Lessons and gaps in the prediction and prevention of type 1 diabetes

Authors: Mameli, Chiara, Triolo, Taylor M., Chiarelli, Francesco, Rewers, Marian, Zuccotti, Gianvincenzo, Simmons, Kimber M.

Source: In Pharmacological Research July 2023 193

Genetic Associations With C-peptide Levels Before Type 1 Diabetes Diagnosis in At-risk Relatives.

Authors: Triolo, Taylor M, Parikh, Hemang M, Tosur, Mustafa, Ferrat, Lauric A, You, Lu, Gottlieb, Peter A, Oram, Richard A, Onengut-Gumuscu, Suna, Krischer, Jeffrey P, Rich, Stephen S, Steck, Andrea K, Redondo, Maria J

Source: Journal of Clinical Endocrinology & Metabolism; Apr2025, Vol. 110 Issue 4, pe1046-e1050, 5p

Subject Terms: C-peptide, TYPE 1 diabetes, SINGLE nucleotide polymorphisms, GLUCOSE tolerance tests, AUTOANTIBODIES, DISEASE risk factors, CLINICAL trials, GENETIC correlations

Proinsulin:C-peptide ratio trajectories over time in relatives at increased risk of progression to type 1 diabetes

Authors: Triolo, Taylor M., Pyle, Laura, Seligova, Sona, Yu, Liping, Simmons, Kimber, Gottlieb, Peter, Evans-Molina, Carmella, Steck, Andrea K.

Source: In Journal of Translational Autoimmunity 2021 4

Effect of Oral Insulin on Early Combined Glucose and C‐Peptide Endpoints in Individuals at High‐Risk for Type 1 Diabetes.

Authors: Triolo, Taylor M.¹ taylor.triolo@cuanschutz.edu, Jacobsen, Laura M.² lauraj@ufl.edu, Cuthbertson, David³, Sims, Emily K.⁴, Ismail, Heba M.⁴, Redondo, Maria J.⁵, Lundgren, Markus⁶, DiMeglio, Linda A.⁴, Gottlieb, Peter A.¹, Atkinson, Mark A.⁷, Krischer, Jeffrey P.³, Schatz, Desmond A.², Sosenko, Jay M.⁸, Scaramuzza, Andrea a.scaramuzza@gmail.com

Source: Pediatric Diabetes. 10/3/2024, Vol. 2024, p1-6. 6p.

Subject Terms: *INSULIN therapy, *BLOOD sugar analysis, *TYPE 1 diabetes, *EARLY medical intervention, *RESEARCH funding, *DATA analysis, *CLINICAL trials, *GLUCOSE tolerance tests, *PROBABILITY theory, *ORAL drug administration, *CHI-squared test, *DESCRIPTIVE statistics, *C-peptide, *DRUG efficacy, *RESEARCH, *STATISTICS, *ANALYSIS of variance, *DATA analysis software, *BIOMARKERS, *REGRESSION analysis, *EVALUATION

Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity.

Authors: Triolo, Taylor M.¹ (AUTHOR) taylor.triolo@cuanschutz.edu, Matuschek, J. Quinn¹ (AUTHOR), Castro-Gutierrez, Roberto¹ (AUTHOR), Shilleh, Ali H.¹ (AUTHOR), Williams, Shane P. M.¹ (AUTHOR), Hansen, Maria S.¹ (AUTHOR), McDaniel, Kristen¹ (AUTHOR), Barra, Jessie M.¹ (AUTHOR), Michels, Aaron¹ (AUTHOR), Russ, Holger A.¹ (AUTHOR)

Source: Cells (2073-4409). Dec2022, Vol. 11 Issue 23, p3845. 16p.

Subject Terms: *IMMUNE response, *TYPE 1 diabetes, *PANCREATIC beta cells, *PLURIPOTENT stem cells, *HUMAN stem cells, *T cells

Longitudinal Quality of Life and Glycemic Outcomes of Total Pancreatectomy With Islet Autotransplantation in Children With Chronic Pancreatitis Followed in a Pediatric Multidisciplinary Pancreas Clinic.

Authors: Khatter, Neil J., Hum, Stephanie W., Mark, Jacob A., Forlenza, Gregory, Triolo, Taylor M.

Source: Pediatric Transplantation; Aug2024, Vol. 28 Issue 5, p1-8, 8p

Subject Terms: PANCREATECTOMY, CHRONIC pancreatitis, AUTOTRANSPLANTATION, CHILD patients, QUALITY of life, INSULIN therapy

Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes.

Authors: Virostko, John, Wright, Jordan J., Williams, Jonathan M., Hilmes, Melissa A., Triolo, Taylor M., Broncucia, Hali, Du, Liping, Kang, Hakmook, Nallaparaju, Shreya, Valencia, Leah Galvez, Reyes, Demetra, Hammel, Brenna, Russell, William E., Philipson, Louis H., Waibel, Michaela, Kay, Thomas W.H., Thomas, Helen E., Greeley, Siri Atma W., Steck, Andrea K., Powers, Alvin C.

Source: Diabetes Care; Mar2024, Vol. 47 Issue 3, p393-400, 8p

Subject Terms: TYPE 1 diabetes, PANCREAS, RECEIVER operating characteristic curves, DISEASE risk factors, GLUCOSE tolerance tests

Increased Technology Use Associated With Lower A1C in a Large Pediatric Clinical Population.

Authors: Alonso, G. Todd¹ guy.alonso@cuanschutz.edu, Triolo, Taylor M.¹, Akturk, Halis Kaan¹, Pauley, Meghan E.¹, Sobczak, Marisa², Forlenza, Gregory P.¹, Sakamoto, Casey¹, Pyle, Laura^1,3, Frohnert, Brigitte I.¹

Source: Diabetes Care. Jun2023, Vol. 46 Issue 6, p1218-1222. 5p. 1 Chart, 3 Graphs.

Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System

Authors: Hudish, Laura I., Bubak, Andrew, Triolo, Taylor M., Niemeyer, Christy S., Lorberbaum, David S., Sussel, Lori, Nagel, Maria, Taliaferro, J. Matthew, Russ, Holger A.

Source: In Stem Cell Reports 9 June 2020 14(6):1033-1043

Association of High-Affinity Autoantibodies With Type 1 Diabetes High-Risk HLA Haplotypes.

Authors: Triolo, Taylor M., Pyle, Laura, Broncucia, Hali, Armstrong, Taylor, Liping Yu, Gottlieb, Peter A., Steck, Andrea K.

Source: Journal of Clinical Endocrinology & Metabolism; Apr2022, Vol. 107 Issue 4, pe1510-e1517, 8p

ENTPD3 Marks Mature Stem Cell-Derived β-Cells Formed by Self-Aggregation In Vitro.

Authors: Docherty, Fiona M., Riemondy, Kent A., Castro-Gutierrez, Roberto, Dwulet, JaeAnn M., Shilleh, Ali H., Hansen, Maria S., Williams, Shane P.M., Armitage, Lucas H., Santostefano, Katherine E., Wallet, Mark A., Mathews, Clayton E., Triolo, Taylor M., Benninger, Richard K.P., Russ, Holger A.

Source: Diabetes; Nov2021, Vol. 70 Issue 11, p2554-2567, 14p

Subject Terms: ADULTS, CELLULAR therapy, DIABETES, PEOPLE with diabetes, CALCIUM metabolism, RESEARCH, DNA, RESEARCH methodology, EVALUATION research, ADENOSINE triphosphatase, ISLANDS of Langerhans, COMPARATIVE studies, STEM cells, GENES, GENE expression profiling, RESEARCH funding

Development of a standardized MRI protocol for pancreas assessment in humans.

Authors: Virostko, John, Craddock, Richard C., Williams, Jonathan M., Triolo, Taylor M., Hilmes, Melissa A., Kang, Hakmook, Du, Liping, Wright, Jordan J., Kinney, Mara, Maki, Jeffrey H., Medved, Milica, Waibel, Michaela, Kay, Thomas W. H., Thomas, Helen E., Greeley, Siri Atma W., Steck, Andrea K., Moore, Daniel J., Powers, Alvin C.

Source: PLoS ONE; 8/24/2021, Vol. 16 Issue 8, p1-16, 16p

Subject Terms: ARTIFICIAL pancreases, PANCREAS, MAGNETIC resonance imaging, IMAGE processing, TYPE 1 diabetes, MAGNETIZATION transfer

Lessons from Human Islet Transplantation Inform Stem Cell-Based Approaches in the Treatment of Diabetes.

Authors: Triolo, Taylor M., Bellin, Melena D.

Source: Frontiers in Endocrinology; 3/11/2021, Vol. 11, pN.PAG-N.PAG, 7p

Subject Terms: GLUCOSE clamp technique, ISLANDS of Langerhans, PANCREATIC beta cells, PLURIPOTENT stem cells, INSULIN sensitivity, HUMAN stem cells, BACTERIAL vaccines

Risk of Islet and Celiac Autoimmunity in Cotwins of Probands With Type 1 Diabetes.

Authors: Triolo, Taylor M, Pyle, Laura, Seligova, Sona, Yu, Liping, Gottlieb, Peter A, Steck, Andrea K

Source: Journal of the Endocrine Society; Jun2020, Vol. 4 Issue 6, p1-9, 9p

Subject Terms: AUTOIMMUNITY, TYPE 1 diabetes, TWINS

Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System

Authors: Hudish, Laura I., Bubak, Andrew, Triolo, Taylor M., Niemeyer, Christy S., Lorberbaum, David S., Sussel, Lori, Nagel, Maria, Taliaferro, J. Matthew, Russ, Holger A.

Source: In Stem Cell Reports 13 April 2021 16(4):1009-1009

Identical and Nonidentical Twins: Risk and Factors Involved in Development of Islet Autoimmunity and Type 1 Diabetes.

Authors: Triolo, Taylor M.¹ triolo@childrenscolorado.org, Fouts, Alexandra¹, Pyle, Laura², Liping Yu¹, Gottlieb, Peter A.¹, Steck, Andrea K.¹, Yu, Liping, Type 1 Diabetes TrialNet Study Group

Source: Diabetes Care. Feb2019, Vol. 42 Issue 2, p192-199. 8p. 2 Charts, 2 Graphs.

Subject Terms: *AUTOANTIBODY analysis, *AUTOANTIBODIES, *COMPARATIVE studies, *DISEASE susceptibility, *ECOLOGY, *ENZYMES, *EPIDEMIOLOGICAL research, *IMMUNITY, *INSULIN, *TYPE 1 diabetes, *ISLANDS of Langerhans, *RESEARCH methodology, *MEDICAL cooperation, *MEDICAL screening, *RESEARCH, *TWINS, *SYMPTOMS, *EVALUATION research, *DISEASE progression

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