H., Ng, Clifford, Arvai, Andrew S., Shin, David S., Shih, Brian, Jiang, Shuai, Thwin, Aye C., Tsai, Miaw-Sheue, Willcox, Alexandra, Her, Mai Zong, Trego, Kelly S., Raetz, Alan G., Rosenberg, Daniel, Bacolla, Albino, Hammel, Michal, Griffith, Jack D., Cooper, Priscilla K., Tainer, John A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Jun . 117(25), 14127-14138.

Access URL: https://www.jstor.org/stable/26934940

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

Authors: Rashid, Ishtiaque, Hammel, Michal, Sverzhinsky, Aleksandr, Tsai, Miaw-Sheue, Pascal, John M., Tainer, John A., Tomkinson, Alan E.

Source: In Journal of Biological Chemistry August 2021 297(2)

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex

Authors: Hammel, Michal, Yu, Yaping, Radhakrishnan, Sarvan K., Chokshi, Chirayu, Tsai, Miaw-Sheue, Matsumoto, Yoshihiro, Kuzdovich, Monica, Remesh, Soumya G., Fang, Shujuan, Tomkinson, Alan E., Lees-Miller, Susan P., Tainer, John A.

Source: In Journal of Biological Chemistry December 2016 291(53):26987-27006

Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability

Authors: Trego, Kelly S., Groesser, Torsten, Davalos, Albert R., Parplys, Ann C., Zhao, Weixing, Nelson, Michael R., Hlaing, Ayesu, Shih, Brian, Rydberg, Björn, Pluth, Janice M., Tsai, Miaw-Sheue, Hoeijmakers, Jan H.J., Sung, Patrick, Wiese, Claudia, Campisi, Judith, Cooper, Priscilla K.

Source: In Molecular Cell 18 February 2016 61(4):535-546

Structure of RADX and mechanism for regulation of RAD51 nucleofilaments.

Authors: Balakrishnan, Swati, Adolph, Madison, Tsai, Miaw-Sheue, Akizuki, Tae, Gallagher, Kaitlyn, Cortez, David, Chazin, Walter J.

Source: Proceedings of the National Academy of Sciences of the United States of America; 3/19/2024, Vol. 121 Issue 12, p1-12, 39p

Subject Terms: MOLECULAR structure, X chromosome, SINGLE-stranded DNA, DNA damage, FIBERS

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.

Authors: Syed, Aleem, Filandr, Frantisek, Patterson-Fortin, Jeffrey, Bacolla, Albino, Ravindranathan, Ramya, Zhou, Jia, McDonald, Drew T, Albuhluli, Mohammed E, Verway-Cohen, Amy, Newman, Joseph A, Tsai, Miaw-Sheue, Jones, Darin E, Schriemer, David C, D'Andrea, Alan D, Tainer, John A

Source: Nucleic Acids Research; 10/13/2023, Vol. 51 Issue 18, p9920-9937, 18p

Xeroderma pigmentosum complementation group C protein (XPC) serves as a general sensor of damaged DNA

Authors: Shell, Steven M., Hawkins, Edward K., Tsai, Miaw-Sheue, Hlaing, Aye Su, Rizzo, Carmelo J., Chazin, Walter J.

Source: In DNA Repair November 2013 12(11):947-953

The Interaction between Polynucleotide Kinase Phosphatase and the DNA Repair Protein XRCC1 Is Critical for Repair of DNA Alkylation Damage and Stable Association at DNA Damage Sites

Authors: Della-Maria, Julie, Hegde, Muralidhar L., McNeill, Daniel R., Matsumoto, Yoshihiro, Tsai, Miaw-Sheue ^**, Ellenberger, Tom, Wilson, David M., III, Mitra, Sankar, Tomkinson, Alan E.

Source: In Journal of Biological Chemistry 9 November 2012 287(46):39233-39244

Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability

Authors: Querol-Audí, Jordi, Yan, Chunli, Xu, Xiaojun, Tsutakawa, Susan E., Tsai, Miaw-Sheue, Tainer, John A., Cooper, Priscilla K., Nogales, Eva, Ivanov, Ivaylo

Source: Proceedings of the National Academy of Sciences of the United States of America, 2012 May . 109(22), 8528-8533.

Access URL: https://www.jstor.org/stable/41602589

Mechanistic Insights into RAD51-associated Protein 1 (RAD51AP1) Action in Homologous DNA Repair

Authors: Dunlop, Myun Hwa, Dray, Eloïse, Zhao, Weixing, San Filippo, Joseph, Tsai, Miaw-Sheue, Leung, Stanley G., Schild, David, Wiese, Claudia, Sung, Patrick

Source: In Journal of Biological Chemistry 6 April 2012 287(15):12343-12347

Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1)

Authors: Dray, Eloïse, Dunlop, Myun Hwa, Kauppi, Liisa, San Filippo, Joseph, Wiese, Claudia, Tsai, Miaw-Sheue, Begovic, Sead, Schild, David, Jasin, Maria, Keeney, Scott, Sung, Patrick, Kowalczykowski, Stephen C.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2011 Mar 01. 108(9), 3560-3565.

Access URL: https://www.jstor.org/stable/41060971

RAD51-associated Protein 1 (RAD51AP1) Interacts with the Meiotic Recombinase DMC1 through a Conserved Motif

Authors: Dunlop, Myun Hwa, Dray, Eloïse, Zhao, Weixing, Tsai, Miaw-Sheue, Wiese, Claudia, Schild, David, Sung, Patrick

Source: In Journal of Biological Chemistry 28 October 2011 286(43):37328-37334

Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway

Authors: Della-Maria, Julie, Zhou, Yi, Tsai, Miaw-Sheue, Kuhnlein, Jeff, Carney, James P., Paull, Tanya T., Tomkinson, Alan E.

Source: In Journal of Biological Chemistry 30 September 2011 286(39):33845-33853

MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ

Authors: Iyer, Ravi R., Pluciennik, Anna, Genschel, Jochen, Tsai, Miaw-Sheue, Beese, Lorena S., Modrich, Paul

Source: In Journal of Biological Chemistry 9 April 2010 285(15):11730-11739

The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome

Authors: Trego, Kelly S., Chernikova, Sophia B., Davalos, Albert R., Perry, J. Jefferson P., Finger, L. David, Ng, Cliff, Tsai, Miaw-Sheue, Yannone, Steven M., Tainer, John A., Campisi, Judith, Cooper, Priscilla K.

Source: Cell cycle. 10(12):1998-2007

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100050661722.0x000001&indx=1&recIds=ETOCvdc_100050661722.0x000001