Effect of substituents at the C3´, C3´N, C10 and C2-meta-benzoate positions of taxane derivatives on their activity against resistant cancer cells

Authors: Daniel, Petr, Balušíková, Kamila, Truksa, Jaroslav, Černý, Jiří, Jaček, Martin, Jelínek, Michael, Mulenga, Mutale Jane Vobruba, Voráčová, Kateřina, Chen, Lei, Wei, Longfei, Sun, Yi, Ojima, Iwao, Kovář, Jan

Source: In Toxicology and Applied Pharmacology August 2024 489

Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma

Authors: Sychra, Tomas ^{1, 2}, Spalenkova, Alzbeta ^{3, 4}, Balatka, Stepan ^{3, 4}, Vaclavikova, Radka ^{3, 4}, Seborova, Karolina ^{3, 4}, Ehrlichova, Marie ^{3, 4}, Truksa, Jaroslav ⁵, Sandoval-Acuña, Cristian ⁵, Nemcova, Vlasta ⁶, Szabo, Arpad ^{2, 7}, Koci, Kamila ², Tesarova, Tereza ^{3, 4}, Chen, Lei ⁸, Ojima, Iwao ⁸, Oliverius, Martin ^{1, 2}, Soucek, Pavel ^{3, 4, 9, ∗}

Source: In iScience 16 February 2024 27(2)

Mitochondrial fragmentation, elevated mitochondrial superoxide and respiratory supercomplexes disassembly is connected with the tamoxifen-resistant phenotype of breast cancer cells

Authors: Tomková, Veronika, Sandoval-Acuña, Cristian, Torrealba, Natalia, Truksa, Jaroslav

Source: In Free Radical Biology and Medicine 1 November 2019 143:510-521

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Authors: Bajzikova, Martina, Kovarova, Jaromira, Coelho, Ana R., Boukalova, Stepana, Oh, Sehyun, Rohlenova, Katerina, Svec, David, Hubackova, Sona, Endaya, Berwini, Judasova, Kristyna, Bezawork-Geleta, Ayenachew, Kluckova, Katarina, Chatre, Laurent, Zobalova, Renata, Novakova, Anna, Vanova, Katerina, Ezrova, Zuzana, Maghzal, Ghassan J., Magalhaes Novais, Silvia, Olsinova, Marie, Krobova, Linda, An, Yong Jin, Davidova, Eliska, Nahacka, Zuzana, Sobol, Margarita, Cunha-Oliveira, Teresa, Sandoval-Acuña, Cristian, Strnad, Hynek, Zhang, Tongchuan, Huynh, Thanh, Serafim, Teresa L., Hozak, Pavel, Sardao, Vilma A., Koopman, Werner J.H., Ricchetti, Miria, Oliveira, Paulo J., Kolar, Frantisek, Kubista, Mikael, Truksa, Jaroslav, Dvorakova-Hortova, Katerina, Pacak, Karel, Gurlich, Robert, Stocker, Roland, Zhou, Yaoqi, Berridge, Michael V., Park, Sunghyouk, Dong, Lanfeng, Rohlena, Jakub, Neuzil, Jiri

Source: In Cell Metabolism 5 February 2019 29(2):399-416

Acquisition of respiration-competent mitochondria is necessary for glioblastoma formation

Authors: Zobalová, Renata, Brisudová, Petra, Novák, Jaromír, Nahácka, Zuzana, Oliveira, Gabriela Lopes, Dvořáková, Šárka, Truksa, Jaroslav, Neužil, Jiří

Source: In BBA - Molecular Basis of Disease December 2024 1870(8)

Metabolic Changes in Breast Cancer Cells: The Role of Glycerolipid Metabolism in the Development of Tamoxifen Resistance

Authors: Baslarová, Kamila, Gotvaldová, Klára, Špačková, Jitka, Truksa, Jaroslav, Smolková, Katarína

Source: In BBA - Bioenergetics 1 September 2024 1865 Supplement

Erythropoietin administration increases splenic erythroferrone protein content and liver TMPRSS6 protein content in rats

Authors: Gurieva, Iuliia, Frýdlová, Jana, Rychtarčíková, Zuzana, Vokurka, Martin, Truksa, Jaroslav, Krijt, Jan

Source: In Blood Cells, Molecules and Diseases May 2017 64:1-7

NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation.

Authors: Jadhav, Sukanya B., Vondrackova, Michaela, Potomova, Petra, Sandoval-Acuña, Cristian, Smigova, Jana, Klanicova, Kristyna, Rosel, Daniel, Brabek, Jan, Stursa, Jan, Werner, Lukas, Truksa, Jaroslav

Source: Frontiers in Pharmacology; 2024, p01-17, 17p

Subject Terms: TRIPLE-negative breast cancer, CHELATION, ONCOGENES, IRON chelates, MITOCHONDRIA

MiR-301a-3p Suppresses Estrogen Signaling by Directly Inhibiting ESR1 in ERα Positive Breast Cancer

Authors: Lettlova, Sandra, Brynychova, Veronika, Blecha, Jan, Vrana, David, Vondrusova, Magdalena, Soucek, Pavel, Truksa, Jaroslav

Source: Cellular physiology and biochemistry. 46(6):2601-2615

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087397412.0x000001&indx=1&recIds=ETOCvdc_100087397412.0x000001

Chelation of Mitochondrial Iron as an Antiparasitic Strategy.

Authors: Arbon, Dominik, Mach, Jan, Čadková, Aneta, Sipkova, Anna, Stursa, Jan, Klanicová, Kristýna, Machado, Marta, Ganter, Markus, Levytska, Viktoriya, Sojka, Daniel, Truksa, Jaroslav, Werner, Lukáš, Sutak, Robert

Source: ACS Infectious Diseases; 2/9/2024, Vol. 10 Issue 2, p676-687, 12p

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

Authors: Tan, An S., Baty, James W., Dong, Lan-Feng, Bezawork-Geleta, Ayenachew, Endaya, Berwini, Goodwin, Jacob, Bajzikova, Martina, Kovarova, Jaromira, Peterka, Martin, Yan, Bing, Pesdar, Elham Alizadeh, Sobol, Margarita, Filimonenko, Anatolyj, Stuart, Shani, Vondrusova, Magdalena, Kluckova, Katarina, Sachaphibulkij, Karishma, Rohlena, Jakub, Hozak, Pavel, Truksa, Jaroslav, Eccles, David, Haupt, Larisa M., Griffiths, Lyn R., Neuzil, Jiri, Berridge, Michael V.

Source: In Cell Metabolism 6 January 2015 21(1):81-94

Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans

Authors: Stapelberg, Michael, Zobalova, Renata, Nguyen, Maria Nga, Walker, Tom, Stantic, Marina, Goodwin, Jacob, Pasdar, Elham Alizadeh, Thai, Thuan, Prokopova, Katerina, Yan, Bing, Hall, Susan, de Pennington, Nicholas, Thomas, Shane R., Grant, Gary, Stursa, Jan, Bajzikova, Martina, Meedeniya, Adrian C.B., Truksa, Jaroslav, Ralph, Stephen J., Ansorge, Olaf, Dong, Lan-Feng, Neuzil, Jiri

Source: In Free Radical Biology and Medicine February 2014 67:41-50

Classification of mitocans, anti-cancer drugs acting on mitochondria

Authors: Neuzil, Jiri, Dong, Lan-Feng, Rohlena, Jakub, Truksa, Jaroslav, Ralph, Stephen J.

Source: In Mitochondrion May 2013 13(3):199-208

The Effect of Mitochondrially Targeted Anticancer Agents on Mitochondrial (Super)Complexes

Authors: Vondrusova, Magdalena, Bezawork-Geleta, Ayanachew, Sachaphibulkij, Karishma, Truksa, Jaroslav, Neuzil, Jiri

Source: Methods in molecular biology. 1265:195-208

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN600484965&indx=1&recIds=ETOCRN600484965

Mitochondrially targeted tamoxifen as anticancer therapy: case series of patients with renal cell carcinoma treated in a phase I/Ib clinical trial.

Authors: Bielcikova, Zuzana, Werner, Lukas, Stursa, Jan, Cerny, Vladimir, Krizova, Ludmila, Spacek, Jan, Hlousek, Stanislav, Vocka, Michal, Bartosova, Olga, Pesta, Michal, Kolostova, Katarina, Klezl, Petr, Bobek, Vladimir, Truksa, Jaroslav, Stemberkova-Hubackova, Sona, Petruzelka, Lubos, Michalek, Pavel, Neuzil, Jiri

Source: Therapeutic Advances in Medical Oncology; 9/30/2023, p1-14, 14p

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

Authors: Du, Xin, She, Ellen, Gelbart, Terri, Truksa, Jaroslav, Lee, Pauline, Xia, Yu, Khovananth, Kevin, Mudd, Suzanne, Mann, Navjiwan, Moresco, Eva Marie Y., Beutler, Ernest, Beutler, Bruce

Source: Science, 2008 May . 320(5879), 1088-1092.

Access URL: https://www.jstor.org/stable/20054798

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

Authors: Dong, Lan-Feng, Jameson, Victoria J.A., Tilly, David, Prochazka, Lubomir, Rohlena, Jakub, Valis, Karel, Truksa, Jaroslav, Zobalova, Renata, Mahdavian, Elahe, Kluckova, Katarina, Stantic, Marina, Stursa, Jan, Freeman, Ruth, Witting, Paul K., Norberg, Erik, Goodwin, Jacob, Salvatore, Brian A., Novotna, Jana, Turanek, Jaroslav, Ledvina, Miroslav, Hozak, Pavel, Zhivotovsky, Boris, Coster, Mark J., Ralph, Stephen J., Smith, Robin A.J., Neuzil, Jiri

Source: In Free Radical Biology and Medicine 1 June 2011 50(11):1546-1555

Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II

Authors: Dong, Lan-Feng, Jameson, Victoria J.A., Tilly, David, Cerny, Jiri, Mahdavian, Elahe, Marín-Hernández, Alvaro, Hernández-Esquivel, Luz, Rodríguez-Enríquez, Sara, Stursa, Jan, Witting, Paul K., Stantic, Bela, Rohlena, Jakub, Truksa, Jaroslav, Kluckova, Katarina, Dyason, Jeffrey C., Ledvina, Miroslav, Salvatore, Brian A., Moreno-Sánchez, Rafael, Coster, Mark J., Ralph, Stephen J., Smith, Robin A.J., Neuzil, Jiri

Source: In Journal of Biological Chemistry 4 February 2011 286(5):3717-3728

Mitochondrial targeting of α-tocopheryl succinate enhances its anti-mesothelioma efficacy

Authors: Kovarova, Jaromira, Bajzikova, Martina, Vondrusova, Magdalena, Stursa, Jan, Goodwin, Jacob, Nguyen, Maria, Zobalova, Renata, Pesdar, Elham Alizadeh, Truksa, Jaroslav, Tomasetti, Marco, Dong, Lan-Feng, Neuzil, Jiri

Source: Redox report. 19(1):16-25

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108754955.0x000001&indx=1&recIds=ETOCvdc_100108754955.0x000001

Bone Morphogenetic Proteins 2, 4, and 9 Stimulate Murine Hepcidin 1 Expression Independently of Hfe, Transferrin Receptor 2 (Tfr2), and IL-6

Authors: Truksa, Jaroslav, Peng, Hongfan, Lee, Pauline, Beutler, Ernest

Source: Proceedings of the National Academy of Sciences of the United States of America, 2006 Jul 01. 103(27), 10289-10293.

Access URL: https://www.jstor.org/stable/30049616