NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

Authors: Sun, Congxin, Seranova, Elena, Cohen, Malkiel A., Chipara, Miruna, Roberts, Jennie, Astuti, Dewi, Palhegyi, Adina M., Acharjee, Animesh, Sedlackova, Lucia, Kataura, Tetsushi, Otten, Elsje G., Panda, Prashanta K., Lara-Reyna, Samuel, Korsgen, Miriam E., Kauffman, Kevin J., Huerta-Uribe, Alejandro, Zatyka, Malgorzata, Silva, Luiz F.S.E., Torresi, Jorge, Zhang, Shupei, Hughes, Georgina W., Ward, Carl, Kuechler, Erich R., Cartwright, David, Trushin, Sergey, Trushina, Eugenia, Sahay, Gaurav, Buganim, Yosef, Lavery, Gareth G., Gsponer, Joerg, Anderson, Daniel G., Frickel, Eva-Maria, Rosenstock, Tatiana R., Barrett, Timothy, Maddocks, Oliver D.K., Tennant, Daniel A., Wang, Haoyi, Jaenisch, Rudolf, Korolchuk, Viktor I., Sarkar, Sovan

Source: In Cell Reports 30 May 2023 42(5)

Autophagy promotes cell survival by maintaining NAD levels

Authors: Kataura, Tetsushi, Sedlackova, Lucia, Otten, Elsje G., Kumari, Ruchika, Shapira, David, Scialo, Filippo, Stefanatos, Rhoda, Ishikawa, Kei-ichi, Kelly, George, Seranova, Elena, Sun, Congxin, Maetzel, Dorothea, Kenneth, Niall, Trushin, Sergey, Zhang, Tong, Trushina, Eugenia, Bascom, Charles C., Tasseff, Ryan, Isfort, Robert J., Oblong, John E., Miwa, Satomi, Lazarou, Michael, Jaenisch, Rudolf, Imoto, Masaya, Saiki, Shinji, Papamichos-Chronakis, Manolis, Manjithaya, Ravi, Maddocks, Oliver D.K., Sanz, Alberto, Sarkar, Sovan, Korolchuk, Viktor I.

Source: In Developmental Cell 21 November 2022 57(22):2584-2598

Mitochondrial complex I as a therapeutic target for Alzheimer's disease

Authors: Trushina, Eugenia, Trushin, Sergey, Hasan, Md Fayad

Source: Acta pharmaceutica sinica B. 12(2):483-495

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158505674.0x000001&indx=1&recIds=ETOCvdc_100158505674.0x000001

A genome-wide association study in human lymphoblastoid cells supports safety of mitochondrial complex I inhibitor

Authors: Gao, Huanyao, Tripathi, Utkarsh, Trushin, Sergey, Okromelidze, Lela, Pichurin, Nicholas P., Wei, Lixuan, Zhuang, Yongxian, Wang, Liewei, Trushina, Eugenia

Source: In Mitochondrion May 2021 58:83-94

The large Bakyrchik orogenic gold deposit, eastern Kazakhstan: Geology, mineralization, fluid inclusion, and stable isotope characteristics

Authors: Soloviev, Serguei G., Kryazhev, Sergey G., Dvurechenskaya, Svetlana S., Trushin, Sergey I.

Source: In Ore Geology Reviews December 2020 127

A Comprehensive Approach to Sample Preparation for Electron Microscopy and the Assessment of Mitochondrial Morphology in Tissue and Cultured Cells

Authors: Hinton, Antentor, Katti, Prasanna, Christensen, Trace A., Mungai, Margaret, Shao, Jianqiang, Zhang, Liang, Trushin, Sergey, Alghanem, Ahmad, Jaspersen, Adam, Geroux, Rachel E., Neikirk, Kit, Biete, Michelle, Lopez, Edgar Garza, Shao, Bryanna, Vue, Zer, Vang, Larry, Beasley, Heather K., Marshall, Andrea G., Stephens, Dominique, Damo, Steven, Ponce, Jessica, Bleck, Christopher K. E., Hicsasmaz, Innes, Murray, Sandra A., Edmonds, Ranthony A. C., Dajles, Andres, Koo, Young Do, Bacevac, Serif, Salisbury, Jeffrey L., Pereira, Renata O., Glancy, Brian, Trushina, Eugenia, Abel, E. Dale

Source: Advanced biology. 7(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196434373.0x000001&indx=1&recIds=ETOCvdc_100196434373.0x000001

Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane

Authors: Zhang, Liang, Trushin, Sergey, Christensen, Trace A., Tripathi, Utkarsh, Hong, Courtney, Geroux, Rachel E., Howell, Kyle G., Poduslo, Joseph F., Trushina, Eugenia

Source: In Neurobiology of Disease June 2018 114:1-16

Development of Novel Partial Mitochondrial Complex I Inhibitors as a Therapy for Alzheimer Disease.

Authors: Trushin, Sergey, Stojakovic, Andrea, Chang, Su‐Youne, Macura, Slobodan, Trushina, Eugenia

Source: Alzheimer's & dementia. 18(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176997418.0x000001&indx=1&recIds=ETOCvdc_100176997418.0x000001

Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models.

Authors: Kataura, Tetsushi, Sedlackova, Lucia, Sun, Congxin, Kocak, Gamze, Wilson, Niall, Banks, Peter, Hayat, Faisal, Trushin, Sergey, Trushina, Eugenia, Maddocks, Oliver D. K., Oblong, John E., Miwa, Satomi, Imoto, Masaya, Saiki, Shinji, Erskine, Daniel, Migaud, Marie E., Sarkar, Sovan, Korolchuk, Viktor I.

Source: Cell Death & Disease; May2024, Vol. 15 Issue 5, p1-13, 13p

Numerical Evaluation of Stress-Strain State of Bending Plates Based on Various Models

Authors: Trushin, Sergey, Goryachkin, Dmitry

Source: In Procedia Engineering 2016 153:781-784

Author Correction: Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice.

Authors: Stojakovic, Andrea¹ (AUTHOR), Trushin, Sergey¹ (AUTHOR), Sheu, Anthony² (AUTHOR), Khalili, Layla¹ (AUTHOR), Chang, Su-Youne^3,4 (AUTHOR), Li, Xing⁵ (AUTHOR), Christensen, Trace⁶ (AUTHOR), Salisbury, Jeffrey L.^6,7 (AUTHOR), Geroux, Rachel E.¹ (AUTHOR), Gateno, Benjamin¹ (AUTHOR), Flannery, Padraig J.¹ (AUTHOR), Dehankar, Mrunal⁵ (AUTHOR), Funk, Cory C.⁸ (AUTHOR), Wilkins, Jordan¹ (AUTHOR), Stepanova, Anna⁹ (AUTHOR), O'Hagan, Tara⁹ (AUTHOR), Galkin, Alexander⁹ (AUTHOR), Nesbitt, Jarred¹ (AUTHOR), Zhu, Xiujuan¹ (AUTHOR), Tripathi, Utkarsh¹ (AUTHOR)

Source: Communications Biology. 2/26/2024, Vol. 7 Issue 1, p1-9. 9p.

Subject Terms: *ALZHEIMER'S disease, *PATHOLOGY, *MICE, *AMYLOID beta-protein precursor, *MITOCHONDRIA, *GLUCOSE transporters

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Authors: Zhang, Liang, Zhang, Song, Maezawa, Izumi, Trushin, Sergey, Minhas, Paras, Pinto, Matthew, Jin, Lee-Way, Prasain, Keshar, Nguyen, Thi D.T., Yamazaki, Yu, Kanekiyo, Takahisa, Bu, Guojun, Gateno, Benjamin, Chang, Kyeong-Ok, Nath, Karl A., Nemutlu, Emirhan, Dzeja, Petras, Pang, Yuan-Ping, Hua, Duy H., Trushina, Eugenia

Source: In EBioMedicine April 2015 2(4):294-305

Partial inhibition of mitochondrial complex I ameliorates Alzheimer's disease pathology and cognition in APP/PS1 female mice

Authors: Stojakovic, Andrea, Trushin, Sergey, Sheu, Anthony, Khalili, Layla, Chang, Su-Youne, Li, Xing, Christensen, Trace, Salisbury, Jeffrey L., Geroux, Rachel E., Gateno, Benjamin, Flannery, Padraig J., Dehankar, Mrunal, Funk, Cory C., Wilkins, Jordan, Stepanova, Anna, O'Hagan, Tara, Galkin, Alexander, Nesbitt, Jarred, Zhu, Xiujuan, Tripathi, Utkarsh, Macura, Slobodan, Tchkonia, Tamar, Pirtskhalava, Tamar, Kirkland, James L., Kudgus, Rachel A., Schoon, Renee A., Reid, Joel M., Yamazaki, Yu, Kanekiyo, Takahisa, Zhang, Song, Nemutlu, Emirhan, Dzeja, Petras, Jaspersen, Adam, Kwon, Ye In Christopher, Lee, Michael K., Trushina, Eugenia

Source: Communications biology. 4(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191107488.0x000001&indx=1&recIds=ETOCvdc_100191107488.0x000001

Immunologic and mass-spectrometric estimates of SHBG concentrations in healthy women

Authors: Veldhuis, Johannes D., Dyer, Roy B., Trushin, Sergey A., Bondar, Olga P., Singh, Ravinder J., Klee, George G.

Source: In Metabolism June 2014 63(6):783-792

Structure‐activity relationship study of neuroprotective complex I inhibitor CP2.

Authors: Petrova, Olga, Trushin, Sergey A, Nguyen, Thi Kim Oanh, Ostroot, Mark, Schellenberg, Matthew, Johnson, Graham, Trushina, Eugenia, Sazanov, Leonid

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2024 Supplement 6, Vol. 20 Issue S6, p1-2, 2p

Mild inhibition of mitochondrial complex I improves glucose metabolism and energy homeostasis in a cellular model of Alzheimer's disease.

Authors: Nguyen, Thi Kim Oanh, Trushin, Sergey A, Ostroot, Mark, Trushina, Eugenia

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2024 Supplement 1, Vol. 20, p1-2, 2p

Isolation of a TRAIL Antagonist from the Serum of HIV-infected Patients

Authors: Schnepple, David J., Shepard, Brett, Bren, Gary D., Cummins, Nathan W., Natesampillai, Sekar, Trushin, Sergey, Algeciras-Schimnich, Alicia, Meng, Xue W., Sainski, Amy M. ^**, Rizza, Stacey A., Kaufmann, Scott H. ^**, Badley, Andrew D.

Source: In Journal of Biological Chemistry 14 October 2011 286(41):35742-35754

Serum Concentrations of Prostate-Specific Antigen Measured Using Immune Extraction, Trypsin Digestion, and Tandem Mass Spectrometry Quantification of LSEPAELTDAVK Peptide

Authors: Klee, Eric W., Bondar, Olga P., Goodmanson, Marcia K., Trushin, Sergey A., Bergstralh, Eric J., Singh, Ravinder J., Anderson, N. Leigh, Klee, George G.

Source: Archives of pathology & laboratory medicine. 138(10):1381-1386

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN600262012&indx=1&recIds=ETOCRN600262012

Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice.

Authors: Panes, Jessica, Nguyen, Thi Kim Oanh, Gao, Huanyao, Christensen, Trace A., Stojakovic, Andrea, Trushin, Sergey, Salisbury, Jeffrey L., Fuentealba, Jorge, Trushina, Eugenia

Source: Cells (2073-4409); Apr2023, Vol. 12 Issue 8, p1111, 24p

Subject Terms: HOMEOSTASIS, UNFOLDED protein response, MITOCHONDRIA, ARTIFICIAL membranes, OXYGEN consumption, MORPHOLOGY, ALZHEIMER'S disease, WESTERN immunoblotting

Protein Kinase Cβ Modulates Ligand-induced Cell Surface Death Receptor Accumulation: A MECHANISTIC BASIS FOR ENZASTAURIN-DEATH LIGAND SYNERGY

Authors: Meng, Xue Wei, Heldebrant, Michael P., Flatten, Karen S., Loegering, David A., Dai, Haiming, Schneider, Paula A., Gomez, Timothy S., Peterson, Kevin L., Trushin, Sergey A., Hess, Allan D. ^**, Smith, B. Douglas ^**, Karp, Judith E. ^**, Billadeau, Daniel D., Kaufmann, Scott H.

Source: In Journal of Biological Chemistry 8 January 2010 285(2):888-902