Rethinking Optimal Immunogens to Face SARS‐CoV‐2 Evolution Through Vaccination.

Authors: Blanco, Julià^1,2,3,4 (AUTHOR) jblanco@irsicaixa.es, Trinité, Benjamin¹ (AUTHOR), Puig‐Barberà, Joan⁵ (AUTHOR)

Source: Influenza & Other Respiratory Viruses. Jan2025, Vol. 19 Issue 1, p1-10. 10p.

Subject Terms: *SARS-CoV-2, *BOOSTER vaccines, *VIRAL ecology, *IMMUNOGENETICS, *COVID-19, *ANTIBODY formation, *VACCINATION, *BINDING sites

Initial antigen encounter determines robust T-cell immunity against SARS-CoV-2 BA.2.86 variant three years later

Authors: Rubio, Rocío ^{a, b}, Yavlinsky, Alexei ^c, Escalera Zamudio, Marina ^d, Molinos-Albert, Luis M. ^{a, b}, Martín Pérez, Carla ^{a, b}, Pradenas, Edwards ^e, Canyelles, Mar ^{a, b}, Torres, Cèlia ^{a, b}, Tan, Cedric ^d, Swadling, Leo ^f, Ramírez-Morros, Anna ^g, Trinité, Benjamin ^e, Vidal-Alaball, Josep ^{h, i}, Aguilar, Ruth ^{a, b}, Ruiz-Comellas, Anna ^{g, h, i}, Blanco, Julià ^{e, j, k, l}, van Dorp, Lucy ^d, Balloux, François ^d, Dobaño, Carlota ^{a, b, l, ⁎}, Moncunill, Gemma ^{a, b, l, ⁎}

Source: In Journal of Infection February 2025 90(2)

Efficacy and safety of mRNA1273 SARS-CoV-2 vaccination in hematopoietic stem cell transplant recipients: Single center experience

Alternate Title: Eficacia y seguridad de la vacuna mRNA1273 SARS-CoV-2 en pacientes receptores de un trasplante hematopoyético: experiencia de un centro (Spanish; Castilian)

Authors: Huguet, Maria, Boigues, Marc, Morgades, Mireia, Felip, Eudald, Morán, Teresa, Pradenas, Edwards, Marfil, Silvia, Trinité, Benjamin, Sorigué, Marc, Torrent, Anna, Abril, Laura, Blanco, Julià, Sancho, Juan-Manuel, Quirant, Bibiana, Ferrà, Christelle

Source: In Medicina Clinica 12 April 2024 162(7):313-320

Impact of chemotherapy and/or immunotherapy on neutralizing antibody response to SARS‐CoV‐2 mRNA‐1237 vaccine in patients with solid tumors

Authors: Felip, Eudald, Pradenas, Edwards, Romeo, Margarita, Marfil, Silvia, Trinité, Benjamin, Urrea, Víctor, Hernández, Ainhoa, Ballana, Ester, Cucurull, Marc, Mateu, Lourdes, Massanella, Marta, Clotet, Bonaventura, Morán, Teresa, Blanco, Julià

Source: Molecular oncology. 17(4):686-694

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182090230.0x000001&indx=1&recIds=ETOCvdc_100182090230.0x000001

Safety and immunogenicity of the protein-based PHH-1V compared to BNT162b2 as a heterologous SARS-CoV-2 booster vaccine in adults vaccinated against COVID-19: a multicentre, randomised, double-blind, non-inferiority phase IIb trial

Authors: Corominas, Júlia, Garriga, Carme, Prenafeta, Antoni, Moros, Alexandra, Cañete, Manuel, Barreiro, Antonio, González-González, Luis, Madrenas, Laia, Güell, Irina, Clotet, Bonaventura, Izquierdo-Useros, Nuria, Raïch-Regué, Dàlia, Gallemí, Marçal, Blanco, Julià, Pradenas, Edwards, Trinité, Benjamin, Prado, Julia G., Blanch-Lombarte, Oscar, Pérez-Caballero, Raúl, Plana, Montserrat, Esteban, Ignasi, Pastor-Quiñones, Carmen, Núñez-Costa, Xavier, Taleb, Rachel Abu, McSkimming, Paula, Soriano, Alex, Nava, Jocelyn, Anagua, Jesse Omar, Ramos, Rafel, Lluch, Ruth Martí, Comes, Aida Corpes, Romero, Susana Otero, Gomez, Xavier Martinez, Sans-Pola, Carla, Moltó, José, Benet, Susana, Bailón, Lucía, Arribas, Jose R., Borobia, Alberto M., Parada, Javier Queiruga, Navarro-Pérez, Jorge, Forner Giner, Maria José, Lucas, Rafael Ortí, Jiménez, María del Mar Vázquez, Compán, Salvador Oña, Alvarez-Mon, Melchor, Troncoso, Daniel, Arana-Arri, Eunate, Meijide, Susana, Imaz-Ayo, Natale, García, Patricia Muñoz, de la Villa Martínez, Sofía, Fernández, Sara Rodríguez, Prat, Teresa, Torroella, Èlia, Ferrer, Laura

Source: In The Lancet Regional Health - Europe May 2023 28

Impact of hybrid immunity booster vaccination and Omicron breakthrough infection on SARS-CoV-2 VOCs cross-neutralization

Authors: Pradenas, Edwards ¹, Marfil, Silvia ¹, Urrea, Víctor ¹, Trigueros, Macedonia ¹, Pidkova, Tetyana ¹, Pons-Grífols, Anna ¹, Ortiz, Raquel ¹, Rovirosa, Carla ¹, Tarrés-Freixas, Ferran ¹, Aguilar-Gurrieri, Carmen ¹, Toledo, Ruth ², Chamorro, Anna ², Noguera-Julian, Marc ¹, Mateu, Lourdes ², Blanco, Ignacio ³, Grau, Eulàlia ¹, Massanella, Marta ^{1, 4, 5}, Carrillo, Jorge ¹, Clotet, Bonaventura ^{1, 2, 4}, Trinité, Benjamin ^{1, 6, 7, ∗}, Blanco, Julià ^{1, 4, 5, 6, ∗∗}

Source: In iScience 21 April 2023 26(4)

Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2

Authors: Barreiro, Antonio ^{1, 11, ∗}, Prenafeta, Antoni ^{1, 11, 12, ∗∗}, Bech-Sabat, Gregori ¹, Roca, Mercè ¹, Perozo Mur, Eva ¹, March, Ricard ¹, González-González, Luis ¹, Madrenas, Laia ¹, Corominas, Júlia ¹, Fernández, Alex ¹, Moros, Alexandra ¹, Cañete, Manuel ¹, Molas, Mercè ¹, Pentinat-Pelegrin, Thais ¹, Panosa, Clara ¹, Moreno, Alberto ¹, Puigvert Molas, Ester ¹, Pol Vilarrassa, Eva ¹, Palmada, Jordi ¹, Garriga, Carme ¹, Prat Cabañas, Teresa ¹, Iglesias-Fernández, Javier ², Vergara-Alert, Júlia ³, Lorca-Oró, Cristina ³, Roca, Núria ³, Fernández-Bastit, Leira ³, Rodon, Jordi ³, Pérez, Mònica ³, Segalés, Joaquim ^{4, 5}, Pradenas, Edwards ⁶, Marfil, Silvia ⁶, Trinité, Benjamin ⁶, Ortiz, Raquel ⁶, Clotet, Bonaventura ^{6, 7}, Blanco, Julià ^{6, 7}, Díaz Pedroza, Jorge ⁸, Ampudia Carrasco, Rosa ⁸, Rosales Salgado, Yaiza ⁸, Loubat-Casanovas, Jordina ⁸, Capdevila Larripa, Sara ⁸, Prado, Julia Garcia ^{6, 8}, Barretina, Jordi ⁸, Sisteré-Oró, Marta ⁹, Cebollada Rica, Paula ⁹, Meyerhans, Andreas ^{9, 10}, Ferrer, Laura ¹

Source: In iScience 17 March 2023 26(3)

Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals

Authors: Ainsua-Enrich, Erola, Pedreño-Lopez, Núria, Bracke, Carmen, Ávila-Nieto, Carlos, Rodríguez de la Concepción, María Luisa, Pradenas, Edwards, Trinité, Benjamin, Marfil, Silvia, Miranda, Cristina, González, Sandra, Toledo, Ruth, Font, Marta, Benet, Susana, Escribà, Tuixent, Jimenez-Moyano, Esther, Peña, Ruth, Cedeño, Samandhy, Prado, Julia G., Mothe, Beatriz, Brander, Christian, Izquierdo-Useros, Nuria, Vergara-Alert, Julia, Segalés, Joaquim, Massanella, Marta, Benitez, Rosa María, Romero, Alba, Molina-Morant, Daniel, Blanco, Julià, Clotet, Bonaventura, Mateu, Lourdes, Pedro-Botet, María Luisa, Carrillo, Jorge

Source: In iScience 18 November 2022 25(11)

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and humoral responses against different variants of concern in domestic pet animals and stray cats from North‐Eastern Spain

Authors: Fernández‐Bastit, Leira, Marfil, Silvia, Pradenas, Edwards, Valle, Rosa, Roca, Núria, Rodon, Jordi, Pailler‐García, Lola, Trinité, Benjamin, Parera, Mariona, Noguera‐Julian, Marc, Martorell, Jaume, Izquierdo‐Useros, Nuria, Carrillo, Jorge, Clotet, Bonaventura, Blanco, Julià, Vergara‐Alert, Júlia, Segalés, Joaquim

Source: Transboundary and emerging diseases. 69(6):3518-3529

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189620300.0x000001&indx=1&recIds=ETOCvdc_100189620300.0x000001

High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

Authors: Ferrer, Susana, Gallardo, Mireia, Ubals, Maria, González-Beiras, Camila, Vall-Mayans, Martí, Suñer, Clara, Laporte-Villar, Clàudia, Nieto, Aroa, Comas-Leon, Xavier, Jiménez, Zahida, Ramírez-Viaplana, Ferran, Delgado-Capel, Maria, Díez Sánchez, Beatriz, Pons Barber, Maria, Gonzalez Ruiz, Cristian, Navarrete Gonzalez, Laura, González García, David, Vivero Larraza, Ainhoa, Carceles Peiró, Victor, Roquer López, Clàudia, Robert, Neus, Palet, Carles, Gudiol, Carlota, Casares Gonzalez, Pablo, Arcos Vila, Gemma, Flores Aguilera, Begoña, Rodríguez-Sevilla, Graciela, Dastis Arias, Macarena, Roca Font, Judit, Carrasco Matos, Katherine M., Saüch Valmaña, Glòria, Vidal Obradors, Carla, Tarres García, Silvia, Curriu Sabatès, Margarida, Nieto Rodríguez, Raquel, Línio, Rosa, Fornos, Míriam, Casamitjana, Natàlia, Alonso, Eva, Martínez, Núria, Maglio, Laura Analía, Comellas Fernandez, Laura, Garcia, Nadia, Hernández, Luis, González, Maria Isabel, Bravo, Anna, García, Yolanda, Sauleda Oliveras, Silvia, Vertiz, Tatiana, Benavent, Sergio, Bianco, Andrea Sofia, Verdaguer, Joaquim, Briones Zambrano, Ney Nicanor, Viozquez Meya, Maria, Hernández, Águeda, Casaña Lopez, Cristina, Bordoy, Antoni E., González Soler, Victoria, Giménez, Montserrat, París, Alexa, Marfil, Silvia, Trinité, Benjamin, Grau, Eulàlia, Alemany, Andrea ^{*, *}, Millat-Martinez, Pere ^*, Corbacho-Monné, Marc, Malchair, Pierre, Ouchi, Dan, Ruiz-Comellas, Anna, Ramírez-Morros, Anna, Rodríguez Codina, Joana, Amado Simon, Rosa, Videla, Sebastian, Costes, Gèlia, Capdevila-Jáuregui, Mar, Torrano-Soler, Pamela, San José, Alba, Bonet Papell, Glòria, Puig, Jordi, Otero, Aurema, Ruibal Suarez, Jose Carlos, Zarauza Pellejero, Alvaro, Llopis Roca, Ferran, Rodriguez Cortez, Orlando, Garcia Garcia, Vanesa, Vidal-Alaball, Josep, Millan, Anna, Contreras, Enric, Grifols, Joan-Ramon, Ancochea, Àgueda, Galvan-Femenia, Ivan, Piccolo Ferreira, Francini, Bonet, Mireia, Cantoni, Jordi, Prat, Núria, Ara, Jordi, Forcada Arcarons, Anna, Farré, Magí, Pradenas, Edwards, Blanco, Julià, Àngel Rodriguez-Arias, Miquel, Fernández Rivas, Gema, Marks, Michael, Bassat, Quique, Blanco, Ignacio, Baro, Bàrbara ^*, Clotet, Bonaventura ^*, Mitjà, Oriol

Source: In The Lancet Respiratory Medicine March 2022 10(3):278-288

PSGL-1 restricts HIV-1 infectivity by blocking virus particle attachment to target cells

Authors: Fu, Yajing, He, Sijia, Waheed, Abdul A., Dabbagh, Deemah, Zhou, Zheng, Trinité, Benjamin, Wang, Zhao, Yu, Jieshi, Wang, Dan, Li, Feng, Levy, David N., Shang, Hong, Freed, Eric O., Wu, Yuntao

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Apr . 117(17), 9537-9545.

Access URL: https://www.jstor.org/stable/26929961

Humoral and cellular immune responses after 6 months of a heterologous SARS-CoV-2 booster with the protein-based PHH-1V vaccine in a phase IIb trial

Authors: Corominas, Júlia ^{a, 1}, Garriga, Carme ^{a, 1}, Prenafeta, Antoni ^a, Moros, Alexandra ^{a, ⁎}, Cañete, Manuel ^a, Barreiro, Antonio ^a, González-González, Luis ^a, Madrenas, Laia ^a, Güell, Irina ^a, Clotet, Bonaventura ^{b, c}, Izquierdo-Useros, Nuria ^{b, d}, Raïch-Regué, Dàlia ^b, Gallemí, Marçal ^b, Blanco, Julià ^{b, c, d, e}, Pradenas, Edwards ^b, Trinité, Benjamin ^{b, d}, G. Prado, Julia ^{b, d, e}, Pérez-Caballero, Raúl ^{b, e}, Bernad, Laia ^b, Plana, Montserrat ^{d, f}, Esteban, Ignasi ^f, Aurrecoechea, Elena ^f, Taleb, Rachel Abu ^g, McSkimming, Paula ^f, Soriano, Alex ^{d, h}, Nava, Jocelyn ^h, Anagua, Jesse Omar ^h, Ramos, Rafel ^{i, j}, Martí Lluch, Ruth ^{i, j}, Corpes Comes, Aida ⁱ, Otero Romero, Susana ^{k, l, m}, Martínez-Gómez, Xavier ^{k, l}, Camacho-Arteaga, Lina ^k, Molto, Jose ⁿ, Benet, Susana ⁿ, Bailón, Lucía ⁿ, Arribas, Jose R. ^{d, o}, Borobia, Alberto M. ^{d, p, q}, Queiruga Parada, Javier ^{p, q}, Navarro-Pérez, Jorge ^r, Forner Giner, Maria José ^r, Lucas, Rafael Ortí ^r, Vázquez Jiménez, María del Mar ^s, López Fernández, María Jesús ^s, Alvarez-Mon, Melchor ^t, Troncoso, Daniel ^t, Arana-Arri, Eunate ^u, Meijide, Susana ^u, Imaz-Ayo, Natale ^u, García, Patricia Muñoz ^{v, w}, de la Villa, Sofía ^v, Rodríguez Fernández, Sara ^v, Prat, Teresa ^a, Torroella, Èlia ^a, Ferrer, Laura ^a

Source: In Vaccine 15 February 2025 47

Omicron XBB.1.16-Adapted Vaccine for COVID-19: Interim Immunogenicity and Safety Clinical Trial Results.

Authors: López Fernández, María Jesús, Narejos, Silvia, Castro, Antoni, Echave-Sustaeta, José María, Forner, María José, Arana-Arri, Eunate, Molto, José, Bernad, Laia, Pérez-Caballero, Raúl, Prado, Julia G., Raïch-Regué, Dàlia, Boreika, Rytis, Izquierdo-Useros, Nuria, Trinité, Benjamin, Blanco, Julià, Puig-Barberà, Joan, Natalini Martínez, Silvina

Source: Vaccines; Aug2024, Vol. 12 Issue 8, p840, 16p

Subject Terms: COVID-19, SARS-CoV-2 Omicron variant, BOOSTER vaccines, COVID-19 pandemic, COVID-19 vaccines

NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal

Authors: Trinité, Benjamin, Zhang, Hongtao, Levy, David

Source: Retrovirology. 16(1):1-11

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189163072.0x000001&indx=1&recIds=ETOCvdc_100189163072.0x000001

Reduced humoral response 3 months following BNT162b2 vaccination in SARS-CoV-2 uninfected residents of long-term care facilities

Authors: Trigueros, Macedonia, Pradenas, Edwards, Palacín, Dolors, Muñoz-López, Francisco, Ávila-Nieto, Carlos, Trinité, Benjamin, Bonet-Simó, Josep Maria, Isnard, Mar, Moreno, Nemesio, Marfil, Silvia, Rovirosa, Carla, Puig, Teresa, Grau, Eulàlia, Chamorro, Anna, Martinez, Ana, Toledo, Ruth, Font, Marta, Ara, Jordi, Carrillo, Jorge, Mateu, Lourdes, Blanco, Julià, Clotet, Bonaventura, Prat, Nuria, Massanella, Marta

Source: Age and ageing. 51(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165584278.0x000001&indx=1&recIds=ETOCvdc_100165584278.0x000001

Production and Immunogenicity of FeLV Gag-Based VLPs Exposing a Stabilized FeLV Envelope Glycoprotein.

Authors: Ortiz, Raquel, Barajas, Ana, Pons-Grífols, Anna, Trinité, Benjamin, Tarrés-Freixas, Ferran, Rovirosa, Carla, Urrea, Víctor, Barreiro, Antonio, Gonzalez-Tendero, Anna, Rovira-Rigau, Maria, Cardona, Maria, Ferrer, Laura, Clotet, Bonaventura, Carrillo, Jorge, Aguilar-Gurrieri, Carmen, Blanco, Julià

Source: Viruses (1999-4915); Jun2024, Vol. 16 Issue 6, p987, 14p

Subject Terms: FELINE leukemia virus, IMMUNE response, GLYCOPROTEINS, HUMORAL immunity, MEMBRANE proteins, DNA vaccines, VIRAL envelope proteins

VLPs generated by the fusion of RSV-F or hMPV-F glycoprotein to HIV-Gag show improved immunogenicity and neutralizing response in mice.

Authors: Trinité, Benjamin¹ (AUTHOR) btrinite@irsicaixa.es, Durr, Eberhard² (AUTHOR), Pons-Grífols, Anna¹ (AUTHOR), O'Donnell, Gregory² (AUTHOR), Aguilar-Gurrieri, Carmen¹ (AUTHOR), Rodriguez, Silveria² (AUTHOR), Urrea, Victor¹ (AUTHOR), Tarrés, Ferran¹ (AUTHOR), Mane, Joel² (AUTHOR), Ortiz, Raquel¹ (AUTHOR), Rovirosa, Carla¹ (AUTHOR), Carrillo, Jorge¹ (AUTHOR), Clotet, Bonaventura^1,3 (AUTHOR), Zhang, Lan^1,2 (AUTHOR) lan_zhang2@merck.com, Blanco, Julià^1,3,4,5 (AUTHOR) jblanco@irsicaixa.es

Source: Vaccine. May2024, Vol. 42 Issue 15, p3474-3485. 12p.

Subject Terms: *RESPIRATORY syncytial virus, *IMMUNE response, *PREGNANT women, *GAG proteins, *RESPIRATORY syncytial virus infection vaccines, *OLDER people, *VIRUS-like particles

Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal models.

Authors: Usai, Carla, Ainsua-Enrich, Erola, Gales, Victor Urrea, Pradenas, Edwards, Lorca-Oró, Cristina, Tarrés-Freixas, Ferran, Roca, Núria, Pérez, Mónica, Ávila-Nieto, Carlos, Rodríguez de la Concepción, María Luisa, Pedreño-Lopez, Núria, Carabelli, Julieta, Trinité, Benjamin, Ballana, Ester, Riveira-Muñoz, Eva, Izquierdo-Useros, Nuria, Clotet, Bonaventura, Blanco, Julià, Guallar, Victor, Cantero, Guillermo

Source: NPJ Vaccines; 2/27/2024, Vol. 9 Issue 1, p1-12, 12p

Subject Terms: IMMUNIZATION, BOOSTER vaccines, VACCINE effectiveness, COVID-19 vaccines, SARS-CoV-2, MICE, NUCLEOPROTEINS, HAMSTERS

Virus-like particle-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice.

Authors: Barajas, Ana, Amengual-Rigo, Pep, Pons-Grífols, Anna, Ortiz, Raquel, Gracia Carmona, Oriol, Urrea, Victor, de la Iglesia, Nuria, Blanco-Heredia, Juan, Anjos-Souza, Carla, Varela, Ismael, Trinité, Benjamin, Tarrés-Freixas, Ferran, Rovirosa, Carla, Lepore, Rosalba, Vázquez, Miguel, de Mattos-Arruda, Leticia, Valencia, Alfonso, Clotet, Bonaventura, Aguilar-Gurrieri, Carmen, Guallar, Victor

Source: Journal of Translational Medicine; 1/3/2024, Vol. 22 Issue 1, p1-14, 14p

Subject Terms: IMMUNE response, T cell receptors, BACTERIAL vaccines, OPTIMIZATION algorithms, SOMATIC mutation, CANCER vaccines, VIRUS-like particles

Critical Presentation of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection: A Case Report

Authors: Massanella, Marta, Martin-Urda, Anabel, Mateu, Lourdes, Marín, Toni, Aldas, Irene, Riveira-Muñoz, Eva, Kipelainen, Athina, Jiménez-Moyano, Esther, Rodriguez de la Concepción, Maria Luisa, Avila-Nieto, Carlos, Trinité, Benjamin, Pradenas, Edwards, Rodon, Jordi, Marfil, Silvia, Parera, Mariona, Carrillo, Jorge, Blanco, Julià, Prado, Julia G, Ballana, Ester, Vergara-Alert, Júlia, Segalés, Joaquim, Noguera-Julian, Marc, Masabeu, Àngels, Clotet, Bonaventura, Toda, Maria de la Roca, Paredes, Roger

Source: Open forum infectious diseases. 8(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135863711.0x000001&indx=1&recIds=ETOCvdc_100135863711.0x000001