Repurposing of Food and Drug Admnistration (FDA) approved library to identify a potential inhibitor of trypanothione synthetase for developing an antileishmanial agent

Authors: Vemula, Divya ¹, Mohanty, Shreelekha ¹, Bhandari, Vasundhra ^⁎

Source: In Heliyon 30 March 2024 10(6)

Targeting Trypanothione Metabolism in Trypanosomatids

Authors: María-Cristina González-Montero, Julia Andrés-Rodríguez, Nerea García-Fernández, Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Carlos García-Estrada

Source: Molecules, Vol 29, Iss 10, p 2214 (2024)

Subject Terms: trypanothione, redox metabolism, oxidative stress, trypanosomatids, trypanothione reductase, trypanothione synthetase, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/10/2214; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/e500faf17275494eaf64e296fef2bc03

Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

Authors: Diego Benítez, Jaime Franco, Florencia Sardi, Alejandro Leyva, Rosario Durán, Gahee Choi, Gyongseon Yang, Taehee Kim, Namyoul Kim, Jinyeong Heo, Kideok Kim, Honggun Lee, Inhee Choi, Constantin Radu, David Shum, Joo Hwan No, Marcelo A. Comini

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 912-929 (2022)

Subject Terms: Trypanothione synthetase, Leishmania, Trypanosoma, covalent inhibitor, non-competitive inhibition, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/d6287e9bbb0746028794672207991f63

Screening and identification of potential inhibitor for visceral leishmaniasis (VL) through computational analysis

Authors: N. Shaslinah, P. Sangavi, R. Sangeetha, S. Gowthamkumar, V. Sindhu, K. Langeswaran

Source: Journal of Genetic Engineering and Biotechnology, Vol 20, Iss 1, Pp 1-12 (2022)

Subject Terms: Trypanothione synthetase, CASTp, Visceral leishmaniasis, Molecular docking, Molecular dynamics, Binding free energy, Biotechnology, TP248.13-248.65, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/2090-5920

Access URL: https://doaj.org/article/0415a0c8d766402cad951987637f24a8

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Authors: Andrea Medeiros, Diego Benítez, Ricarda S. Korn, Vinicius C. Ferreira, Exequiel Barrera, Federico Carrión, Otto Pritsch, Sergio Pantano, Conrad Kunick, Camila I. de Oliveira, Oliver C. F. Orban, Marcelo A. Comini

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1345-1358 (2020)

Subject Terms: paullone, trypanothione synthetase, leishmania, thiol, inhibition mode, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Access URL: https://doaj.org/article/c7e8b72ceda647528cd31f98709c09d0

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