Spatial transcriptomics reveals profound subclonal heterogeneity and T-cell dysfunction in extramedullary myeloma

Authors: John, Mara, Helal, Moutaz, Duell, Johannes, Mattavelli, Greta, Stanojkovska, Emilia, Afrin, Nazia, Leipold, Alexander M., Steinhardt, Maximilian J., Zhou, Xiang, Žihala, David, Anilkumar Sithara, Anjana, Mersi, Julia, Waldschmidt, Johannes M., Riedhammer, Christine, Kadel, Sofie-Katrin, Truger, Marietta, Werner, Rudolf A., Haferlach, Claudia, Einsele, Hermann, Kretzschmar, Kai, Jelínek, Tomáš, Rosenwald, Andreas, Kortüm, K. Martin, Riedel, Angela, Rasche, Leo

Source: In Blood 14 November 2024 144(20):2121-2135

Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022

Authors: Baumgartner, Francis, Baer, Constance, Bamopoulos, Stefanos, Ayoub, Edward, Truger, Marietta, Meggendorfer, Manja, Lenk, Miriam, Hoermann, Gregor, Hutter, Stephan, Müller, Heiko, Walter, Wencke, Müller, Martha-Lena, Nadarajah, Niroshan, Blombery, Piers, Keller, Ulrich, Kern, Wolfgang, Haferlach, Claudia, Haferlach, Torsten

Source: In Blood 21 March 2024 143(12):1139-1156

Combining SKY92 gene expression profiling and FISH (according to R2‐ISS) defines ultra‐high‐risk Multiple Myeloma.

Authors: Zhou, Xiang, Hofmann, Annika, Engel, Benedict, Vogt, Cornelia, Nerreter, Silvia, Tamamushi, Yoko, Schmitt, Friederike, leberzammer, Maria, Stanojkovska, Emilia, Truger, Marietta, Xiao, Xianghui, Riedhammer, Christine, Steinhardt, Maximilian J., John, Mara, Mersi, Julia, Han, Seungbin, Munawar, Umair, Waldschmidt, Johannes M., Haferlach, Claudia, Einsele, Hermann

Source: HemaSphere; Jan2025, Vol. 9 Issue 1, p1-11, 11p

Impaired FADD/BID signaling mediates cross-resistance to immunotherapy in Multiple Myeloma.

Authors: Munawar, Umair, Zhou, Xiang, Prommersberger, Sabrina, Nerreter, Silvia, Vogt, Cornelia, Steinhardt, Maximilian J., Truger, Marietta, Mersi, Julia, Teufel, Eva, Han, Seungbin, Haertle, Larissa, Banholzer, Nicole, Eiring, Patrick, Danhof, Sophia, Navarro-Aguadero, Miguel Angel, Fernandez-Martin, Adrian, Ortiz-Ruiz, Alejandra, Barrio, Santiago, Gallardo, Miguel, Valeri, Antonio

Source: Communications Biology; 12/21/2023, Vol. 6 Issue 1, p1-9, 9p

Subject Terms: MULTIPLE myeloma, DEATH receptors, IMMUNOTHERAPY, MONOCLONAL antibodies, LYMPHOBLASTIC leukemia, DISEASE relapse, GENETIC toxicology

Activation of Phenylalanine Hydroxylase Induces Positive Cooperativity toward the Natural Cofactor

Authors: Gersting, Søren W., Staudigl, Michael, Truger, Marietta S., Messing, Dunja D., Danecka, Marta K., Sommerhoff, Christian P., Kemter, Kristina F., Muntau, Ania C.

Source: In Journal of Biological Chemistry 1 October 2010 285(40):30686-30697

Single- and double-hit events in genes encoding immune targets before and after T cell–engaging antibody therapy in MM

Authors: Truger, Marietta S., Duell, Johannes, Zhou, Xiang, Heimeshoff, Larissa, Ruckdeschel, Anna, John, Mara, Riedel, Angela, Hüper, Sebastian, Peter, Jessica, Walter, Wencke, Haertle, Larissa, Meggendorfer, Manja, Topp, Max S., Rosenwald, Andreas, Da Via, Matteo Claudio, Bolli, Niccolo, Weinhold, Niels, Einsele, Hermann, Haferlach, Claudia, Kortüm, K. Martin ^*, Rasche, Leo ^{*, *}

Source: In Blood Advances 12 October 2021 5(19):3794-3798

Functional Characterization of GPRC5D alteration and Its Impact on Talquetamab Resistance in Relapsed/ Refractory Multiple Myeloma

Authors: Han, Seungbin, Munawar, Umair, Haertle, Larissa, Vogt, Cornelia, Nerreter, Silvia, Teufel, Eva, Zhou, Xiang, Steinhardt, Max, Eisele, Florian, Raab, Peter, Truger, Marietta, Dorado, Sara, Barrio, Santiago, Haferlach, Claudia, Martínez-López, Joaquin, Einsele, Hermann, Rasche, Leo, Waldschmidt, Johannes M, Kortüm, K. Martin

Source: In Blood 28 November 2023 142 Supplement 1:3323-3323

P-417 SKY92 gene expression profiling and cytogenetics according to R2-ISS for multiple myeloma risk classification

Authors: Zhou, Xiang, Engel, Benedict, Hofmann, Annika, Vogt, Cornelia, Nerreter, Silvia, Teufel, Eva, Stanojkovska, Emilia, Truger, Marietta, Xiao, Xianghui, Riedhammer, Christine, Munawar, Umair, Han, Seungbin, Haertle, Larissa, Haferlach, Claudia, Einsele, Hermann, Rasche, Leo, Kortüm, Martin

Source: In Clinical Lymphoma, Myeloma and Leukemia September 2023 23 Supplement 2:S271-S271

P-027 Hotspot mutations in BCMA extracellular domain lead to differential susceptibility to anti-BCMA targeted immunotherapies

Authors: Lee, Holly, Ahn, Sungwoo, Maity, Ranjan, Leblay, Noemie, Ziccheddu, Bachisio, Truger, Marietta, Chojnacka, Monika, Cirrincione, Anthony, Durante, Michael, Tilmont, Remi, Barakat, Elie, Poorebrahim, Mansour, Landgren, Ola, Einsele, Hermann, Alberge, Jean-Baptiste, Keats, Jonathan, Rasche, Leo, Maura, Francesco, Neri, Paola, Bahlis, Nizar

Source: In Clinical Lymphoma, Myeloma and Leukemia September 2023 23 Supplement 2:S48-S48

OA-24 Sequential and persistent loss of BCMA and GPRC5D after bispecific antibodies in multiple myeloma revealed by whole genome sequencing

Authors: Rasche, Leo, Truger, Marietta, Munawar, Umair, Helal, Moutaz, Han, Seungbin, Zhou, Xiang, Eisele, Florian, Riedhammer, Christine, Duell, Johannes, Meggendorfer, Manja, Müller, Heiko, Waldschmidt, Johannes, Mersi, Julia, Panther, Franziska, Rosenwald, Andreas, Haferlach, Claudia, Einsele, Hermann, Kortüm, Martin

Source: In Clinical Lymphoma, Myeloma and Leukemia September 2023 23 Supplement 2:S15-S15

How Whole Genome and Transcriptome Sequencing (WGTS) Can Contribute to Unsolved Cases in Hematology That Have Undergone Extensive Standard Diagnostic Workup: A Prospective Head-to-Head Study

Authors: Truger, Marietta ^*, Meggendorfer, Manja, Walter, Wencke ^*, Hutter, Stephan ^*, Baer, Constance, Nadarajah, Niroshan ^*, Kern, Wolfgang, Haferlach, Claudia, Haferlach, Torsten

Source: In Blood 15 November 2022 140 Supplement 1:7824-7825

Detecting the Unusual without Compromising Diagnostic Accuracy - a Prospective WGS/Wts Pilot Study in Acute Leukemias Provided Additional Information for Diagnosis, Prognosis and Treatment

Authors: Meggendorfer, Manja, Truger, Marietta ^*, Walter, Wencke ^*, Baer, Constance, Hutter, Stephan ^*, Nadarajah, Niroshan ^*, Kern, Wolfgang, Haferlach, Torsten, Haferlach, Claudia

Source: In Blood 15 November 2022 140 Supplement 1:4959-4960

Advanced Risk Stratification in Multiple Myeloma Beyond Traditional FISH: The First Prospective Real-World Evidence for SKY92 Gene Expression Profiling

Authors: Zhou, Xiang ^*, Hofmann, Annika ^*, Vogt, Cornelia ^*, Nerreter, Silvia ^*, Teufel, Eva ^*, Stanojkovska, Emilia ^*, Truger, Marietta ^*, Engel, Benedict ^*, Barcic, Anastasia ^*, Peter, Jessica ^*, Riedhammer, Christine ^*, Steinhardt, Max Johannes ^*, Xiao, Xianghui ^*, Hornburger, Hannah ^*, Han, Seungbin ^*, Haertle, Larissa ^*, Munawar, Umair ^*, Mersi, Julia ^*, Haferlach, Claudia, Einsele, Hermann, Rasche, Leo ^*, Kortuem, K. Martin ^*

Source: In Blood 15 November 2022 140 Supplement 1:4273-4274

Multiomic Analysis of CD38 Expression Levels in 209 Untreated and Daratumumab-Resistant Patients

Authors: Steinhardt, Max Johannes ^*, Eiring, Patrick ^*, Munawar, Umair ^*, Haertle, Larissa ^*, Han, Seungbin ^*, Vogt, Cornelia ^*, Nerreter, Silvia ^*, Teufel, Eva ^*, Mersi, Julia ^*, Bittrich, Max, Danhof, Sophia ^*, Truger, Marietta ^*, Haaf, Thomas ^*, Barrio, Santiago ^*, Zhou, Xiang ^*, Martínez-López, Joaquín ^*, Haferlach, Claudia, Hudecek, Michael ^*, Einsele, Hermann, Rasche, Leo ^*, Sauer, Markus ^*, Kortuem, K. Martin ^*

Source: In Blood 15 November 2022 140 Supplement 1:4230-4231

Impaired Death Receptor Signaling Mediates Cross-Resistance to Immunotherapy in MM

Authors: Munawar, Umair ^*, Zhou, Xiang ^*, Prommersberger, Sabrina ^*, Steinhardt, Max Johannes ^*, Mersi, Julia ^*, Bittrich, Max, Nerreter, Silvia ^*, Vogt, Cornelia ^*, Teufel, Eva ^*, Han, Seungbin ^*, Haertle, Larissa ^*, Eiring, Patrick ^*, Banholzer, Nicole ^*, Danhof, Sophia ^*, Fernández-Martín, Adrián ^*, Truger, Marietta ^*, Barrio, Santiago ^*, Gallardo, Miguel ^*, Valeri, Antonio ^*, Castellano, Eva ^*, Raab, Peter ^*, Haferlach, Claudia, Sauer, Markus ^*, Hudecek, Michael ^*, Martinez-Lopez, Joaquin ^*, Einsele, Hermann, Rasche, Leo ^*, Kortuem, Martin ^*

Source: In Blood 15 November 2022 140 Supplement 1:4226-4227

FISH and WGS in Newly Diagnosed and Relapsed/Refractory Multiple Myeloma - WGS Will Affect Future Treatment Decisions

Authors: Truger, Marietta, Hutter, Stephan, Meggendorfer, Manja, Kortuem, K. Martin, Nadarajah, Niroshan, Walter, Wencke, Baer, Constance, Rasche, Leo, Kern, Wolfgang, Haferlach, Torsten, Einsele, Hermann, Haferlach, Claudia

Source: In Blood 23 November 2021 138 Supplement 1:397-397

P814: ANALYSIS OF TP53 ALTERATIONS BY WGS REVEALS BIALLELIC 17P DELETIONS IN MULTIPLE MYELOMA.

Authors: Truger, Marietta, Hutter, Stephan, Walter, Wencke, Zhou, Xiang, Riedhammer, Christine, Meggendorfer, Manja, Müller, Heiko, Kern, Wolfgang, Haferlach, Torsten, Einsele, Hermann, Martin Kortum, K, Haferlach, Claudia, Rasche, Leo

Source: HemaSphere; 2023 Supplement 3, Vol. 7, p1-2, 2p

P890: COMBINING SKY92 GENE EXPRESSION PROFILING WITH CYTOGENETICS ACCORDING TO R2‐ISS FOR MULTIPLE MYELOMA RISK CLASSIFICATION: THE FIRST PROSPECTIVE EVIDENCE.

Authors: Zhou, Xiang, Engel, Benedict, Hofmann, Annika, Vogt, Cornelia, Nerreter, Silvia, Teufel, Eva, Stanojkovska, Emilia, Truger, Marietta, Weis, Philipp, Xiao, Xianghui, Eisele, Florian, Riedhammer, Christine, Johannes Steinhardt, Maximilian, Munawar, Umair, Han, Seungbin, Haertle, Larissa, Haferlach, Claudia, Einsele, Hermann, Martin Kortum, K, Rasche, Leo

Source: HemaSphere; 2023 Supplement 3, Vol. 7, p1-2, 2p

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